ABSTRACT
Peripheral distal neuropathy associated with hypoglycemia secondary to insulinoma is quite rare. So far, less than 40 cases have been reported in literature. In this report, we describe a 50-year-old patient with insulinoma-polineuropathy and neuropsychiatric symptoms, interpreted as temporal lobe epilepsy, over the preceding 7 years. Due to the variability of the clinical presentation, diagnostic mistakes are frequent, and diagnosis of insulinoma is often delayed. Thus, the hypoglycemic nature of neuropathy can be lately recognized.
Subject(s)
Diabetic Neuropathies/diagnosis , Epilepsy, Temporal Lobe/diagnosis , Insulinoma/diagnosis , Pancreatic Neoplasms/diagnosis , Blood Glucose/metabolism , Diabetic Neuropathies/pathology , Diagnosis, Differential , Electroencephalography , Humans , Insulinoma/complications , Insulinoma/pathology , Male , Middle Aged , Pancreatic Neoplasms/complications , Pancreatic Neoplasms/pathologyABSTRACT
Biologically active neuroendocrine tumours produce early symptoms and are often difficult to diagnose owing to their small dimensions (<1 cm), whereas biologically inactive forms are often coarse and sometimes found by chance. As well as identifying the lesion, locoregional staging is also particularly important for therapeutic planning. Morphological imaging plays an important role in the identification of gastroenteropancreatic neuroendocrine tumours, providing an anatomic substrate for receptorial imaging which usually precede it in the diagnostic work-up, whereas it plays a primary role in the locoregional staging of these neoplasms for which surgery is the first and essential therapeutic approach. In the case of endocrine tumours of the pancreas alone, the most accurate method of diagnosis is currently echo-endoscopy using high-frequency probes. Two-phase spiral CT and dynamic MR have proved equally effective means of identifying endocrine tumours of the pancreas with slightly higher sensitivity for MR, both playing a role in the locoregional staging of biologically active and inactive tumours. Traditional radiology also plays a role in the identification of intestinal carcinoids.
Subject(s)
Adenoma, Islet Cell/pathology , Diagnostic Imaging , Gastrointestinal Neoplasms/pathology , Neuroendocrine Tumors/pathology , Pancreatic Neoplasms/pathology , Adenoma, Islet Cell/diagnosis , Adenoma, Islet Cell/diagnostic imaging , Carcinoid Tumor/diagnosis , Carcinoid Tumor/diagnostic imaging , Carcinoid Tumor/pathology , Contrast Media , Gadolinium , Gastrointestinal Neoplasms/diagnosis , Gastrointestinal Neoplasms/diagnostic imaging , Humans , Magnetic Resonance Imaging , Neoplasm Metastasis , Neoplasm Staging , Neuroendocrine Tumors/diagnosis , Neuroendocrine Tumors/diagnostic imaging , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/diagnostic imaging , Sensitivity and Specificity , Tomography, X-Ray Computed/methodsABSTRACT
With the purpose of a practical synthesis the Authors consider their personal experience and an overview of the international literature on the topic, making a point of the actual knowledge on stimulation to treat the sepsis. Therefore their study take in account the characteristics of the human immune system and the peculiarities of the immunostimulating drugs today at hand, going down to practical employment of the last therapeutical applications.
