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Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin.
Peteroy, M; Severin, A; Zhao, F; Rosner, D; Lopatin, U; Scherman, H; Belanger, A; Harvey, B; Hatfull, G F; Brennan, P J; Connell, N D.
Antimicrob Agents Chemother ; 44(6): 1701-4, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10817733

ABSTRACT

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.


Subject(s)
Cycloserine/pharmacology , Mycobacterium smegmatis/genetics , Vancomycin Resistance , Vancomycin/pharmacology , Amino Acid Sequence , Drug Resistance, Microbial , Molecular Sequence Data , Mutation , Mycobacterium smegmatis/drug effects , Sequence Alignment
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