ABSTRACT
OBJECTIVE: To study clinical presentations and neuroimaging results in post chemotherapy encephalopathy. MATERIAL AND METHODS: We examined 27 patients with cancer after chemotherapy (n=16) or chemoradiation (n=11). RESULTS AND CONCLUSION: All patients complained of memory impairment, sluggish mentality, moderate headache, fatigue, sleep disorder, irritability. Their neurologic status included different organic symptoms. Post chemotherapy encephalopathy is characterized by the combination of severe cerebral asthenia and different organic neurologic symptoms with moderate cephalgic syndrome. MRT showed single and multiple loci of gliosis in the white matter.
Subject(s)
Antineoplastic Agents/adverse effects , Brain Diseases/chemically induced , Brain Diseases/diagnosis , Neoplasms/drug therapy , Adult , Aged , Antineoplastic Agents/therapeutic use , Brain Diseases/physiopathology , Fatigue/chemically induced , Fatigue/diagnosis , Fatigue/physiopathology , Female , Headache/chemically induced , Headache/diagnosis , Headache/physiopathology , Humans , Male , Middle Aged , Neuroglia/drug effects , Neuroglia/pathology , Sleep Wake Disorders/chemically induced , Sleep Wake Disorders/diagnosis , Sleep Wake Disorders/physiopathologyABSTRACT
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main problem of modern cytotoxic therapy. Drug dose reduction, delay or even complete stopping of chemotherapy until the regression of CIPN symptoms impair treatment effectiveness and patients' survival. We studied 44 cancer patients with CIPN developed after polychemotherapy. We suggested a treatment regimen that included a complex of allopathic, homeopathic drugs and hydrotherapy. The treatment resulted in a subjective and objective regression of neuropathy symptoms and improving of quality of life in all patients. Patients who had to delay chemotherapy were able to restart it.
