ABSTRACT
BACKGROUND AND OBJECTIVE: A significant proportion of women of childbearing age have psoriasis. The aim of this study was to examine family planning concerns in this population. MATERIAL AND METHODS: Observational, descriptive, cross-sectional, multicenter study conducted between March 2020 and October 2021. We collected sociodemographic data and analyzed responses to a family planning questionnaire administered to women aged 18 to 45 years with plaque psoriasis who were candidates for systemic treatment. RESULTS: We studied 153 patients (mean [SD] age, 35.4 [8.0] years; mean disease duration, 16.7 years) being treated at 11 Spanish hospitals. Overall, 38.4% of women were considered to have moderate to severe psoriasis by their physicians; perceived severity ratings were significantly higher among women. Psoriasis affected the women's desire to become pregnant or led to their delaying pregnancy in 1 in 3 respondents. They were concerned that their condition might worsen if they had to discontinue or switch treatment or that the treatment might harm the baby. Approximately half of the women had not received family planning counseling from their physicians, and this was more likely to be the case among never-pregnant women. Women on biologic therapy (58.7%) had better psoriasis control and a better quality of life than women on other treatments. Their sexual health was also less affected. CONCLUSIONS: Women with psoriasis have numerous family planning concerns, which in some cases can lead them to delay pregnancy or affect their desire to become pregnant. Dermatologists need to receive better training regarding family planning in women with psoriasis so that they can provide their patients with more and better information.
Subject(s)
Family Planning Services , Psoriasis , Humans , Female , Pregnancy , Adult , Cross-Sectional Studies , Quality of Life , Surveys and Questionnaires , Psoriasis/drug therapyABSTRACT
BACKGROUND AND OBJECTIVE: A significant proportion of women of childbearing age have psoriasis. The aim of this study was to examine family planning concerns in this population. MATERIAL AND METHODS: Observational, descriptive, cross-sectional, multicenter study conducted between March 2020 and October 2021. We collected sociodemographic data and analyzed responses to a family planning questionnaire administered to women aged 18 to 45 years with plaque psoriasis who were candidates for systemic treatment. RESULTS: We studied 153 patients (mean [SD] age, 35.4 [8.0] years; mean disease duration, 16.7 years) being treated at 11 Spanish hospitals. Overall, 38.4% of women were considered to have moderate to severe psoriasis by their physicians; perceived severity ratings were significantly higher among women. Psoriasis affected the women's desire to become pregnant or led to their delaying pregnancy in 1 in 3 respondents. They were concerned that their condition might worsen if they had to discontinue or switch treatment or that the treatment might harm the baby. Approximately half of the women had not received family planning counseling from their physicians, and this was more likely to be the case among never-pregnant women. Women on biologic therapy (58.7%) had better psoriasis control and a better quality of life than women on other treatments. Their sexual health was also less affected. CONCLUSIONS: Women with psoriasis have numerous family planning concerns, which in some cases can lead them to delay pregnancy or affect their desire to become pregnant. Dermatologists need to receive better training regarding family planning in women with psoriasis so that they can provide their patients with more and better information.
Subject(s)
Family Planning Services , Psoriasis , Humans , Female , Pregnancy , Adult , Cross-Sectional Studies , Quality of Life , Surveys and Questionnaires , Psoriasis/drug therapyABSTRACT
INTRODUCCIÓN: La psoriasis es una enfermedad inflamatoria crónica que se ha asociado a un aumento de riesgo de enfermedad arterial coronaria isquémica (EACI) en algunas poblaciones. El objetivo de nuestro estudio fue determinar la asociación entre psoriasis y EACI en nuestro medio. MATERIAL Y MÉTODO: Se realizó un estudio transversal en la provincia de Castellón con datos procedentes del sistema de información asistencial Abucasis (Datamart) desde el año 2005 hasta el 2012. Se seleccionó a los pacientes con psoriasis y como grupo control a los pacientes con nevus melanocítico. Se estudió la prevalencia de EACI en ambos grupos estratificando por los principales factores de riesgo cardiovascular. RESULTADOS: Se estudiaron 9.181 pacientes con psoriasis y 21.925 con nevus melanocítico. En el análisis de regresión logística univariante la EACI se asoció significativamente a las variables psoriasis, edad (en años), sexo, hipertensión, diabetes mellitus, dislipidemia y obesidad (p < 0,05). En el análisis de regresión logística multivariante, tras ajustar por edad, sexo y el resto de los factores de riesgo cardiovascular, se establece una relación independiente entre la presencia de EACI y psoriasis (p < 0,029). CONCLUSIÓN: Nuestros resultados apoyan la existencia de mayor riesgo de EACI en pacientes con psoriasis en una población amplia del área mediterránea
INTRODUCTION: Psoriasis is a chronic inflammatory disease associated with an increased risk of ischemic coronary artery disease (CAD) in some populations. We aimed to determine the association between these 2 diseases in our geographic area. MATERIAL AND METHOD: We performed a cross-sectional study of patient records between 2005 and 2012 in the database (Abucacis, Datamart) that contains all medical case histories in the province of Castellón, Spain. Patients diagnosed with psoriasis were compared with a control group of patients diagnosed with melanocytic nevus. The prevalence of CAD and the presence or absence of the main cardiovascular risk factors were analyzed in each group. RESULTS: A total of 9181 patients with psoriasis and 21925 with melanocytic nevus were studied. Univariate logistic regression analysis showed that CAD was significantly associated with psoriasis, age (in years), sex, hypertension, diabetes mellitus, dyslipidemia, and obesity (P < .05). On adjustment for age, sex, and the other cardiovascular risk factors, multivariate regression analysis established that psoriasis was independently associated with CAD (P < .029). CONCLUSION: Our findings in a large sample of patients in a Mediterranean area support the hypothesis that patients in this population have an increased risk of ischemic CAD
Subject(s)
Humans , Male , Female , Aged , Middle Aged , Coronary Artery Disease/etiology , Psoriasis/complications , Myocardial Ischemia/etiology , Coronary Artery Disease/epidemiology , Cross-Sectional Studies , Risk Factors , Myocardial Ischemia/epidemiologyABSTRACT
INTRODUCTION: Psoriasis is a chronic inflammatory disease associated with an increased risk of ischemic coronary artery disease (CAD) in some populations. We aimed to determine the association between these 2 diseases in our geographic area. MATERIAL AND METHOD: We performed a cross-sectional study of patient records between 2005 and 2012 in the database (Abucacis, Datamart) that contains all medical case histories in the province of Castellón, Spain. Patients diagnosed with psoriasis were compared with a control group of patients diagnosed with melanocytic nevus. The prevalence of CAD and the presence or absence of the main cardiovascular risk factors were analyzed in each group. RESULTS: A total of 9181 patients with psoriasis and 21925 with melanocytic nevus were studied. Univariate logistic regression analysis showed that CAD was significantly associated with psoriasis, age (in years), sex, hypertension, diabetes mellitus, dyslipidemia, and obesity (P<.05). On adjustment for age, sex, and the other cardiovascular risk factors, multivariate regression analysis established that psoriasis was independently associated with CAD (P<.029). CONCLUSION: Our findings in a large sample of patients in a Mediterranean area support the hypothesis that patients in this population have an increased risk of ischemic CAD.
Subject(s)
Coronary Artery Disease/etiology , Myocardial Ischemia/etiology , Psoriasis/complications , Aged , Coronary Artery Disease/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Myocardial Ischemia/epidemiology , Risk FactorsABSTRACT
La foliculitis de la barba candidomicética es una infección muy poco frecuente. Aunque se han citado diferentes factores predisponentes, la mayoríade los casos ocurren en personas sanas. Presentamos un caso de foliculitis de la barba candidomicética en un individuo sano de 41 años, tratado satisfactoriamentecon itraconazol durante 4 semanas. Sugerimos que en este paciente pudiera tratarse de una infección de transmisión sexual por contactoorogenital (AU)
Folliculitis barbae candidomycetica is a very rare infection. Although many predisposing factors have been cited, most cases occur in healthy individuals.We present a case of folliculitis barbae candidomycetica in a 41-year-old healthy man, successfully treated with itraconazole during 4 weeks. Wesuggest in this patient it could be a sexually transmitted infection due to orogenital contact (AU)
Subject(s)
Humans , Male , Adult , Folliculitis/diagnosis , Candida albicans/isolation & purification , Candidiasis/diagnosis , Face/microbiology , Folliculitis/drug therapy , Candidiasis/drug therapy , Folliculitis/etiology , Folliculitis/microbiology , Candidiasis/etiology , Itraconazole/therapeutic use , Antifungal Agents/therapeutic useABSTRACT
El síndrome de McCune-Albright se caracteriza por la tríada de manchas café con leche, displasia fibrosa ósea y endocrinopatías hiperfuncionantes.Presentamos una niña de 9 años con manchas café con leche irregulares en mejilla izquierda, cuello y región frontal, así como displasia fibrosa de loshuesos subyacentes del cráneo. No se encontraron endocrinopatías ni pubertad precoz (AU)
The McCune-Albright syndrome is characterized by a triad of café-au-lait macules, bone fibrous dysplasia and hyperfunctioning endocrinopathies.A nine-year-old girl with irregular café-au-lait macules on the left cheek, neck and frontal areas, as well as fibrous dysplasia of underlying bones of theskull is reported. No endocrinopathies nor precocious puberty were found (AU)
Subject(s)
Humans , Female , Child , Fibrous Dysplasia, Polyostotic/diagnosis , Facial Bones/pathology , Skull/pathology , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells. It presents clinically as a solitary asymptomatic nodule and its pathogenesis has been the subject of much debate in the literature. OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature. METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases). RESULTS: In total, 58.82 % were men and 41.18 % were women, and the mean age was 31.74 years. The most common site was the oral cavity (61.76 %). The most frequently suspected clinical diagnosis was fibroma (17.65 %). The lesion was poorly defined and diffuse in 85.29 %. Pseudoepitheliomatous hyperplasia was present in 58.82 %. Nuclear atypia was found in 29.41 % and mitoses in 20.59 %. One case was considered malignant (2.94 %) and 2 atypical (5.88 %). Pustulo-ovoid bodies were present in 47.06 % of the cases and S-100 staining was positive in all cases analyzed. CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
Subject(s)
Granular Cell Tumor/epidemiology , Mouth Neoplasms/epidemiology , Adolescent , Adult , Biomarkers, Tumor , Child , Child, Preschool , Cytoplasmic Granules/ultrastructure , Diagnosis, Differential , Female , Fibroma/diagnosis , Granular Cell Tumor/chemistry , Granular Cell Tumor/diagnosis , Granular Cell Tumor/pathology , Humans , Male , Middle Aged , Mouth Neoplasms/chemistry , Mouth Neoplasms/diagnosis , Mouth Neoplasms/pathology , Retrospective Studies , Skin Neoplasms/chemistry , Skin Neoplasms/diagnosis , Skin Neoplasms/epidemiology , Skin Neoplasms/pathology , Staining and Labeling , Young AdultABSTRACT
La enfermedad periodontal necrosante es una infección con necrosis de las papilas interdentarias, dolor y hemorragia gingival. Las espiroquetas sonlos patógenos implicados en la gingivitis necrosante aguda. Los factores predisponentes son el consumo de tabaco y alcohol, el déficit alimentario, lainmunosupresión, especialmente en pacientes infectados por VIH, el estrés emocional y la gingivitis preexistente. Presentamos el caso de un hombrede 38 años con lesiones en encías y labio superior, tratado con éxito con metronidazol y espiramicina (AU)
Necrotizing periodontal disease is an infection characterized by gingival necrosis, pain and gingival bleeding. Spirochetes are pathogens usually involvedin acute necrotizing gingivitis. Predisposing factors are tobacco smoking, alcohol abuse, poor diet, inmunosupression, specially in HIV infectedpatients, emotional stress and preexisting gingivitis. We present a 38-year-old man with gingival and upper lip lesiones, successfully treated withmetronidazole and spiramycin (AU)
Subject(s)
Humans , Male , Adult , Periodontal Diseases/drug therapy , Periodontal Diseases/diagnosis , Anti-Infective Agents/therapeutic use , Metronidazole/therapeutic use , Spiramycin/therapeutic use , NecrosisABSTRACT
Introducción: El tumor de células granulares cutáneo (TCG) o de Abrikossoff es una neoplasia benigna e infrecuente, probablemente de origen neural a partir de las células de Schwann. Clínicamente se manifiesta como un nódulo solitario y asintomático, y su etiopatogenia ha estado ampliamente debatida en la literatura. Objetivos: Analizar las características clínicas, histológicas e inmunohistoquímicas asociadas a este tumor y determinar si estos hallazgos se corresponden con lo descrito hasta el momento en la literatura. Métodos: Se realiza un estudio retrospectivo de treinta y cuatro casos con diagnóstico histológico de TCG donde se analizan las características clínicas (localización, edad, sexo, tiempo de evolución y sospecha diagnóstica), histológicas (delimitación, atipia, mitosis, afectación de anejos cutáneos, hiperplasia seudoepiteliomatosa y presencia de los recientemente descritos cuerpos pústulo-ovoides [CPO]) e inmunohistoquímicas (tinción S-100 en 16 casos seleccionados aleatoriamente). Resultados: El 58,82 % fueron hombres y el 41,18 % mujeres. La edad media fue de 31,74 años. La localización más frecuente fue la cavidad oral (61,76 %). El diagnóstico clínico más comúnmente sospechado fue el de fibroma (17,65 %). En un 85,29 % se presentaba como una lesión mal delimitada y difusa. La hiperplasia seudoepiteliomatosa estuvo presente en el 58,82 %. Se encontraron atipias nucleares en el 29,41 % y mitosis en un 20,59 %. Hubo un caso maligno (2,94 %) y dos se consideraron atípicos (5,88 %). Los CPO estuvieron presentes en el 47,06 %. La tinción con S-100 fue positiva en el 100 % de los casos analizados. Conclusiones: Nuestra serie confirmaría las características descritas hasta el momento para el TCG salvo con algunas peculiaridades y apoyaría la existencia de los CPO como un nuevo hallazgo histológico adicional para el diagnóstico de este tumor (AU)
Background: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells. It presents clinically as a solitary asymptomatic nodule and its pathogenesis has been the subject of much debate in the literature. Objectives: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature. Methods: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases). Results: In total, 58.82% were men and 41.18% were women, and the mean age was 31.74 years. The most common site was the oral cavity (61.76%). The most frequently suspected clinical diagnosis was fibroma (17.65%). The lesion was poorly defined and diffuse in 85.29%. Pseudoepitheliomatous hyperplasia was present in 58.82%. Nuclear atypia was found in 29.41% and mitoses in 20.59%. One case was considered malignant (2.94%) and 2 atypical (5.88%). Pustulo-ovoid bodies were present in 47.06% of the cases and S-100 staining was positive in all cases analyzed. Conclusions: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor (AU)
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Young Adult , Adult , Middle Aged , Granular Cell Tumor/epidemiology , Mouth Neoplasms/epidemiology , Cytoplasmic Granules , Fibroma/diagnosis , Skin Neoplasms/epidemiology , Skin Neoplasms/pathology , Biomarkers, Tumor , Granular Cell Tumor/chemistry , Granular Cell Tumor/diagnosis , Granular Cell Tumor/pathology , Mouth Neoplasms/chemistry , Mouth Neoplasms/diagnosis , Mouth Neoplasms/pathology , Diagnosis, Differential , Retrospective Studies , Skin Neoplasms/chemistry , Skin Neoplasms/diagnosis , Staining and LabelingSubject(s)
Axilla/pathology , Hyperpigmentation/etiology , Papilloma/diagnosis , Skin Neoplasms/diagnosis , Adult , Biopsy , Diagnosis, Differential , Female , Humans , Hyperpigmentation/pathology , Papilloma/complications , Papilloma/pathology , Skin Neoplasms/complications , Skin Neoplasms/pathologyABSTRACT
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