Building national patient registries in Mexico: insights from the MexOMICS Consortium.

Objective: To introduce MexOMICS, a Mexican Consortium focused on establishing electronic databases to collect, cross-reference, and share health-related and omics data on the Mexican population. Methods: Since 2019, the MexOMICS Consortium has established three electronic-based registries: the Mexican Twin Registry (TwinsMX), Mexican Lupus Registry (LupusRGMX), and the Mexican Parkinson's Research Network (MEX-PD), designed and implemented using the Research Electronic Data Capture web-based application. Participants were enrolled through voluntary participation and on-site engagement with medical specialists. We also acquired DNA samples and Magnetic Resonance Imaging scans in subsets of participants. Results: The registries have successfully enrolled a large number of participants from a variety of regions within Mexico: TwinsMX (n = 2,915), LupusRGMX (n = 1,761) and MEX-PD (n = 750). In addition to sociodemographic, psychosocial, and clinical data, MexOMICS has collected DNA samples to study the genetic biomarkers across the three registries. Cognitive function has been assessed with the Montreal Cognitive Assessment in a subset of 376 MEX-PD participants. Furthermore, a subset of 267 twins have participated in cognitive evaluations with the Creyos platform and in MRI sessions acquiring structural, functional, and spectroscopy brain imaging; comparable evaluations are planned for LupusRGMX and MEX-PD. Conclusions: The MexOMICS registries offer a valuable repository of information concerning the potential interplay of genetic and environmental factors in health conditions among the Mexican population.

[Giant Baker's cyst treated with intralessional methotrexate]. / Quiste de Baker gigante tratado con metrotrexato intralesional.

INTRODUCTION: Synovial cyst is composed by a fibrous wall; lining by a thin layer of synovial cells containing synovial fluid, the prototype of these, in the knee is the Baker's cyst, which is located abnormally in the gastrocnemius semimembranous bursa. Baker's cyst prevalence ranges from 5 - 38%. Clinical diagnosis is supported by the presence of increased volume of soft tissues located in the popliteal region. CLINICAL CASE: A 74 year-old woman with longstanding active rheumatoid arthritis who developed a large, recurrent Baker's cyst. The Baker's cyst had two flare-ups of pain and soft tissue swelling which eventually limited knee movements; was treated with needle aspiration guided by ultrasound and synovectomy with methotrexate twice. At 18-months follow-up, the patient remains without evidence of recurrence. CONCLUSIONS: Local infiltration of methotrexate represents an alternative therapy for those refractory Baker's cyst with partial response to conventional treatment, where the surgical procedure carries a high risk.

Clinical significance of auditive involvement in rheumatoid arthritis: a case-control study.

Introduction. Rheumatoid arthritis (RA) can involve the incudomalleolar or incudostapedial articulations. Objective. To know the punctual prevalence of audiological alterations in patients with RA. Patients and Methods. RA patients and their controls (Cs), were evaluated by Tonal Audiometry (AU); if there were alterations in the air conduction (AC), bone conduction (BC), Logoaudiometry (LG), and Tympanometry (T) were performed. Results. 45 RA patients and 45 Cs were evaluated. RA patients had 40% of bilateral and 17.8% unilateral alteration versus Cs with 22.2% bilateral and 4.4% unilateral alteration versus Cs with 22.2% bilateral and 4.4% unilateral in AC audiometry. In conventional T (CT) As-type curves in patients with RA, there were 22 LE (48.8%) and 26 RE (57.7%) versus Cs, there were16 RE (35.5%) and 20 LE (44.4%). In High-frequency T (HFT): the 3B1G pattern in RA more frequent versus Controls (Cs) in RE (P = .002 and LE (P = .01). There were no differences according to RA activity or RA disease evolution. Conclusions. There is a greater tendency of auditive loss of As curves in CT (rigidity in ossicular chain) and of the 3B1G pattern in HFT in RA.

Estudios de imagen y electromiografía en las miopatías inflamatorias / Imaging techniques and electromyography in inflammatory myopathies

Las diferentes técnicas de imagen son empleadas en el diagnóstico, evaluación y seguimiento de las miopatías inflamatorias (MI); de ellas, las que mayor información proporcionan son el ultrasonido y las imágenes por resonancia magnética. El electrodiagnóstico en las MI se basa principalmente en la electromiografía (EMG), que presenta diferentes patrones sobre la base del tiempo de evolución de la enfermedad. En la fase aguda se documentan potenciales polifásicos con duración y amplitud disminuidas, mientras que en la fase crónica se encuentran patrones mixtos neuropáticos y miopáticos. Posterior al tratamiento con esteroides tiende a normalizarse la EMG (AU)

Different imaging techniques are used for the diagnosis, evaluation and follow-up of inflammatory myopathies; of these techniques, the ones that provide the largest amount of information are ultrasonography and magnetic resonance imaging. Electrodiagnosis in inflammatory myopathies is based mainly on electromyography (EMG), which shows different patterns according to the different disease presentations. In the acute phase, polyphasic potentials with diminished amplitude and duration are seen, whereas in its chronic phases, mixed neuropathic and myopathic patterns are found. After corticosteroid treatment, EMG tends to return to normal (AU)

[Imaging techniques and electromyography in inflammatory myopathies]. / Estudios de imagen y electromiografía en las miopatías inflamatorias.

Different imaging techniques are used for the diagnosis, evaluation and follow-up of inflammatory myopathies; of these techniques, the ones that provide the largest amount of information are ultrasonography and magnetic resonance imaging. Electrodiagnosis in inflammatory myopathies is based mainly on electromyography (EMG), which shows different patterns according to the different disease presentations. In the acute phase, polyphasic potentials with diminished amplitude and duration are seen, whereas in its chronic phases, mixed neuropathic and myopathic patterns are found. After corticosteroid treatment, EMG tends to return to normal.

Prevalencia y factores de riesgo de la osteoartritis / Prevalence and risk factors in osteoarthritis

La osteoartritis es una de las condiciones médicas más frecuentes en la población, es una causa importante de discapacidad en los adultos mayores, y genera altos costos. La incidencia y la prevalencia de la enfermedad varían de acuerdo con el tipo de definiciones que se utilice. El diagnóstico se establece por criterios clínicos, radiológicos e, idealmente, ambos. Las articulaciones más afectadas son las manos, las rodillas y las caderas, aunque con una distribución variable dependiendo de la población estudiada. Se revisa la prevalencia de estos tres tipos de osteoartritis en los cinco continentes y se comenta los factores de riesgo más estudiados en cada uno (AU)

Osteoarthritis is one of the most common chronic conditions; it is a leading cause of disability in older adults and generates high costs. Incidence and prevalence of the disease varies according to the definition used. Diagnosis is established according to clinical or radiological, and ideally according to both. Joints most frequently affected are hands, knees and hip, although population distribution varies depending on the population studied. We review the prevalence of these three groups of osteoarthritis in the five continents, and we discuss the risk factors most frequently associated to each one (AU)

[Prevalence and risk factors in osteoarthritis]. / Prevalencia y factores de riesgo de la osteoartritis.

Osteoarthritis is one of the most common chronic conditions; it is a leading cause of disability in older adults and generates high costs. Incidence and prevalence of the disease varies according to the definition used. Diagnosis is established according to clinical or radiological, and ideally according to both. Joints most frequently affected are hands, knees and hip, although population distribution varies depending on the population studied. We review the prevalence of these three groups of osteoarthritis in the five continents, and we discuss the risk factors most frequently associated to each one.