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ABSTRACT

We explored the impact of the Spanish COVID-19 strict home confinement on mental health and cognition in non-infected subjects (Nâ=â16, 60-80 years) diagnosed with subjective cognitive decline and APOEÉ3/É4 carriers. Mental health was monitored for 2 months on a daily, weekly, or monthly basis, and compared to pre-confinement values. Emotional distress, anxiety, and depression scores increased to pathological threshold values during and after confinement. Those with lower mood during confinement experienced a decline in their mood after confinement. Cognition did not change. These preliminary results suggest that mental health consequences of corona measures in preclinical stages of Alzheimer's disease should be further evaluated.

Subject(s)

Alzheimer Disease/psychology , COVID-19/psychology , Cognition Disorders/psychology , Mental Health , Quarantine/psychology , Aged , Aged, 80 and over , Alzheimer Disease/diagnosis , Alzheimer Disease/genetics , Anxiety Disorders/diagnosis , Anxiety Disorders/genetics , Anxiety Disorders/psychology , Apolipoprotein E3/genetics , Apolipoprotein E4/genetics , COVID-19/genetics , COVID-19/therapy , Cognition Disorders/diagnosis , Cognition Disorders/genetics , Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/genetics , Cognitive Dysfunction/psychology , Depressive Disorder/diagnosis , Depressive Disorder/genetics , Depressive Disorder/psychology , Female , Humans , Male , Middle Aged , Psychological Distress , Risk , Spain

ABSTRACT

Subject(s)

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