Antibiotic-Loaded Coatings to Reduce Fracture-Related Infections: Retrospective Case Series of Patients with Increased Infectious Risk.

Local antibiotic delivery strategies have been increasingly employed for the prevention of fracture-related infections (FRIs). The aim of this study is to evaluate the efficacy and safety of antibiotic-coated implants in the prevention of FRIs after surgical treatment in patients with increased infectious risk. A retrospective observational study has been conducted on patients with upper and lower limb fractures treated with internal fixation or prosthetic replacements, using a gentamicin coated nail (CN) and/or antibiotic-loaded hydrogel applied to the implant of choice (ALH). The study included 37 patients (20 M, 17 F), with a mean age of 63 years. The mean estimated preoperative infectious risk score was 6.4%. ALH was used in 27 cases, tibial CNs were implanted in 4 cases, and both were employed in 6 cases. The antibiotics used locally were gentamicin in 72.97% of cases (27 patients) and a combination of gentamicin + vancomycin in 27.03% of cases (10 patients). Mean follow-up was 32 months. Only one case (2.94%) showed onset of FRI at 5 months after surgery. Local antibiotic prophylaxis by coating resulted in a reduction in the incidence FRI, as compared to the estimated preoperative risk. The use of ALH allows for the choice of antibiotic; however, the application of antibiotics seems more nonuniform when applied to a nail.

Primary complex total knee arthroplasty with severe varus deformity and large bone defects: mid-term results of a consecutive series treated with primary implants.

INTRODUCTION: In recent years, the use of constrained implants in complex primary TKA has gained popularity since these implants may better and more easily address severe instability present in complex primary cases (CPC). However, the need for a constrained TKA in CPC is controversial. We hypothesized that a standard TKA may be successful in most of CPC and that an intraoperative switching to a constrained device is rarely need even in the presence of severe instability and bone loss. MATERIALS AND METHODS: A consecutive series of 24 CPC (28 knees) were analysed retrospectively. Inclusion criteria were a femoro-tibial angle > 12° and bone defect of grade 2-3 (group 1). Forty-eight patients (52 knees) were analysed as controls (group 2). Patients were followed up clinically and radiographically up to a minimum of 5 years. RESULTS: In group 1, a PS was used in 24 knees and a CR in 4. In no patient, a CCK or RHK was implanted. Bone defect was treated with bone cement plus cortical screws in 15 knees (53.5%), a medial wedge in 8 (28.5%), a medial wedge plus bone grafting with cancellous screws in 5 (17.8%). Metaphyseal sleeve or cone was not used. At the last follow-up, no significant difference was found in the clinical scores between the 2 groups. CONCLUSION: In CPC with marked varus deformity, instability and bone loss, the use of primary TKA is associated with a clinical outcome comparable to standard cases. Ligamentous balancing may be addressed using primary implants and simple cost-effective techniques may be used to manage an extensive bone loss. In most CPC, an intraoperative switching to a constrained device is not necessary.