Sorption of non-narcotic analgetic drugs of medicinal charcoal.

Adsorption of four 5-pyrazolone derivatives and two carboxylic acids from aqueous solutions was studied. Partition coefficients for the analyzed drugs were calculated. Good corelation between log(k1, k2) (Langmuir constants) and log (octanol-water partition coefficient) of the drugs were found. The higher log(k1k2) value the higher solubility of the non-narcotic and analgetic drugs.

[Adsorption of tetracycline and oxytetracycline on Alusal]. / Sorpcja chlorowodorków oksytetracykliny i tetracykliny na alusalu.

The sorption of tetracycline and oxytetracycline on Alusal was studied. The proton complexes between tetracyclines and aluminium ions are formed.

[Effect of antacids on pepsin activity in gastric acid]. / Badanie wplywu preparatów z grupy antacida naaktywnosc pepsyny w sztucznym soku zoladkowym.

The 9 widely used antacids were studied for antipepsic activity.

[Evaluation of the liberation of aluminum and magnesium ions from preparations made up of antacid ]. / Badanie uwalniania jonów glinu i magnezu z preparatów zlozonych z grupy antacida.

Releasing of Al3+, Mg2+ and Ca2+ cations from 24 antacid mixtures, 15 from which were prepared in our Department and 9 of foreign origin, during the neutralization reaction of HC10,1 mol/dm3 was determined. Duration of action at pH 3-5 and acid consuming capacity of HCl 1 mol/dm3 acc. to USP XX was also performed. It was stated that magnesium cations were first than Al3+ released from the antacid mixtures during the neutralization reaction.

[Drug interactions during storage of mixtures of the antacid group. II. Effect of temperature on the formation of hydrotalcite in neutralizing suspensions]. / Badanie oddzialywan zachodzacych podczas przechowywania mieszanin z grupy antacida. II. Wplyw temperatury na powstawanie hydrotalcytu w zawiesinach zobojetniajacych.

Eight antacid mixtures were stored for 110 days at 25 degrees C, 35 degrees C and 45 degrees C in the form of suspensions in water. Changes in pH were followed, and the structural changes in suspension components were studied by X-ray analysis. It has been stated that formation of hydrotalcite, the product od interaction of the mixture components depends mainly on the kind and ratio of the suspension reactants, and only to a little degree on the storage temperature.

[Drug interactions during storage of mixtures of the antacid group. III. Effect of relative humidity on structural changes in mixtures aluminum hydroxide gel and magnesium hydroxide in the solid phase]. / Badanie oddzialywan zachodzacych podczas przechowywania mieszanin z grupy antacida.III. WpLyw wilgotnosci wzglednej na zmiany struktury mieszanin zelu wodorotlenku glinowego i magnezowego w fazie staLej.

Mixtures of A1(OH)3 gel and Mg(OH)2 were stored for 14 months in the solid phase in chambers with relative air humidity of 35%, 55%, 76% and 92%. IR spectra of the stored mixtures were measured. In mixtures stored at relative air humidity of 35% there were found no changes in IR spectra, while the mixtures stored at relative air humidity of 92% proved to exhibit IR spectra characteristic for hydrotalcite.

[Study on the interactions during storage of compounds of the antacid group. I. Interactions of the components in suspensions]. / Badanie oddzialywan zachodzacych podczas przechowywania mieszanin z grupy antacida. I. Oddzialywania miedzy skladnikami mieszanin w zawiesinie.

Twenty antacid mixtures of six quality groups containing Al(OH)3, gel, Mg(OH)2, Mg2Si3O8, CaCO3 and NaAl(OH)2CO3 at different ratios were prepared and stored for 150 days at 20 degrees C in the form of aqueous suspensions. Changes of pH in the suspensions were measured, and the accompanying structural changes were examined by IR spectrometry and X-ray diffraction analysis. Hydrotalcite was found to be formed during storage of aqueous suspensions of mixtures of Al(OH)3 Mg(OH)2; Al(OH)3: Mg(OH)2: CaCO3; Al(OH)3: Mg(OH)2: NaAl(OH)2CO3 and Mg(OH)2: NaAl(OH)2CO3. Initial neutralization activities of the suspensions and those found after the storage were compared.

[Studies of physico-chemical properties and structure of aluminum hydrochloride obtained from aluminum isopropanolane]. / Badanie wlasciwosci fizykochemicznych i przemian fazowych zeli wodorotlenku glinowego otrzymanego z izopropanolanu glinu.

Aluminium hydroxide gels were precipitated from aluminium isopropoxide by addition of water or aqueous solutions of Na2SO4, NaCl and NaNO3. The antacid activity of the gels was assessed on the basis of determinations of their total capacity to neutralize HCl, while structure of the gels was studied by X-ray diffraction analysis and IR spectrometry. It has been stated that prolonged storage, higher storage temperature and presence of water promote conversion of the active form of aluminium hydroxide gels in pharmaceutical preparations into less active forms.

[Comparison of the methods of in vitro evaluation of the neutralizing properties of drugs from the antacid group]. / Porównanie metod oceny in vitro wlasciwosci zobojetniajacych preparatów z grupy antacida.

Usefulness of the pH-stat method for assaying the neutralizing activity of antacids was compared with the ones of the methods based on the determination of the action time by dynamic methods. A high level of correlation between the antacid dose and the neutralization capacity has been stated. The found relationships proved to enable optimization of the antacid dosage as well as prediction of the therapeutic effect.

Effect of composition on the neutralizing properties of antacid preparations.

11 antacid mixtures made up to simulate the preparations available on the market were prepared. These mixtures contain aluminium hydroxide gel, calcium carbonate, magnesium hydroxide and magnesium trisilicate. The antacid properties of the mixtures obtained were characterized by total acid consuming capacity, rate of neutralization and duration of action. It was indicated that the composition of the mixtures influenced their neutralizing properties; an interaction between constituents of these preparations was noted.