Surgical management of primary and recurrent carcinoma showing thymous-like elements (CASTLE).

INTRODUCTION: Carcinoma showing thymous-like elements (CASTLE) is a rare tumor with only a few cases described in the scientific literature. The aim of the present review is to analyze the data available on the therapeutic options employed in CASTLE tumors and to outline the best surgical management to adopt. MATERIALS AND METHODS: English-language articles published from 1985 through November 2016, and related to CASTLE cases were retrieved using the Pubmed database and specific key-words. RESULTS: Eighty seven cases included in 23 papers, published in the period under investigation, were analyzed in detail. The mean age of the patients was 50.2 years and the male to female ratio 1:1.2. There were performed 31 (35.6%) lobectomies, 29 (33.3%) total thyroidectomies, 15 (17.2%) subtotal thyroidectomies, 4 (4.6%) excisions, 3 (3.4%) partial thyroidectomies, 1 (1.1%) hemithyroidectomy, and 8 (9.2%) additional procedures including tracheal, pharyngeal, and esophageal resections. Lymph node dissection and radiotherapy were associated in 59 (67.8%) and 44 (50.6%) cases respectively. Among the patients with available data 62 (75.6%) were free of disease, 16 (19.5%) were alive with disease, 3 (3.7%) died for the disease, and 1 (1.2%) died for cerebrovascular complications at the time of follow-up. Globally 20 (24.4%) cases of local or distant recurrence were reported. Surgery and radiotherapy, alone or in combination were the treatments most frequently used for recurrences. CONCLUSIONS: CASTLE is a rare tumor which generally respond well to complete surgical resection and adjuvant radiotherapy. These treatments can be further employed for the recurrences, which occur in 24.4% of the cases, along with specific chemotherapy regimens and palliative procedures. KEY WORDS: Cancer, CASTLE, Excision, Lobectomy, Thymous-like elements, Thyroidectomy.

Prophylactic central neck lymphadenectomy in high risk patients with T1 or T2 papillary thyroid carcinoma: is it useful?

INTRODUCTION: The aim of this study was to evaluate the role of prophylactic central neck lymph node dissection in high risk patients with T1 or T2 papillary thyroid cancer. MATERIALS AND METHODS: Seventy-three patients who had undergone total thyroidectomy for papillary thyroid cancer smaller than 4cm, without cervical lymphadenopathy and prophylactic central neck lymph node dissection were included. Patients were divided in two groups: low risk patients (group A) and high risk patients (group B). High risk patients were considered those with at least one of the followings: male sex, age ≥ 45 years, and extracapsular or extrathyroid disease. Statistical significant differences in persistent disease, recurrence and complications rates between the two groups were studied. RESULTS: Persistence of the disease was observed in one case in group A (5.9%) and in three cases in group B (5.4%), while thyroid cancer recurrence was registered in zero and two (3.6%) cases respectively. One single case (5.9%) of transitory recurrent laryngeal nerve damage was reported in group A and none in group B, while transitory hypoparathyroidism was observed in 2 (3.6%) patients in group A, and 1 (1.8%) patient in group B. Permanent recurrent laryngeal nerve damage was observed in one patient in group A, while permanent hypoparathyroidism was registered in one case in group B. Logistic regression evidenced that multifocality was the only risk factor significantly related to persistence of disease and recurrence. CONCLUSIONS: Our results suggests that prophylactic central neck lymph node dissection can be safely avoided in patients with T1 or T2 papillary thyroid cancer, except in those with multifocal disease. KEY WORDS: Cancer, Central neck, Cervical, Lymphadenectomy, Lymph nodes, Papillary carcinoma, Thyroid.

[Endovenous radiofrequency obliteration of the saphenous veins in the treatment of venous insufficiency of lower legs. Our experience]. / Obliterazione safenica con radiofrequenza nel trattamento dell'insufficienza venosa degli arti inferiori. Nostra esperienza.

OBJECTIVE: To determine the efficacy and safety of endovascular radiofrequency obliteration of refluxing greater saphenous veins in patients eligible for vein ligation and stripping METHOD: From 2002 to 2007, 107 patients, classified a C2 CEAP, were treated. The ablation of the greater saphenous vein was performed using a radiofrequency generator and a VNUS Closer catheter, for endovascular radiofrequency ablation. This procedure avoids groin surgery. The catheter is inserted in the saphenous vein with the use of a introducer through the skin. When necessary, the procedure was complemented by phlebectomy (Muller's method). In all cases, the duplex/color ultrasound was used in guiding the pre- intra and post-operative phase. RESULTS: The procedure was carried out in all cases without complications, with immediate improvement of clinical symptoms and immediate return to normal activities. At 5-year follow-up no recurrent varicose veins were detected CONCLUSIONS: The endovenous radiofrequency ablation of the saphenous veins represents a valid alternative to GSF ligation and saphenous vein stripping. The rigorous application of the protocol, both before and after the operation, is an essential condition to keep complications to a minimum. Because of the long term results, the level of patient satisfaction, the ease with which the procedure is carried out, we have extended its adoption to patients with an advanced stage of the disease, whom in the past would have only been treated with stripping.