Occupational external exposure to ionizing radiation in research-associated activities in Iran (2015-2020).

Research is an integral part of radiological and nuclear activities; thus, workers may receive different levels of occupational exposure. In the present study, occupational external exposure of workers was studied at the largest radiological and nuclear research institute of Iran from 2015-2020. The activities included research reactors, nuclear fuel cycle, development on radiopharmaceuticals and radioisotopes, particle accelerators, plasma and fusion, and nuclear agriculture. The average doses of the monitored and exposed workers were calculated to be 0.095 and 0.575 mSv, respectively, which were around their corresponding worldwide values. Moreover, the results showed that in comparison with other research activities, the workers in research reactors, nuclear fuel cycle, and development of radiopharmaceuticals and radioisotopes may face higher occupational risks. It could be, therefore, concluded that all the radiation protection measures have been effective at achieving safe research activities in Iran.

ASSESSMENT OF WHOLE BODY, SKIN AND EYE LENS DOSES OF THE INTERVENTIONAL RADIOLOGISTS AT SELECTED HOSPITALS IN IRAN.

High radiation doses to the body may lead to the stochastic/deterministic effects of ionizing radiation on the critical organs as well as causing the cataract in eye lens of the clinical staff in interventional radiology. In this study, the received doses of the eyes, skin and whole body of 38 clinical staff including physicians, residents, nurses and radiotechnologists in cardiac angiography departments in three selected hospitals were assessed using personal dosemeters during two bimonthly dosimetry periods. Moreover, the correlation coefficients among the measured dose components including eye lens dose, skin dose and whole body dose equivalent in both area of under and over their lead-apron were calculated for all these occupational groups. The results show that the occupational annual dose values of the clinical staff are below the annual dose limits recommended by International Commission on Radiation Protection. Furthermore, among the measured dose components, the highest correlation coefficient value was obtained between the eye lens dose and personal dose equivalent measured over the lead apron for all the occupational groups.

DOSIMETRIC ASPECTS OF OPTIMIZATION OF PROTECTION IN IRAN INDUSTRIAL RADIOGRAPHY PRACTICE.

According to the worldwide reports, industrial radiography is one of the highest risk radiation practices due to handling high activity sources. Therefore, an optimization of protection along with appropriate investigation level and/or dose constraint is required to achieve appropriate radiological safety. This research, presents some statistical aspects of this optimization using frequency distributions and percentiles of individual recorded dose of industrial radiographers from the years 2002 to 2016 in Iran. The results show that, considering an investigation level of 4 mSv for bimonthly monitoring periods, 3-7% of population of workers has been investigated during these years. Moreover, an overall reduction on average annual and collective doses is observed, despite of the relative increasing in the number of workers. Since the frequency of periodical recorded dose at lower dose range (e.g. <4 mSv) causes greater impacts on the reduction of collective dose than the higher ranges, a retrospective average dose of non-investigated workers can also be substitute with a constant value as a dose constraint. It can be concluded that all the past measures of regulatory body and attempts of the employers have been effective improving the radiological protection in this practice in Iran. However, establishing a dose constraint seems to be essential to continue and improve this optimization of protection.

A comprehensive dose assessment of irradiated hand by iridium-192 source in industrial radiography.

Among the various incidents in industrial radiography, inadvertent handling of sources by hands is one of the most frequent incidents in which some parts of the hands may be locally exposed to high doses. An accurate assessment of extremity dose assists medical doctors in selecting appropriate treatments, preventing the injury expansion in the region. In this study, a phantom was designed to simulate a fisted hand of a radiographer when the worker holds a radioactive source in their hands. The local doses were measured using implanted TLDs in the phantom at different distances from a source. Furthermore, skin dose distribution was measured by Gaf-chromic films in the palm region of the phantom. The reliability of the measurements has been studied via analytical as well as Monte-Carlo simulation methods. The results showed that the new phantom design can be used reliably in extremity dose assessments, particularly at the points next to the source.

Comparative Analysis of Neural Network Training Methods in Real-time Radiotherapy.

BACKGROUND: The motions of body and tumor in some regions such as chest during radiotherapy treatments are one of the major concerns protecting normal tissues against high doses. By using real-time radiotherapy technique, it is possible to increase the accuracy of delivered dose to the tumor region by means of tracing markers on the body of patients. OBJECTIVE: This study evaluates the accuracy of some artificial intelligence methods including neural network and those of combination with genetic algorithm as well as particle swarm optimization (PSO) estimating tumor positions in real-time radiotherapy. METHOD: One hundred recorded signals of three external markers were used as input data. The signals from 3 markers thorough 10 breathing cycles of a patient treated via a cyber-knife for a lung tumor were used as data input. Then, neural network method and its combination with genetic or PSO algorithms were applied determining the tumor locations using MATLAB© software program. RESULTS: The accuracies were obtained 0.8%, 12% and 14% in neural network, genetic and particle swarm optimization algorithms, respectively. CONCLUSION: The internal target volume (ITV) should be determined based on the applied neural network algorithm on training steps.

Type Testing of Model 7200 Automatic TLD Reader.

The type testing of measuring devices is one of the most important parts of a quality management system in a personal dosimetry services program. In this study, based upon the International Electrotechnical Commission (IEC) 62387 criteria, a reader-testing program was performed for a home-made personal thermoluminescent dosimetry (TLD) reader. The stability of the reader, the effects of light exposure, temperature and fluctuations of primary power supply on TLD read-outs as the main parameters were investigated in this program. Moreover, this study assesses some important criteria of dosimetry system including the non-linearity of response, reusability, after effect and overload that may include significant contribution in the performance of a reader. The results showed that the TLD reader met all requirements of the IEC for the reader tests by a large margin.

A root cause analysis of the high occupational doses of industrial radiographers in Iran.

The Iran Nuclear Regulatory Authority has investigated overexposure cases in industrial radiography over a period of three years. Radiographers with thermoluminescence dosimeter (TLD) records of more than 4 mSv in any 2 month routine monitoring period were asked to fill in a questionnaire explaining their points of view of the reasons for such relatively high doses. The responses showed that more than 50% of the radiographers did not agree with their recorded TLD doses, although the majority of the alternative explanations were weak. The main causes of overexposures were found to be difficult working conditions and ignoring safety principles while accidents or device failures were a minor contribution. Also, there was poor correlation between the TLDs and direct reading dosimeters worn by the radiographers, indicating that personal monitoring instructions were not being implemented appropriately.

Improvement of Accuracy in Environmental Dosimetry by TLD Cards Using Three-dimensional Calibration Method.

INTRODUCTION: The angular dependency of response for TLD cards may cause deviation from its true value on the results of environmental dosimetry, since TLDs may be exposed to radiation at different angles of incidence from the surrounding area. OBJECTIVE: A 3D setting of TLD cards has been calibrated isotropically in a standard radiation field to evaluate the improvement of the accuracy of measurement for environmental dosimetry. METHOD: Three personal TLD cards were rectangularly placed in a cylindrical holder, and calibrated using 1D and 3D calibration methods. Then, the dosimeter has been used simultaneously with a reference instrument in a real radiation field measuring the accumulated dose within a time interval. RESULT: The results show that the accuracy of measurement has been improved by 6.5% using 3D calibration factor in comparison with that of normal 1D calibration method. CONCLUSION: This system can be utilized in large scale environmental monitoring with a higher accuracy.

Public exposure due to external gamma background radiation in boundary areas of Iran.

A monitoring program in boundary areas of a country is an appropriate way to indicate the level of public exposure. In this research, gamma background radiation was measured using TL dosimeters at 12 boundary areas as well as in the capital city of Iran during the period 2010 to 2011. The measurements were carried out in semi-annual time intervals from January to June and July to December in each year. The maximum average dose equivalent value measured was approximately 70 µSv/month for Tehran city. Also, the average dose values obtained were less than 40 µSv/month for all the cities located at the sea level except that of high level natural radiation area of Ramsar, and more than 55 µSv/month for the higher elevation cities. The public exposure due to ambient gamma dose equivalent in Iran is within the levels reported by UNSCEAR.

Assessment of the radiological safety of a Genoray portable dental X-ray unit.

OBJECTIVES: The portable dental radiographic systems are generally used in emergency situations (e.g. during natural disasters) for disabled/aged patients and in patient rooms. This study assesses the output exposure of a portable dental radiographic system measured using thermoluminescent dosemeters (TLDs). METHODS: Occupational exposure of the operator was determined when the portable dental unit was used for mandibular and maxillary teeth exposure. RESULTS: The doses of some critical organs of an operator were measured using TLDs implanted within the Rando phantom. CONCLUSIONS: Considering the annual organ dose limits, the eye lens dose limit is the main factor determining the frequency of system application.

Study of runaway electrons using dosimetry of hard x-ray radiations in Damavand tokamak.

In this work several studies have been conducted on hard x-ray emissions of Damavand tokamak based on radiation dosimetry using the Thermoluminescence method. The goal was to understand interactions of runaway electrons with plasma particles, vessel wall, and plasma facing components. Total of 354 GR-200 (LiF:Mg,Cu,P) thermoluminescence dosimeter (TLD) crystals have been placed on 118 points--three TLDs per point--to map hard x-ray radiation doses on the exterior of the vacuum vessel. Results show two distinctive levels of x-ray radiations doses on the exterior of the vessel. The low-dose area on which measured dose is about 0.5 mSv/shot. In the low-dose area there is no particular component inside the vessel. On the contrary, on high-dose area of the vessel, x-ray radiations dose exceeds 30 mSv/shot. The high-dose area coincides with the position of limiters, magnetic probe ducts, and vacuum vessel intersections. Among the high-dose areas, the highest level of dose is measured in the position of the limiter, which could be due to its direct contact with the plasma column and with runaway electrons. Direct collisions of runaway electrons with the vessel wall and plasma facing components make a major contribution for production of hard x-ray photons in Damavand tokamak.

Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1.

Vitamin B12 (cobalamin) is a key determinant of S-adenosyl methionine (SAM)-dependent epigenomic cellular regulations related to methylation/acetylation and its deficiency produces neurodegenerative disorders by elusive mechanisms. Sirtuin 1 deacetylase (SIRT1) triggers cell response to nutritional stress through endoplasmic reticulum (ER) stress. Recently, we have established a N1E115 dopaminergic cell model by stable expression of a transcobalamin-oleosin chimera (TO), which impairs cellular availability of vitamin B12, decreases methionine synthase activity and SAM level, and reduces cell proliferation. In contrast, oleosin-transcobalamin chimera (OT) does not modify the phenotype of transfected cells. Presently, the impaired cellular availability of vitamin B12 in TO cells activated irreversible ER stress pathways, with increased P-eIF-2α, P-PERK, P-IRE1α, ATF6, ATF4, decreased chaperon proteins and increased pro-apoptotic markers, CHOP and cleaved caspase 3, through reduced SIRT1 expression and consequently greater acetylation of heat-shock factor protein 1 (HSF1). Adding either B12, SIRT1, or HSF1 activators as well as overexpressing SIRT1 or HSF1 dramatically reduced the activation of ER stress pathways in TO cells. Conversely, impairing SIRT1 and HSF1 by siRNA, expressing a dominant negative form of HSF1, or adding a SIRT1 inhibitor led to B12-dependent ER stress in OT cells. Addition of B12 abolished the activation of stress transducers and apoptosis, and increased the expression of protein chaperons in OT cells subjected to thapsigargin, a strong ER stress stimulator. AdoX, an inhibitor of methyltransferase activities, produced similar effects than decreased B12 availability on SIRT1 and ER stress by a mechanism related to increased expression of hypermethylated in cancer 1 (HIC1). Taken together, these data show that cellular vitamin B12 has a strong modulating influence on ER stress in N1E115 dopaminergic cells. The impaired cellular availability in vitamin B12 induces irreversible ER stress by greater acetylation of HSF1 through decreased SIRT1 expression, whereas adding vitamin B12 produces protective effects in cells subjected to ER stress stimulation.

A calibration setting with uncertainty measurements for passive/active radon monitors using flow-through source type.

Based upon the steady flow method, a setting has been introduced for fast calibration of almost all types of active and passive radon detectors. In this method, a traceable radon reference flow-through sources is connected to a portable rectangular cubic transparent chamber (volume of 50 L) which is completely sealed and has 6 valves on its sides. The initializing calibration times are less than 150 min by this chamber. The radon concentration in the chamber is in consistent with the source activity. The Best Measurement Capability (BMC) of the method has been calculated less than 5% at 68% confidence level. As well by using grab-sampling method, the difference of radon concentration of different points in the chamber was measured less than 1.2%. So the flow-through sources can be developed for a fast calibration of almost all types of the radon monitors with an acceptable uncertainty using this calibration setting.

Comparative Measurements of Radon Concentration in Soil Using Passive and Active Methods in High Level Natural Radiation Area (HLNRA) of Ramsar.

BACKGROUND: Radon and its daughters are amongst the most important sources of natural exposure in the world. Soil is one of the significant sources of radon/thoron due to both radium and thorium so that the emanated thoron from it may cause increased uncertainties in radon measurements. Recently, a diffusion chamber has been designed and optimized for passive discriminative measurements of radon/thoron concentrations in soil. OBJECTIVE: In order to evaluate the capability of the passive method, some comparative measurements (with active methods) have been performed. METHOD: The method is based upon measurements by a diffusion chamber, including two Lexan polycarbonate SSNTDs, which can discriminate the emanated radon/thorn from the soil by delay method. The comparative measurements have been done in ten selected points of HLNRA of Ramsar in Iran. The linear regression and correlation between the results of two methods have been studied. RESULTS: The results show that the radon concentrations are within the range of 12.1 to 165 kBq/m(3) values. The correlation between the results of active and passive methods was measured by 0.99 value. As well, the thoron concentrations have been measured between 1.9 to 29.5 kBq/m(3) values at the points. CONCLUSION: The sensitivity as well as the strong correlation with active measurements shows that the new low-cost passive method is appropriate for accurate seasonal measurements of radon and thoron concentration in soil.

Homocysteine predicts increased NT-pro-BNP through impaired fatty acid oxidation.

BACKGROUND: The deficiency in methyl donors, folate and vitamin B12, increases homocysteine and produces myocardium hypertrophy with impaired mitochondrial fatty acid oxidation and increased BNP, through hypomethylation of peroxisome-proliferator-activated-receptor gamma co-activator-1α, in rat. This may help to understand better the elusive link previously reported between hyperhomocysteinemia and BNP, in human. We investigated therefore the influence of methyl donors on heart mitochondrial fatty acid oxidation and brain natriuretic peptide, in two contrasted populations. METHODS: Biomarkers of heart disease, of one carbon metabolism and of mitochondrial fatty acid oxidation were assessed in 1020 subjects, including patients undergoing coronarography and ambulatory elderly subjects from OASI cohort. RESULTS: Folate deficit was more frequent in the coronarography population than in the elderly ambulatory volunteers and produced a higher concentration of homocysteine (19.3 ± 6.8 vs. 15.3 ± 5.6, P<0.001). Subjects with homocysteine in the upper quartile (≥ 18 µmol/L) had higher concentrations of NT-pro-BNP (or BNP in ambulatory subjects) and of short chain-, medium chain-, and long chain-acylcarnitines, compared to those in the lower quartile (≤ 12 µmol/L), in both populations (P<0.001). Homocysteine and NT-pro-BNP were positively correlated with short chain-, medium chain-, long chain-acylcarnitines and with acylcarnitine ratios indicative of decreased mitochondrial acyldehydrogenase activities (P<0.001). In multivariate analysis, homocysteine and long chain acylcarnitines were two interacting determinants of NT-pro-BNP, in addition to left ventricular ejection fraction, body mass index, creatinine and folate. CONCLUSIONS: This study showed that homocysteine predicts increased NT-pro-BNP (or BNP) through a link with impaired mitochondrial fatty oxidation, in two contrasted populations.

An investigation of gamma background radiation in Hamadan province, Iran.

The general population, everywhere in the world is exposed to a small dose of ionising radiation from natural sources. Stochastic effects such as cancer and genetic disorders are caused when living creatures are exposed to low doses. In Iran, it is measured in some cities, especially in high-background areas such as Ramsar, but so far there is no measurement in the Hamadan province. Hamadan is located in the west of Iran. Measurements were performed using a RDS-110 survey meter, CaSO(4):Dy thermoluminecense dosimetries (TLDs) and a Harshaw 4000 TLD reader. To estimate the dose rate  outdoors, four stations along the main directions (north, south, west and east) and one in the town centre were selected. Mean annual X and gamma equivalent dose in Hamadan province are 1.12±0.22  and 1.66±0.07 mSv, which related to RDS-110 survey meter and TLDs measurements, respectively. The TLDs and RDS-110 results are representative of the external photon radiation doses for the selected monitoring locations and for those locations for the hours during which the measurements were taken, respectively. Maximum and minimum of external photon radiation doses are related to Hamadan and Kaboudar-Ahang towns, respectively. According to the results of the study, it seems that the annual X and gamma equivalent dose in Hamadan province exceeded the global mean external exposure amounts by the UNSCEAR, and further studies are needed to measure internal exposures to determine the total environmental radiation level in  Hamadan province.

Doses to the scanned individual and to the operator from an X-ray body scanner system.

The X-ray body scanner (BS) is going to find common use as a body-checking equipment at the entrance borders of countries, to find illicit drugs or forbidden items which have been hidden inside the body cavities, or attached to the body parts of the passengers. Considering the tissue weighting factors of the sensitive organs, the total effective dose due to the scanning by the system was estimated to be 3.8 µSv per scan. The ambient dose equivalent rates within the distance range of 300-40 cm from the X-ray generator were measured to be 4.5 up to 50 µSv h(-1). It is concluded that, in general, BS systems could be a safe device for the operators and people who are being scanned. But using such systems should be justified for everybody and special care should be taken for children and pregnant ladies.

Occupational dose assessment and National Dose Registry System in Iran.

This report presents status of external and internal dose assessment of workers and introducing the structure of National Dose Registry System of Iran (NDRSI). As well as types of individual dosemeters in use, techniques for internal dose assessment are presented. Results obtained from the International Atomic Energy Agency intercomparison programme on measurement of personal dose equivalent H(p) (10) and consistency of the measured doses with the delivered doses are shown. Also, implementation of dosimetry standards, establishment of quality management system, authorisation and approval procedure of dosimetry service providers are discussed.

Privatization within the Dutch context: a comparison of the health insurance systems of the Netherlands and the United States.

In 2006, the Netherlands passed the Health Insurance Act requiring all legal residents to obtain health insurance from private insurance companies. The reform created a national health insurance system guaranteed to all citizens regardless of income or labor force status and introduced a market orientation that makes private insurance companies the sole providers of health insurance. How does the new policy compare to the US model of private health insurance provision? Is this reform evidence of a shift toward the American model? We use a comparative case study method to distinguish the new Dutch system from the private insurance system in the United States. We find that although the Dutch system includes market solutions similar to the US model, it still provides a universal guarantee of coverage to all of its citizens and should be viewed as 'privatization' within the Dutch context rather than a cooptation of American health policy.

A method for calculation of radiation quantities at all points in gamma radiation calibration fields.

Radiation quantity values at all points of a known distance range of gamma radiation calibration fields were calculated using a mathematical method. The method is based on interpolation using Chi-square test on a set of experimental data at optional points of both collimated and un-collimated calibration set-ups by means of a reference instrument. In comparison with Monte Carlo calculations, the values that were calculated by this method differ by <1% for collimated and 2% for un-collimated calibration set-ups. Consequently, the radiation quantities at all points of gamma radiation calibration field set-ups can accurately be formulated and determined by this method. In addition, all points in the radiation fields can be regarded as test points.