ABSTRACT
The high-profile paper contains manipulated images, senior author acknowledges.
ABSTRACT
Steven Newmaster had been cleared, but fresh inquiry concludes he likely made up data.
ABSTRACT
Inspectors faulted analyses of clinical trial samples by Hoau-Yan Wang for drug developer Cassava Sciences.
Subject(s)
Alzheimer Disease , Scientific Misconduct , Spiro Compounds , United States Food and Drug Administration , Humans , Alzheimer Disease/drug therapy , Spiro Compounds/therapeutic use , United States , Clinical Trials as TopicABSTRACT
Whistleblowers and former lab members suggest a star neuroscientist routinely manipulated data, compromising a planned NIH stroke trial and key Alzheimer's research.
Subject(s)
Alzheimer Disease , Scientific Misconduct , Stroke , Whistleblowing , Humans , Alzheimer Disease/therapy , Brain , Stroke/therapy , Clinical Trials as Topic , National Institutes of Health (U.S.)ABSTRACT
Co-developer of biotech's drug couldn't supply original data.
Subject(s)
Alzheimer Disease , Scientific Misconduct , Spiro Compounds , Humans , Alzheimer Disease/prevention & control , Biotechnology , United StatesABSTRACT
Amyloid-clearing antibody lecanemab faces key FDA hearing in June.
Subject(s)
Alzheimer Disease , Amyloid beta-Peptides , Antibodies, Monoclonal, Humanized , Brain , Humans , Alzheimer Disease/drug therapy , Alzheimer Disease/mortality , Amyloid beta-Peptides/immunology , Antibodies, Monoclonal, Humanized/adverse effects , Antibodies, Monoclonal, Humanized/therapeutic use , Autopsy , Brain/pathology , Clinical Trials as Topic , Fear , United States Food and Drug Administration , Female , AgedABSTRACT
Antibody slows cognitive decline, but deaths, brain bleeds, and swelling mar results.
Subject(s)
Alzheimer Disease , Antibodies, Monoclonal, Humanized , Apolipoprotein E4 , Humans , Alzheimer Disease/drug therapy , Alzheimer Disease/genetics , Apolipoprotein E4/genetics , Antibodies, Monoclonal, Humanized/therapeutic use , Randomized Controlled Trials as TopicABSTRACT
Matthew Schrag confronts a mentor after their joint work is flagged on the PubPeer website.
Subject(s)
Neurosciences , Scientific Misconduct , Whistleblowing , Humans , Mentors , Neurosciences/ethics , Alzheimer DiseaseABSTRACT
A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer's articles, threatening a reigning theory of the disease.
Subject(s)
Alzheimer Disease , Amyloid beta-Peptides , Blotting, Western , Scientific Misconduct , Alzheimer Disease/drug therapy , Alzheimer Disease/metabolism , Amyloid beta-Peptides/chemistry , Amyloid beta-Peptides/metabolism , HumansABSTRACT
Report sees "insufficient evidence" of misconduct.
ABSTRACT
[Figure: see text].