[Effect of protein isolated from soya on the biotransformation of xenobiotics in the rat liver]. / Vliianie belkovogo izoliata iz soi na biotransformatsiiu chuzherodnykh veshchestv v pecheni krys.

Processes of biotransformation of xenobiotics in the rat liver at consumption of rations containing caseine (5, 14 or 18%) or 18% of soya protein isolate (SPI). Consumption of SPI caused a decrease of restored glutathione concentration in the liver, an increase of glutathione reductase and a sharp activation of glutathione peroxidase in the liver cytosole. The equalizing of the amount of sulfur-containing amino acids in the ration with 14% of caseine with their amount in the ration containing 18% of SPI was followed by the equalizing of the liver restored glutathione concentration. The enrichment of SPI ration with 0.35% of L-methionine led to an increase of the liver restored glutathione concentration to the level observed at 18% of caseine. The activity of the liver microsomal uridine diphosphate-glucuronyltransferase raised under the influence of SPI.