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1.
Nanotechnology ; 35(9)2023 Dec 15.
Article in English | MEDLINE | ID: mdl-38035378

ABSTRACT

The morphology of numerous nanocolumnar thin films deposited by the magnetron sputtering technique at oblique geometries and at relatively low temperatures has been analyzed for materials as different as Au, Pt, Ti, Cr, TiO2, Al, HfN, Mo, V, WO3and W. Despite similar deposition conditions, two characteristic nanostructures have been identified depending on the material: a first one defined by highly tilted and symmetric nanocolumnar structures with a relatively high film density, and a second one characterized by rather vertical and asymmetric nanocolumns, with a much lower film density. With the help of a model, the two characteristic nanostructures have been linked to different growth dynamics and, specifically, to different surface relaxation mechanisms upon the incorporation of gaseous species with kinetic energies above the surface binding energy. Moreover, in the case of Ti, a smooth structural transition between the two types of growths has been found when varying the value of the power used to maintain the plasma discharge. Based on these results, the existence of different surface relaxation mechanisms is proposed, which quantitatively explains numerous experimental results under the same conceptual framework.

2.
Nanotechnology ; 34(25)2023 Apr 11.
Article in English | MEDLINE | ID: mdl-36947879

ABSTRACT

The low temperature formation of monoclinic VO2crystal domains in nanocolumnar vanadium/oxygen thin films prepared by magnetron sputtering at oblique angles is analyzed. The synthesis procedure involved the deposition of amorphous nanocolumnar VO1.9thin films at room temperature and its subsequent annealing at temperatures between 250 °C and 330 °C in an oxygen atmosphere. The thermochromic transition of these films was found at a temperature of 47 °C when the annealing temperature was 270 °C and 58 °C when the annealing temperature was 280 °C and 290 °C, presenting a clear drop of the optical transmittance in the infrared region of the spectrum. The significant downshift in the temperature window to obtain VO2in comparison with compact films and other strategies in literature is explained by the particular morphology of the nanocolumnar structures, which contains numerous defects along with open and embedded porosity.

3.
Nanotechnology ; 30(47): 475603, 2019 Nov 22.
Article in English | MEDLINE | ID: mdl-31426050

ABSTRACT

We experimentally analyze different growth regimes of Ti thin films associated to the existence of kinetic energy-induced relaxation mechanisms in the material's network when operating at oblique geometries. For this purpose, we have deposited different films by evaporation and magnetron sputtering under similar geometrical arrangements and at low temperatures. With the help of a well-established growth model we have found three different growth regimes: (i) low energy deposition, exemplified by the evaporation technique, carried out by species with typical energies in the thermal range, where the morphology and density of the film can be explained by solely considering surface shadowing processes, (ii) magnetron sputtering under weak plasma conditions, where the film growth is mediated by surface shadowing mechanisms and kinetic-energy-induced relaxation processes, and (iii) magnetron sputtering under intense plasma conditions, where the film growth is highly influenced by the plasma, and whose morphology is defined by nanocolumns with similar tilt than evaporated films, but with much higher density. The existence of these three regimes explains the variety of morphologies of nanocolumnar Ti thin films grown at oblique angles under similar conditions in the literature.

4.
Nanotechnology ; 28(46): 465605, 2017 11 17.
Article in English | MEDLINE | ID: mdl-29063864

ABSTRACT

In this work we analyze a phenomenon that takes place when growing magnetron sputtered porous/compact multilayer systems by alternating the oblique angle and the classical configuration geometries. We show that the compact layers develop numerous fissures rooted in the porous structures of the film below, in a phenomenon that amplifies when increasing the number of stacked layers. We demonstrate that these fissures emerge during growth due to the high roughness of the porous layers and the coarsening of a discontinuous interfacial region. To minimize this phenomenon, we have grown thin interlayers between porous and compact films under the impingement of energetic plasma ions, responsible for smoothing out the interfaces and inhibiting the formation of structural fissures. This method has been tested in practical situations for compact TiO2/porous SiO2 multilayer systems, although it can be extrapolated to other materials and conditions.

5.
Nanotechnology ; 27(39): 395702, 2016 Sep 30.
Article in English | MEDLINE | ID: mdl-27535651

ABSTRACT

Porous thin films grown at oblique angles by evaporation techniques are formed by tilted nanocolumnar structures which, depending on the material type and growth conditions, associate along certain preferential directions, giving rise to large domains. This arrangement, commonly denoted as bundling association, is investigated in the present work by performing fundamental experiments and growth simulations. It is proved that trapping processes of vapor species at the film surface, together with the shadowing mechanism, mediate the anisotropic widening of the nanocolumns and promote their preferential coalescence along certain directions, giving rise to domains with different shape and size. The role of these two processes is thoroughly studied in connection with the formation of these domains in materials as different as SiO2 and TiO2.

6.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 42(5): 287-292, jul.-ago. 2016. tab
Article in Spanish | IBECS | ID: ibc-154507

ABSTRACT

Objetivo. Calcular el tiempo en rango terapéutico (TRT) de los pacientes con fibrilación auricular no valvular anticoagulados del Centro de Salud de Aravaca, y la puntuación en la escala CHADS2. Emplazamiento. Zona básica de salud de Aravaca (Madrid). Diseño. Estudio retrospectivo observacional. Participantes. La Comunidad de Madrid facilita un listado de los pacientes con fibrilación auricular no valvular y tratamiento anticoagulante del centro. Se excluyen aquellos con menos de 8 INR, los que comenzaron el tratamiento después de enero 2011, interrumpieron el tratamiento por procesos intercurrentes o presentaban cáncer o coagulopatías. El periodo de estudio es del 1-01-2012 al 1-01-2013. Mediciones principales. El TRT (fracción de INR en rango) fue la variable principal. También se calculó la puntuación en la escala CHADS2. Resultados. Obtuvimos un valor de TRT de 56,28% (59,5-53,1) de una muestra de 963 INR. El 52% de los pacientes tenían un TRT<60%. Los pacientes fueron 65, con una media de edad de 80±7,5 años. La distribución de los factores de riesgo de la escala CHADS2 fue: insuficiencia cardíaca 18,5%; hipertensión arterial 80%; diabetes 29,2%, y episodios embólicos 18,5%. Conclusión. El resultado del TRT de nuestra muestra es subóptimo (<60%), lo que implica un mayor riesgo de episodios cardioembólicos y un aumento de la probabilidad de sangrado. Creemos necesario incorporar a nuestra práctica clínica una medida objetiva de la calidad de la anticoagulación que identifique los pacientes mal controlados para introducir medidas correctoras (AU)


Objective. To calculate the time in therapeutic range (TTR), as well as the scores on the CHADS2 scale in anticoagulated patients with non-valvular atrial fibrillation, attending the Primary Care Health Centre of Aravaca. Location. Basic health area of Aravaca (Madrid). Design. Retrospective observational study. Participants. The Community of Madrid provides a list of patients with non-valvular atrial fibrillation and on anticoagulant therapy in the centre. Excluding those with less than 8 INRs, who began treatment after January 2011, interrupted by inter-current treatment or had cancer or coagulopathy. The study period is from 1 January 2012 to 1 January 2013. Main measurements. The TTR (fraction of INRs in range) was the primary endpoint. The score was also calculated on the CHADS2 scale. Results. A value of 56.28% TTR (59.5-53.1) was obtained from a sample of 963 INRs. Just over half (52%) of patients had a TTR<60%. There were 65 patients with a mean age of 80±7.5 years. The distribution of risk factors for the CHADS2 scale was: Heart failure 18.5%; hypertension 80%; diabetes 29.2%, and embolic events 18.5%. Conclusion. The results of our sample TTR is suboptimal (<60%), which implies an increased risk for embolic episodes and increased likelihood of bleeding. We need to incorporate into our clinical practice an objective measure of the quality of anticoagulation in order to identify poorly controlled patients and introduce corrective measures (AU)


Subject(s)
Humans , Male , Female , Quality Control , Atrial Fibrillation/epidemiology , Atrial Fibrillation/prevention & control , Anticoagulants/therapeutic use , Primary Health Care/methods , Risk Factors , Atrial Fibrillation/diagnosis , Atrial Fibrillation/therapy , Family Practice/methods , Retrospective Studies , Heart Failure/complications , Cross-Sectional Studies/methods
7.
Semergen ; 42(5): 287-92, 2016.
Article in Spanish | MEDLINE | ID: mdl-26272881

ABSTRACT

OBJECTIVE: To calculate the time in therapeutic range (TTR), as well as the scores on the CHADS2 scale in anticoagulated patients with non-valvular atrial fibrillation, attending the Primary Care Health Centre of Aravaca. LOCATION: Basic health area of Aravaca (Madrid). DESIGN: Retrospective observational study. PARTICIPANTS: The Community of Madrid provides a list of patients with non-valvular atrial fibrillation and on anticoagulant therapy in the centre. Excluding those with less than 8 INRs, who began treatment after January 2011, interrupted by inter-current treatment or had cancer or coagulopathy. The study period is from 1 January 2012 to 1 January 2013. MAIN MEASUREMENTS: The TTR (fraction of INRs in range) was the primary endpoint. The score was also calculated on the CHADS2 scale. RESULTS: A value of 56.28% TTR (59.5-53.1) was obtained from a sample of 963 INRs. Just over half (52%) of patients had a TTR<60%. There were 65 patients with a mean age of 80±7.5 years. The distribution of risk factors for the CHADS2 scale was: Heart failure 18.5%; hypertension 80%; diabetes 29.2%, and embolic events 18.5%. CONCLUSION: The results of our sample TTR is suboptimal (<60%), which implies an increased risk for embolic episodes and increased likelihood of bleeding. We need to incorporate into our clinical practice an objective measure of the quality of anticoagulation in order to identify poorly controlled patients and introduce corrective measures.


Subject(s)
Anticoagulants/therapeutic use , Atrial Fibrillation/drug therapy , International Normalized Ratio , Primary Health Care/standards , Quality Control , Quality Indicators, Health Care , Adult , Aged , Aged, 80 and over , Drug Monitoring , Female , Humans , Male , Middle Aged , Retrospective Studies , Spain , Treatment Outcome
8.
Nanotechnology ; 25(35): 355705, 2014 Sep 05.
Article in English | MEDLINE | ID: mdl-25120129

ABSTRACT

The formation of the porous structure in dc magnetron sputtered amorphous silicon thin films at low temperatures is studied when using helium and/or argon as the processing gas. In each case, a-Si thin films were simultaneously grown at two different locations in the reactor which led to the assembly of different porous structures. The set of four fabricated samples has been analyzed at the microstructural level to elucidate the characteristics of the porous structure under the different deposition conditions. With the help of a growth model, we conclude that the chemical nature of the sputter gas not only affects the sputtering mechanism of Si atoms from the target and their subsequent transport in the gaseous/plasma phase towards the film, but also the pore formation mechanism and dynamics. When Ar is used, pores emerge as a direct result of the shadowing processes of Si atoms, in agreement with Thornton's structure zone model. The introduction of He produces, in addition to the shadowing effects, a new process where a degree of mobility results in the coarsening of small pores. Our results also highlight the influence of the composition of sputtering gas and tilt angles (for oblique angle deposition) on the formation of open and/or occluded porosity.

9.
Nanotechnology ; 24(4): 045604, 2013 Feb 01.
Article in English | MEDLINE | ID: mdl-23299349

ABSTRACT

Growth regimes of gold thin films deposited by magnetron sputtering at oblique angles and low temperatures are studied from both theoretical and experimental points of view. Thin films were deposited in a broad range of experimental conditions by varying the substrate tilt angle and background pressure, and were analyzed by field emission scanning electron microscopy and grazing-incidence small-angle x-ray scattering techniques. Results indicate that the morphological features of the films strongly depend on the experimental conditions, but can be categorized within four generic microstructures, each of them defined by a different bulk geometrical pattern, pore percolation depth and connectivity. With the help of a growth model, a microstructure phase diagram has been constructed where the main features of the films are depicted as a function of experimentally controllable quantities, finding a good agreement with the experimental results in all the studied cases.


Subject(s)
Gold/chemistry , Membranes, Artificial , Metal Nanoparticles/chemistry , Metal Nanoparticles/ultrastructure , Models, Chemical , Models, Molecular , Computer Simulation , Crystallization/methods , Hot Temperature , Macromolecular Substances/chemistry , Magnetic Fields , Materials Testing , Molecular Conformation , Particle Size , Porosity , Surface Properties
10.
Gerokomos (Madr., Ed. impr.) ; 23(1): 35-41, mar. 2012. ilus, tab
Article in Spanish | IBECS | ID: ibc-102947

ABSTRACT

Los trastornos cutáneos son derivados, en la mayoría de las ocasiones, de agresiones continuas por elementos externos que tiene como respuesta reacciones como la pérdida de lípidos epidérmicos por efecto de la humedad, cambios en el pH cutáneo (alcalinización) y aumento del coeficiente de fricción (denudación) junto al desequilibrio de la flora saprofita de la piel, que se traducen en procesos irritativos y en un aumento de la infecciones fúngicas y bacterianas en la zona expuesta a humedad. Dada la importancia de evaluar la calidad de vida de los pacientes con dermatitis que son tratados con productos barrera no irritantes (PBNI) se ha desarrollado un estudio multicéntrico, con el objetivo de evaluar los aspectos relacionados con la mejora en la calidad de cuidados a pacientes tratados con Cavilon® que presentaban dermatitis por incontinencia mediante la escala ESCLI. Los pacientes incluidos en el estudio fueron 25. Los resultados muestran una mejora importante de los aspectos evaluados mediante la escala ESCLI (..) (AU)


The skin disorders are derived in most cases continuous injuries by external factors that have how responses the loss of epidermal lipids by the effect of moisture, derived of changes in skin pH (alkalinization), an increased coefficient of friction (denudation) and the imbalance of the saprophytic flora of the skin, give how a result an increase to the irritative processes and the fungal and bacterian infections in the area exposed to moisture. Given the importance of assessing the quality of life of patients with dermatitis who are treated with No Sting Barrier Film (NSBF) CavilonTM has developed a multicenter study, in order to evaluate the related to improving the quality of care that patients Incontinence Dermatitis with ESCLI scale. Patients included in the study were 25. The results show a significant improvement aspects ESCLI assessed by the scale of the evolution of the dermatitis. This scale assesses aspects such as the area affected by the redness and severity. Show a reversal 47% of cases. The denudation of the skin in the diaper area disappears in 56% of cases and the severity of the denudation which has a 47% improvement. The assessment of pain in the area of incontinence, is reduced by 76% in the area of incontinence and a 73% when cleaning the area. The findings of this study prove indicates that the application of forming products of a No Sting Barrier Film (NSBF) in patients with incontinence dermatitis is an alternative to conventional treatments such as creams or ointments or zinc oxide paste water. The reversal and reduction of dermatitis is an aspect that has improved important. The results that we can relate to quality of life or longer specifically with the improvement of pain are significant (AU)


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Dermatitis, Contact/prevention & control , Diaper Rash/prevention & control , Skin Care/methods , Protective Agents/therapeutic use , Urinary Incontinence/complications , Quality of Life
11.
Nutr Hosp ; 25(3): 400-5, 2010.
Article in Spanish | MEDLINE | ID: mdl-20593122

ABSTRACT

UNLABELLED: 40-80% of cancer patients suffer from diverse degrees of malnutrition, depending on tumor subtype, location and staging and treatment strategy. Malnutrition is associated with increased morbidity and mortality in cancer patients. Both the high prevalence and prognostic significance of malnutrition imply the need for accurate malnutrition screening in cancer patients, which could select those patients at risk of nutritional derangements who would benefit from nutritional therapy. Patient-generated subjective global screening (VSG-GP) remains the reference malnutrition screening method, but its complexity and training requirements prevent wider applicability by oncologists. Thus, easier, more clinic-based malnutrition screening tools are required for cancer patients. In this article we propose a basic screening tool based on three items: weight loss, changes in physical activity and decrease in food intake. Two affirmative responses out of the three questions is considered as a positive response, and would prompt expert nutritional assessment. RESULTS: Our screening interview showed positive correlation with VSG-GP (ROC 0.85, p<0.001) and allowed for a rapid and accurate identification of patients with cancer-related malnutrition.


Subject(s)
Malnutrition/diagnosis , Malnutrition/etiology , Neoplasms/complications , Surveys and Questionnaires , Adolescent , Adult , Female , Humans , Male , Young Adult
12.
Nutr. hosp ; 25(3): 400-405, mayo-jun. 2010. ilus, graf
Article in Spanish | IBECS | ID: ibc-84718

ABSTRACT

La desnutrición es muy frecuente en los pacientes oncológicos y está presente en el 40-80% de los casos dependiendo del tipo de tumor, localización y estadio tumoral. La malnutrición se asocia a un aumento en el número y gravedad de las complicaciones, lo que conlleva una mayor morbimortalidad en estos pacientes. Por ello es prioritario realizar una adecuada valoración del estado nutricional para diagnosticar los casos de malnutrición y establecer un tratamiento correcto y, además detectar aquellos pacientes con un mayor riesgo de padecerla, con el fin de iniciar un tratamiento nutricional preventivo. La valoración global subjetiva generada por el paciente (VSG-GP) es una herramienta muy útil pero que no es aplicada por los oncólogos en las consultas porque es compleja y precisa de mayor entrenamiento para su realización. Se propone un método de cribado más sencillo basado en 3 cuestiones: pérdida de peso, cambio en la actividad física y en la ingesta y se compara dicho método con el de referencia que es la VSG- GP. El método de cribado permite determinar la presencia de desnutrición si hay un mínimo de 2 respuestas afirmativas. Posteriormente se debe realizar una VSG-GP para catalogar el grado de desnutrición existente y en función de ello el experto en nutrición planificar un abordaje nutricional adecuado. RESULTADOS: nuestro método de cribaje mostró una correlación positiva con la VSG-GP (ROC 0.85, p<0.001) y permitió una identificación rápida y precisa de los pacientes oncológicos con desnutrición (AU)


40-80% of cancer patients suffer from diverse degrees of malnutrition, depending on tumor subtype, location and staging and treatment strategy. Malnutrition is associated with increased morbidity and mortality in cancer patients. Both the high prevalence and prognostic significance of malnutrition imply the need for accurate malnutrition screening in cancer patients, which could select those patients at risk of nutritional derangements who would benefit from nutritional therapy. Patient-generated subjective global screening (VSG-GP) remains the reference malnutrition screening method, but its complexity and training requirements prevent wider applicability by oncologists. Thus, easier, more clinic-based malnutrition screening tools are required for cancer patients. In this article we propose a basic screening tool based on three items: weight loss, changes in physical activity and decrease in food intake. Two affirmative responses out of the three questions is considered as a positive response, and would prompt expert nutritional assessment. RESULTS: Our screening interview showed positive correlation with VSG-GP (ROC 0.85, p<0.001) and allowed for a rapid and accurate identification of patients with cancer-related malnutrition (AU)


Subject(s)
Humans , Malnutrition/diagnosis , Neoplasms
13.
J Biosci ; 34(6): 891-8, 2009 Dec.
Article in English | MEDLINE | ID: mdl-20093742

ABSTRACT

Sticholysins I and II (St I/II) are cytolysins purified from the sea anemone Stichodactyla helianthus. In this study, we show their pharmacological action on guinea-pig and snail models in native and pH-denatured conditions in order to correlate the pharmacological findings with the pore-forming activity of both isoforms. In guinea-pig erythrocytes (N=3), St II possessed higher haemolytic activity in comparison with St I and this activity was lost at an alkaline pH. In molluscan central neurons (N=30), they irreversibly decreased the amplitude of the cholinergic response; St I (EC (50) 0.6 micromolL (-1)) was more potent than St II (EC50 > 6.6 micromolL (-1)) and they both increased the duration of the action potential; these effects were absent at an alkaline pH. In guinea-pig isolated atrium (N=25), both increased the amplitude of the contraction force, but St II was more potent than St I (EC (50) 0.03 micromolL (-1) and 0.3 micromolL (-1), respectively) and this effect persisted at an alkaline pH. In summary, both cytolysins have neuroactive and cardioactive properties. The main mechanism in molluscan neurons seems to be associated with the cytolytic activity of these molecules, whereas inguinea-pig atrium, the existence of an additional pharmacological mechanism might be contributing to the observed effect.


Subject(s)
Cnidarian Venoms/pharmacology , Cytotoxins/pharmacology , Pore Forming Cytotoxic Proteins/pharmacology , Sea Anemones/chemistry , Action Potentials/drug effects , Animals , Cnidarian Venoms/isolation & purification , Cytotoxins/isolation & purification , Erythrocytes/drug effects , Guinea Pigs , Heart Atria/drug effects , Hemolysis/drug effects , Neurons/cytology , Neurons/drug effects , Neurons/physiology , Organic Chemicals/isolation & purification , Organic Chemicals/pharmacology , Pore Forming Cytotoxic Proteins/isolation & purification , Snails
14.
J Biosci ; 34(6)Dec. 2009.
Article in Spanish | CUMED | ID: cum-43861

ABSTRACT

Sticholysins I and II (St I/II) are cytolysins purified from the sea anemone Stichodactyla helianthus. In this study, we show their pharmacological action on guinea-pig and snail models in native and pH-denatured conditions in order to correlate the pharmacological findings with the pore-forming activity of both isoforms. In guinea-pig erythrocytes (N=3), St II possessed higher haemolytic activity in comparison with St I and this activity was lost at an alkaline pH. In molluscan central neurons (N=30), they irreversibly decreased the amplitude of the cholinergic response; St I (EC (50) 0,6 micromolL (-1)) was more potent than St II (EC50 > 6,6 micromolL (-1)) and they both increased the duration of the action potential; these effects were absent at an alkaline pH. In guinea-pig isolated atrium (N=25), both increased the amplitude of the contraction force, but St II was more potent than St I (EC (50) 0,03 micromolL (-1) and 0,3 micromolL (-1), respectively) and this effect persisted at an alkaline pH. In summary, both cytolysins have neuroactive and cardioactive properties. The main mechanism in molluscan neurons seems to be associated with the cytolytic activity of these molecules, whereas inguinea-pig atrium, the existence of an additional pharmacological mechanism might be contributing to the observed effect(AU)


Subject(s)
Humans , Cytotoxins/isolation & purification , Cytotoxins/pharmacology , Sea Anemones/chemistry
15.
Rev Neurol ; 47(10): 509-16, 2008.
Article in Spanish | MEDLINE | ID: mdl-19012254

ABSTRACT

INTRODUCTION: The term 'oro-motor disorders' refers to a group of diseases that predominantly affect sensory inputs, motor systems and movement organization involved in sucking, chewing, swallowing, speech articulation and facial non-verbal communication. Loss of any of the aforementioned functions results in poor social integration and significant quality of life reduction. PATIENTS AND METHODS: Retrospective, observational study of 64 patients with oro-motor disorders diagnosed and followed-up at the Child Neurology Service of Vall d'Hebron University Hospital. The oro-motor disorder cause, age at the beginning of symptoms, type of feeding difficulties, type of speech disorders and other associated clinical manifestations were investigated in all patients. Changes in clinical manifestations throughout the period of follow-up in this cohort were analyzed as well. RESULTS: Classification of oro-motor disorders in childhood can be achieved combining the etiology and the anatomical location of the underlying disease. Four main groups can be distinguished: due to dysmorphological syndromes; secondary to bilateral perisylvian cortical dysplasias; due to brainstem dysgenesis, and secondary to congenital muscular diseases. CONCLUSIONS: Establishing the origin, nervous system location and pathophysiology of diseases leading to oro-motor disorders provides clues to natural history and permits anticipation in terms of treatment and care provision.


Subject(s)
Psychomotor Disorders/classification , Psychomotor Disorders/physiopathology , Adolescent , Child , Child, Preschool , Female , Hospital Units , Humans , Infant , Infant, Newborn , Male , Neurology , Pediatrics , Psychomotor Disorders/genetics , Retrospective Studies , Young Adult
16.
Rev. neurol. (Ed. impr.) ; 47(10): 509-516, 16 nov., 2008. tab
Article in Es | IBECS | ID: ibc-71121

ABSTRACT

Introducción. El concepto ‘trastornos oromotores’ engloba al conjunto de enfermedades que afectan de forma predominante a las estructuras que intervienen en la movilidad facial y orofaríngea, y que son imprescindibles para una correcta mecánica de la alimentación y para la articulación del lenguaje y la expresividad facial. La alteración de estas funcionespuede afectar significativamente a la calidad de vida y a la integración social de estos pacientes. Pacientes y métodos. Estudio descriptivo retrospectivo de 64 pacientes diagnosticados de trastornos oromotores, controlados en el Servicio de Neurología Pediátrica del Hospital Universitari Vall d’Hebron. De cada uno de ellos, detallamos: etiología, edad de presentación, información acerca del trastorno de la alimentación, de la articulación del lenguaje y de posibles manifestaciones asociadas, y evolución durante el período de seguimiento de los diferentes aspectos clínicos. Resultados. La revisión de la casuística delservicio nos ha permitido clasificar a los enfermos afectos de trastornos oromotores en función de la localización de la lesión y su enfermedad de base, distribuyéndolos en cuatro grupos principales: pacientes con síndromes polimalformativos, con afectación cortical perisilviana, con disgenesia troncoencefálica y con afectación del sistema nervioso periférico. Conclusiones. La clasificación de los pacientes afectos de trastornos oromotores y el estudio de la evolución natural de cada uno de los grupos facilitan el abordaje y permiten optimizar el manejo y realizar una prevención adecuada de las posibles complicaciones de este tipo de pacientes


Introduction. The term ‘oro-motor disorders’ refers to a group of diseases that predominantly affect sensory inputs, motor systems and movement organization involved in sucking, chewing, swallowing, speech articulation and facial nonverbal communication. Loss of any of the aforementioned functions results in poor social integration and significant quality of life reduction. Patients and methods. Retrospective, observational study of 64 patients with oro-motor disorders diagnosed andfollowed-up at the Child Neurology Service of Vall d’Hebron University Hospital. The oro-motor disorder cause, age at the beginning of symptoms, type of feeding difficulties, type of speech disorders and other associated clinical manifestations were investigated in all patients. Changes in clinical manifestations throughout the period of follow-up in this cohort wereanalyzed as well. Results. Classification of oro-motor disorders in childhood can be achieved combining the etiology and the anatomical location of the underlying disease. Four main groups can be distinguished: due to dysmorphological syndromes; secondary to bilateral perisylvian cortical dysplasias; due to brainstem dysgenesis, and secondary to congenital musculardiseases. Conclusions. Establishing the origin, nervous system location and pathophysiology of diseases leading to oro-motor disorders provides clues to natural history and permits anticipation in terms of treatment and care provision


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Motor Neuron Disease/classification , Deglutition Disorders/classification , Motor Neuron Disease/diagnosis , Clinical Evolution , Abnormalities, Multiple/classification , Abnormalities, Multiple/diagnosis , Deglutition Disorders/diagnosis
17.
Rev Enferm ; 31(2): 43-50, 2008 Feb.
Article in Spanish | MEDLINE | ID: mdl-18496967

ABSTRACT

To evaluate the properties of the Indafoam hydro-regulating dressing, the authors planned a study on the clinical application these materials have in relation to the evolution of injuries and their etiology at the same time evaluating the behavior of these products in diverse aspects related to the healing processes. This study is an open, multi-centric prospective observational study having repeated measurements in a group of patients who suffered from injuries having diverse etiology


Subject(s)
Hydrotherapy/methods , Wounds and Injuries/therapy , Acute Disease , Bandages, Hydrocolloid/statistics & numerical data , Chronic Disease , Humans , Hydrotherapy/statistics & numerical data , Prospective Studies , Wound Healing , Wounds and Injuries/epidemiology , Wounds and Injuries/etiology
18.
Neuropediatrics ; 39(1): 29-32, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18504679

ABSTRACT

Vanishing white matter disease (VWM) is one of the most frequent inherited childhood leukoencephalopathies. Five genes have been implicated in this disease ( EIF2B1-5), which encode the five subunits of translation initiation factor eIF2B. The disease has an autosomal recessive mode of inheritance. The age of onset and clinical severity vary widely. The diagnosis is based on magnetic resonance imaging (MRI) findings and is confirmed by molecular studies. We describe an affected female patient with a common and a novel mutation of the EIF2B5 gene, who demonstrated a progressive neurological and radiological deterioration. An unusual feature was her striking macrocephaly. She had an early clinical onset at two years of age and is currently still alive at 26 years of age.


Subject(s)
Brain/pathology , Eukaryotic Initiation Factor-2/genetics , Hereditary Central Nervous System Demyelinating Diseases/diagnosis , Mutation , Adolescent , Adult , Cerebellar Ataxia/etiology , Cerebellar Ataxia/pathology , Child , Child, Preschool , Female , Follow-Up Studies , Hereditary Central Nervous System Demyelinating Diseases/complications , Hereditary Central Nervous System Demyelinating Diseases/genetics , Humans , Magnetic Resonance Imaging , Phenotype , Prognosis , Tomography, X-Ray Computed
19.
Rev. Rol enferm ; 31(2): 123-130, feb. 2008. ilus, tab
Article in Spanish | IBECS | ID: ibc-79033

ABSTRACT

Para evaluar las propiedades del apósito hidrorregulador Indafoam®, se planteó un estudio de la aplicación clínica de estos materiales en relación a la evolución de las heridas y su etiología, y se evaluó su comportamiento en diferentes aspectos relacionados con el proceso de curación. Se trata de un estudio prospectivo observacional, abierto y multicéntrico, de medidas repetidas en una cohorte de pacientes que presentan heridas de diversa etiología(AU)


To evaluate the properties of the Indafoam® hydro-regulating dressing, the authors planned a study on the clinical application these materials have in relation to the evolution of injuries and their etiology, at the same time evaluating the behavior of these products in diverse aspects related to the healing processes. This study is an open, multi-centric prospective observational study, having repeated measurements in a group of patients who suffered from injuries having diverse etiology(AU)


Subject(s)
Humans , Wound Healing , Wound Infection/prevention & control , Disinfectants/therapeutic use , Bandages , Disinfection/methods , Wound Infection/nursing
20.
Rev. Rol enferm ; 30(12): 843-850, dic. 2007. tab, ilus, graf
Article in Spanish | IBECS | ID: ibc-80458

ABSTRACT

La incontinencia supone un problema añadido para el paciente encamado, entre otras razones, porque aumenta el riesgo de dermatitis perineal. Recientemente se han desarrollado escalas de valoración que permiten valorar los efectos que provoca sobre la integridad de la piel y han surgido nuevos productos que actúan como barreras no irritantes y que permiten inspeccionar visualmente la zona afectada. Se sumarían al arsenal de productos y herramientas ya conocidos (colectores, catéteres, etc.) de que se dispone para manejar la incontinencia(AU)


Incontinence presents an additional problem for a bedridden patient, among other reasons because incontinence increases the risk of perineal dermatitis. Recently, evaluation scales have been drawn up which permit evaluating the effects incontinence provokes on the integrity of the skin and new products have been developed which act as non-irritating barriers and which permit professionals to visually inspect the affected area. These new products increase the arsenal of already known products and tools such as bed pans, catheters, etc. which professionals have at their disposal to control incontinence(AU)


Subject(s)
Humans , Urinary Incontinence/nursing , Immobilization/adverse effects , Fecal Incontinence/nursing , Pressure Ulcer/prevention & control , Skin Care/methods , Urinary Incontinence/epidemiology , Fecal Incontinence/epidemiology , Incontinence Pads
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