Identification of the Identical Human Mutation in ACVR1 in 2 Cats With Fibrodysplasia Ossificans Progressiva.

Two domestic shorthair cats, 1 intact female and 1 intact male, presented with progressive limb lameness and digital deformities at 4 and 6 months of age. Stiffness and swelling of the distal thoracic and pelvic limb joints progressed to involve hip and shoulder joints, resulting in reduced mobility. Radiographs in both cats and computed tomography of the male cat revealed ankylosing, polyarticular deposits of extracortical heterotopic bone spanning multiple axial and appendicular joints, extending into adjacent musculotendinous tissues. All findings supported fibrodysplasia ossificans progressiva (FOP), a disorder characterized by toe malformations and progressive heterotopic ossification in humans. In both cats, molecular analyses revealed the same heterozygous mutation in the activin A receptor type I (ACVR1) gene that occurs in humans with FOP. Several reports of heterotopic ossification in cats exist, but this is the first one to identify clinical FOP in 2 cats with the identical mutation that occurs in >95% of humans with FOP.

Use of cystoscopic-guided laser ablation for treatment of intramural ureteral ectopia in male dogs: four cases (2006-2007).

OBJECTIVE: To describe and evaluate the outcome of cystoscopic-guided laser ablation of intramural ureteral ectopia in male dogs. DESIGN: Retrospective case series. ANIMALS: 4 incontinent male dogs with intramural ureteral ectopia. PROCEDURES: Intramural ectopic ureters were diagnosed via preoperative computed tomography-IV urography and subsequent cystoscopy. Transurethral cystoscopic-guided laser ablation (diode laser [n = 3 dogs] and holmium:yttrium aluminum garnet laser [1]) was performed to proximally relocate the ectopic ureteral orifice to the urinary bladder. Fluoroscopy was used during the procedures to confirm that the ureteral tract was intramural and the ureteral orifice was intravesicular after the procedure. In 1 dog with bilateral ureteral ectopia, staged laser ablation was performed at 6-week intervals because of difficulty viewing the second ureter on the first attempt. All ureteral orifices were initially located in the middle to proximal portion of the prostatic portion of the urethra. Six weeks after surgery, imaging was repeated in 3 of 4 dogs. RESULTS: Postoperative dysuria or hematuria did not develop. All dogs were immediately continent after laser treatment and remained so at a median follow-up period of 18 months (range, 15 to 20 months) without medical management. CONCLUSIONS AND CLINICAL RELEVANCE: Ureteral ectopia can cause urinary incontinence in male dogs and is usually associated with other urinary tract abnormalities. Cystoscopic-guided laser ablation provided an effective and minimally invasive alternative to surgical management of intramural ureteral ectopia.

Thick-section reformatting of thinly collimated computed tomography for reduction of skull-base-related artifacts in dogs and horses.

Computed tomography (CT) of the caudal fossa of 10 canine and nine equine cadaver heads was performed with conventional slice widths of 5 and 10 mm, respectively, and with thin collimations of 1 and 2 mm, respectively. Reformatting of thinly collimated slices was done by addition of thinly collimated slices to section thicknesses of 5 and 10 mm, respectively. Seventy-six pairs of conventional and reformatted images of identical anatomic locations were evaluated for magnitude of skull-base-related artifacts and image noise. A film-based subjective evaluation of artifact and noise was performed by four radiologists on a five-point score system. There was a statistically significant reduction of artifacts of canine and equine heads by 33% and 50%, respectively, on reformatted images compared with conventional ones but no difference in image noise. On objective artifact assessment based on the magnitude of standard deviation of attenuation values in the interpetrosal region, there was a statistically significant reduction of artifacts of canine and equine heads by 23% and 39%, respectively, on reformatted images. Thick-section reformatting significantly improves image quality of CT scans of the caudal fossa in dogs and horses.