ABSTRACT
Introduction The aim of this study was to determine if the combined use of curcumin and platelet-rich plasma (PRP) improves the axonal regeneration process in acutely repaired nerve injuries. Materials and Methods The right sciatic nerves of 32 Holtzman albino rats were transected and immediately repaired. Four treatments were randomly allocated: (1) nerve repair only; (2) nerve repair + local PRP; (3) nerve repair + intraperitoneal curcumin; and (4) nerve repair + local PRP + intraperitoneal curcumin. Clinical (estimation of sciatic functional index) and electrophysiological outcomes were assessed 4 and 12 weeks after surgery, and histologic evaluations performed 12 weeks after surgery. Results Group IV (PRP + curcumin) resulted in significantly better outcomes across all the evaluation parameters, compared with the other three groups ( p < 0.05). Additionally, when used as single adjuvants, both the curcumin (group III) and PRP (group II) groups showed significant improvement over the control group ( p < 0.05). No significant differences were found between PRP and curcumin when used as sole adjuvants. Conclusion The combined administration of curcumin + PRP as adjuvants to nerve repair could enhance axonal regeneration in terms of clinical, electrophysiological, and histological parameters in a rat model of acute sciatic nerve injury.
ABSTRACT
RESUMEN La infección por SARS-CoV-2 se ha diseminado rápidamente, provocando una pandemia mundial en la cual nos vemos afectados. En el Instituto Nacional de Salud del Niño de San Borja, centro de referencia nacional de pacientes pediátricos quirúrgicos, desde el 14 de abril al 12 de agosto del 2020, se hospitalizaron 106 pacientes con infección por SARS-CoV-2, de los cuales 11 tuvieron diagnostico quemadura y dos fueron pacientes grandes quemados con diagnóstico COVID-19 por prueba molecular. Detallamos el caso de una paciente pediátrica, de siete años, gran quemada que fue atendida en unidad de cuidados intensivos, y con COVID-19 asintomática, presentó evolución y pronóstico favorable, con recuperación total de su lesión. Por otro lado, el COVID-19 se puede manifestar de forma severa produciendo un síndrome inflamatorio multisistémico que presenta manifestaciones clínicas poco comunes y que puede empeorar el pronóstico, como fue observado en nuestro otro paciente de siete meses que falleció pese a recibir manejo especializado y oportuno.
ABSTRACT SARS-CoV-2 infection is rapidly disseminating, leading to a world pandemics in which we are also affected. In San Borja Peruvian National Children Health Institute, which is the reference center for surgical pediatric patients, 106 patients infected with SARS-CoV-2 were hospitalized. Of them, 11 presented with burns and two had large burns. The viral infection was diagnosed using molecular testing. We present in detail the case of a pediatric seven-year old patient who had large burns and was taken care of in the intensive care unit. She had asymptomatic SARS-CoV-2 infection, and her outcome was good, with a good prognosis, and she recovered completely and uneventfully. On the other hand, COVID-19 may present as a severe disease leading to a multi- systemic inflammatory syndrome with some uncommon clinical manifestations which affect its prognosis , as it was the case with another seven-month old patient who passed away in spite of having received specialized and timely therapy.