Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters











Database
Language
Publication year range
1.
Cell Mol Neurobiol ; 43(5): 2377-2384, 2023 Jul.
Article in English | MEDLINE | ID: mdl-36107359

ABSTRACT

The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson's disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD.


Subject(s)
Parkinson Disease , Rats , Mice , Animals , Parkinson Disease/drug therapy , Parkinson Disease/pathology , Oxidopamine , Dopamine , Amphetamine/pharmacology , Dopaminergic Neurons
2.
BMJ Case Rep ; 12(7)2019 Aug 01.
Article in English | MEDLINE | ID: mdl-31371329

ABSTRACT

Hepatocellular carcinoma (HCC) uncommonly metastasises to the heart. We present a case of new onset bilateral leg swelling and suspected right heart failure in a previously fit and healthy man, which on further investigation revealed a new diagnosis of HCC with extension into the inferior vena cava and right atrium. This case highlights the importance of considering alternative possibilities when physical examination does not match the initial clinical diagnosis. The management approach was for best supportive care in view of extensive metastatic disease.


Subject(s)
Carcinoma, Hepatocellular/diagnosis , Heart Failure/diagnosis , Heart Neoplasms/diagnosis , Liver Neoplasms/pathology , Aged, 80 and over , Carcinoma, Hepatocellular/secondary , Diagnosis, Differential , Diagnostic Errors , Heart Atria/pathology , Heart Neoplasms/secondary , Humans , Male , Physical Examination , Vena Cava, Inferior/pathology
SELECTION OF CITATIONS
SEARCH DETAIL