ABSTRACT
Los nevus epidérmicos son hamartomas originados en la epidermis y/o en las estructuras anexiales de la piel que se han clasificado clásicamente partiendo de la morfología. En los últimos años se han descrito variantes nuevas y se han producido avances en el campo de la genética que han permitido caracterizar mejor estas lesiones y comprender su relación con algunas de las manifestaciones extracutáneas a las que se han asociado. En esta primera parte revisaremos los nevus derivados de la epidermis y los síndromes que se han descrito asociados a ellos
Epidermal nevi are hamartomatous lesions derived from the epidermis and/or adnexal structures of the skin; they have traditionally been classified according to their morphology. New variants have been described in recent years and advances in genetics have contributed to better characterization of these lesions and an improved understanding of their relationship with certain extracutaneous manifestations. In the first part of this review article, we will look at nevi derived specifically from the epidermis and associated syndromes
Subject(s)
Humans , Nevus/epidemiology , Skin/pathology , Hamartoma Syndrome, Multiple , Skin Neoplasms/epidemiology , Nevus/pathology , Nevus/classification , Nevus/geneticsABSTRACT
Los nevus epidérmicos son hamartomas originados en la epidermis y/o en las estructuras anexiales de la piel que se han clasificado clásicamente partiendo de la morfología. En los últimos años se han descrito variantes nuevas y se han producido avances en el campo de la genética que han permitido caracterizar mejor estas lesiones y comprender su relación con algunas de las manifestaciones extracutáneas a las que se han asociado. En esta segunda parte revisaremos los nevus derivados de estructuras anexiales de la piel y los síndromes que se asocian
Epidermal nevi are hamartomatous lesions derived from the epidermis and/or adnexal structures of the skin; they have traditionally been classified according to their morphology. New variants have been described in recent years and advances in genetics have contributed to better characterization of these lesions and an improved understanding of their relationship with certain extracutaneous manifestations. In the second part of this review article, we will look at nevi derived from the adnexal structures of the skin and associated syndromes
Subject(s)
Humans , Nevus/epidemiology , Epidermis/pathology , Nevus, Sebaceous of Jadassohn/pathology , Sebaceous Glands/pathology , Carcinoma, Basal Cell/complications , Nevus/pathology , Hair Follicle/pathology , Sweat Gland Neoplasms/pathology , Skin Neoplasms/pathologyABSTRACT
Epidermal nevi are hamartomatous lesions derived from the epidermis and/or adnexal structures of the skin; they have traditionally been classified according to their morphology. New variants have been described in recent years and advances in genetics have contributed to better characterization of these lesions and an improved understanding of their relationship with certain extracutaneous manifestations. In the first part of this review article, we will look at nevi derived specifically from the epidermis and associated syndromes.
Subject(s)
Epidermis/pathology , Keratinocytes/pathology , Nevus/classification , Skin Neoplasms/classification , Abnormalities, Multiple/classification , Abnormalities, Multiple/genetics , Abnormalities, Multiple/pathology , Darier Disease/classification , Darier Disease/pathology , Genetic Association Studies , Genetic Diseases, X-Linked/classification , Genetic Diseases, X-Linked/genetics , Genetic Diseases, X-Linked/pathology , Humans , Ichthyosiform Erythroderma, Congenital/classification , Ichthyosiform Erythroderma, Congenital/genetics , Ichthyosiform Erythroderma, Congenital/pathology , Limb Deformities, Congenital/classification , Limb Deformities, Congenital/genetics , Limb Deformities, Congenital/pathology , Mosaicism , Mutation , Nevus/genetics , Nevus/pathology , Pemphigus, Benign Familial/classification , Pemphigus, Benign Familial/pathology , Proteus Syndrome/classification , Proteus Syndrome/genetics , Proteus Syndrome/pathology , Skin Neoplasms/genetics , Skin Neoplasms/pathology , SyndromeABSTRACT
Epidermal nevi are hamartomatous lesions derived from the epidermis and/or adnexal structures of the skin; they have traditionally been classified according to their morphology. New variants have been described in recent years and advances in genetics have contributed to better characterization of these lesions and an improved understanding of their relationship with certain extracutaneous manifestations. In the second part of this review article, we will look at nevi derived from the adnexal structures of the skin and associated syndromes.
Subject(s)
Neoplasms, Adnexal and Skin Appendage/classification , Nevus/classification , Epidermal Cyst/classification , Epidermal Cyst/pathology , Hair Diseases/classification , Hair Diseases/pathology , Hair Follicle/pathology , Humans , Neoplasms, Adnexal and Skin Appendage/genetics , Neoplasms, Adnexal and Skin Appendage/pathology , Nevus/genetics , Nevus/pathology , Nevus, Pigmented/classification , Nevus, Pigmented/genetics , Nevus, Pigmented/pathology , Nevus, Sebaceous of Jadassohn/classification , Nevus, Sebaceous of Jadassohn/genetics , Scalp , Skin Neoplasms/classification , Skin Neoplasms/genetics , Skin Neoplasms/pathologyABSTRACT
Schnitzler's syndrome (SS) is a rare entity characterized by the association of chronic urticaria and monoclonal IgM gammopathy. Usually, intermittent fever, arthralgia and elevation of erythrocyte sedimentation rate also occur. We report a patient with the same symptoms, but with monoclonal IgG instead of IgM paraproteinaemia. Histological examination of the urticarial lesions showed signs of leucocytoclastic vasculitis. After 20 years of therapeutic failure, cyclosporin has achieved a total clearance of urticarial lesions in our patient. Two previous similar cases with clinical features of SS and monoclonal IgG immunoglobulin have been described. We suggest our case also represents a variant of SS with IgG gammopathy.
Subject(s)
Cyclosporine/therapeutic use , Immunoglobulin G/immunology , Immunosuppressive Agents/therapeutic use , Schnitzler Syndrome/drug therapy , Schnitzler Syndrome/immunology , Adult , Female , HumansSubject(s)
Benzoyl Peroxide/adverse effects , Dermatitis, Allergic Contact/etiology , Acne Vulgaris/drug therapy , Adolescent , Adult , Female , Humans , Male , Patch TestsABSTRACT
Se presenta el montaje de la tecnica bioquimica de determinacion del receptor de progesterona en utero de rata. Se analizan y discuten los resultados encontrados en la utilizacion de esta tecnica en 87 pacientes con tumores mamarios malignos, a los que se les realizo, simultaneamente la determinacion del receptor estrogenico. Se evalua, ademas, el control de calidad propuesto por nuestro laboratorio para el uso sistematico de estas dos tecnicas, conjuntamente, como mejor criterio bioquimico de hormonodependencia
Subject(s)
Breast Neoplasms , Receptors, Estrogen , Receptors, ProgesteroneABSTRACT
The principal aims of this paper were to know the epidemiologic and clinical aspects of epilepsy in children and the use of an original methodology in the study of chronic illnesses. A survey was carried out through home calls by sampling an area in Havana City, Cuba; 14,445 children were studied. The sample was chosen at random by groups with proportional probabilities as to size, single stage. It was carried out by: --Detection of suspects by questioning. --Confirmation of suspects by means of a clinical exmination performed by specialists. Prevalence in children resulted in 7.5 epileptic children out of a thousand inhabitants. The lowest rate present was from 0 to 4 years of age (3.5) and the highest, from 10 to 14 (10). 39.4% of the cases had their first attack during the first year of lie. A highest rate was present was from 0 to 4 years of age (3.5) and the highest, from 10 to 14 (10). 39.4% of the cases had their first attack during the first year of life. A highest rate was present in the male sex (8.4 and lowest in females (6.5). Educational level was lower than the population's average; 37% did not attend classes, 87% of children showed generalized attacks, 48.1% were classified as having primary epilepsy (idiopathic) and 51.8% as organic (secondary). Some other clinical phenomena are also described, as well as aspects of medical care.
