ABSTRACT
The astrophysical phenomenon of mimetic helical magnetic field (hB)-assisted self-assembly is herein introduced to build helical superstructures that display chiroptical properties. As a building block, magnetoplasmonic (MagPlas) Ag@Fe3O4 core-shell nanoparticles are used to guide plasmonic Ag nanoparticles onto a helical magnetic flux. The chirality of the assembled helical structures and tailored circular dichroism are successfully tuned in real time, and the handedness of the assembled structures is dynamically switched by the hB at the millisecond level, which is at least 6000-fold faster than other template-assisted methods. The peak position of circular dichroism can be reconfigured by altering the plasmonic resonance or coupling by controlling the size of the Ag core and magnetic flux density. The hB-induced chirality modulation represents a method to control the polarization state of light at the nexus of plasmonics, magnetic self-assembly, colloidal science, liquid crystals, and chirality. It presents active and dynamic chiral assemblies of magnetoplasmonic nanomaterials, enabling further practical applications in optical devices.
ABSTRACT
HGTD-P is a hypoxia-responsive pro-apoptotic protein that transmits hypoxic signals directly to mitochondria. When overexpressed, HGTD-P induces cell death via typical mitochondrial apoptotic cascades. However, much is unknown about post-transcriptional modification and signaling networks of HGTD-P in association with cell death-regulating proteins. We performed yeast two-hybrid screening to identify the molecules involved in HGTD-P-mediated cell death pathways. In this study, we show that heat shock protein 90 physically interacts with HGTD-P and that suppression of Hsp90 activity by low concentrations of geldanamycin reduced HGTD-P-induced mitochondrial catastrophe through inhibition of mitochondrial translocation of HGTD-P.
