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1.
Hematol Rep ; 11(2): 7914, 2019 May 23.
Article in English | MEDLINE | ID: mdl-31285809

ABSTRACT

Even though the Centers for Medicare and Medicaid Services is penalizing hospitals for readmissions, and postoperative prophylaxis has demonstrated reduced complications associated with deep vein thrombosis (DVT), few studies have examined patient compliance with (DVT) prophylaxis at home. A survey querying DVT prophylaxis management and adherence was administered to patients who were within the one to three-month postoperative period after a total knee or total hip replacement. A total of 103 patients completed the survey. A considerable number of patients (17.0%) were non-adherent to DVT prophylaxis. Patients had a lower understanding of the side effects of their DVT prophylaxis, with 30% responding that they had a poor to simple understanding. There is a high rate of non-compliance and there is a poor understanding of complications related to venous thromboembolism prophylaxis. As the population undergoing arthroplasties grows, this study demonstrates the importance of investigating the role of medication adherence in the rate of postoperative DVT.

2.
Inquiry ; 56: 46958019838118, 2019.
Article in English | MEDLINE | ID: mdl-30947608

ABSTRACT

Medicaid patients are known to have reduced access to care compared with privately insured patients; however, quantifying this disparity with large controlled studies remains a challenge. This meta-analysis evaluates the disparity in health services accessibility of appointments between Medicaid and privately insured patients through audit studies of health care appointments and schedules. Audit studies evaluating different types of outpatient physician practices were selected. Studies were categorized based on the characteristics of the simulated patient scenario. The relative risk of appointment availability was calculated for all different types of audit scenario characteristics. As a secondary analysis, appointment availability was compared pre- versus post-Medicaid expansion. Overall, 34 audit studies were identified, which demonstrated that Medicaid insurance is associated with a 1.6-fold lower likelihood in successfully scheduling a primary care appointment and a 3.3-fold lower likelihood in successfully scheduling a specialty appointment when compared with private insurance. In this first meta-analysis comparing appointment availability between Medicaid and privately insured patients, we demonstrate Medicaid patients have greater difficulty obtaining appointments compared with privately insured patients across a variety of medical scenarios.


Subject(s)
Appointments and Schedules , Health Services Accessibility , Healthcare Disparities , Insurance Coverage , Insurance, Health , Humans , Medicaid , Patient Protection and Affordable Care Act , Primary Health Care , United States
3.
Glob Pediatr Health ; 6: 2333794X19831299, 2019.
Article in English | MEDLINE | ID: mdl-30815517

ABSTRACT

The Patient Protection and Affordable Care Act had a profound impact on health insurance coverage of children. Given the importance of pediatric specialty care, this study assessed access to pediatric orthopedic urgent care for a child's likely operative distal radius fracture. Researchers called 180 pediatric orthopedic surgeons in 8 states requesting appointments for the caller's fictitious 11-year-old child who suffered a distal radius fracture. Each office was called twice to assess the ability to obtain an appointment for Medicaid and privately insured patients. Overall, significantly fewer offices scheduled appointments for Medicaid than privately insured patients (38.3% vs 82.8%, P < .001). Patients with Medicaid in states without Medicaid expansion were more successful in obtaining appointments than patients with Medicaid in states with Medicaid expansion (41 [47%] vs 28 [30%]; P < .001; 95% confidence interval = 0.3-0.9). Pediatric Medicaid patients experienced reduced access to care, and this access was worse in states that had expanded Medicaid eligibility.

4.
Arthroplast Today ; 4(2): 158-161, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29896545

ABSTRACT

Lyme arthritis, caused by the spirochete Borrelia burgdorferi sensu stricto, is a common tick-borne illness in New England and the upper Midwest. Most often, the disease affects the knee and has typically been reported as a cause of native joint infection. There has been only 1 case of Lyme periprosthetic joint infection (associated with a total knee arthroplasty) reported in the literature, and to our knowledge, no other reported cases of Lyme periprosthetic joint infections exist. In this article, we report on 2 patients diagnosed with prosthetic joint infections who were subsequently found to have Lyme prosthetic joint infections, with B burgdorferi as the infectious organism. We discuss the medical and surgical management of these patients.

5.
Orthopedics ; 41(1): e98-e103, 2018 Jan 01.
Article in English | MEDLINE | ID: mdl-29156069

ABSTRACT

Venous thromboembolism (VTE) is a common complication after total hip arthroplasty (THA) and total knee arthroplasty (TKA), occurring in up to 85% of patients who are not treated with prophylaxis. The initiation of VTE development may occur intraoperatively. This study investigated whether this gap in VTE prophylaxis can be addressed by the use of intraoperative intermittent pneumatic compression devices (IPCDs) and if intraoperative IPCDs have a meaningful benefit in preventing symptomatic VTE. The authors defined symptomatic VTE as deep venous thrombosis in either lower extremity or a pulmonary embolism. The authors evaluated the medical records of 3379 patients who underwent THA or TKA at their institution in 2014 and 2015. Effects of various factors, including age, sex, body mass index, and smoking status, were compared between these 2 cohorts. Patients who experienced a symptomatic VTE were also matched by age, sex, and procedure type with randomly selected controls. In the patient sample, 47 patients (1.4%) developed VTE. Forty (1.2%) of these patients underwent TKA, whereas 7 (0.2%) underwent THA. Venous thromboembolism occurred less frequently in patients who received intraoperative IPCDs (0.8%) than in patients who did not receive them (1.5%); however, this difference did not reach statistical significance. Total knee arthroplasty was associated with increased odds of VTE compared with THA, as was female sex. These results did not show a statistically significant benefit to the intraoperative use of IPCDs. Pneumatic compression remains a fast, easy, low-cost, low-risk, intuitive intervention that can supplement the postoperative multimodal approach and is worthy of further study. Intraoperative IPCD use should be considered for patients with a higher risk of VTE. [Orthopedics. 2018; 41(1):e98-e103.].


Subject(s)
Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Knee/adverse effects , Intermittent Pneumatic Compression Devices , Venous Thromboembolism/prevention & control , Adolescent , Adult , Aged , Aged, 80 and over , Anticoagulants/therapeutic use , Body Mass Index , Case-Control Studies , Combined Modality Therapy , Female , Humans , Intraoperative Care/methods , Male , Middle Aged , Pulmonary Embolism/etiology , Pulmonary Embolism/prevention & control , Venous Thromboembolism/etiology , Venous Thrombosis/etiology , Venous Thrombosis/prevention & control , Young Adult
6.
Orthop J Sports Med ; 5(7): 2325967117714140, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28812034

ABSTRACT

BACKGROUND: The goal of the Patient Protection and Affordable Care Act (PPACA) was to expand patient access to health care. Since the rollout of the PPACA, Medicaid patients have demonstrated difficulty obtaining appointments in some specialty care settings. PURPOSE: To assess the effect of insurance type (Medicaid and private) on patient access to orthopaedic surgery sports medicine specialists for a semiurgent evaluation of a likely operative bucket-handle meniscus tear. The study was designed to determine whether disparities in access exist since the PPACA rollout. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: The design was to call 180 orthopaedic surgery sports medicine specialists in 6 representative states (California, Ohio, New York, Florida, Texas, and North Carolina) between June 2015 and December 2015. An appointment was requested for the caller's fictitious 25-year-old-brother who had suffered a bucket-handle meniscus tear. Each office was called twice to assess the ease of obtaining an appointment: once for patients with Medicaid and once for patients with private insurance. For each call, data pertaining to whether an appointment was given, wait times, and barriers to receiving an appointment were recorded. RESULTS: A total of 177 surgeons were called within the study period. Overall, 27.1% of offices scheduled an appointment for a patient with Medicaid, compared with 91.2% (P < .0001) for a patient with private insurance. Medicaid patients were significantly more likely to be denied an appointment due to lack of referral compared with private patients (40.2% vs 3.7%, P < .0001), and Medicaid patients were more likely to experience longer wait times for an appointment (15 vs 12 days, P < .029). No significant differences were found in patients' access to orthopaedic surgery sports medicine specialists between Medicaid-expanded and -nonexpanded states. Medicaid reimbursement for knee arthroscopy with meniscus repair was not significantly correlated with appointment success rate or patient waiting periods. CONCLUSION: Despite the passage of the PPACA, patients with Medicaid have reduced access to care. In addition, patients with Medicaid confront more barriers to receiving appointments than patients with private insurance and wait longer for an appointment.

7.
Spine (Phila Pa 1976) ; 42(15): 1179-1183, 2017 Aug 01.
Article in English | MEDLINE | ID: mdl-27902558

ABSTRACT

STUDY DESIGN: Prospective cohort study. OBJECTIVE: To determine the effects of insurance type (Medicaid vs. a specific private insurance) on patient access to spine surgeons for lumbar disc herniation as measured by (A) acceptance of insurance, (B) need for a referral, and (C) wait time for appointment. SUMMARY OF BACKGROUND DATA: Limited studies have been conducted to examine the issue of patient access to spine surgeons based on different insurance types (Medicaid vs. a specific private insurance), especially in relation to the Medicaid expansion that resulted from the Affordable Care Act. METHODS: Appointment success rates, the need for a referral, and waiting periods were compared between Medicaid and a specific private insurance for patients needing an evaluation for a herniated lumbar disc. The waiting period was studied in the context of comparing states that have expanded Medicaid eligibility to ones that have not, and the surgical training of the spine surgeon (orthopaedic surgeons vs. neurosurgeons). RESULTS: Appointment success rate for patients seeking access to lumbar spine care was significantly higher for patients with BlueCross insurance (95.0%) versus patients with Medicaid insurance (0.8%) (P <0.001). The need for referrals was significantly higher for patients with Medicaid insurance (93.3%) versus patients with BlueCross insurance (4.2%) (P <0.001). Among BlueCross patients, wait times were longer in Medicaid-expanded states. However, the same trend was not seen among patients with Medicaid insurance. CONCLUSION: Patients with Medicaid were less successful at scheduling an appointment and faced more barriers to care, such as the need for a referral, compared with the private insurance studied. In the states with expanded Medicaid, wait times for appointments were longer for BlueCross patients, but were not longer for patients with Medicaid insurance. Overall, this study suggests that increased coverage resulting from Medicaid expansion does not necessarily equate to increased access to care. LEVEL OF EVIDENCE: 2.


Subject(s)
Health Services Accessibility/trends , Insurance Coverage/trends , Intervertebral Disc Displacement/surgery , Lumbar Vertebrae/surgery , Neurosurgeons/trends , Patient Protection and Affordable Care Act/trends , Blue Cross Blue Shield Insurance Plans/economics , Blue Cross Blue Shield Insurance Plans/trends , Cohort Studies , Health Services Accessibility/economics , Humans , Insurance Coverage/economics , Insurance, Health/economics , Insurance, Health/trends , Intervertebral Disc Displacement/economics , Intervertebral Disc Displacement/epidemiology , Medicaid/economics , Medicaid/trends , Neurosurgeons/economics , Patient Protection and Affordable Care Act/economics , Prospective Studies , United States/epidemiology , Waiting Lists
8.
J Arthroplasty ; 31(7): 1395-9, 2016 07.
Article in English | MEDLINE | ID: mdl-27036921

ABSTRACT

BACKGROUND: The opinions of nonspecialists and patients will be important to determining reimbursements for specialists such as orthopedic surgeons. In addition, primary care physician (PCP) perceptions of reimbursements may affect utilization of orthopedic services. METHODS: We distributed a web-based survey to PCPs, asking how much they believed orthopedic surgeons were reimbursed for total hip arthroplasty (THA) and total knee arthroplasty (TKA). We also proctored a paper-based survey to postoperative patients, asking how much orthopedic surgeons should be reimbursed. RESULTS: There was a significant difference between perceived and actual reimbursement values for THA and TKA. Hospital-affiliated PCPs estimated higher reimbursements for both THA ($1657 vs $838, P < .0001 for Medicaid and $2246 vs $1515, P = .018 for Medicare) and TKA ($1260 vs $903, P = .052 for Medicaid and $2022 vs $1514, P = .049 for Medicare). Similarly, larger practices estimated higher reimbursements for both THA ($1861 vs $838, P < .0001 for Medicaid and $2635 vs $1515, P = .004 for Medicare) and TKA ($1583 vs $903, P = .005 for Medicaid and $2380 vs $1514, P = .011 for Medicare). Compared to PCPs, patients estimated that orthopedic surgeons should be paid 4 times higher for both THA ($9787 vs $2235, P < .0001) and TKA ($9088 vs $2134, P < .0001). CONCLUSION: PCPs believe that reimbursements for orthopedic procedures are higher than actual values. The effect that these perceptions will have on efforts at cost reform and utilization of orthopedic services requires further study.


Subject(s)
Arthroplasty, Replacement, Hip/economics , Arthroplasty, Replacement, Knee/economics , Medicare/economics , Physicians, Primary Care , Primary Health Care/economics , Reimbursement Mechanisms , Aged , Attitude of Health Personnel , Female , Hospitals , Humans , Male , Medicaid , Medicare/statistics & numerical data , Middle Aged , Orthopedic Procedures , Primary Health Care/organization & administration , Surveys and Questionnaires , United States
9.
Foot Ankle Int ; 37(7): 776-81, 2016 Jul.
Article in English | MEDLINE | ID: mdl-27026727

ABSTRACT

BACKGROUND: The purpose of this study was to assess the effect of insurance type (Medicaid, Medicare, and private insurance) on access to foot and ankle surgeons for total ankle arthroplasty. METHODS: We called 240 foot and ankle surgeons who performed total ankle arthroplasty in 8 representative states (California, Massachusetts, Ohio, New York, Florida, Georgia, Texas, and North Carolina). The caller requested an appointment for a fictitious patient to be evaluated for a total ankle arthroplasty. Each office was called 3 times to assess the responses for Medicaid, Medicare, and BlueCross. From each call, we recorded appointment success or failure and any barriers to an appointment, such as need for a referral. RESULTS: Patients with Medicaid were less likely to receive an appointment compared to patients with Medicare (19.8% vs 92.0%, P < .0001) or BlueCross (19.8% vs 90.4%, P < .0001) and experienced more requests for referrals compared to patients with Medicare (41.9% vs 1.6%, P < .0001) or BlueCross (41.9% vs 4%, P < .0001). Waiting periods were longer for patients with Medicaid compared to those with Medicare (22.6 days vs 11.7 days, P = .004) or BlueCross (22.6 days vs 10.7 days, P = .001). Reimbursement rates did not correlate with appointment success rate or waiting period. CONCLUSION: Despite the passage of the PPACA, patients with Medicaid continue to have difficulty finding a surgeon who will provide care, increased need for a primary care referral, and longer waiting periods for appointments. LEVEL OF EVIDENCE: Level II, prognostic study.


Subject(s)
Ankle Joint/surgery , Arthroplasty/methods , Health Services Accessibility/economics , Insurance Coverage/economics , Patient Protection and Affordable Care Act/economics , Ankle Joint/physiopathology , Arthroplasty/economics , Medicaid , Medicare , United States
10.
J Hand Surg Am ; 41(4): 503-509.e1, 2016 Apr.
Article in English | MEDLINE | ID: mdl-26908020

ABSTRACT

PURPOSE: To assess the effect of insurance type (Medicaid, Medicare, and private insurance) on access to hand surgeons for carpal tunnel syndrome (CTS). METHODS: The research team called 240 hand surgeons in 8 states (California, Massachusetts, Ohio, New York, Florida, Georgia, Texas, and North Carolina). The caller requested an appointment for her fictitious mother to be evaluated for CTS and possible surgical management through carpal tunnel release (CTR). Each office was called 3 times to assess the responses for Medicaid, Medicare, or Blue Cross Blue Shield. From each call, we recorded whether an appointment was given and whether there were barriers to an appointment, such as the need for a referral. RESULTS: Twenty percent of offices scheduled an appointment for a patient with Medicaid, compared with 89% for Medicare and 97% for Blue Cross Blue Shield. Patients with Medicaid had an easier time scheduling appointments (28% vs 13%) and experienced fewer requests for referrals (25% vs 67%) in states with expanded Medicaid eligibility. Neither Medicaid nor Medicare reimbursement for CTR was significantly correlated with the incidence of successful appointments. Although the difference in Medicaid and Medicare reimbursements for CTR was small, the appointment success incidence for Medicare was approximately 5 times higher. CONCLUSIONS: Despite the passage of the Affordable Care Act, patients with Medicaid have reduced access to surgical care for CTS and more complex barriers to receiving an appointment. Although Medicaid was accepted at a higher rate in states with expanded Medicaid eligibility, a more robust strategy for increasing access to care may be helpful for patients with Medicaid. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic II.


Subject(s)
Carpal Tunnel Syndrome/surgery , Health Services Accessibility , Insurance Coverage , Patient Protection and Affordable Care Act , Appointments and Schedules , Elective Surgical Procedures , Humans , Insurance, Health, Reimbursement , Medicaid , Medicare , Referral and Consultation , United States
11.
J Arthroplasty ; 30(9): 1498-501, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25891434

ABSTRACT

This study evaluated access to knee arthroplasty and revision in 8 geographically representative states. Patients with Medicaid were significantly less likely to receive an appointment compared to patients with Medicare or BlueCross. However, patients with Medicaid had increased success at making an appointment in states with expanded Medicaid eligibility (37.7% vs 22.8%, P=0.011 for replacement, 42.6% vs 26.9%, P=0.091 for revision), although they experienced longer waiting periods (31.5 days vs 21.1 days, P=0.054 for replacement, 45.5 days vs 22.5 days, P=0.06 for revision). Higher Medicaid reimbursement also had a direct correlation with appointment success rate for Medicaid patients (OR=1.232, P=0.001 for replacement, OR=1.314, P=0.014 for revision).


Subject(s)
Appointments and Schedules , Arthroplasty, Replacement, Knee/economics , Health Services Accessibility/economics , Insurance, Health/economics , Medicaid/economics , Medicare/economics , Reoperation/economics , Health Care Costs , Humans , Orthopedics/economics , Patient Protection and Affordable Care Act/economics , Time-to-Treatment , United States
12.
Proc Natl Acad Sci U S A ; 108(36): 14867-72, 2011 Sep 06.
Article in English | MEDLINE | ID: mdl-21856950

ABSTRACT

The proinflammatory and catabolic cytokine IL-1ß has been implicated in the pathogenesis of osteoarthritis (OA) by mediating synovial inflammation and cartilage degeneration. Although synovial macrophages are suggested to be the source of IL-1ß, the mechanism remains unclear. Ectopic deposition of hydroxyapatite (HA) crystals in joints is closely associated with OA and other arthropathies, but the precise role of HA in arthritis pathogenesis has not been clearly demonstrated. Here we show that HA crystals of a particular size and shape can stimulate robust secretion of proinflammatory cytokines IL-1ß and IL-18 from murine macrophages in a NLRP3 inflammasome-dependent manner. HA-induced inflammasome activation is dependent on potassium efflux, generation of reactive oxygen species (ROS), and lysosomal damage, but independent of cell death. Mice lacking the inflammasome components are protected against HA-induced neutrophilic inflammation in the air-pouch model of synovitis, and they show decreased joint pathology accompanying spontaneous HA deposition in the ank-deficient mouse model of arthritis. Moreover, calcium crystal positive synovial fluids from some OA patients exhibited inflammasome-stimulatory activity in vitro. These results demonstrate that the NLRP3 inflammasome mediates the pathological effect of HA crystals in vitro and in vivo and suggest a critical role for the inflammasome in the pathogenesis of OA.


Subject(s)
Biocompatible Materials/adverse effects , Carrier Proteins/metabolism , Durapatite/adverse effects , Inflammasomes/metabolism , Osteoarthritis/metabolism , Animals , Biocompatible Materials/pharmacology , Carrier Proteins/genetics , Cartilage, Articular/metabolism , Cartilage, Articular/pathology , Disease Models, Animal , Durapatite/pharmacology , Inflammasomes/genetics , Interleukin-18/genetics , Interleukin-18/metabolism , Interleukin-1beta/genetics , Interleukin-1beta/metabolism , Macrophages/metabolism , Mice , Mice, Knockout , NLR Family, Pyrin Domain-Containing 3 Protein , Neutrophil Infiltration/drug effects , Neutrophil Infiltration/genetics , Osteoarthritis/chemically induced , Osteoarthritis/genetics , Osteoarthritis/pathology , Phosphate Transport Proteins/genetics , Phosphate Transport Proteins/metabolism , Potassium/metabolism , Reactive Oxygen Species/metabolism , Synovial Membrane/metabolism , Synovial Membrane/pathology
13.
Clin Orthop Relat Res ; 467(10): 2656-61, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19247728

ABSTRACT

Investigations of the usefulness of continuous passive motion (CPM) after TKA have yielded mixed results, with evidence suggesting its efficacy is contingent on the presence of larger motion arcs. Surprisingly, the range of motion (ROM) the knee actually experiences while in a CPM machine has not been elucidated. In this study, the ability of a CPM apparatus to bring about a desired knee ROM was assessed with an electrogoniometer. The knee experienced only 68% to 76% of the programmed CPM arc, with the higher percentages generated by elevating the head of the patient's bed. This disparity between true knee motion and CPM should be accounted for when designing CPM protocols for patients or investigations evaluating efficacy of CPM.


Subject(s)
Knee Joint/physiology , Motion Therapy, Continuous Passive , Clinical Protocols , Equipment Design , Humans , Motion Therapy, Continuous Passive/instrumentation , Posture , Range of Motion, Articular , Stockings, Compression
14.
J Bone Joint Surg Am ; 89(6): 1194-204, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17545421

ABSTRACT

BACKGROUND: There is currently no standardized protocol for evaluating and treating osteonecrosis of the femoral head in adults in the United States. We sought to understand current treatment practices of a group of surgeons who commonly treat this disease to determine if there was agreement on some aspects of care. METHODS: We designed a two-staged mixed-mode (mailed and faxed) sixteen-question self-administered descriptive survey questionnaire to be sent to all 753 active members of the American Association of Hip and Knee Surgeons (AAHKS). The survey design was based on Dillman's survey research methodology, and the questionnaire included hypothetical clinical scenarios based on the Steinberg classification system. The responses elucidated the opinions and treatment preferences of high-volume arthroplasty surgeons who treat adult patients with osteonecrosis of the femoral head. RESULTS: Of the 753 active members of the AAHKS, 403 (54%) responded to the questionnaire. Total hip replacement was reported to be the most frequent intervention for treatment of postcollapse (Steinberg stage-IIIB, IVB, V, and VI) osteonecrosis; core decompression was reported to be the most commonly offered intervention for symptomatic, precollapse (Steinberg stage-IB and IIB) osteonecrosis. Less frequently offered treatments included nonoperative management, osteotomy, vascularized and non-vascularized bone-grafting, hemiarthroplasty, and arthrodesis. CONCLUSIONS: The care of adults with osteonecrosis of the femoral head varies among American orthopaedic surgeons specializing in hip and knee surgery. A consensus may evolve with a continued concerted effort on the part of interested surgeons, but it will require randomized, controlled, prospective studies of treatment of each stage of the disease and collaborative multicenter studies. LEVEL OF EVIDENCE: Therapeutic Level V.


Subject(s)
Femur Head Necrosis/surgery , Practice Patterns, Physicians' , Acetabulum/pathology , Adult , Age Factors , Decompression, Surgical , Female , Femur Head/pathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Sclerosis , Surveys and Questionnaires
15.
Am J Orthop (Belle Mead NJ) ; 31(3): 129-34, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11922455

ABSTRACT

Femurs of Sprague-Dawley rats were subjected to in vitro 3-Mrad irradiation and/or freeze-drying to investigate whether these processes have an order-dependent effect on the biomechanical properties of bone. Four experimental groups were designated-irradiated (RAD); freeze-dried (FD); irradiated, then freeze-dried (RAD/FD); and freeze-dried, then irradiated (FD/RAD). After the various treatments, the bones were inspected for microfractures and then torsion-tested. Microfractures were seen in more than 90% of the specimens that had undergone freeze-drying alone or with irradiation. Regarding the normalized relative ratios of torque, there was a statistically significant difference (P < .05) between the RAD group (1.0) and the 3 other groups (FD, .32; RAD/FD, .40; FD/RAD, .14). Differences among the FD, RAD/FD, and FD/RAD groups were not significant. However, a trend was bones were weaker than FD and noted: FD/RAD RAD/FD bones.


Subject(s)
Bone Transplantation , Bone and Bones/radiation effects , Freeze Drying , Animals , Biomechanical Phenomena , Female , Femur/radiation effects , Rats , Rats, Sprague-Dawley
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