ABSTRACT
Background/Objective: Source monitoring refers to the ability to determine the source of memories and encompasses three subprocesses: internal source monitoring, reality monitoring, and external source monitoring. Neuroimaging studies provide valuable insights about neural correlates of source monitoring, but the causal relationship between brain and behavior is lacking. This study aimed to identify brain circuits involved in source monitoring by synthesizing the effects of brain stimulation on source monitoring as a function of the targeted brain regions or circuits. Method: We conducted a systematic review of interventional studies that have examined the effects of brain stimulation on source monitoring across six databases. The principal outcome was the difference of source monitoring performance between active and control stimulation conditions. Results: 23 studies (920 healthy participants and 54 patients with schizophrenia) were included. Our findings revealed the involvement of i) the lateral prefrontal and temporoparietal cortices in internal source monitoring, ii) the medial prefrontal and temporoparietal cortices in reality monitoring, and iii) the precuneus and the left angular gyrus in external source monitoring. Conclusions: These findings deepen our understanding of the brain mechanisms of source monitoring and highlight specific stimulation targets to alleviate source monitoring deficits.
ABSTRACT
BACKGROUND: Reality-monitoring process enables to discriminate memories of internally generated information from memories of externally derived information. Studies have reported impaired reality-monitoring abilities in schizophrenia patients with auditory hallucinations (AHs), specifically with an exacerbated externalization bias, as well as alterations in neural activity within frontotemporoparietal areas. In healthy subjects, impaired reality-monitoring abilities have been associated with reduction of the paracingulate sulcus (PCS). The current study aimed to identify neuroanatomical correlates of reality monitoring in patients with schizophrenia. METHODS: Thirty-five patients with schizophrenia and AHs underwent a reality-monitoring task and a 3D anatomical MRI scan at 1.5 T. PCS lengths were measured separately for each hemisphere, and whole-brain voxel-based morphometry analyses were performed using the Computational Anatomy Toolbox (version 12.6) to evaluate the gray-matter volume (GMV). Partial correlation analyses were used to investigate the relationship between reality-monitoring and neuroanatomical outcomes (PCS length and GMV), with age and intracranial volume as covariates. RESULTS: The right PCS length was positively correlated with reality-monitoring accuracy (Spearman's ρ = 0.431, p = 0.012) and negatively with the externalization bias (Spearman's ρ = -0.379, p = 0.029). Reality-monitoring accuracy was positively correlated with GMV in the right angular gyrus, whereas externalization bias was negatively correlated with GMV in the left supramarginal gyrus/superior temporal gyrus, in the right lingual gyrus and in the bilateral inferior temporal/fusiform gyri (voxel-level p < 0.001 and cluster-level p < 0.05, FDR-corrected). CONCLUSIONS: Reduced reality-monitoring abilities were significantly associated with shorter right PCS and reduced GMV in temporal and parietal regions of the reality-monitoring network in schizophrenia patients with AHs.
Subject(s)
Schizophrenia , Brain/diagnostic imaging , Gray Matter , Hallucinations/diagnostic imaging , Humans , Magnetic Resonance Imaging , Schizophrenia/diagnostic imagingABSTRACT
The aim of this comparative retrospective short- and long-term study was to evaluate the interceptive treatment in Class III malocclusion in daily orthodontic practice. The sample was composed of 69 children divided into two groups according to the interceptive treatment applied: 31 children in group F (facial mask) and 38 in group M (interceptive fixed appliance). A Pancherz cephalometric analysis was carried out on the lateral head films at the start of the study (t(0), after the active treatment (t(1) and 29 months after t(1) (t(2). The two groups were compared at the beginning of the study by t-test and chi-squared test: there were no difference between groups M and F except for facial divergence, which was greater in group M. Long-term comparison (interceptive and post-interceptive stage i.e. six years) showed that (i) overjet was corrected in each group: molar discrepancy was stable in both groups, (ii) alveolar discrepancy was stable and (iii) antero-posterior discrepancy was not improved in either group. At t(2) there were no differences, either qualitative or quantitative between groups M and F. In the end, more than 80% of the children did not need an orthognathic surgery.