1.
Bioorg Med Chem Lett
; 14(7): 1673-7, 2004 Apr 05.
Article
in English
| MEDLINE
| ID: mdl-15026048
ABSTRACT
Based on molecular modeling studies, macrocyclic inhibitors of phosphatase cdc25B were synthetically derived from steroids. A preliminary SAR for this new template was elaborated. A series of compounds shows inhibition of cdc25B in the low micromolar range and good selectivity versus other phosphatases. The compounds did not show a significant antiproliferative effect in MaTu or HaCaT cells.
Subject(s)
Cell Cycle Proteins/antagonists & inhibitors , Drug Design , Protease Inhibitors/chemical synthesis , cdc25 Phosphatases/antagonists & inhibitors , Cell Cycle Proteins/metabolism , Protease Inhibitors/metabolism , Structure-Activity Relationship , cdc25 Phosphatases/metabolism
2.
Angew Chem Int Ed Engl
; 42(33): 3961-4, 2003 Aug 25.
Article
in English
| MEDLINE
| ID: mdl-12949881