ABSTRACT
BACKGROUND: Cryptococcal meningoencephalitis is an opportunistic infection that predominantly affects immunocompromised patients. Hyper immunoglobulin M syndrome is a primary immunodeficiency syndrome that increases susceptibility to several opportunistic infections. Here, we report a case of cryptococcal meningoencephalitis in the context of hyper immunoglobulin M syndrome, a situation that has been reported very few times and whose management is not clearly defined. We describe our management of this case and the outcome of the patient to help in future similar situations. CASE PRESENTATION: The patient is a 19-year-old Caucasian male student diagnosed with X-linked hyper immunoglobulin M syndrome and treated chronically with weekly intravenous immunoglobulin and daily sulfamethoxazole-trimethoprim. He was admitted to the infectious diseases ward because of headache, diplopia and a cerebral-spinal fluid analysis revealing cryptococcal meningoencephalitis. The patient was treated with liposomal amphotericin and flucytosine with a favorable outcome. Maintenance therapy with fluconazole has continued and will be sustained for 6 months following his upcoming bone marrow transplantation. CONCLUSION: Monitoring for cryptococcal meningoencephalitis should be considered in patients with primary immunodeficiencies, as clinical manifestations may go unnoticed. In these patients, it is expected that chronic treatment with fluconazole will be the only treatment that will prevent reinfection or reactivation, and therefore should be kept at least until bone marrow transplant, the only curative treatment, is performed. It may, however, lead to intolerable side effects and hepatic toxicity.
Subject(s)
Hypergammaglobulinemia/complications , Immunoglobulin M/blood , Meningitis, Cryptococcal/complications , Adolescent , Genetic Diseases, X-Linked , Humans , Hypergammaglobulinemia/genetics , Male , Meningitis, Cryptococcal/drug therapyABSTRACT
We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial ß-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro.
Subject(s)
Aspergillosis/veterinary , Aspergillus/physiology , Cat Diseases/microbiology , Communicable Diseases, Emerging/veterinary , Dog Diseases/microbiology , Rhinitis/veterinary , Sinusitis/veterinary , Air Microbiology , Animals , Antifungal Agents/pharmacology , Aspergillosis/microbiology , Aspergillus/drug effects , Aspergillus/isolation & purification , Caspofungin , Cats , Communicable Diseases, Emerging/microbiology , Dogs , Drug Resistance, Fungal , Echinocandins/pharmacology , Fluconazole/pharmacology , Genes, Fungal , Humans , Lipopeptides , Male , Microbial Sensitivity Tests , Middle Aged , Multilocus Sequence Typing , Phylogeny , Rhinitis/microbiology , Sinusitis/microbiologyABSTRACT
In contrast with the common hematogenous dissemination of invasive aspergillosis (IA), we present case with a protracted course through anatomical planes in an immunocompromised adult male. The unusual clinical features and laboratory findings led to fungal genotyping and identification of the mold as Aspergillus viridinutans. It appears to be the first described case of IA caused by this agent in an adult patient.
Subject(s)
Aspergillus/classification , Aspergillus/isolation & purification , Invasive Pulmonary Aspergillosis/microbiology , Invasive Pulmonary Aspergillosis/pathology , Neuroaspergillosis/microbiology , Neuroaspergillosis/pathology , Adult , Antifungal Agents/pharmacology , Aspergillus/genetics , Chronic Disease , Genotype , Humans , Immunocompromised Host , Lung/microbiology , Lung/pathology , Male , Microbial Sensitivity Tests , Microscopy , Middle Aged , Mycological Typing Techniques , Radiography, Thoracic , Tomography, X-Ray ComputedABSTRACT
Streptococcus gallolyticus is a microorganism belonging to the Streptococcus bovis I group isolated in humans, bovines and equines pigeons, among other animals. Streptococcus bovis is a Streptococcus strain found in the rumen, and has been isolated in the milk of animals with mastitis. The authors describe a case of an adult immunocompetent patient with underlying valvular heart disease, with bacteraemia and infective endocarditis by Streptococcus gallolyticus, in whom adenomatous colonic polyps with dysplasia were identified.