How different attributes are weighted in professionals' decision-making in Pediatric Dentistry-a protocol for guiding discrete choice experiment focused on shortening the evidence-based practice implementation for dental care.

BACKGROUND: Important evidence has been constantly produced and needs to be converted into practice. Professional consumption of such evidence may be a barrier to its implementation. Then, effective implementation of evidence-based interventions in clinical practice leans on the understanding of how professionals value attributes when choosing between options for dental care, permitting to guide this implementation process by maximizing strengthens and minimizing barriers related to that. METHODS: This is part of a broader project investigating the potential of incorporating scientific evidence into clinical practice and public policy recommendations and guidelines, identifying strengths and barriers in such an implementation process. The present research protocol comprises a Discrete Choice Experiment (DCE) from the Brazilian oral health professionals' perspective, aiming to assess how different factors are associated with professional decision-making in dental care, including the role of scientific evidence. Different choice sets will be developed, either focusing on understanding the role of scientific evidence in the professional decision-making process or on understanding specific attributes associated with different interventions recently tested in randomized clinical trials and available as newly produced scientific evidence to be used in clinical practice. DISCUSSION: Translating research into practice usually requires time and effort. Shortening this process may be useful for faster incorporation into clinical practice and beneficial to the population. Understanding the context and professionals' decision-making preferences is crucial to designing more effective implementation and/or educational initiatives. Ultimately, we expect to design an efficient implementation strategy that overcomes threats and potential opportunities identified during the DCEs, creating a customized structure for dental professionals. TRIAL REGISTRATION: https://osf.io/bhncv .

Prevalence and circulant genotypes of Chlamydia trachomatis in university women from cities in the Brazilian Amazon.

BACKGROUND: Approximately 80% of infected women infected by Chlamydia trachomatis are asymptomatic, although this infection can lead to serious complications in the female reproductive tract. Few data on Chlamydia infection and genotypes are available in Amazonian communities. OBJECTIVES: To describe the prevalence of and associated factors and to identify the genotypes of sexual C. trachomatis infection in female university students in different urban centers (capital and interiors) in the Brazilian state of Pará, in the eastern Amazon region. METHODS: A cross-sectional study was performed among young women attending public universities in four different urban centers in the eastern Amazon region. They were invited to participate in the studt and cervical secretions were collected for molecular diagnosis of C. trachomatis. We utilized amplification of the ompA gene by nested PCR. Positive samples were genotyped by nucleotide sequencing. Study participants completed a questionnaire on social, epidemiological, and reproductive health variables. A Qui-square and Binominal regression test were used to evaluate the degree of association of these variables with the infection. RESULTS: A total of 686 female students was included in the study. The overall prevalence of C. trachomatis was 11.2% (77/686). The prevalence of this infection was higher in interiors (15.2% vs 9.5%/ p: 0.0443). Female university students who do not have a sexual partner (11.8%/p <0.008), who do not use a condom in their sexual relations (17.8%/p <0.0001) and who reported having suffered a miscarriage (32%/p <0.0001) have high chances of acquiring this sexual infection. The ompA gene was sequenced in only 33 (42.8%) samples, revealing the genotype J was the most frequent (27.2% [9/33]), followed by genotypes D (24.2% [8/33]), and then genotypes F (18.2% [6/33]), E (15.1% [5/33]) K (6.1% [2/33]), Ia (6.1% [2/33]), and G (3.1% [1/33]). CONCLUSIONS: The high prevalence of sexual infection by C. trachomatis in the female university students from the interior of the state of Pará, individuals with no fixed sexual partner, those that had had a miscarriage, the students that do not use condoms in their sexual relations. The genotype J of C. trachomatis genotypes was the most frequent. These data are important to help defining the epidemiological effects of chlamydial infections in Amazonian populations.

An electrogram-guided transvenous temporary pacemaker implant simulator.

INTRODUCTION: Transvenous temporary pacemaker (TvTP) implantation is a critical procedure often performed under time limitations, playing a crucial role in patient survival. However, the amount of training provided for resident cardiologists is variable, due to the availability of patients. Thus, the use of simulators for this cardiologic procedure could be used as training tools. OBJECTIVE: The present study aimed to develop a simulator system for TvTP implantation based on electrograms, called ETTIS (Electrogram-guided Transvenous Temporary-pacemaker Implantation Simulator), and to evaluate its educational potential and cardiology residents' perceived learning efficacy as a training tool. METHODOLOGY: The development of the ETTIS involved three stages: (1) Adaptation of an anatomical mannequin; (2) Design and manufacture of electronic circuits and software capable of identifying the catheter contact site within the heart chambers and reproducing electrograms in both surfaces (mode-on) and intracavitary (mode-off); (3) To evaluate its educational potential, a modified Likert questionnaire was administered to nine cardiology experts. Additionally, to evaluate the perceived learning efficacy, another modified Likert questionnaire was given to six cardiology residents both before and after training with the ETTIS. Descriptive statistics with measures of position and dispersion were employed, and the weighted Kappa test was used for agreement analysis. RESULTS: A high rate of acceptance (over 90%) was found among experts who evaluated the ETTIS. The cardiology residents showed significant self-perceived learning gains, as evidenced by a lack of agreement between their responses to a questionnaire before and after training. CONCLUSION: The ETTIS is a promising tool for medical training, displaying both educational potential and efficacy. It has been shown to be effective in learning a variety of skills, including cardiac catheterization and electrophysiology. Additionally, the ETTIS is highly engaging and allows cardiology residents to practice in a safe and controlled environment.

Sistema de cotas e desempenho acadêmico: estudo seccional em uma universidade pública brasileira / Quota system and academic performance: sectional study in a brazilian public university / Sistema de cuotas y rendimiento académico: estudio seccional en una universidad pública brasileña

Introdução: A lei de cotas (nº 12.711/2012) foi criada com o intuito de oportunizar o acesso de alunos oriundos de escolas públicas ao ensino superior. Desde então, medidas adicionais foram tomadas para garantir, não só o acesso, mas a permanência destes alunos nas universidades. Objetivo: Este estudo teve como objetivo avaliar o desempenho acadêmico dealunos cotistas e não cotistas da Faculdade de Odontologia da Universidade Federal do Pará. Metodologia: Foram coletados dados de alunos matriculados nos anos de 2020 e2021 por meio de um questionário on-line e realizada a análise de histórico acadêmico dos voluntários. A análise dos dados foi realizada com software Jamovi versão 1.6.23, utilizando os testesQui-quadrado, t de Student para amostras independentes e análise de regressão linear multivariada. Em todas as análises foi adotado o nível de significância de 0,05. Resultados: Com uma taxa de resposta de 39,92% (n=200), os resultados demonstraram haver um melhor desempenho acadêmico para o grupo não-cotista no que se refere ao Coeficiente de Rendimento Geral (p=0,001). Além disso, alunos do grupo cotista enfrentam mais dificuldades quando comparados aos não-cotistas (p<0,0001). Na análise múltipla verificou-se que juntas, forma de ingresso (cotista ou não), o enfrentamento de dificuldades, recebimento de auxílios e atividades fora da Faculdade explicam quase 10% da variável Coeficiente de Rendimento Geral (R² = 0,098). Conclusões: A complexidade da comparação sugere a possibilidade de múltiplas causas, entre elas o fator socioeconômico e outras dificuldades experienciadas. Entender e atuar nestas causas é de fundamental importância para a construção de uma universidade inclusiva de qualidade (AU).

Introduction:The quota law (nº 12.711/2012) was created with the objective of providing opportunities for students from public schools to enter federal universities. Since then, additional measures have been taken to ensure not only the access, but the permanence of these students in universities. Objectives:This study aimed to assess the academic performance of quota students and non-quota students at the Faculty of Dentistry of the Federal University of Pará. Methods:Data were collected from students enrolled in the years 2020 and 2021 through an online questionnaire and the academic history of the volunteers was analyzed. Data analysis was performed with Jamovi software version 1.6.23, using the chi-square test, Student's t test for independent samples, and multivariate linear regression analysis. In all analyses, a significance level of 0.05 was adopted. Results:With a response rate of 39.92% (n=200), the results showed a better academic performance for the non-quotastudents with regard to the General PerformanceCoefficient (p=0.001). In addition, quota students face more difficulties when compared to non-quota students (p<0.0001). In the multiple analysis, it was found that the admission modality (quota students or non-quota students), facing difficulties, receiving aid, and activities outside the University explained together almost 10% of the General Performance Coefficient variable (R² = 0.098). Conclusion:The complexity of the comparison suggests the possibility of multiple causes, including the socioeconomic factor and other difficulties experienced. Understanding and acting on these causes is of fundamental importance for the construction of a quality inclusive university (AU).

Introducción: La ley de cuotas (nº 12.711/2012) fue creada con el objetivo de brindar a estudiantes de colegios públicosla oportunidad de ingresar a una universidad federal. Desde entonces, se han tomado medidas adicionales para asegurar, no solo el acceso, sino también la permanencia de estos estudiantes en las universidades. Objetivos:Este estudio tuvo como objetivo evaluar el rendimiento académico de los alumnos con cuota y los sin cuota de la Facultad de Odontología de la Universidad Federal de Pará. Métodos:Se recolectaron datos de estudiantes matriculados en los años 2020 y 2021 a través de un cuestionario en línea y se realizó el análisis del historial académico de los voluntarios. El análisis de datos se realizó con el software Jamovi versión 1.6.23, utilizando la prueba de qui-cuadrado, prueba t de Student para muestras independientes y análisis de regresión lineal multivariado. En todos los análisis se adoptó un nivel de significación de 0.05. Resultados:Con una tasa de respuesta del 39.92% (n=200), los resultados mostraron un mejor rendimiento académico de los alumnos sin cuotacon respecto al Coeficiente de Rendimiento General (p=0.001). Además, los estudiantes con cuota enfrentan más dificultades cuando comparados a los estudiantes sin cuota (p<0.0001). En el análisis múltiple, se encontró que,en conjunto, la forma de ingreso (alumnos con cuota o sin cuota), enfrentar las dificultades, recibir ayudas y actividades fuera de la Facultad explican casi el 10% de la variable Coeficiente de Rendimiento General(R² = 0,098). Conclusión:La complejidad de la comparación sugiere la posibilidad de múltiples causas, incluido el factor socioeconómico y otras dificultades experimentadas. Comprender y actuar sobre estas causas es de fundamental importancia para la construcción de una universidad inclusiva de calidad (AU).

Fatal Case of Progressive Mpox in a Patient with AIDS-Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir.

We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccination orthopoxviruses in immunosuppressed patients. Severe small bowel involvement jeopardized normal oral tecovirimat and antiretroviral therapy absorption. This problem prompted the use of full parenteral antiretrovirals and endovenous cidofovir. Although a remarkable decrease in HIV viral load occurred in six days, mpox infection continued to progress, and the patient died of septic shock. This case offers new clinical insights on the presentation of severe disease in AIDS patients. Moreover, this case alerts for the need for prompt therapy initiation in patients at risk of ominous clinical progression.

Clinical and Epidemiological Features of Hospitalized and Ambulatory Patients with Human Monkeypox Infection: A Retrospective Observational Study in Portugal.

Monkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central and Western Africa for decades. More recently, an outbreak has spread to a global level, occurring in sites with no previous reported cases and being clustered among men who have sex with men, suggesting new modes of transmission. There is an urgent need for research for a better understanding of the genomic evolution and changing epidemiology of the Orthopoxvirus group. Our work aimed to characterize the clinical and epidemiological features of a cohort of patients with MPXV infection in a Portuguese hospital, admitted between 5 May and 26 July 2022. In this retrospective observational study, aggregate data of a case series on the presentation, clinical course, and outcomes of confirmed MPXV infections are reported. The study included 40 men and 1 woman, with a mean age of 37.2 years old; 92.7% identified as men who have sex with men, 90.2% had unprotected sex or sex with multiple or anonymous partners in the previous month, and 39.0% reported to have had sex with an MPXV-confirmed case; 59.5% had previously known human immunodeficiency virus (HIV) infection, all of whom were under antiretroviral therapy, and no patients had acquired immunodeficiency syndrome (AIDS) criteria. About a quarter of patients were observed only a week after symptom onset. All patients had skin or mucosal lesions and the anogenital region was the most frequent lesion site. There were no statistically significant clinical differences between HIV-positive and negative individuals. Four patients were admitted to the inpatient clinic, two of whom had proctitis with difficult-to-manage anal pain. There were no reported deaths. Our findings suggest the sexual route as a relevant mode of transmission of MPXV and confirm the mostly benign presentation of this disease.

A case of central nervous system infection by Candida famata in an immunosuppressed patient with HIV-1 infection.

Invasive fungal infections caused by Candida species are increasingly observed in immunosuppressed patients. Candida albicans is the more often identified species and neurocandidiasis is associated with high mortality rates. Diagnosis and treatment of these infections are frequently challenging. We report a case of central nervous system infection caused by Candida famata in an HIV-1 infected patient. To our best knowledge this is just the second published case of neural infection by this agent.

Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study.

OBJECTIVES: This study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the concordance of EBV-DNA frequency in subgingival sites and in the OSCC. METHODS: A cross-sectional study with 30 OSCC patients, aged from 44 to 88 years old, was conducted. Samples were collected in subgingival sites and at the OSCC, then submitted to DNA isolation, qPCR, and genotyping. Descriptive statistic was performed to report the frequency of EBV-DNA in all samples, and McNemar test was applied to verify the concordance among the EBV-DNA frequency in both sites. RESULTS: The individuals presented 62 years old in average, and the majority were male (66.6%). EBV-DNA was detected in 56.7% OSCC lesions. Among the subgroup of 19 dentate individuals, high concordance (73.7%) in both EBV-DNA detection and the absence in subgingival sites and OSCC was observed, and it was statistically significant (p < 0.05). CONCLUSIONS: We report the notable occurrence of EBV-DNA in OSCC; also, the presence of EBV in periodontal sites may contribute to find it in OSCC, although the possible contribution of EBV in the OSCC remains to be investigated. CLINICAL RELEVANCE: The identification of this easily accessible site of EBV latent infection may help to improve the patient's quality of life by maintenance of oral/periodontal health condition and preventing further possible disorders related to the virus, and also encourages new approaches for investigating EBV, periodontitis, and OSCC.

Thromboembolic Risk in COVID-19 Patients: Is There a Hidden Link?

Background Although evidence has emerged indicating that patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia present a high risk of venous thromboembolism (VTE), its real incidence and best diagnosis course remain unclear. In this study, we aimed to determine the incidence of pulmonary embolism in these patients and the role of D-dimer serum level as a predictive factor of a new VTE event. Methodology This was a single-center retrospective observational cohort study conducted in a tertiary hospital. All patients admitted to the infectious diseases ward with SARS-CoV-2 pneumonia with clinical or laboratory criteria for suspected VTE events were eligible for inclusion in the study. The t-test or Mann-Whitney U test was used to analyze the differences between the with-VTE group and the without-VTE group. Results Overall, VTE incidence was registered to be 30%. Chest computed tomography angiography data revealed thrombus mainly in segmental (five patients, 71%) and subsegmental pulmonary artery branches (four patients, 57%). No thrombus on major branches was documented. D-dimer serum levels (collected at hospital admission, 48 hours before the suspected VTE event date and at suspected VTE event date) were analyzed, and, despite a consistent tendency of higher values in the with-VTE group, no statistical difference was observed. Moreover, no statistical difference was observed between the two groups in mortality rates. Conclusions A clear higher risk of VTE events in SARS-CoV-2 pneumonia patients was not documented, and a link between the impact of VTE occurrence and a worse prognosis was not demonstrated. Therefore, we suggest that the use of D-dimer serum level should not be used as a predictor of VTE in SARS-CoV-2 pneumonia patients.

Ocurrence of rotavirus and picobirnavirus in wild and exotic avian from amazon forest.

The present study reports the occurrence of rotavirus A (RVA), rotavirus D (RVD), rotavirus F (RVF), rotavirus G (RVG), and picobirnavirus (PBV) in fecal specimens of wild (n = 22), and exotic birds (n = 1) from different cities of Pará state. These animals were hospitalized at Veterinary Hospital of the Federal University of Pará, Brazil, in a period from January 2018 to June 2019. The animals exhibited different clinical signs, such as diarrhea, malnutrition, dehydration, and fractures. The results showed 39.1% (9/23) of positivity for RVA by RT-qPCR. Among these, one sample (1/9) for the NSP3 gene of T2 genotype was characterized. About 88.9% (8/9) for the VP7 gene belonging to G1, G3 equine like and G6 genotypes, and 55.5% (5/9) for the VP4 gene of P[2] genotype were obtained. In the current study, approximately 4.5% of the samples (1/23) revealed coinfection for the RVA, RVD and RVF groups. Furthermore, picobirnavirus (PBV) was detected in one of the 23 samples tested, and was classified in the Genogroup I. The findings represent the first report of RVA, RVD, RVF, RVG, and PBV genotypes in wild birds in Brazil, and due to wide distribution it can implies potential impacts of RVs, and PBVs on avian health, and other animals contributing to construction of new knowledge, and care perspectives.

Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients.

The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale-mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19-ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09-7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33-8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity.

Serological evidence of Eastern equine encephalitis circulation in equids in Pará state, Brazil.

Serum samples from 89 equids were analyzed (75 horses, 9 donkeys, and 5 mules) from the municipality of Viseu, Pará state, Brazil. Samples were collected in November 2014 and August 2015. The antibody prevalence against the following alphaviruses was estimated: Eastern equine encephalitis virus, Western equine encephalitis virus, Mucambo virus, and Mayaro virus. Seroprevalence was determined by the hemagglutination inhibition (HI) technique. Sera that exhibited HI antibodies with heterotypic reactions for the analyzed viruses were subjected to the 90% plaque reduction neutralization test (PRNT90). The HI prevalence of monotypic reactions to EEEV was 7.9%, and that of WEEV was 1.1%, as confirmed by PRNT90. Viral isolation attempts were negative for all tested blood samples. Our results suggest the circulation of equine encephalitis complex viruses. Future studies should evaluate the possible involvement of arthropod hosts and residents in the viral transmission in the study area.

Foram analisadas amostras de soros de 89 equídeos (75 equinos, 9 asininos e 5 muares) oriundos do município de Viseu, estado do Pará. As amostras foram coletadas no período de novembro de 2014 e agosto de 2015. Foram estimadas as prevalências de anticorpos contra os seguintes Alfavírus: vírus da Encefalite equina leste (EEEV), vírus da Encefalite equina oeste (WEEV), vírus Mucambo (MUCV), and vírus Mayaro (MAYV). A soroprevalência foi determinada por técnicas de Inibição da Hemaglutinação (IH), porém os soros que apresentaram anticorpos IH com reações heterotípicas para os vírus analisados foram submetidos ao PRNT90. A prevalência de reações monotípicas por IH para EEEV foi de 7, 9% e para WEEV foi de 1,1%, confirmadas por PRNT90. A tentativa de isolamento viral foi negativa em todas as amostras de sangue testadas. Nossos resultados sugerem a circulação de vírus do complexo das encefalites equinas. Estudos futuros devem ser realizados para avaliar possível envolvimento de hospedeiros artrópodes e residentes na área de abrangência do estudo.

Percepção sobre o mercado de trabalho odontológico dos estudantes do curso de odontologia da Universidade Federal do Pará / Perception of the undergraduate students in dentistry at the Federal University of Pará of the job market for dentists

Objetivo: Avaliar o perfil do estudante do Curso de Odontologia da Universidade Federal do Pará e sua percepção quanto à formação e mercado de trabalho. Métodos: Participaram do estudo 100 estudantes com idade igual ou superior a 18 anos, que estavam cursando o 2º, 4º, 6º, 8º e 10º períodos do curso. O instrumento de pesquisa foi um questionário com 18 questões de múltipla escolha e 1 discursiva, elaboradas por dois estudantes do 10º período e um docente. Os estudantes foram divididos em 2 grupos: grupo 1 correspondente ao período pré-clínico e grupo 2 ao clínico. Para análise de dados foi realizada estatística descritiva e Teste G com nível de significância de 0,05. Resultados: A maioria dos estudantes era do sexo feminino (67%), com renda familiar de até 06 salários mínimos (70%), que escolheram a odontologia por vocação (37%) e primeira opção de curso (55%). A maioria relatou que o curso tem condições adequadas para formação, apesar das dificuldades existentes (53%). O mercado de trabalho foi percebido como bom por 56%. O interesse em aprimorar os estudos antes da inserção no mercado foi predominante (83%), com pretensão salarial de 04 a 06 salários mínimos (31%). Não houve associação estatística entre as variáveis e semestres do curso (p > 0,05). Conclusão: O perfil dos estudantes foi de jovens, predominando o sexo feminino e renda salarial de até 06 salários mínimos, ingressantes pelos sistemas de ampla concorrência e cotas. O curso de Odontologia foi considerado adequado, apesar das dificuldades apresentadas. O mercado de trabalho foi percebido como bom pela maioria dos entrevistados.

Aim:To evaluate the profile of undergraduate students in Dentistry at the Federal University of Pará and their perception of education and the job market. Methods:A hundred students participated in the study, 18 years of age or over, who were in the 2nd, 4th, 6th, 8th, and 10th periods of the course. The research instrument was a questionnaire with 18 multiple choice questions and one discursive question, which was prepared by two students from the 10th period and one teacher. The students were divided into 2 groups: group 1 corresponding to the preclinical and group 2 to the clinician period. Descriptive statistics and G test were used in the data analysis with a 0.05 significance level. Results: Most students were female (67%), with a family income of up to 06 minimum wages (70%), who chose dentistry by vocation (37%) and as their first course option (55%). Most reported that the course has suitable conditions for training, despite the existing difficulties (53%). The job market was perceived as good by 56%. They showed interest in improving studies before entering the market (83%), with a wage expectation of 04 to 06 minimum wages (31%). There was no statistical association between the variables and periods of the course (p > 0.05). Conclusion: The profile of the students was of young individuals (23.4 years old), with predominance of females and salary income of up to 06 minimum wages, who entered the university through the systems of wide competition (49%) and quotas (43%). The undergraduate dentistry course was considered suitable, despite the adversities. The job market was perceived as good by the majority of respondents.

Capacidade para o trabalho em trabalhadores de um instituto de pesquisa / Working ability in workers of a research institute

O estudo objetivou avaliar a capacidade para o trabalho (CT) e analisar os fatores associados à capacidade inadequada em funcionários de um instituto de pesquisa, segundo o vínculo empregatício. Realizou-se uma pesquisa transversal com 515 servidores e terceirizados de uma instituição de pesquisa no Estado do Pará. Utilizou-se um questionário com variáveis sociodemográficas, funcionais e o Índice de Capacidade para o Trabalho (ICT). A média do ICT do grupo dos servidores foi 40,9, e a CT inadequada somou 20,7%. Para os terceirizados, os valores foram 44,3 e 5,1%, respectivamente. A análise múltipla dos servidores mostrou que apenas as variáveis sexo e idade permaneceram significativas. Para os terceirizados, nenhuma variável apresentou significância estatística. As categorias profissionais com maior prevalência de ICT inadequado foram: entre os servidores, os pesquisadores; entre os terceirizados, os trabalhadores da manutenção. Os resultados demonstram que as diferenças existentes entre esses funcionários estão fortemente relacionadas ao vínculo empregatício.

Current study assessed work ability ( WA) and analyzed factors associated with inadequate capacity in employees of a research institute, according to their work contract. A cross-sectional study was conducted with 515 civil servants and outsourced employees of a research institution in the state of Pará, Brazil. A questionnaire with sociodemographic, functional variables and the Work Ability Index ( WAI) was applied. Average WAI of the civil servant group was 40.9 and inadequate WA was 20.7%. Rates for outsourced workers were 44.3 and 5.1%, respectively. Multiple analysis of civil servants showed that only variables of gender and age remained significant. For the outsourced agents, no variable presented any statistical significance. The professional category with the highest prevalence of inadequate WAI were researchers, among civil servants; construction workers, among outsourced workers. Results show that the differences between these employees are strongly related to work contract.

Prevalence and risk indicators of non-carious cervical lesions in male footballers.

BACKGROUND: Non-carious cervical lesions (NCCLs) have shown a significant incidence and prevalence and have been increasingly associated with people's lifestyles and youths. This cross-sectional study aimed to determine the prevalence of NCCLs in footballers and to address potential risk indicators. METHODS: Fourty-three male semi-professional footballers with an average of 27 years old completed a questionnaire and were subjected to intraoral examination in terms of cervical tooth wear, morphological characteristics of NCCLs, tooth sensitivity, occlusal/incisal wear, and malocclusion classification. Also, laboratory assays were performed to determine salivary parameters: flow rate, pH, buffer capacity, level of Ca (calcium), Na (sodium), and K (potassium) ions, and level of cortisol. The data obtained from the questionnaire and intraoral examinations were subjected to Chi-square and Poisson regression models while the data obtained from the laboratory assays were analyzed by using analysis of variance (p <  0.05). RESULTS: The prevalence of NCCLs was 39.5%. The participants presented predominantly initial lesions with signs of mechanical stress. The daily training time was found as a significant risk indicator (p = 0.028). The multivariate analysis showed a significant difference in the variables daily training time (p = 0.023), lemon water intake while fasting (p = 0.002), toothpaste type (p = 0.004), tooth sensitivity (p = 0.006); previous orthodontic treatment (p = 0.003), and occlusion type (p = 0.008). All participants presented normal salivary parameters and levels of cortisol. CONCLUSION: The prevalence of NCCLs among footballers was remarkable. The premolars were the most affected teeth and presented symptoms/signs of initial lesions. The daily training time was a dominant risk indicator of NCCLs development. Footballers presented adequate salivary parameters and cortisol levels.

Acesso e acessibilidade na atenção primária à saúde no Brasil / Access and accessibility in primary health care in Brazil

Objetivos: Avaliar o acesso e a acessibilidade às Unidades Básicas de Saúde (UBS) nas diferentes regiões do Brasil, caracterizando-os segundo os componentes organizacional e de infraestrutura. Metodologia: Pesquisa avaliativa, de natureza quantitativa, com delineamento transversal descritivo, fundamentada nos dados do terceiro ciclo do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica. Resultados: A maioria das UBS (84,4%) possuem horário fixo de funcionamento; 46,3% mantém atividades no horário do almoço; 87,1% apresentaram todos os ambientes com sinalização, facilitando acesso dos usuários; 21,7% apresenta estrutura divergente do estabelecido pelo Ministério da Saúde. Conclusão: Houve disparidades regionais nos achados encontrados em âmbito nacional quanto ao acesso e à acessibilidade. Na avaliação geral, o componente organizacional aponta conformidade com o preconizado pelo Ministério da Saúde e, no componente infraestrutura, a acessibilidade indicou percentuais que demandam avanços para melhoria do acesso. (AU)

Objectives: Evaluate access and accessibility to Basic Health Units (BHU) in different regions of Brazil, characterizing them according to organizational and infrastructure components. Methodology: Evaluative research, of quantitative nature, with descriptive cross-sectional design, based on data from the third cycle of National Program for Improvement of Access and Quality of Primary Care. Results: Most BHU (84.4%) have fixed opening hours; 46.3% maintain activities at lunchtime; 87.1% presented all environments with signage, facilitating access of users; 21.7% presents a structure that differs from that established by the Ministry of Health. Conclusão: There were regional disparities in the findings found nationwide regarding access and accessibility. In the overall assessment, the organizational component points to compliance with the recommended by the Ministry of Health, and the infrastructure component, accessibility indicated percentages that require advances to improve access. (AU)

Objectivos: Evaluar el acceso y la accesibilidad a las Unidades Básicas de Salud (UBS) en diferentes regiones de Brasil, multiplasándolas de acuerdo con los componentes organizativos y de infraestructura. Metodología: Investigación evaluativa, de naturaleza cuantitativa, con diseño transversal descriptivo, basada en datos del tercer ciclo del Programa Nacional para la Mejora del Acceso y la Calidad de la Atención Primaria. Resultados: Más UBS (84,4%) tienen horarios de apertura fijos; 46,3% mantener actividades a la hora del almuerzo; El 87,1% presentó todos los entornos con señalización, facilitando el acceso de los usuarios; El 21,7% presenta una estructura que difiere de la establecida por el Ministerio de Salud. Conclusión: Hubo disparidades regionales en los resultados encontrados en todo el país con respecto al acceso y la accesibilidad. En la evaluación general, el componente organizacional apunta al cumplimiento del componente recomendado por el Ministerio de Salud y del componente de infraestructura, la accesibilidad indicó porcentajes que requieren avances para mejorar el acceso. (AU)

Desafios à ampliação da cobertura da fluoretação da água em municípios brasileiros com mais de 50 mil habitantes na primeira metade do século XXI / Challenges to spreading water fluoridation coverage in Brazilian municipalities with 50 thousand inhabitants or more at first half of XXI century / Desafíos para el aumento de la cobertura de la fluoruración del agua en municipios brasileños com más de 50 mil habitantes en la primera mitad del siglo XXI

Embora a fluoretação da água de abastecimento público seja um importante determinante para explicar o declínio da cárie dentária nos países que implementaram sua provisão, é grande o desafio para assegurar sua expansão para todas as regiões e territórios. O objetivo do estudo foi determinar as características dos municípios brasileiros com mais de 50 mil habitantes correlacionadas com a cobertura da fluoretação da água. Estudo ecológico transversal com 614 municípios cujo desfecho é representado pela cobertura populacional da política pública e as variáveis independentes referem-se a indicadores municipais socioeconômicos, de saneamento e de serviços de atenção primária à saúde. As relações foram analisadas por meio de regressão linear múltipla. Na análise ajustada (R2=0,39), a cobertura populacional correlacionou-se positivamente com a renda familiar percapita e negativamente com desigualdade da renda, água e esgoto inadequados, cobertura potencial da saúde bucal na estratégia saúde da família. Nas regiões Sudeste, Sul e Centro-Oeste (R2=0,33), analfabetismo e nível de desenvolvimento humano mostraram correlação positiva, enquanto desigualdade de renda e saneamento inadequado apresentaram correlação negativa. Já nas regiões Norte e Nordeste (R2=0,40), saneamento inadequado e nível de desenvolvimento humano mostraram correlação negativa. As desigualdades na expansão dos serviços de saneamento e dos sistemas de vigilância da concentração do fluoreto entre as regiões brasileiras trazem importantes desafios nas próximas décadas que vão requerer sua inclusão na agenda regulatória dos respectivos setores e a implementação de mecanismos de coordenação intersetorial da política pública. (AU)

Although fluoridation of public water is an important determinant to explain the decline in dental caries in countries that have implemented it, the challenge to ensure its expansion to all regions and territories is great. The objective of this study was to determine the characteristics of Brazilian municipalities with more than 50,000 inhabitants correlated with water fluoridation coverage. Method: Cross-sectional ecological study encompassing Brazilian municipalities with more than 50,000 inhabitants in which the outcome is represented by population coverage of the public policy and the independent variables refer to municipal socioeconomic, sanitation and primary health care services indicators. Relations were analyzed by multiple linear regression. Results: 614 municipalities were analyzed. In the adjusted analysis (R2 = 0.39), population coverage correlated positively with per capita household income and negatively correlated with income inequality, inadequate water and sewage, potential oral health coverage in the family health strategy. While illiteracy and human development level showed positive correlation and income inequality and inadequate sanitation, negative correlation in the Southeast, South and Central West (R2 = 0.33) Brazilian regions; in the North and Northeast (R2 = 0.40) regions, inadequate sanitation and human development level showed a negative correlation. Inequalities in the expansion of sanitation services and fluoride concentration adjustment systems among Brazilian regions pose important challenges in the coming decades that will require their inclusion in the regulatory agenda of the corresponding sectors and the implementation of intersectoral coordination mechanisms for public policy. (AU)

Aunque la fluoruración del agua proveniente del abastecimiento público sea un determinante importante del declive de la prevalencia de caries en los países que han implementado su provisión, es grande el desafío para garantizar su expansión a todas las regiones y territorios. El objetivo de este estudio fue determinar las características de los municipios brasileños con más de 50.000 habitantes en relación con la cobertura de fluoruración del agua. Estudio ecológico transversal que abarcó 614 municipios. La variable dependiente es la población cubierta por la política pública y las variables independientes se refieren a los indicadores municipales socioeconómicos, de saneamiento y de servicios de atención primaria de salud. Las relaciones se analizaron utilizando una regresión lineal múltiple. En el análisis ajustado (R2 = 0,39), la cobertura de la población mostró una correlación positiva con el ingreso familiar per cápita y negativa con la insuficiencia de ingresos, la desigualdad de agua y alcantarillado, y la cobertura potencial de salud bucal en la estrategia de salud familiar. En las regiones Sureste, Sur y Centro Oeste (R2 = 0,33), el analfabetismo y el nivel de desarrollo humano mostraron una correlación positiva, mientras que la desigualdad de ingresos y el saneamiento inadecuado presentaron una correlación negativa. Por otro lado, las regiones Norte y Noreste (R2=0,40) mostraron una correlación negativa entre el saneamiento inadecuado y el nivel de desarrollo humano. Las desigualdades tanto en la expansión de los servicios de saneamiento cuanto en los sistemas de vigilancia de concentración de fluoruro entre las regiones brasileñas plantean retos importantes en las próximas décadas que requerirán su inclusión en la agenda reguladora de los sectores respectivos, así como la implementación de mecanismos de coordinación intersectorial de esa política pública. (AU)

Water fluoridation in the ten largest municipalities of the state of Tocantins, Brazil. / Fluoretação da água dos dez maiores municípios do estado do Tocantins, Brasil.

Water fluoridation is a strategy for caries control recommended by the WHO. In Brazil, it is regulated by law but this program has not been successfully implemented in the North region. This research aimed to collect data on the existence of external control (heterocontrol) in the ten largest municipalities in the state of Tocantins, Brazil, and to analyze fluoride concentration in the public water supply of these cities. The study was conducted from May-August/17, and its theoretical-methodological framework was a quantitative, descriptive and cross-sectional analysis. Water collections were carried out monthly, using sampling protocol of water collection of the network. Fluoride concentration in the waters was determined with ion specific electrode by the direct technique. It was verified that water fluoridation monitoring is only been done in Palmas, capital of the state, starting in 2016. Thirty-two percent of waters samples analyzed showed fluoride concentration to obtain the maximum benefit of reduction caries and 27.5% of them presented a high or very high risk of dental fluorosis. It is necessary to implement a program to control the concentration of fluoride in the water of the municipalities of Tocantins, in order to ensure that the population is not deprived of the anticaries' benefits of the adjustment of fluoride concentration of the treated water.

Fluoretação da água é uma estratégia de controle da cárie, recomendada pela OMS. No Brasil ela é regulamentada por lei, mas não tem sido implementada com sucesso na região Norte. Os objetivos desta pesquisa foram levantar dados sobre a existência do heterocontrole nos 10 maiores municípios tocantinenses e analisar a concentração de fluoreto presente na água de abastecimento público destas cidades. A pesquisa foi realizada de maio-agosto/17 e teve como marco teórico-metodológico a análise quantitativa, descritiva e transversal. Coletas de água foram realizadas mensalmente, utilizando protocolo de amostragem de coleta de água da rede. A concentração de fluoreto nas águas foi feita com eletrodo íon específico pela técnica direta. Constatou-se que a vigilância da fluoretação da água está em operação na capital do estado desde 2016. Com relação a concentração de fluoreto na água, foi encontrado que 31,6% das amostras analisadas estavam adequadas para o máximo benefício de redução de cárie e 27,5% delas apresentavam risco alto ou muito alto de fluorose dentária. É necessário implementar um programa de controle da concentração de flúor na água no Tocantins, a fim de garantir que a população não seja privada dos benefícios anticárie da agregação de flúor à agua tratada.

Fluoretação da água dos dez maiores municípios do estado do Tocantins, Brasil / Water fluoridation in the ten largest municipalities of the state of Tocantins, Brazil

Resumo Fluoretação da água é uma estratégia de controle da cárie, recomendada pela OMS. No Brasil ela é regulamentada por lei, mas não tem sido implementada com sucesso na região Norte. Os objetivos desta pesquisa foram levantar dados sobre a existência do heterocontrole nos 10 maiores municípios tocantinenses e analisar a concentração de fluoreto presente na água de abastecimento público destas cidades. A pesquisa foi realizada de maio-agosto/17 e teve como marco teórico-metodológico a análise quantitativa, descritiva e transversal. Coletas de água foram realizadas mensalmente, utilizando protocolo de amostragem de coleta de água da rede. A concentração de fluoreto nas águas foi feita com eletrodo íon específico pela técnica direta. Constatou-se que a vigilância da fluoretação da água está em operação na capital do estado desde 2016. Com relação a concentração de fluoreto na água, foi encontrado que 31,6% das amostras analisadas estavam adequadas para o máximo benefício de redução de cárie e 27,5% delas apresentavam risco alto ou muito alto de fluorose dentária. É necessário implementar um programa de controle da concentração de flúor na água no Tocantins, a fim de garantir que a população não seja privada dos benefícios anticárie da agregação de flúor à agua tratada.

Abstract Water fluoridation is a strategy for caries control recommended by the WHO. In Brazil, it is regulated by law but this program has not been successfully implemented in the North region. This research aimed to collect data on the existence of external control (heterocontrol) in the ten largest municipalities in the state of Tocantins, Brazil, and to analyze fluoride concentration in the public water supply of these cities. The study was conducted from May-August/17, and its theoretical-methodological framework was a quantitative, descriptive and cross-sectional analysis. Water collections were carried out monthly, using sampling protocol of water collection of the network. Fluoride concentration in the waters was determined with ion specific electrode by the direct technique. It was verified that water fluoridation monitoring is only been done in Palmas, capital of the state, starting in 2016. Thirty-two percent of waters samples analyzed showed fluoride concentration to obtain the maximum benefit of reduction caries and 27.5% of them presented a high or very high risk of dental fluorosis. It is necessary to implement a program to control the concentration of fluoride in the water of the municipalities of Tocantins, in order to ensure that the population is not deprived of the anticaries' benefits of the adjustment of fluoride concentration of the treated water.

Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial.

PURPOSE: Wheat bran fibre has a beneficial effect on gastrointestinal function, but evidence for wheat germ is scarce. Accordingly, we evaluated the effects of daily intake of wheat germ on gastrointestinal discomfort and gut microbiota by adding wheat germ to refined (white) wheat bread, the most consumed bread type. We hypothesised that an improvement in the composition of refined bread could beneficially affect intestinal health without compromising consumers' acceptance. METHODS: Fifty-five healthy adults were recruited for a randomised, double-blind, crossover, controlled trial comprising two 4-week intervention periods separated by a 5-week washout stage. During the first 4-week period, one group consumed wheat bread enriched with 6 g of wheat germ and the control group consumed non-enriched wheat bread. RESULTS: Wheat germ-enriched bread was well-appreciated and the number of participants that demonstrated minimal gastrointestinal improvements after wheat-germ intake was higher than in the control arm. Importantly, intake of wheat germ-enriched bread decreased the perceived gastrointestinal discomfort-related quality of life (subscale worries and concerns) over refined white bread. The improvements in the gastrointestinal function were accompanied by favourable changes in gut microbiota, increasing the number of Bacteroides spp. and Bifidobacterium spp. CONCLUSIONS: Adding wheat germ to industrially made white bread without altering sensory properties may promote a healthy gut bacterial microbiota and the gastrointestinal health.