Cross-linked cellulose beads as an eco-friendly support for ZnO/SnO2/carbon xerogel hybrid photocatalyst: Exploring the synergy between adsorption and photocatalysis under simulated sunlight.

This paper explores the application of cross-linked cellulose beads as a sustainable and cost-effective support for the ZnO/SnO2/carbon xerogel hybrid photocatalyst. The application of the developed photocatalytic beads, named CB-Cat, was directed at a simultaneous adsorption/photocatalysis process, which was carried out under simulated sunlight. The characterization of the CB-Cat indicated a good dispersion of the photocatalyst of choice throughout the cellulose matrix, confirming its incorporation into the cellulose beads. Furthermore, it is possible to observe the presence of the photocatalyst on the surface of the CB-Cat, confirming its availability for the photonic activation process. The results showed that the simultaneous adsorption/photocatalysis process was optimal for enhancing the efficiency of methylene blue (MB) removal, especially when compared to the isolated adsorption process. Additionally, the regeneration of the CB-Cat between cycles was favorable toward the maintenance of the MB removal efficiency, as the process carried out without regeneration displayed significant efficiency drops between cycles. Finally, the mechanism evaluation evidenced that hydroxyl and superoxide radicals were the main responsible for the MB photocatalytic degradation during illumination with simulated sunlight.

New Perspectives about Drug Candidates Targeting HTLV-1 and Related Diseases.

Among the human T-lymphotropic virus (HTLV) types, HTLV-1 is the most prevalent, and it has been linked to a spectrum of diseases, including HAM/TSP, ATLL, and hyperinfection syndrome or disseminated strongyloidiasis. There is currently no globally standard first-line treatment for HTLV-1 infection and its related diseases. To address this, a comprehensive review was conducted, analyzing 30 recent papers from databases PubMed, CAPES journals, and the Virtual Health Library (VHL). The studies encompassed a wide range of therapeutic approaches, including antiretrovirals, immunomodulators, antineoplastics, amino acids, antiparasitics, and even natural products and plant extracts. Notably, the category with the highest number of articles was related to drugs for the treatment of ATLL. Studies employing mogamulizumab as a new perspective for ATLL received greater attention in the last 5 years, demonstrating efficacy, safe use in the elderly, significant antitumor activity, and increased survival time for refractory patients. Concerning HAM/TSP, despite corticosteroid being recommended, a more randomized clinical trial is needed to support treatment other than corticoids. The study also included a comprehensive review of the drugs used to treat disseminated strongyloidiasis in co-infection with HTLV-1, including their administration form, in order to emphasize gaps and facilitate the development of other studies aiming at better-directed methodologies. Additionally, docking molecules and computer simulations show promise in identifying novel therapeutic targets and repurposing existing drugs. These advances are crucial in developing more effective and targeted treatments against HTLV-1 and its related diseases.

Transforming drug discovery with a high-throughput AI-powered platform: A 5-year experience with Patrimony.

High-throughput computational platforms are being established to accelerate drug discovery. Servier launched the Patrimony platform to harness computational sciences and artificial intelligence (AI) to integrate massive multimodal data from internal and external sources. Patrimony has enabled researchers to prioritize therapeutic targets based on a deep understanding of the pathophysiology of immuno-inflammatory diseases. Herein, we share our experience regarding main challenges and critical success factors faced when industrializing the platform and broadening its applications to neurological diseases. We emphasize the importance of integrating such platforms in an end-to-end drug discovery process and engaging human experts early on to ensure a transforming impact.

Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS).

Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients with CANDLE/PRAAS present with mostly chronically elevated type I interferon scores that emerge as a consequence of increased proteotoxic stress by mechanisms that are not fully understood. Here, we report on five unrelated patients with CANDLE/PRAAS carrying novel inherited proteasome missense and/or nonsense variants. Four patients were compound heterozygous for novel pathogenic variants in the known CANDLE/PRAAS associated genes, PSMB8 and PSMB10, whereas one patient showed additive loss-of-function mutations in PSMB8. Variants in two previously not associated proteasome genes, PSMA5 and PSMC5, were found in a patient who also carried the PSMB8 founder mutation, p.T75M. All newly identified mutations substantially impact the steady-state expression of the affected proteasome subunits and/or their incorporation into mature 26S proteasomes. Our observations expand the spectrum of PRAAS-associated genetic variants and improve a molecular diagnosis and genetic counseling of patients with sterile autoinflammation.

Immunoglobulin G and subclasses placental transfer in fetuses and preterm newborns: a systematic review.

Immunoglobulin G (IgG) and subclasses are the only class of antibodies capable of crossing placenta and providing protection against neonatal infectious diseases, especially in premature infants. This systematic review aimed to review the literature concerning the transplacental transfer of IgG and its subclasses in fetuses and preterm newborns and compare the results with data from term neonates. Eleven studies were included in the final review. Most studies demonstrated a lower transplacental passage of IgG2 than other subclasses in term and preterm newborns and a more efficient passage of total IgG and IgG1 after 37 weeks of gestational age. These results elucidate the physiology of IgG subclass transfer during pregnancy and may explain one of the reasons preterm newborns are especially susceptible to specific pathogens, such as encapsulated bacteria.

Fatores associados ao alto risco cardiovascular segundo o escore de framingham: revisão integrativa / Factores asociados al alto riesgo cardiovascular según la puntuación de framingham: revisión integradora / Factors associated with high cardiovascular risk according to framingham score: integrative review

RESUMO Objetivo: investigar na literatura científica os fatores associados ao alto risco cardiovascular de 10 e de 30 anos. Método: revisão integrativa da literatura realizada entre julho e novembro de 2021 nas bases de dados MEDLINE, CINAHL, WoS e EMBASE e no portal da Biblioteca Virtual de Saúde. Os artigos duplicados foram identificados com o software EndNote e o processo de seleção dos estudos foi apresentado no diagrama da declaração PRISMA. Resultados: foram selecionados 13 artigos com um ou mais fatores associados ao alto risco cardiovascular, segundo o escore de Framingham de 10 anos. Nenhum artigo selecionado investigou os fatores associados ao alto risco de 30 anos. Os maus hábitos alimentares, a baixa posição socioeconômica, a baixa prática de atividade física/sedentarismo, o padrão de sono prejudicado, a adiposidade abdominal, os níveis aumentados do Antígeno Prostático Específico nos homens, a pré-fragilidade em mulheres mais velhas, o estado civil (homem divorciado ou viúvo), a profissão (motorista) e a cor (mulher branca) se associam ao alto risco cardiovascular de 10 anos. Conclusão: fatores de risco que não compõem o escore de Framingham deverão ser investigados durante a coleta de dados de enfermagem visando à implementação de ações de prevenção e promoção da saúde cardiovascular.

RESUMEN Objetivo: investigar en la literatura científica los factores asociados al alto riesgo cardiovascular de 10 y 30 años. Método: revisión integradora de la literatura realizada entre julio y noviembre de 2021 en las bases de datos MEDLINE, CINAHL, WoS y EMBASE y en el portal de la Biblioteca Virtual de Salud. Los artículos duplicados fueron identificados con el software EndNote y el proceso de selección de los estudios fue presentado en el diagrama de la declaración PRISMA. Resultados: fueron seleccionados 13 artículos con uno o más factores asociados al alto riesgo cardiovascular, según la puntuación de Framingham de 10 años. Ningún artículo seleccionado investigó los factores asociados al alto riesgo de 30 años. Los malos hábitos alimenticios, la baja posición socioeconómica, la baja práctica de actividad física/sedentarismo, el patrón de sueño comprometido, la adiposidad abdominal, los niveles crecientes del Antígeno Prostático Específico en los hombres, la prefragilidad en mujeres mayores, el estado civil (hombre divorciado o viudo), la profesión (conductor) y el color (mujer blanca) se asocian al alto riesgo cardiovascular de 10 años. Conclusión: factores de riesgo que no componen la puntuación de Framingham deberán ser investigados durante la recolección de datos de enfermería para la implementación de acciones de prevención y promoción de la salud cardiovascular.

ABSTRACT Objective: to investigate in the scientific literature the factors associated with high cardiovascular risk of 10 and 30 years. Method: an integrative review of the literature conducted between July and November 2021 in the MEDLINE, CINAHL, WoS and EMBASE databases and in the Virtual Health Library portal. Duplicate articles were identified with EndNote software and the process of selecting the studies was presented in the PRISMA statement diagram. Results: 13 articles with one or more factors associated with high cardiovascular risk were selected, according to the Framingham score of 10 years. No selected article investigated the factors associated with high risk of 30 years. Poor eating habits, low socioeconomic status, low physical activity/sedentary lifestyle, impaired sleep pattern, abdominal adiposity, increased levels of Specific Prostatic Antigen in men, pre-frailty in older women, marital status (divorced or widowed man), profession (driver) and color (white woman) are associated with high cardiovascular risk of 10 years. Conclusion: risk factors that do not make up the Framingham score should be investigated during the collection of nursing data aiming at the implementation of actions to prevent and promote cardiovascular health.

Organizational climate, job satisfaction, and burnout in nursing workers.

Introduction: Characterized by high levels of emotional exhaustion and depersonalization and reduced professional accomplishment, burnout syndrome has been a major cause of psychic illness in nursing workers, with a serious impact on the quality of services and on patient safety. Objectives: To analyze the correlation between organizational climate, job satisfaction, and burnout in nursing workers. Methods: This is a cross-sectional study with a sample of 534 Brazilian nursing workers. We used the Organizational Climate Scale for Health Organizations, the Job Satisfaction Questionnaire (S20/23), and the Maslach Burnout Inventory. An analytical descriptive analysis of the data was performed using relative and absolute frequencies, mean, standard deviation, minimum, maximum, and correlation test between the variables. Results: Organizational climate and job satisfaction were evaluated as regular. With regard to burnout, moderate levels of emotional exhaustion, low levels of depersonalization, and high levels of professional accomplishment were observed. A strong positive correlation was found between job satisfaction and organizational climate; in addition to a moderate negative correlation between emotional exhaustion and both organizational climate and job satisfaction, and a moderate negative correlation between depersonalization and job satisfaction. Conclusions: Organizational climate and job satisfaction had a negative correlation with burnout dimensions, representing possible protective factors.

Introdução: Caracterizada por elevados níveis de exaustão emocional, despersonalização e diminuição da realização profissional, a síndrome de burnout tem sido uma grande causa de adoecimento psíquico em trabalhadores de enfermagem, com sérios impactos na qualidade dos serviços e na segurança do paciente. Objetivos: Analisar a correlação entre clima organizacional, satisfação no trabalho e burnout em trabalhadores de enfermagem. Métodos: Trata-se de um estudo transversal, realizado com uma amostra de 534 trabalhadores de enfermagem brasileiros. Utilizou-se a Escala de Clima Organizacional para Organizações de Saúde, o Questionário de Satisfação no Trabalho (S20/23) e o Inventário de Burnout de Maslach. Foi realizada uma análise analítica e descritiva dos dados por meio de frequências relativas e absolutas, média, desvio padrão, mínimo, máximo e teste de correlação entre as variáveis. Resultados: O clima organizacional e a satisfação no trabalho foram avaliados como regulares. Quanto ao burnout, observou-se moderada exaustão emocional, baixa despersonalização e elevada realização profissional. Verificou-se correlação positiva forte entre satisfação no trabalho e clima organizacional; correlação negativa moderada entre exaustão emocional e clima organizacional; correlação negativa moderada entre exaustão emocional e satisfação no trabalho; e correlação negativa moderada entre despersonalização e satisfação no Trabalho. Conclusões: Clima organizacional e satisfação no trabalho apresentaram correlação negativa com as dimensões de burnout, constituindo-se em possíveis fatores de proteção.

Neonatal diseases and oxidative stress in premature infants: an integrative review

Abstract Objective To describe the relationship of oxidative stress and antioxidant biomarkers in cord blood of premature newborns and the prognosis of diseases in the neonatal period. Sources This study consists of an integrative review. Searches were conducted in electronic databases Scopus, PubMed, Web of Science, and Medline/Lilacs through the Virtual Library on Health Issues, using the descriptors: "premature infants", "preterm infants", "preterm birth", "preterm", "oxidative stress", "antioxidants", "infant, premature, diseases" and "cord blood". Original articles published between 2016 and 2021 in Portuguese, English, or Spanish, which analyzed oxidative stress and/or antioxidant levels through cord blood of premature newborns and evaluated clinical outcomes, were included. Summary of the findings Of the 1,003 studies reviewed, after exclusion of duplicate articles, analysis of titles, abstracts, and full texts, 18 articles were included. 72.2% (n = 13) of analyzed studies reported a positive association between oxidative stress and the development of prematurity-related diseases; 27.7% (n = 5) showed no significant relation. Outcomes that showed a positive association were: intrauterine growth restriction, necrotizing enterocolitis, bronchopulmonary dysplasia, intraventricular hemorrhage, fetal inflammatory response syndrome, early-onset neonatal sepsis, retinopathy of prematurity, morbidity, and mortality. Conclusion The analysis of oxidative stress and antioxidants in cord blood of premature newborns may be useful in the prognosis of some pathologies. The consequences of oxidative damage are known to be associated with increased morbidity in the short and long term. Further investigation is needed in this population in order to define normality parameters of biomarkers, clinical manifestations, diagnosis and treatment of these conditions.

Temporal trend of accidents due to percutaneous exposure in a public hospital in Brazil, 2007-2019.

OBJECTIVES: to analyze the temporal trend of accidents due to percutaneous exposure in a public hospital in Brazil, between 2007 and 2019, according to sociodemographic and professional characteristics. METHODS: analysis of time series of accidents due to percutaneous exposure that occurred in health workers. Sociodemographic and professional variables, accident profile, post-accident behavior and accident incidence rates were evaluated. The Prais Winsten regression was used for trend analysis and calculation of the annual percentage change, with a significance level of 5%. RESULTS: 761 occupational accidents were recorded. There was a downward trend in the rate of percutaneous injuries among female workers (-0.012%; p=0.009), who had secondary education (-0.011%; p=0.035) and among all health professional categories (-0.010%; p =0.019). There was an increasing trend (0.018%; p= 0.050) among workers with ≥ 61 months of professional experience. CONCLUSIONS: the analysis showed a decreasing incidence of percutaneous accidents, which can be explained by multiple factors.

Conhecimentos e práticas sobre telemedicina entre alergistas e imunologistas brasileiros / Telemedicine knowledge and practices among Brazilian allergists and immunologists

Introdução: O objetivo deste estudo foi avaliar as características das práticas de telemedicina (TM) entre médicos alergistas/ imunologistas (A/I) brasileiros e avaliar seu conhecimento sobre as recomendações regulatórias. Métodos: Uma pesquisa eletrônica autorreferida foi enviada por e-mail uma vez por semana entre agosto e outubro/2021 a 2.600 médicos A/I brasileiros. Resultados: 205 (7,9%) participantes preencheram os formulários. 143 (70,2%) médicos usaram TM em sua prática clínica, e 184 (89,9%) nunca o usaram antes da pandemia de COVID-19. Dentre os médicos, 192 (93,8%) utilizaram a TM para consultas de acompanhamento, 186 (91%) para verificação de exames complementares e 136 (66,7%) nas primeiras consultas. Cento e quarenta e três médicos A/I (70,2%) sentiram-se seguros em seu diagnóstico por meio da TM, e 7 (3,5%) responderam que não conseguiram encontrar um diagnóstico correto usando a TM. Os principais benefícios da TM relatados foram: maior acessibilidade, principalmente em áreas mais distantes 159 (77,6%), redução dos custos de deslocamento 158 (77,1%) e segurança quanto à transmissão do COVID-19 145 (71,2%). Por outro lado, algumas desvantagens da TM foram listadas pelos participantes: ausência de exame físico 183 (89,7%), relação médico-paciente fragilizada 59 (28,8%) e problemas de Internet 45 (22%). Em relação ao campo jurídico/ético, 105 (51,4%) dos especialistas aplicaram o termo de consentimento e 34 (16,7%) registraram a teleconsulta, ambas as etapas exigidas em uma consulta de TM, conforme recomendações regulatórias locais. Além disso, plataformas online inadequadas para TM, como aplicativos de mídia social e programas de reuniões online não específicos, foram relatadas como sendo usadas por 131 (64,1%) dos participantes. Oitenta (40%) não leram as declarações e recomendações oficiais que regulamentam a prática da TM no Brasil. Conclusões: Observouse um uso crescente de TM no Brasil, influenciado principalmente pela pandemia de COVID-19. Apesar de ser ferramenta útil na pandemia, com vantagens e desvantagens, há necessidade de conhecer as recomendações regulatórias.

Introduction: The aim of this study was to evaluate the characteristics of telemedicine (TM) practices among Brazilian allergists/immunologists (A/I) and to assess their knowledge of regulatory recommendations. Methods: A self-report electronic survey was sent by email once a week between August and October 2021 to 2,600 Brazilian A/I physicians. Results: A total of 205 (7.9%) participants completed the survey. TM was used in clinical practice by 143 (70.2%) physicians, and 184 (89.9%) had never used it before the COVID-19 pandemic. Among participants, 192 (93.8%) used TM for follow-up consultations, 186 (91%) for checking complementary exams, and 136 (66.7%) for first consultations. The number of A/I physicians (70.2%) that felt confident in their diagnosis using TM was 143, and 7 (3.5%) reported that they could not reach the correct diagnosis using TM. Participants reported that the main benefits of TM were greater accessibility, especially in more distant areas (159, 77.6%), reduced travel costs (158, 77.1%), and safety regarding the transmission of COVID-19 (145, 71.2%). Conversely, the lack of physical examination (183, 89.7%), poor doctor-patient relationship (59, 28.8%), and internet connection problems (45, 22%) were mentioned as disadvantages. Regarding legal/ethical aspects, 105 (51.4%) physicians reported applying a consent form and 34 (16.7%) reported making a record of the teleconsultation, both of which are required for TM consultations, according to local regulatory recommendations. The use of inappropriate online platforms for TM, such as social media applications and nonspecific online meeting programs, was reported by 131 (64.1%) participants. Eighty (40%) participants did not read the official statements and recommendations that regulate the practice of TM in Brazil. Conclusions: An increasing use of TM was observed in Brazil, mainly influenced by the COVID-19 pandemic. Despite being a useful tool in the pandemic, with advantages and disadvantages, physicians should have knowledge of regulatory recommendations.

Effects of nebulized epinephrine in association with hypertonic saline for infants with acute bronchiolitis: A systematic review and meta-analysis.

Background: Nebulized epinephrine and hypertonic saline have been extensively studied in infants with acute bronchiolitis, with conflicting results. Aims: To evaluate the efficacy on length of stay (LOS), clinical severity scores (CSS), oxygen saturation (SaO2), and safety profile of nebulized epinephrine plus hypertonic saline (HS) in infants with acute bronchiolitis. Materials & Methods: This is a systematic review and meta-analysis. Outcomes were represented by mean differences (MD) or standard mean differences (SMD) and 95% confidence intervals (CIs) were utilized. Results: Eighteen trials were systematically selected and 16 of them contributed to the meta-analysis (1756 patients). Overall, a modest but significant positive impact was observed of the combination therapy on LOS (MD of -0.35 days, 95% CI -0.62 to -0.08, p = 0.01, I 2 = 91%). Stratification by time of CSS assessment unveiled positive results in favor of the combination therapy in CSS assessed 48 and 72 h after the admission (SMD of -0.35, 95% CI -0.62 to -0.09, p = 0.008, I 2 = 41% and SMD of -0.27, 95% CI -0.50 to -0.04, p = 0.02, I 2 = 0%, respectively). No difference in SaO2 was observed. Additional data showed a consistent safety profile, with a low rate of adverse events (1%), most of them mild and transient. Conclusion: Low-quality evidence from this systematic review suggests that nebulized epinephrine plus HS may be considered as a safe and efficient therapy for decreasing LOS and CSS in infants with acute bronchiolitis, especially in those who require hospitalization for more than 48 h.

Chemical study of Mimosa tenuiflora barks.

Mimosa tenuiflora (Willd.) Poir., popularly known as "black jurema", is a plant that is predominant in the Caatinga Biome. Drinks used in indigenous rituals use the barks of this plant that are rich in N,N-dimethyltryptamine (DMT), an indolic alkaloid responsible for hallucinogenic activity. The objective of this study was to evaluate the chemical and pharmacognostic characteristics of the Mimosa tenuiflora bark using nuclear magnetic resonance(NMR) analytical techniques and gas chromatography coupled to mass spectrometry(GC-MS) to identify and quantify the DMT present in the extract of Mimosa tenuiflora. The results showed that the plant material is within the recommended standards. Both NMR and GC-MS techniques were able to identify and quantify the DMT with NMR being the best option. In conclusion this study contributes significantly to the standardization of the studied plant material and assists in the use of these data for future development of products from on this forestry species.

Neonatal diseases and oxidative stress in premature infants: an integrative review.

OBJECTIVE: To describe the relationship of oxidative stress and antioxidant biomarkers in cord blood of premature newborns and the prognosis of diseases in the neonatal period. SOURCES: This study consists of an integrative review. Searches were conducted in electronic databases Scopus, PubMed, Web of Science, and Medline/Lilacs through the Virtual Library on Health Issues, using the descriptors: "premature infants", "preterm infants", "preterm birth", "preterm", "oxidative stress", "antioxidants", "infant, premature, diseases" and "cord blood". Original articles published between 2016 and 2021 in Portuguese, English, or Spanish, which analyzed oxidative stress and/or antioxidant levels through cord blood of premature newborns and evaluated clinical outcomes, were included. SUMMARY OF THE FINDINGS: Of the 1,003 studies reviewed, after exclusion of duplicate articles, analysis of titles, abstracts, and full texts, 18 articles were included. 72.2% (n = 13) of analyzed studies reported a positive association between oxidative stress and the development of prematurity-related diseases; 27.7% (n = 5) showed no significant relation. Outcomes that showed a positive association were: intrauterine growth restriction, necrotizing enterocolitis, bronchopulmonary dysplasia, intraventricular hemorrhage, fetal inflammatory response syndrome, early-onset neonatal sepsis, retinopathy of prematurity, morbidity, and mortality. CONCLUSION: The analysis of oxidative stress and antioxidants in cord blood of premature newborns may be useful in the prognosis of some pathologies. The consequences of oxidative damage are known to be associated with increased morbidity in the short and long term. Further investigation is needed in this population in order to define normality parameters of biomarkers, clinical manifestations, diagnosis and treatment of these conditions.

Temporal trend of accidents due to percutaneous exposure in a public hospital in Brazil, 2007-2019 / Tendencia temporal de los accidentes por exposición percutánea en un hospital público en Brasil, 2007-2019 / Tendência temporal dos acidentes por exposição percutânea em um hospital público no Brasil, 2007-2019

ABSTRACT Objectives: to analyze the temporal trend of accidents due to percutaneous exposure in a public hospital in Brazil, between 2007 and 2019, according to sociodemographic and professional characteristics. Methods: analysis of time series of accidents due to percutaneous exposure that occurred in health workers. Sociodemographic and professional variables, accident profile, post-accident behavior and accident incidence rates were evaluated. The Prais Winsten regression was used for trend analysis and calculation of the annual percentage change, with a significance level of 5%. Results: 761 occupational accidents were recorded. There was a downward trend in the rate of percutaneous injuries among female workers (-0.012%; p=0.009), who had secondary education (-0.011%; p=0.035) and among all health professional categories (-0.010%; p =0.019). There was an increasing trend (0.018%; p= 0.050) among workers with ≥ 61 months of professional experience. Conclusions: the analysis showed a decreasing incidence of percutaneous accidents, which can be explained by multiple factors.

RESUMEN Objetivos: analizar tendencia temporal de accidentes por exposición percutánea en un hospital público brasileño, entre 2007 y 2019, segundo características sociodemográficas y profesionales. Métodos: análisis de series temporales de los accidentes por exposición percutánea ocurridos en trabajadores de salud. Fueron evaluadas las variables sociodemográficas, profesionales, perfil de los accidentes, conductas post-accidentes y tasas de incidencia de los accidentes. La regresión de Prais-Winsten fue empleada para análisis de tendencia y cálculo de la variación porcentual anual, con nivel de significación de 5%. Resultados: fueron registrados 761 accidentes ocupacionales. Hubo tendencia decreciente de la tasa de accidente percutáneo en trabajadores del sexo femenino (-0,012%; p=0,009), que poseían enseñanza media (-0,011%; p=0,035) y entre todas categorías profesionales de salud (-0,010%; p=0,019). Observado tendencia creciente (0,018%; p= 0,050) entre trabajadores con tiempo ≥ 61 meses de experiencia profesional. Conclusiones: el análisis evidenció incidencia decreciente de accidentes percutáneos, que puede ser explicada por múltiples factores.

RESUMO Objetivos: analisar a tendência temporal dos acidentes por exposição percutânea em um hospital público no Brasil, entre 2007 e 2019, segundo características sociodemográficas e profissionais. Métodos: análise de séries temporais dos acidentes por exposição percutânea ocorridos em trabalhadores de saúde. Foram avaliadas as variáveis sociodemográficas, profissionais, perfil dos acidentes, condutas pós-acidentes e as taxas de incidência dos acidentes. A regressão de Prais Winsten foi empregada para análise de tendência e cálculo da variação percentual anual, com nível de significância de 5%. Resultados: foram registrados 761 acidentes ocupacionais. Houve tendência decrescente da taxa de acidente percutâneo nos trabalhadores do sexo feminino (-0,012%; p=0,009), que possuíam ensino médio (-0,011%; p=0,035) e entre todas as categorias profissionais de saúde (-0,010%; p=0,019). Observou-se tendência crescente (0,018%; p= 0,050) entre trabalhadores com tempo ≥ 61 meses de experiência profissional. Conclusões: a análise evidenciou incidência decrescente de acidentes percutâneos, que pode ser explicada por múltiplos fatores.

Implementação do programa de prevenção de acidentes com materiais perfurocortantes: análise documental / Implementation of the program to prevent accidents with sharps: a documentary analysis / Implementación del programa de prevención de accidentes con objetos punzocortantes: análisis de documentos

OBJETIVO: descrever o processo de implementação do programa de prevenção de acidentes com materiais perfurocortantes em um hospital público. MÉTODO: estudo descritivo, com análise retrospectiva documental, desenvolvido a partir da leitura exploratória, seletiva e analítica dos conteúdos presentes em registros do Serviço Especializado em Engenharia de Segurança e em Medicina do Trabalho. A coleta de dados foi realizada com o preenchimento de um formulário semiestruturado e as análises foram baseadas nas adequações do programa às diretrizes da Portaria n° 1.748 do Ministério do Trabalho e Emprego. RESULTADOS: o processo de implementação do programa foi concluído em oito etapas e atendeu às diretrizes da Portaria. O programa aperfeiçoou as medidas de controle convencionais e levou à adoção de medidas de engenharia. Pela avaliação da Comissão Gestora, o programa contribuiu para a redução dos acidentes. CONCLUSÃO: a implantação do programa foi bem-sucedida, servindo como modelo para outros hospitais brasileiros.

OBJECTIVE: to describe the implementation process of the program to prevent accidents with sharps in a public hospital. METHOD: a descriptive study, with retrospective documentary analysis, developed from the exploratory, selective and analytical reading of the contents present in records of the Specialized Service in Safety Engineering and Occupational Medicine. Data collection was performed by filling out a semi-structured form and the analyses were based on the program's adaptations to the guidelines set forth in Ordinance No.1,748 of the Ministry of Labor and Employment. RESULTS: the program's implementation process was completed in eight stages and met the directives set forth in the Ordinance. The program improved the conventional control measures and led to the adoption of engineering measures. According to the evaluation by the Management Commission, the program contributed to a reduction in the number of accidents. CONCLUSION: implementation of the program was successful, serving as a model for other Brazilian hospitals

OBJETIVO: describir el proceso de implementación del programa de prevención de accidentes con objetos punzocortantes en un hospital público. MÉTODO: estudio descriptivo con análisis documental retrospectivo, llevado a cabo a partir de la lectura exploratoria, selectiva y analítica de los contenidos presentes en los registros del Servicio Especializado en Ingeniería de la Seguridad y Medicina del Trabajo. La recolección de datos se realizó mediante la cumplimentación de un formulario semiestructurado y los análisis sebasaron en las adaptaciones del programa a las directrices de la Disposición nro. 1.748 del Ministerio de Trabajo y Empleo. RESULTADOS: el proceso de implementación del programa se completó en ocho etapas y cumplió con las directrices de la Disposición. El programa perfeccionó las medidas de control convencionales y condujo a la adopción de medidas de ingeniería. Según la evaluación del Comité de Gestión, el programa contribuyó a la reducción de accidentes. CONCLUSIÓN: la implementación del programa fue exitosa y sirve de modelo para otros hospitales brasileños.

Vacinas contra a COVID-19 e os erros inatos da imunidade (ou imunodeficiências primárias) / COVID-19 vaccines and inborn errors of immunity (or primary immunodeficiencies)

Desde o início da pandemia de COVID-19 iniciou-se a corrida por uma imunização ativa, eficaz e segura. Todas as vacinas desenvolvidas até o momento vêm demostrando boa eficácia na prevenção de casos graves de COVID-19, de hospitalizações e mortes. Muitos pacientes com erros inatos da imunidade (EII) não terão capacidade de desenvolver uma resposta imune semelhante ao indivíduo imunocompetente. Esses pacientes foram incluídos nos grupos prioritários definidos pelo Ministério da Saúde, como pessoas entre 18 a 59 anos com uma ou mais das comorbidades, incluindo as imunodeficiências primárias. Eles podem e devem receber as vacinas em uso contra o SARS-CoV-2, mas nem sempre apresentarão uma resposta imunológica satisfatória e protetora, e, portanto, seus contactantes também devem ser vacinados.

Since the beginning of the COVID-19 pandemic, the race for an active, effective, and safe immunization has started. All vaccines developed to date have shown good efficacy in preventing serious cases of COVID-19, hospitalization, and death. Many patients with inborn errors of immunity will not be able to develop an immune response similar to that of immunocompetent individuals. These patients were included in the priority groups defined by the Brazilian Ministry of Health, as people between 18 and 59 years of age with one or more comorbidities, including primary immunodeficiencies. They can and should receive the vaccines in use against SARS-CoV-2, but they will not always have a satisfactory and protective immune response, and, therefore, those in direct contact with them should also be vaccinated.

Percepção de pessoas com hipertensão arterial sobre aspectos que influenciam a adesão ao tratamento' / Percepción de las personas con hipertensión arterial sobre aspectos que influyen en la adherencia al tratamento / Perception of people with arterial hypertension about aspects that influence treatment adherence

Objetivo: descrever a percepção de pessoas com hipertensão arterial sobre aspectos que facilitam e dificultam a adesão ao tratamento. Método: estudo qualitativo descritivo desenvolvido com 16 pessoas atendidas em consultas de enfermagem. Realizaram-se entrevistas com roteiro semiestruturado e utilizou-se a técnica de análise de conteúdo. Os dados foram coletados entre os meses de janeiro e agosto de 2017. Resultados: observou-se que ter força de vontade, apoio familiar e multiprofissional, conhecimento sobre a patologia e formas de prevenção e medo da morte facilitou a adesão; por outro lado, pouco conhecimento, preguiça, falta de infraestrutura urbana e condições climáticas, hábito de consumir alimentos não saudáveis, bebidas alcoólicas e tabaco, custo do tratamento e esquecimento de tomar a medicação dificultaram a adesão. Conclusão: o tratamento da hipertensão acarreta mudanças na dinâmica da vida para as quais é fundamental ter força de vontade, apoio familiar e profissional, além de superar hábitos não saudáveis.

Objective: to describe the perception of people with arterial hypertension of the aspects that facilitate and hinder treatment adherence. Method: descriptive qualitative study developed with 16 people met in Nursing consultations. Interviews were conducted with a semi-structured guide and the content analysis technique was used. Data were collected between January and August 2017. Results: having willpower, family and multidisciplinary support, knowledge about the pathology and forms of prevention and fear of death facilitated adherence; on the other hand, little knowledge, laziness, lack of urban infrastructure and climatic conditions, habit of consuming unhealthy foods, alcoholic beverages and tobacco, cost of treatment and forgetfulness of taking the medication hindered adherence. Conclusion: the treatment of hypertension causes changes in the dynamics of life, being essential to have willpower, family and professional support, in addition to overcoming unhealthy habits.

Objetivo: describir la percepción de las personas con hipertensión arterial sobre los aspectos que facilitan y dificultan la adherencia al tratamiento. Método: estudio cualitativo descriptivo desarrollado con 16 personas atendidas en consultas de enfermería. Se realizaron entrevistas con un guion semiestructurado y se utilizó la técnica de análisis de contenido. Los datos se recopilaron entre enero y agosto de 2017. Resultados: se observó que tener fuerza de voluntad, apoyo familiar y multidisciplinario, conocimiento sobre la patología y las formas de prevención y miedo a la muerte facilitaba la adherencia; por otro lado, poco conocimiento, pereza, falta de infraestructura urbana y condiciones climáticas, hábito de consumir alimentos no saludables, bebidas alcohólicas y tabaco, costo de tratamiento y olvido de tomar el medicamento obstaculizaba la adherencia. Conclusión: el tratamiento de la hipertensión provoca cambios en la dinámica de la vida para los que es esencial contar con fuerza de voluntad, apoyo familiar y profesional, además de superar hábitos poco saludables.

Percepción del estudiante del curso técnico en enfermería sobre la sistematización de la asistencia a la enfermería / Perception of the nursing technical course student of the nursing care systematization

Introducción: La forma en que se visualiza la sistematización del cuidado de enfermería implica el reconocimiento de la profesión y las prácticas de las acciones de enfermería. La compresión de esta herramienta por parte de los estudiantes en el curso de enfermería técnica es poco explorada, lo que constituye una de las brechas en el área de enfermería. Objetivo: Describir la percepción del estudiante del curso técnico en enfermería sobre la sistematización de la asistencia a la enfermería. Métodos: Estudio exploratorio y descriptivo con enfoque cualitativo. Participaron 18 (62,0 por ciento) estudiantes de 29 (27,8 por ciento), quienes cumplieron con los criterios de inclusión, en una Escuela de Enfermería Técnica en el noreste de Bahía, Brasil. Los datos fueron recogidos entre abril y mayo de 2018, por medio de un cuestionario con las siguientes variables: calidad del proceso de enseñanza-aprendizaje a través del cual los estudiantes vislumbran la sistematización de la asistencia a la enfermería; habilidades desarrolladas necesarias para el funcionamiento y la importancia atribuida en el contexto de la labor de los técnicos de enfermería. Se utilizó estadística descriptiva, seguida de un análisis de las características del fenómeno. Resultados: Se encontró que los estudiantes consideran el enfoque teórico de la sistematización de la asistencia de enfermería y las taxonomías insuficientes para apoyar la práctica profesional. Conclusión: La mayoría de estudiantes se manifestaron desconocer las características de la sistematización de la asistencia a la enfermería y del proceso de enfermería(AU)

Introduction: The way in which the Nursing Care Systematization is visualized implies the recognition of the profession and the practices of nursing actions. The understanding of this tool by students in the technical nursing course is little explored, which constitutes one of the gaps in the nursing area. Objective: To describe the perception of students of a nursing technical course about the Nursing Care Systematization. Methods: Exploratory and descriptive study, with a qualitative approach. Participated 18 (62,0 percent) students of the 29 (27,8 percent) who met the inclusion criteria, at a technical nursing school in Northeast Bahia, Brazil. The data were collected between April and May 2018, by means of a questionnaire with the following variables: quality of teaching-learning process through which students glimpse; developed skills necessary for the execution of the systematization of nursing assistance; and the importance attributed to in the context of the work of the nursing technician. Descriptive statistics was used, followed by analysis of the phenomenon's characteristics. Results: The students considered the theoretical approach of the Nursing Care Systematization and the taxonomies insufficient to support the professional practice. Conclusions: Most students showed unaware of the characteristics of the systematization of nursing assistance and of the Nursing Process(AU)