Tuberous sclerosis complex and a calcifying epithelial odontogenic tumor of the mandible.

This article reports the case of a large calcifying epithelial odontogenic tumor in a patient with tuberous sclerosis complex. The calcifying epithelial odontogenic tumor, one of the rarest odontogenic tumors, is reviewed in detail, as is the unusual disorder of tuberous sclerosis complex.

The relationship of the corpus luteum and the endometrium in infertile patients.

A group of 50 females undergoing an infertility work-up had measurements of serum progesterone levels in all cases, endometrial sampling in 49, and biopsy of a grossly identifiable corpus luteum in 42 cases. Of the 41 cases with three parameters available for study, 39 had correlations of all three parameters. The remaining nine cases had two of three parameters available for study. Of these, three showed a secretory endometrium but absent corpus luteum and an anovulatory progesterone level, and a patient showing a proliferative-phase endometrium at the same time had an ovulatory progesterone level and a postovulatory corpus luteum. The evidence presented suggests that, among the three parameters tested, the progesterone level as a noninvasive procedure serves as a good index of ovulation 92% of the time, and occasionally endometrial histologic sampling does not necessarily reflect ovarian function.

Colposcopic evaluation of patients with abnormal cervical cytology.

A total of 1580 new patients underwent colposcopic evalution in the Dysplasia Clinic at Nassau County Medical Center. Of these patients, 186 had abnormal Papanicolaou smears associated with pregnancy, 150 were referred because of in utero exposure to diethylstilbestrol, and 1244 were referred because of abnormal cervical cytologic smear or suspicious cervical or vaginal lesion. Further analysis of this latter group revealed that 1184 (95%) patients had satisfactory colposcopic evaluation, and directed biopsy showed the following: 10 cases of invasive cervical carcinoma, 9 of carcinoma in situ with microinvasion, 118 of cervical carcinoma in situ, 110 of severe dysplasia, and 424 cases of mild to moderate cervical dysplasia. All of these patients subsequently were treated accordingly. Evaluation of final histologic specimen revealed a very high correlation with colposcopically guided biopsies. In 54 patients, where colposcopic evaluation was unsatisfactory, diagnostic cold knife conization was performed. Final histologic diagnosis disclosed a more advanced lesion in 30 patients (or 56%) of this group. The result of this study shows that satisfactory colposcopic evaluation is a highly accurate method of evaluation of abnormal cervical and vaginal cytologic smear.