[Ukrainians Refugees: how to address their health needs in times of migration crisis?] / Réfugiés d'Ukraine : comment répondre à leurs besoins de santé en période de crise migratoire ?

February 2022: Russia attacks Ukraine. Anticipating the wave of refugees generated by this war, the Geneva University Hospitals create a Ukraine Task Force. In this context, the Programme Santé Migrants (PSM), a reference consultation for refugees, realises that it will not be able to cope with the number of those coming from Ukraine in addition to the others, and creates a parallel structure: the PSM bis. The article describes how it was set up and the challenges that were faced, in particular: express training of staff in ambulatory medicine in a context of migratory crisis, focus on early identification of mental health problems and their management. This experience highlights the importance of a coordinated, interdisciplinary, and culturally adapted approach to responding to a crisis situation.

Février 2022 : la Russie attaque l'Ukraine. Anticipant la vague de réfugiés générée par cette guerre, les Hôpitaux universitaires de Genève créent une Task Force Ukraine. Dans ce contexte, le Programme santé migrants (PSM), consultation de référence pour les réfugiés, réalise qu'il ne pourra pas faire face au nombre de ceux venant d'Ukraine en plus des autres et créé une structure parallèle : le PSM bis. L'article relate comment elle s'est mise en place et les défis qui ont été affrontés, notamment : formation express du personnel à la médecine ambulatoire dans un contexte de crise migratoire et focus sur l'identification précoce des problèmes de santé mentale et leur prise en charge. Cette expérience souligne l'importance d'une approche coordonnée, interprofessionnelle et culturellement adaptée, pour répondre à une situation de crise.

[New reimbursement criteria for vitamin D measurements: what about our migrant patients?] / Nouveaux critères de remboursement du dosage de la vitamine D : et nos patients migrants ?

Vitamin D deficiency is a global health burden, which has been subject to debate in recent years. Although its consequences on patients' general health are debatable, the association between severe vitamin D deficiency and osteomalacia are clearly established. Since the 1st of July 2022, blood testing in individuals who do not meet the recognized risk factors for deficiency is no longer reimbursed in Switzerland. Being a migrant (or refugee) does not constitute a risk factor even though it has repeated been shown that this population is at high risk of deficiency, in particular sever deficiency. This article aims to establish new recommendations for vitamin D deficiency diagnosis and substitution for this population. It is sometimes necessary to adapt our national recommendations to take into account our cultural diversity.

Le déficit en vitamine D est un problème de santé publique au cœur de l'actualité. Si les répercussions sur la santé générale des patients sont débattues, l'association entre déficit sévère et ostéomalacie est clairement établie. En Suisse, depuis le 1er juillet 2022, l'assurance obligatoire de soins ne rembourse plus son dosage sanguin, sauf si le patient présente des facteurs de risque avérés. Le fait d'être migrant (ou réfugié) n'est pas considéré comme l'un d'eux. Pourtant, plusieurs études attestent que cette population est à haut risque de déficit, notamment sévère. Cet article a pour but d'établir de nouvelles recommandations de dépistage et de substitution qui s'adaptent à cette population. Il est parfois nécessaire d'adapter les recommandations nationales pour prendre en compte la diversité culturelle populationnelle.

[Latest developments in the non-pharmacological treatment of depression - A more integrative approach]. / Nouveautés dans les traitements non pharmacologiques de la dépression - Place à une approche plus intégrative.

Non-pharmacological treatments of depression have become more widespread recently, especially for mild to moderate forms of depression. These complementary approaches are particularly interesting for patients who are reluctant to start an antidepressant. Novel approaches are found in psychotherapy, alternative treatments, plant-based treatments as well as the prevention of relapse through the use of digital tools. Some are even reimbursed by health insurance. However, these approaches are currently only applicable in combination with usual treatment, pharmacological or psychotherapy, as studies have shown that their efficiency in monotherapy is still limited.

L'intérêt pour les approches non pharmacologiques a augmenté ces dernières années dans la prise en charge des dépressions légères à modérées. Ces nouvelles approches sont intéressantes, notamment pour les patients qui peuvent être réticents à la prise d'un antidépresseur seul. Les nouveautés se trouvent dans les méthodes de psychothérapie, les traitements alternatifs, la phytothérapie ainsi que dans la prévention des rechutes par des outils digitaux. Certaines de ces approches sont remboursées par l'assurance-maladie obligatoire ou complémentaire. Néanmoins, elles restent des traitements complémentaires aux thérapies usuelles, soit pharmacologique et psychothérapeutique, car les preuves de leur efficacité en monothérapie sont encore limitées dans les études.

Nutritional Status and Obstacles to Healthy Eating Among Refugees in Geneva.

Refugees face various nutritional challenges during and after migration. This cross-sectional, mixed-methods study seeks to investigate the prevalence of undernutrition and obesity among refugees in Geneva, and to identify barriers to healthy eating. Anthropometric measurements of 354 adult refugees were collected between 2017 and 2019 by trained nurses and dietitians. Seven focus group discussions totaling 51 participants, refugees and social workers, investigated conceptions and needs regarding diet. The mean Body Mass Index is 24.6 ± 4.8 kg/m2. Women are disproportionately affected by obesity compared to men (p < 0.001). Weight gain post-migration is correlated positively with length of stay in Geneva (p < 0.001). Major obstacles to healthy eating are economic and linguistic. For participants, cooking workshops and free physical activities are highly needed interventions. Post-migration lifestyle interventions should be implemented to prevent weight gain in this population. Such interventions must be multi-level, to overcome structural, social and behavioral barriers to healthy eating.

Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants.

Key message: One QTL for resistance against Leptosphaeria maculans growth in leaves of young plants in controlled environments overlapped with one QTL detected in adult plants in field experiments. The fungal pathogen Leptosphaeria maculans initially infects leaves of oilseed rape (Brassica napus) in autumn in Europe and then grows systemically from leaf lesions along the leaf petiole to the stem, where it causes damaging phoma stem canker (blackleg) in summer before harvest. Due to the difficulties of investigating resistance to L. maculans growth in leaves and petioles under field conditions, identification of quantitative resistance typically relies on end of season stem canker assessment on adult plants. To investigate whether quantitative resistance can be detected in young plants, we first selected nine representative DH (doubled haploid) lines from an oilseed rape DY ('Darmor-bzh' × 'Yudal') mapping population segregating for quantitative resistance against L. maculans for controlled environment experiment (CE). We observed a significant correlation between distance grown by L. maculans along the leaf petiole towards the stem (r = 0.91) in CE experiments and the severity of phoma stem canker in field experiments. To further investigate quantitative trait loci (QTL) related to resistance against growth of L. maculans in leaves of young plants in CE experiments, we selected 190 DH lines and compared the QTL detected in CE experiments with QTL related to stem canker severity in stems of adult plants in field experiments. Five QTL for resistance to L. maculans growth along the leaf petiole were detected; collectively they explained 35% of the variance. Two of these were also detected in leaf lesion area assessments and each explained 10-12% of the variance. One QTL on A02 co-localized with a QTL detected in stems of adult plants in field experiments. This suggests that resistance to the growth of L. maculans from leaves along the petioles towards the stems contributes to the quantitative resistance assessed in stems of adult plants in field experiments at the end of the growing season.

[Level of knowledge and behavior regarding HIV prevention in a population of migrants]. / Niveau de connaissances et comportement en matière de prévention du VIH au sein d'une population de migrants.

In Geneva an HIV voluntary counselling and testing (VCT) consultation for migrants exists in a primary care center. A semi-structured questionnaire, was filled out during the VCT consultations. 650 questionnaires were analyzed. 82 % were asylum seekers. 30 % said they did not really understand how HIV is transmitted and 27 % cited erroneous modes of contamination. 78 % of women who did not use condoms regularly gave having a stable partner as the reason compared to 49 % for men. VCT is a great prevention tool : the counseling accompanying the test provides an opportunity to openly raise various risk practices and to personalize the information. However, this requires a suitable and affordable structure.

A Genève, une consultation de conseil et test volontaire du VIH (VCT, Voluntary Counselling and Testing) pour migrants existe dans une structure de médecine de premier recours. Un questionnaire semi-structuré, servant aussi de guide d'entretien, est rempli durant ces consultations VCT. 650 questionnaires ont été analysés. 82 % sont demandeurs d'asile. 30 % déclarent ne pas vraiment comprendre les modes de transmission du VIH et 27 % citent des modes de contamination erronés. 78 % des femmes n'utilisent pas le préservatif systématiquement, et mentionnent pour motif le partenaire stable contre 49 % pour les hommes. Le VCT constitue un outil de prévention idéal : l'entretien accompagnant le test permet de discuter ouvertement sur les différentes pratiques à risque et individualiser l'information. Cependant, cela nécessite une structure adaptée, accessible financièrement.

[Migrants in a vulnerable situation†: does their access to healthcare match their health needs†?] / Migrants en situation vulnérable†: leur accès aux soins correspond-il à leurs besoins de santé†?

At the beginning of the twenty-first century, migratory movements have never been so large and complex. After describing the risk factors influencing the health of migrants in vulnerable situations (asylum seekers, undocumented migrants), this article attempts to describe a holistic model of access to care for this type of population. It also develops a plea for equitable treatment of migrants in their host country, while respecting basic human rights and the independence of the medical profession.

En ce début de XXIe siècle, les mouvements migratoires n'ont jamais été aussi nombreux et complexes. Après avoir décrits les facteurs de risque influençant la santé des migrants en situation de vulnérabilité (demandeurs d'asile, sans-papiers), cet article s'attache à décrire un modèle holistique d'accès aux soins pour ce type de population. Il développe également un plaidoyer pour une prise en charge équitable des migrants dans leur pays d'accueil, dans le respect des droits humains fondamentaux et de l'indépendance de la profession médicale.

Migrant and refugee populations: a public health and policy perspective on a continuing global crisis.

The 2015-2017 global migratory crisis saw unprecedented numbers of people on the move and tremendous diversity in terms of age, gender and medical requirements. This article focuses on key emerging public health issues around migrant populations and their interactions with host populations. Basic needs and rights of migrants and refugees are not always respected in regard to article 25 of the Universal Declaration of Human Rights and article 23 of the Refugee Convention. These are populations with varying degrees of vulnerability and needs in terms of protection, security, rights, and access to healthcare. Their health status, initially conditioned by the situation at the point of origin, is often jeopardised by adverse conditions along migratory paths and in intermediate and final destination countries. Due to their condition, forcibly displaced migrants and refugees face a triple burden of non-communicable diseases, infectious diseases, and mental health issues. There are specific challenges regarding chronic infectious and neglected tropical diseases, for which awareness in host countries is imperative. Health risks in terms of susceptibility to, and dissemination of, infectious diseases are not unidirectional. The response, including the humanitarian effort, whose aim is to guarantee access to basic needs (food, water and sanitation, healthcare), is gripped with numerous challenges. Evaluation of current policy shows insufficiency regarding the provision of basic needs to migrant populations, even in the countries that do the most. Governments around the world need to rise to the occasion and adopt policies that guarantee universal health coverage, for migrants and refugees, as well as host populations, in accordance with the UN Sustainable Development Goals. An expert consultation was carried out in the form of a pre-conference workshop during the 4th International Conference on Prevention and Infection Control (ICPIC) in Geneva, Switzerland, on 20 June 2017, the United Nations World Refugee Day.

Multi-year linkage and association mapping confirm the high number of genomic regions involved in oilseed rape quantitative resistance to blackleg.

KEY MESSAGE: A repertoire of the genomic regions involved in quantitative resistance to Leptosphaeria maculans in winter oilseed rape was established from combined linkage-based QTL and genome-wide association (GWA) mapping. Linkage-based mapping of quantitative trait loci (QTL) and genome-wide association studies are complementary approaches for deciphering the genomic architecture of complex agronomical traits. In oilseed rape, quantitative resistance to blackleg disease, caused by L. maculans, is highly polygenic and is greatly influenced by the environment. In this study, we took advantage of multi-year data available on three segregating populations derived from the resistant cv Darmor and multi-year data available on oilseed rape panels to obtain a wide overview of the genomic regions involved in quantitative resistance to this pathogen in oilseed rape. Sixteen QTL regions were common to at least two biparental populations, of which nine were the same as previously detected regions in a multi-parental design derived from different resistant parents. Eight regions were significantly associated with quantitative resistance, of which five on A06, A08, A09, C01 and C04 were located within QTL support intervals. Homoeologous Brassica napus genes were found in eight homoeologous QTL regions, which corresponded to 657 pairs of homoeologous genes. Potential candidate genes underlying this quantitative resistance were identified. Genomic predictions and breeding are also discussed, taking into account the highly polygenic nature of this resistance.

Malaria cases in Switzerland from 2005 to 2015 and recent rise of imported Plasmodium vivax malaria.

Reporting cases of malaria to the Federal Office of Public Health has been mandatory in Switzerland since 1974. We analysed notifications of imported confirmed malaria cases between 2005 and 2015 in Switzerland or Liechtenstein. Data for previously visited countries, nationality and reason for travelling were analysed. In contrast with the impressive drop of malaria cases reported worldwide since 2000, we found that the number of malaria cases imported yearly in Switzerland doubled in 2014 and 2015 compared to the average for the preceding decade. Since 2014, Plasmodium vivax infection represented 36% of all diagnosed malaria cases in Switzerland, compared to 11% in the decade leading to 2013. Most of the vivax malaria patients originated from the Horn of Africa, especially from Eritrea. This rise in cases was a consequence not only of an increase in the number of Eritrean refugees, but also their vivax malaria incidence rate, which jumped from 1-3‰ previously to 12‰ in 2014. This is a trend that is not matched by national statistics in Eritrea. An unreported increased incidence in the country of origin (Eritrea) might be the cause of the rise of Pv cases imported into Switzerland, but infections are also likely to occur along the harsh and long migration journey. This epidemiology highlights the need to register and use primaquine for the treatment of latent-phase P. vivax malaria in Switzerland, a medicine currently neither marketed nor systematically reimbursed. Moreover, general practitioners should be aware of this specific epidemiological situation in order to avoid misdiagnosis of febrile Eritreans even months after they reach Switzerland.

[Health risks linked to recent migratory patterns: myth or reality?]. / Risques sanitaires liés aux récents phénomènes migratoires: mythe ou réalité?

The migratory crisis currently faced by Europe is of exceptional magnitude since the Second World War. It is mainly related to the conflict in Syria, as well as recurring violations of human rights in other regions of the world. Widely relayed by the media, the unusual number of refugee applicants and the precariousness of their migration routes raise the question of the health risk. From the old concept of quarantine to the new paradigm of migrants' health, it is important to contextualize the screening measures, taking into account the epidemiology of communicable diseases in the countries of origin and of the regions crossed, the ruptures of access to treatments for chronic diseases, but also the impact of multiple trauma (war, violence) on the mental health of refugees.

Fleshing out vulnerability.

In the literature on medical ethics, it is generally admitted that vulnerable persons or groups deserve special attention, care or protection. One can define vulnerable persons as those having a greater likelihood of being wronged - that is, of being denied adequate satisfaction of certain legitimate claims. The conjunction of these two points entails what we call the Special Protection Thesis. It asserts that persons with a greater likelihood of being denied adequate satisfaction of their legitimate claims deserve special attention, care or protection. Such a thesis remains vague, however, as long as we do not know what legitimate claims are. This article aims at dispelling this vagueness by exploring what claims we have in relation to health care - thus fleshing out a claim-based conception of vulnerability. We argue that the Special Protection Thesis must be enriched as follows: If individual or group X has a greater likelihood of being denied adequate satisfaction of some of their legitimate claims to (i) physical integrity, (ii) autonomy, (iii) freedom, (iv) social provision, (v) impartial quality of government, (vi) social bases of self-respect or (vii) communal belonging, then X deserves special attention, care or protection. With this improved understanding of vulnerability, vulnerability talk in healthcare ethics can escape vagueness and serve as an adequate basis for practice.

["I am a little out of breath". When a commonplace symptom hides a rare disease: cardiac amyloidosis]. / "Je suis un peu essoufflé". Ouand un symptôme banal cache une maladie rare: l'amylöidose cardiaque.

Based on a case report, this article reviews the different forms of cardiac involvement in amyloidosis. This affection refers to the extracellular tissue deposition of protein fibrils (the amyloid substance), which gradually invades a variety of organs, disrupting their function. The clinical presentation depends on the type of the amyloidogenic protein and on its main distribution. The most severe cardiac impairment and with the worse prognosis is seen in its primary form (or AL), while it is less frequent, with a slower course and a better prognosis in its other forms: secondary (AA), familial (ATTR) or senile (SSA).

A "migrant friendly hospital" initiative in Geneva, Switzerland: evaluation of the effects on staff knowledge and practices.

BACKGROUND: International migration poses important challenges to European health care systems. The development of "migrant friendly hospitals" has been identified as a priority in both Europe and Switzerland. METHODS: A multi-pronged initiative was developed at Geneva University Hospitals (HUG) to improve staff knowledge and use of existing "migrant friendly" resources. A self-administered questionnaire was sent pre and post-intervention to random samples of 4 major professional groups with direct patient contact at the HUG. The questionnaire assessed staff knowledge, attitudes and reported practices regarding the care of migrant patients. RESULTS: Overall response rate was 51% (N = 1460) in 2010 but only 19% (N = 761) in 2013 owing to an institutionally imposed change in survey method. Despite these difficulties, and after adjusting for sample differences, we found that respondents in 2013 were significantly more likely to have received training in how to organize an appointment with an interpreter, how to work with an interpreter and about health and social services available for migrant patients. Respondents were also significantly more likely to have used several Migrant Friendly structures at the HUG. Use of, preference for and perceived skill at working with professional interpreters all improved, and respondents were both more likely to be encouraged by their supervisors to use professional interpreters, and less likely to be encouraged to look for alternative solutions for communicating with non francophone patients. Finally, 2013 respondents encountered fewer difficulties caring for migrant patients, although lack of time and language barriers continued to be the most important sources of difficulty. CONCLUSION: Our results suggest that an institution-wide information campaign may contribute to increased awareness and use of migrant friendly resources by clinical staff. Hospital commitment and financing, along with inter-departmental participation in all activities were important in creating and maintaining project visibility, and in contributing to a migrant friendly institutional culture.