ABSTRACT
OBJECTIVE: No gold-standard treatment exists for motor functional neurological disorder (mFND), and limited evidence has been found for the effectiveness of cognitive-behavioral therapy (CBT) in treating the disorder. This study examined sociodemographic and clinical characteristics, treatment outcomes, and treatment dropout among patients with and without mFND who received CBT in a neuropsychiatric outpatient clinic in the United Kingdom. METHODS: Data from a large anonymized psychiatric register were used to identify patients who received outpatient CBT in a neuropsychiatry clinic between 2006 and 2016 and who had either mFND (N=98) or other neuropsychiatric conditions (ONP) (N=76, control group). The study examined sociodemographic characteristics, physical symptom improvement, and changes in clinical outcome and scores on three instruments measuring psychological distress, psychiatric sequelae of brain injury, and depression. RESULTS: The most common mFND symptoms were weakness, pain, and tremors. A logistic regression analysis found no sociodemographic differences between patients with mFND who dropped out early and those who completed CBT. Pre- and post-CBT scores on the three instruments were available for only a small subset of patients; both mFND and ONP patients showed significant improvements in overall scores. A logistic regression analysis found only a single predictor of symptom improvement in the mFND group: acceptance of a psychological explanation of symptoms prior to treatment. CONCLUSIONS: Improvements in physical and psychological functioning were similar for patients with mFND and patients with ONP who were treated in a specialist CBT clinic. This study provides evidence that CBT is feasible and effective for some patients with mFND.
Subject(s)
Cognitive Behavioral Therapy , Conversion Disorder/therapy , Mental Disorders/therapy , Nervous System Diseases/therapy , Outcome Assessment, Health Care , Registries , Adult , Comorbidity , Conversion Disorder/complications , Conversion Disorder/epidemiology , Female , Humans , Male , Mental Disorders/complications , Mental Disorders/epidemiology , Middle Aged , Movement Disorders/epidemiology , Movement Disorders/etiology , Movement Disorders/therapy , Muscle Weakness/epidemiology , Muscle Weakness/etiology , Muscle Weakness/therapy , Nervous System Diseases/complications , Nervous System Diseases/epidemiology , Outpatients , Pain/epidemiology , Pain/etiology , Retrospective Studies , Tremor/epidemiology , Tremor/etiology , Tremor/therapyABSTRACT
BACKGROUND: Gold standard protocols have yet to be established for the treatment of motor conversion disorder (MCD). There is limited evidence to support inpatient, multidisciplinary intervention in chronic, severe cases. AIMS: To evaluate the characteristics and outcomes of MCD patients admitted to a specialist neuropsychiatric inpatient unit. METHODS: All patients admitted to the Lishman Unit (years 2007-2011) with a diagnosis of MCD were included. Data relevant to characteristics and status with regard to mobility, activities of daily living (ADLs) and Modified Rankin Scale (MRS) score at admission and discharge were extracted. RESULTS: Thirty-three cases (78.8% female) were included; the median duration of illness was 48â months. In comparison with brain injury patients admitted to the same unit, more cases had histories of childhood sexual abuse (36.4%, n=12), premorbid non-dissociative mental illness (81.1%, n=27) and employment as a healthcare/social-care worker (45.5%, n=15). Cases showed significant improvements in MRS scores (p<0.001), mobility (p<0.001) and ADL (p=0.002) following inpatient treatment. CONCLUSIONS: Patients with severe, long-standing MCD can achieve significant improvements in functioning after admission to a neuropsychiatry unit.