ABSTRACT
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol >200 mg/dl or triglycerides >130 mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated with dyslipidemia were: low intake of vegetables/fruits (OR = 3.47, 95%CI = 1.04-11.55), current use of lopinavir/ritonavir (OR = 2.91, 95%CI = 1.11-7.67). In conclusion, LSHIV was frequently observed; inadequate dietary intake of sugars and fats, as well as current use of lopinavir/ritonavir was associated with dyslipidemia.
Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Male , Anti-HIV Agents/adverse effects , Dyslipidemias/epidemiology , HIV-Associated Lipodystrophy Syndrome/epidemiology , Antiretroviral Therapy, Highly Active , Brazil/epidemiology , Cross-Sectional Studies , Dyslipidemias/chemically induced , Dyslipidemias/diagnosis , HIV-Associated Lipodystrophy Syndrome/chemically induced , HIV-Associated Lipodystrophy Syndrome/diagnosis , Prevalence , Regression Analysis , Risk FactorsABSTRACT
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol >200mg/dl or triglycerides >130mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated with dyslipidemia were: low intake of vegetables/fruits (OR=3.47, 95%CI=1.04-11.55), current use of lopinavir/ritonavir (OR=2.91, 95%CI=1.11-7.67). In conclusion, LSHIV was frequently observed; inadequate dietary intake of sugars and fats, as well as current use of lopinavir/ritonavir was associated with dyslipidemia.
Subject(s)
Anti-HIV Agents/adverse effects , Dyslipidemias/epidemiology , HIV-Associated Lipodystrophy Syndrome/epidemiology , Adolescent , Antiretroviral Therapy, Highly Active , Brazil/epidemiology , Child , Child, Preschool , Cross-Sectional Studies , Dyslipidemias/chemically induced , Dyslipidemias/diagnosis , Female , HIV-Associated Lipodystrophy Syndrome/chemically induced , HIV-Associated Lipodystrophy Syndrome/diagnosis , Humans , Male , Prevalence , Regression Analysis , Risk FactorsABSTRACT
Objetivos: Comparar os efeitos de sulfadiazina de prata + nitrato de cério e aciclovír no tratamento tópico de lesões de,herpes labial Métodos: Estudo prospectivo duplo- cego realizado em pacientes adultos do Hospital Universitário Clementino Fraga Filho (HUCFF), de maio de 2001 a dezembro de 2002. Resultados: Particíparam do estudo 28 pacientes e as evoluções foram documentadas a partir de critérios objetivos e subjetivos e comparadas através dos testes de Friedman e Wilcoxon. Conclusão: Na maioria dos parâmetros analisados os índices de melhora foram superiores, tanto em relação à sintomatología quanto em relação às manifestações clínicas, quando comparados ao tratamento considerado padrão. Houve boa toferabilidade, ausência de efeitos colaterais lo cais ou sistêmicos e nenhum caso de complicação.(au)
