ABSTRACT
RESUMO Objetivo Mensurar a prevalência de úlcera por pressão e a incidência de queda de pacientes em três hospitais de ensino do Município de São Paulo. Método Estudo quantitativo, exploratório-descritivo. Os dados foram coletados no período de agosto de 2012 a julho de 2013, por meio de um formulário e analisados segundo estatística descritiva e inferencial. Resultados A média anual da prevalência geral de úlcera por pressão (UP) foi de 10,1% e a incidência de queda de pacientes foi de 13,8. Conclusão Os pacientes do Hospital 3 foram os mais vulneráveis às úlceras por pressão e à queda, devido, provavelmente, à agressividade da doença e aos tratamentos complexos a que são submetidos. A aplicação desses indicadores vem possibilitando o benchmarking e a revisão dos protocolos institucionais, tanto assistenciais como gerenciais.
RESUMEN Objetivo Mensurar la prevalencia de úlcera por presión y la incidencia de caídas de pacientes en tres hospitales de enseñanza en São Paulo. Método Un estudio cuantitativo, exploratorio y descriptivo. Los datos fueron recogidos a partir de agosto 2012-julio 2013, a través de un formulario y analizados mediante estadística descriptiva e inferencial. Resultados el promedio anual de la prevalencia general de úlcera por presión (UP) fue 10,1% y la incidencia de caídas de los pacientes fue de 13,8. Conclusión Los pacientes del Hospital 3 fueron más vulnerables a las úlceras por presión y caída, probablemente debido a la agresividad de la enfermedad y los tratamientos complejos a que son sometidos. La aplicación de estos indicadores ha permitido el benchmarking y la revisión de los protocolos institucionales, tanto de asistencia y de gestión.
ABSTRACT Objective To measure the prevalence of pressure ulcers and the incidence of patient falls in three teaching hospitals in the city of São Paulo. Method Quantitative, exploratory and descriptive study. Data were collected from August 2012 to July 2013 using a form. They were analyzed according to descriptive and inferential statistics. Results The annual mean of pressure ulcers overall prevalence (PU) was of 10.1%, and the incidence of patient falls was of 13.8%. Conclusion Patients of Hospital 3 were the most vulnerable to pressure ulcers and falls, probably due to the aggressiveness of the disease and the complex treatments these patients were undergoing. Implementation of such indicators has enabled benchmarking and review of both assistance and management institutional protocols.
Subject(s)
Humans , Accidental Falls/statistics & numerical data , Quality Indicators, Health Care , Pressure Ulcer/epidemiology , Patient Safety , Hospitals, TeachingABSTRACT
Objective To measure the prevalence of pressure ulcers and the incidence of patient falls in three teaching hospitals in the city of São Paulo. Method Quantitative, exploratory and descriptive study. Data were collected from August 2012 to July 2013 using a form. They were analyzed according to descriptive and inferential statistics. Results The annual mean of pressure ulcers overall prevalence (PU) was of 10.1%, and the incidence of patient falls was of 13.8%. Conclusion Patients of Hospital 3 were the most vulnerable to pressure ulcers and falls, probably due to the aggressiveness of the disease and the complex treatments these patients were undergoing. Implementation of such indicators has enabled benchmarking and review of both assistance and management institutional protocols.
ABSTRACT
PURPOSE: We investigated the effects of ischemia/reperfusion in the intestine (I/R-i) on purine receptor P2X2-immunoreactive (IR) neurons of the rat ileum. METHODS: The superior mesenteric artery was occluded for 45 min with an atraumatic vascular clamp and animals were sacrificed 4 h later. Neurons of the myenteric and submucosal plexuses were evaluated for immunoreactivity against the P2X2 receptor, nitric oxide synthase (NOS), choline acetyl transferase (ChAT), calbindin, and calretinin. RESULTS: Following I/R-i, we observed a decrease in P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of neurons of the myenteric and submucosal plexuses. These studies also revealed an absence of calbindin-positive neurons in the I/R-i group. In addition, the colocalization of the P2X2 receptor with NOS, ChAT, and calretinin immunoreactivity in the myenteric plexus was decreased following I/R-i. Likewise, the colocalization between P2X2 and calretinin in neurons of the submucosal plexus was also reduced. In the I/R-i group, there was a 55.8% decrease in the density of neurons immunoreactive (IR) for the P2X2 receptor, a 26.4% reduction in NOS-IR neuron, a 25% reduction in ChAT-IR neuron, and a 47% reduction in calretinin-IR neuron. The density of P2X2 receptor and calretinin-IR neurons also decreased in the submucosal plexus of the I/R-i group. In the myenteric plexus, P2X2-IR, NOS-IR, ChAT-IR and calretinin-IR neurons were reduced in size by 50%, 49.7%, 42%, and 33%, respectively, in the I/R-i group; in the submucosal plexus, P2X2-IR and calretinin-IR neurons were reduced in size by 56% and 72.6%, respectively. CONCLUSIONS: These data demonstrate that ischemia/reperfusion of the intestine affects the expression of the P2X2 receptor in neurons of the myenteric and submucosal plexus, as well as density and size of neurons in this population. Our findings indicate that I/R-i induces changes in P2X2-IR enteric neurons that could result in alterations in intestinal motility.
