Subject(s)
Heart Arrest, Induced , Hypothermia, Induced , Mitochondria, Heart/enzymology , Myocardium/metabolism , Oxidoreductases/metabolism , Animals , Dogs , Glutamate Dehydrogenase/metabolism , Hydroxybutyrate Dehydrogenase/metabolism , Ketoglutarate Dehydrogenase Complex/metabolism , Malate Dehydrogenase/metabolism , Male , Succinate Dehydrogenase/metabolismABSTRACT
Foram estudados 24 caes distribuidos nos seguintes grupos: Grupo I - Oito animais, cujos coracoes foram estudados imediatamente apos anestesia e toratocomia (controle).Grupo II Oito animais submetidos a 60 minutos de parada cardiaca anoxica normotermica. Grupo III Oito animais submetidos a 60 minutos de parada cardiaca anoxica hipotermica (20 graus).Os resultados obtidos possibilitaram as seguintes conclusoes: A) O esfriamento seletivo do miocardio impediu a diminuicao das concentracoes de ATP. B) As alteracoes nos sistemas enzimaticos estudados (alfa-ceco-glutario-desidrogenase: succino-desidrogenase; beta-hidroxi-butirico-desidrogenase; glutamico-desidrogenase e malico-desidrogenase), determinadas pela parada anoxica normotermica, excetuando-se o controle da beta-hidroxi-butiricodesidrogenase, nao foram prevenidas pelo esfriamento do miocardio a 20 graus C
Subject(s)
Heart Arrest, Induced , Hypothermia, Induced , Mitochondria, HeartABSTRACT
Male albino rats of the Wistar strain were deprived of food, but not water, and killed at various periods. Enzymes of the metabolism of carbohydrates were assayed in the submandibular salivary glands after 24, 48, 72, 96 and 120 hours of starvation. The body weight loss was accompanied by a decrease in gland weight and gland protein content. Blood glucose fells to about 70% the control level. Hexokinase showed no variation with increasing periods of food deprivation. The decrease in the activity of phosphofructokinase was greater than that one observed for glucose-6-phosphate dehydrogenase, indicating a shift in glucose utilization by the cells, from the glycolytic to the pentose phosphate pathway.