Subject(s)
Antiretroviral Therapy, Highly Active/adverse effects , Cardiovascular Diseases/prevention & control , HIV Infections/drug therapy , Hypercholesterolemia/prevention & control , Vitamin D Deficiency/prevention & control , Cardiovascular Diseases/etiology , Humans , Hypercholesterolemia/chemically induced , Hypercholesterolemia/complications , Vitamin D Deficiency/chemically induced , Vitamin D Deficiency/complicationsABSTRACT
We suggest that lower body iron stores, and not the loss of ovarian function, explain the differences between men and women, and between fertile and menopausal women in the development of coronary heart disease.
Subject(s)
Coronary Disease/epidemiology , Estrogens/metabolism , Iron, Dietary/metabolism , Coronary Disease/etiology , Coronary Disease/metabolism , Female , Humans , Male , Postmenopause/metabolism , Primary Ovarian Insufficiency/complications , Primary Ovarian Insufficiency/epidemiology , Primary Ovarian Insufficiency/metabolism , Risk Factors , Sex FactorsSubject(s)
Neoplasms/chemically induced , Piperazines/adverse effects , Platelet Aggregation Inhibitors/adverse effects , Thiophenes/adverse effects , Animals , Endothelium, Vascular/cytology , Endothelium, Vascular/drug effects , Humans , Neoplasms/blood supply , Neovascularization, Pathologic/chemically induced , Prasugrel Hydrochloride , Spleen/cytology , Spleen/drug effects , Stem Cells/cytology , Stem Cells/drug effects , T-Lymphocytes, Regulatory/pathologyABSTRACT
The increasing worldwide displacement from the natural outdoor environment of human beings to an indoor sedentary lifestyle, along with the recommendation to avoid any direct sun exposure because of the risk of skin cancer, has resulted in a global pandemic of vitamin D insufficiency. Traditionally, vitamin D has been associated primarily with bone health. However, it has become evident that adequate vitamin D status is important for optimal function of many organs and tissues throughout the body, including the cardiovascular system. Vitamin D insufficiency seems to predispose to hypertension, diabetes and the metabolic syndrome, left ventricular hypertrophy, heart failure, and chronic vascular inflammation. The relationship between baseline vitamin D status, dose of vitamin D supplements, and cardiovascular events remains to be investigated by ongoing randomized trials; however increasing evidence suggests that the provision of a simple, well-tolerated, and inexpensive correction of vitamin D insufficiency favourably affects the morbility and mortality of cardiovascular disease along with the prevention of the most common chronic degenerative diseases.
Subject(s)
Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Vitamin D Deficiency/complications , Vitamin D Deficiency/prevention & control , Vitamin D/therapeutic use , Cardiovascular Diseases/metabolism , Heart Failure/etiology , Heart Failure/prevention & control , Humans , Hypertension/etiology , Hypertension/prevention & control , Hypertrophy, Left Ventricular/etiology , Hypertrophy, Left Ventricular/prevention & control , Risk Factors , Sedentary Behavior , Treatment Outcome , Vitamin D Deficiency/metabolism , Vitamins/therapeutic useABSTRACT
We suggest that the beneficial antioxidant action of olive oil is mediated by interactions of olive oil-derived polyphenols and iron. A plausible mechanism for this interaction is related to a reduction of iron absorption induced by polyphenols.
Subject(s)
Antioxidants/pharmacology , Iron/metabolism , Phenols/pharmacology , Plant Oils/pharmacology , Humans , Olive OilSubject(s)
Anticholesteremic Agents/adverse effects , Cardiovascular Diseases/drug therapy , Diabetes Mellitus, Type 2/chemically induced , Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects , Cholesterol/analysis , Humans , Islets of Langerhans/drug effects , Meta-Analysis as Topic , Risk FactorsABSTRACT
We suggest that surveillance for squamous cell cancer might be particularly useful for transplant patients receiving statin therapy. We recommend that development of non melanoma skin cancer should be specified as a secondary endpoint in future large endpoint statin trials, and suggest that in transplant patients the adverse effects of statin drugs may outweigh benefits, especially in women and the elderly, a subset of population in which even individuals at high risk for cardiovascular disease have shown no trend to net benefit from statins.
