ABSTRACT
OBJETIVO: Classificar os resultados de punções aspirativas prévias de tireoide de acordo com o sistema de Bethesda e verificar sua distribuição frente à nova classificação. MATERIAL E MÉTODOS: Foi realizado um estudo retrospectivo usando laudos citopatológicos de pacientes portadores de nódulos tireoidianos, cujas PAAF foram analisadas no Centro de Patologia de Curitiba Hospital Nossa Senhora das Graças, Curitiba - PR, no período de janeiro 2009 a dezembro de 2010. A amostra analisada constitui-se de 1833 laudos. RESULTADOS: Foram recatalogados 1833 laudos citopatológicos de PAAF de 1476 pacientes, sendo 572 (31%) laudos do ano de 2009 e 1262 (69%) do ano de 2010. Baseado nos 1833 resultados de PAAF analisados, encontrou-se 14,73% de nódulos tireoidianos classificados como insatisfatório, 70,64% como benignos, 7,04% como atipias de significado indeterminado ou lesões foliculares de significado indeterminado, 2,13% como neoplasia folicular ou suspeito de neoplasia folicular, 1,2% suspeito para malignidade e 4,26% malignos. CONCLUSÃO: A reclassificação dos laudos citopatológicos de PAAF de tireoide para a nomenclatura de Bethesda esteve dentro de índices recomendados, auxiliando no monitoramento de boas práticas e controle de qualidade na emissão dos resultados de PAAF de tireoide
AIM: To classify the results of thyroid punctures previous aspiration according to the Bethesda system and verify their distribution across the new classification. MATERIALS AND METHODS : We conducted a retrospective study using cytological reports of patients with thyroid nodules whose FNA were analyzed in Curitiba Pathology Center - Hospital Nossa Senhora das Graças , Curitiba - PR, from January 2009 to December 2010. The sample consisted of 1833 reports . RESULTS: 1833 reports recataloged FNA of cytopathology of 1476 patients, 572 (31%) reports of 2009 and 1262 (69%) in the year 2010. Based on 1833 results of FNA analyzed, we found 14,73%% of thyroid nodules classified as Unsatisfactory, 70,64% as benign, 7,04% as atypia of undetermined significance or follicular lesions of undetermined significance, and 2,13% follicular neoplasm or suspicious for follicular neoplasm, suspicious for malignancy 1,2% and 4,26% malignant. CONCLUSION: The reclassification of cytopathology reports from thyroid FNA for the nomenclature of Bethesda was within recommended levels, assisting in the monitoring of good practices and quality control in issuing the results of thyroid FNA
ABSTRACT
PURPOSE:: To investigate whether there is a difference between Marlex(r) and Dynamesh PP-light Marlex(r) meshes, in the abdominal wall defect correction, on rats in contaminated surgical site. METHODS:: Twenty-eight Wistar rats were divided into two groups of 14, and four subgroups of seven animals. All subgroups underwent similar surgical procedure. One group received the mesh Marlex(r) and the other Dynamesh PP-light(r) for correction of the defect. Before implanting, the meshes went through a contamination process, on which was used standard solution containing 10 UFC of Escherichia coli. Fragments of the animal's abdominal wall received macroscopic, microscopic and microbiological analysis. RESULTS:: There was no statistical significance in the analysis of macroscopic variables. Accentuated inflammatory process was shown in all subgroups. The foreign body type reaction was mild in all subgroups, except Dynamesh(r)-14, which was moderate with no statistical significance. The microbiological analysis of the meshes was also similar between the subgroups. CONCLUSION:: There was no difference between the meshes of Marlex(r) and Dynamesh PP-light(r) in the ventral abdominal wall defect correction on rats in contaminated surgical site.
Subject(s)
Hernia, Ventral/microbiology , Hernia, Ventral/surgery , Herniorrhaphy/methods , Polypropylenes/therapeutic use , Surgical Mesh/microbiology , Animals , Biocompatible Materials , Escherichia coli/growth & development , Hernia, Ventral/pathology , Intraabdominal Infections/microbiology , Intraabdominal Infections/pathology , Male , Materials Testing , Necrosis , Random Allocation , Rats, Wistar , Reproducibility of Results , Severity of Illness Index , Surgical Wound Dehiscence , Time FactorsABSTRACT
ABSTRACT PURPOSE: To investigate whether there is a difference between Marlex(r) and Dynamesh PP-light Marlex(r) meshes, in the abdominal wall defect correction, on rats in contaminated surgical site. METHODS: Twenty-eight Wistar rats were divided into two groups of 14, and four subgroups of seven animals. All subgroups underwent similar surgical procedure. One group received the mesh Marlex(r) and the other Dynamesh PP-light(r) for correction of the defect. Before implanting, the meshes went through a contamination process, on which was used standard solution containing 10 UFC of Escherichia coli. Fragments of the animal's abdominal wall received macroscopic, microscopic and microbiological analysis. RESULTS: There was no statistical significance in the analysis of macroscopic variables. Accentuated inflammatory process was shown in all subgroups. The foreign body type reaction was mild in all subgroups, except Dynamesh(r)-14, which was moderate with no statistical significance. The microbiological analysis of the meshes was also similar between the subgroups. CONCLUSION: There was no difference between the meshes of Marlex(r) and Dynamesh PP-light(r) in the ventral abdominal wall defect correction on rats in contaminated surgical site.
Subject(s)
Animals , Male , Polypropylenes/therapeutic use , Surgical Mesh/microbiology , Herniorrhaphy/methods , Hernia, Ventral/surgery , Hernia, Ventral/microbiology , Surgical Wound Dehiscence , Time Factors , Biocompatible Materials , Severity of Illness Index , Materials Testing , Random Allocation , Reproducibility of Results , Rats, Wistar , Escherichia coli/growth & development , Intraabdominal Infections/microbiology , Intraabdominal Infections/pathology , Hernia, Ventral/pathology , NecrosisABSTRACT
Objetivo: Avaliar as internações e traçar o perfil epidemiológico das queimaduras em crianças internadas no Hospital Universitário Evangélico de Curitiba. Método: Realizado estudo quantitativo, retrospectivo e transversal por meio da análise de prontuários de 666 crianças que deram entrada e foram atendidas no Departamento de Queimados do Hospital Universitário Evangélico de Curitiba, entre julho de 2013 e junho de 2014. Foram incluídos registros de crianças com menos de 5 anos queimadas. Não foram incluídos registros de crianças cujos prontuários não estavam preenchidos completamente e/ou corretamente. Foram analisados indicadores do total de internações, sexo e idade dos pacientes, número de regiões anatômicas lesionadas e a etiologia das queimaduras. Resultados: 59% dos pacientes eram do sexo masculino e 41% do feminino, com idade média de 1 ano e 6 meses. A taxa de internação geral foi de 15%, sendo que crianças com 3 e 4 anos estiveram mais suscetíveis a serem internadas. Os casos ocorridos devido a fogo/brasa/inflamáveis foram frequentes entre as crianças que precisaram ser internadas (33% dos acometidos por esta etiologia foram hospitalizados). Contudo, a escaldadura foi a etiologia que mais gerou internações no serviço, sendo 72 casos das 97 internações. Conclusão: A necessidade ou não de internamento esteve relacionada ao número de regiões lesadas e com a sua etiologia. Obteve-se como perfil epidemiológico mais prevalente de um paciente internado o de menino de 1 ano, com lesão sofrida por escaldadura em duas regiões do corpo.
Objectives: To evaluate the hospitalization and to define the epidemiological profile of burns among hospitalized children at Hospital Universitário Evangélico de Curitiba. Methods: It was performed a quantitative, retrospective and transversal research by analyzing the records of 666 children admitted to the Burns Department of the Hospital Universitário Evangélico de Curitiba from July 2013 to June 2014. Records of burned children who were younger than 5 years old were included in the study. Records of children who had their hospital data filled up wrongly and/or incompletely were not included in this study. The researchers analyzed the number of internments, childrens gender and age, the number of body regions stricken by the lesions and the burn causal agent. Results: 59% of the patients were male and 41% were female. The average age was one year and six months old. The hospitalization rate was 15%, with three and four-year-old children being more susceptible to be hospitalized. Burns caused due to fire/coal/inflammables were frequent among children who needed to be hospitalized (33% of the kids injured by this etiology were hospitalized). However, scalds were the cause that generated more internments (72 out of 97 total hospitalizations). Conclusion: The necessity or not of internment depended on the regions injured and the etiology of the burns. The most prevalent epidemiological profile of a burned kid was one-year-old boy injured by scald in two anatomical surfaces.
Objetivos: Evaluar las hospitalizaciones de pacientes y definir el perfil epidemiológico de quemaduras en niños internados en el Hospital Universitário Evangélico de Curitiba. Método: Se realizó estudio cuantitativo, retrospectivo y transversal mediante el análisis de historias clínicas de 666 niños asistidos en el Servicio de Quemaduras del Hospital Universitário Evangélico de Curitiba, entre julio de 2013 y junio de 2014. Se incluyó registros de niños menores de 5 años quemados. No se incluyó registros de niños que sus archivos médicos no estaban llenados completamente y/o correctamente. Fueron analisados indicadores del total de ingresos, sexo y edad de los pacientes, número de regiones anatómicas quemadas y la etiologia de la quemadura. Resultados: 59% de los pacientes eran hombres y 41% mujeres, mientras que la edad media fue de 1 año y 6 meses. La tasa de hospitalización fue de 15%. Los niños de 3 y 4 años estuvieran más susceptibles a la hospitalización. Las quemaduras por fuego/agua/liquidos inflamables fueron frecuentes entre niños que necesitaran hospitalización (33% de los acometidos por esta etiología fueran hospitalizados). Sin embargo, la escaldadura fue la etiología que más generó ingresos (72 de las 97 hospitalizaciones totales). Conclusión: La necesidad de internamiento se relacionó al número de regiones anatómicas quemadas y su etiología. En este estudio, el perfil epidemiológico más prevalente de un paciente hospitalizado fue de un niño a la edad de 1 año que sufrió lesión por escaldadura en dos sitios de su cuerpo
Subject(s)
Humans , Child , Health Profile , Burns/epidemiology , Hospitalization , Cross-Sectional Studies , Retrospective StudiesABSTRACT
BACKGROUND: Studies with latest technologies such as endoscopy with magnification and chromoendoscopy showed that various endoscopic aspects are clearly related to infection by Helicobacter pylori (HP). The description of different patterns of erythema in gastric body under magnification of images revived interest in identifying these patterns by standard endoscopy. AIM: To validate the morphologic features of gastric mucosa related to H. pylori infection gastritis allowing predictability of their diagnosis as well as proper targeting biopsies. METHODS: Prospective study of 339 consecutive patients with the standard videoendoscope image analysis were obtained, recorded and stored in a program database. These images were studied with respect to the presence or absence of H. pylori, diagnosed by rapid urease test and/or by histological analysis. Were studied: a) normal mucosa appearance; b) mucosal nodularity; c) diffuse nonspecific erythema or redness (with or without edema of folds and exudate) of antrum and body; d) mosaic pattern with focal area of hyperemia; e) erythema in streaks or bands (red streak); f) elevated (raised) erosion; g) flat erosions; h) fundic gland polyps. The main exclusion criteria were the use of drugs, HP pre-treatment and other entities that could affect results. RESULTS: Applying the exclusion criteria, were included 170 of the 339 patients, of which 52 (30.58%) were positive for HP and 118 negative. On the positive findings, the most associated with infection were: nodularity in the antrum (26.92%); presence of raised erosion (15.38%) and mosaic mucosa in the body (21.15%). On the negative group the normal appearance of the mucosa was 66.94%; erythema in streaks or bands in 9.32%; flat erosions 11.86%; and fundic gland polyps 11.86%. CONCLUSION: Endoscopic findings are useful in the predictability of the result and in directing biopsies. The most representative form of HP related gastritis was the nodularity of the antral mucosa. The raised erosion and mucosa in mosaic in the body are suggestive but not specific to the infection. The other forms were not conclusive of the presence of HP.
RACIONAL: Estudos com tecnologias mais recentes como endoscopia com magnificação e cromoscopia mostraram que vários aspectos endoscópicos estão claramente associados à infecção por Helicobacter pylori. A descrição de padrões diferenciados de enantema no corpo gástrico através da magnificação de imagens reavivou o interesse na identificação desses padrões pela endoscopia convencional. OBJETIVO: Validar os padrões morfológicos de mucosa gástrica usando videogastroendoscopia convencional relacionados à gastrite por infecção por Helicobacter pylori, permitindo previsibilidade do seu diagnóstico e o direcionamento de biópsias. MÉTODOS: Estudo prospectivo de 339 pacientes consecutivos com análise das imagens de videogastroendoscopia obtidas, gravadas e armazenadas em banco de dados. Estas imagens foram estudadas com relação à presença ou não do Helicobacter pylori diagnosticado por teste rápido de urease e/ou por pesquisa direta por estudo anatomopatológico. Foram estudados: a) aspecto normal da mucosa; b) nodularidade da mucosa; c) enantema inespecífico difuso de antro e corpo; d) enantema em mosaico ou salpicado; e) enantema em estrias ou faixas; f) erosões elevadas; g) erosões planas; h) pólipos de glândulas fúndicas. Os principais critérios de exclusão foram o uso de medicamentos, tratamento prévio de HP e outras entidades que pudessem interferir nos resultados. RESULTADOS: Aplicando os critérios de exclusão, incluíram-se 170 dos 339 pacientes sendo 52 (30,58%) positivos para Helicobacter pylori e 118 negativos. No grupo positivo os achados que mais se associaram com a infecção foram: nodularidade no antro (26,92%); presença de erosões elevadas (15,38%) e mucosa em mosaico no corpo (21,15%). No grupo negativo o aspecto normal da mucosa foi de 66,94%; enantema em estrias ou faixas em 9,32%; erosões planas em 11,86%; e pólipos de glândulas fúndicas 11,86%. CONCLUSÃO: Achados endoscópicos são úteis na previsibilidade de localização e direcionamento de biópsias na pesquisa do HP. A mais representativa forma de gastrite por HP foi o achado de nodularidade na mucosa antral. As erosões elevadas e mucosa em mosaico no corpo são sugestivas, mas não específicas da infecção. As demais formas não foram conclusivas da presença do HP.
Subject(s)
Gastritis/microbiology , Gastritis/pathology , Gastroscopy , Helicobacter Infections/diagnosis , Helicobacter pylori , Adolescent , Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Prospective Studies , Video Recording , Young AdultABSTRACT
Descreve-se um caso de lúpus eritematoso sistêmico (LES) complicado com vasculite de SNC. Na investigação desta última encontraram-se aneurismas de carótida comum e interna bilateralmente - os quais foram tratados cirurgicamente após imunossupressão.
A case of systemic lupus erythematosus (SLE) complicated by CNS vasculitis is described. In the investigation of the latter we found common and internal carotid aneurysms bilaterally - which were treated surgically after immunosuppression.
ABSTRACT
ABSTRACT Background: Studies with latest technologies such as endoscopy with magnification and chromoendoscopy showed that various endoscopic aspects are clearly related to infection by Helicobacter pylori (HP). The description of different patterns of erythema in gastric body under magnification of images revived interest in identifying these patterns by standard endoscopy. Aim: To validate the morphologic features of gastric mucosa related to H. pylori infection gastritis allowing predictability of their diagnosis as well as proper targeting biopsies. Methods: Prospective study of 339 consecutive patients with the standard videoendoscope image analysis were obtained, recorded and stored in a program database. These images were studied with respect to the presence or absence of H. pylori, diagnosed by rapid urease test and/or by histological analysis. Were studied: a) normal mucosa appearance; b) mucosal nodularity; c) diffuse nonspecific erythema or redness (with or without edema of folds and exudate) of antrum and body; d) mosaic pattern with focal area of hyperemia; e) erythema in streaks or bands (red streak); f) elevated (raised) erosion; g) flat erosions; h) fundic gland polyps. The main exclusion criteria were the use of drugs, HP pre-treatment and other entities that could affect results. Results: Applying the exclusion criteria, were included 170 of the 339 patients, of which 52 (30.58%) were positive for HP and 118 negative. On the positive findings, the most associated with infection were: nodularity in the antrum (26.92%); presence of raised erosion (15.38%) and mosaic mucosa in the body (21.15%). On the negative group the normal appearance of the mucosa was 66.94%; erythema in streaks or bands in 9.32%; flat erosions 11.86%; and fundic gland polyps 11.86%. Conclusion: Endoscopic findings are useful in the predictability of the result and in directing biopsies. The most representative form of HP related gastritis was the nodularity of the antral mucosa. The raised erosion and mucosa in mosaic in the body are suggestive but not specific to the infection. The other forms were not conclusive of the presence of HP.
RESUMO Racional: Estudos com tecnologias mais recentes como endoscopia com magnificação e cromoscopia mostraram que vários aspectos endoscópicos estão claramente associados à infecção por Helicobacter pylori. A descrição de padrões diferenciados de enantema no corpo gástrico através da magnificação de imagens reavivou o interesse na identificação desses padrões pela endoscopia convencional. Objetivo: Validar os padrões morfológicos de mucosa gástrica usando videogastroendoscopia convencional relacionados à gastrite por infecção por Helicobacter pylori, permitindo previsibilidade do seu diagnóstico e o direcionamento de biópsias. Métodos: Estudo prospectivo de 339 pacientes consecutivos com análise das imagens de videogastroendoscopia obtidas, gravadas e armazenadas em banco de dados. Estas imagens foram estudadas com relação à presença ou não do Helicobacter pylori diagnosticado por teste rápido de urease e/ou por pesquisa direta por estudo anatomopatológico. Foram estudados: a) aspecto normal da mucosa; b) nodularidade da mucosa; c) enantema inespecífico difuso de antro e corpo; d) enantema em mosaico ou salpicado; e) enantema em estrias ou faixas; f) erosões elevadas; g) erosões planas; h) pólipos de glândulas fúndicas. Os principais critérios de exclusão foram o uso de medicamentos, tratamento prévio de HP e outras entidades que pudessem interferir nos resultados. Resultados: Aplicando os critérios de exclusão, incluíram-se 170 dos 339 pacientes sendo 52 (30,58%) positivos para Helicobacter pylori e 118 negativos. No grupo positivo os achados que mais se associaram com a infecção foram: nodularidade no antro (26,92%); presença de erosões elevadas (15,38%) e mucosa em mosaico no corpo (21,15%). No grupo negativo o aspecto normal da mucosa foi de 66,94%; enantema em estrias ou faixas em 9,32%; erosões planas em 11,86%; e pólipos de glândulas fúndicas 11,86%. Conclusão: Achados endoscópicos são úteis na previsibilidade de localização e direcionamento de biópsias na pesquisa do HP. A mais representativa forma de gastrite por HP foi o achado de nodularidade na mucosa antral. As erosões elevadas e mucosa em mosaico no corpo são sugestivas, mas não específicas da infecção. As demais formas não foram conclusivas da presença do HP.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Helicobacter pylori , Helicobacter Infections/diagnosis , Gastroscopy , Gastritis/microbiology , Gastritis/pathology , Video Recording , Cross-Sectional Studies , Prospective StudiesABSTRACT
OBJETIVO: Classificar os resultados de punções aspirativas prévias de tireóide de acordo com o sistema de Bethesda e verificar sua distribuição frente à nova classificação. MATERIAL E MÉTODOS: Foi realizado um estudo retrospectivo usando laudos citopatológicos de pacientes portadores de nódulos tireoidianos, cujas PAAF foram analisadas no Centro de Patologia de Curitiba Hospital Nossa Senhora das Graças, Curitiba - PR, no período de janeiro 2009 a dezembro de 2010. A amostra analisada constitui-se de 1833 laudos. RESULTADOS: Foram recatalogados 1833 laudos citopatológicos de PAAF de 1476 pacientes, sendo 572 (31%) laudos do ano de 2009 e 1262 (69%) do ano de 2010. Baseado nos 1833 resultados de PAAF analisados, encontrou-se 14,73% de nódulos tireoidianos classificados como Insatisfatório, 70,64% como benignos, 7,04% como atipias de significado indeterminado ou lesões foliculares de significado indeterminado, 2,13% como neoplasia folicular ou suspeito de neoplasia folicular, 1,2% suspeito para malignidade e 4,26% malignos. CONCLUSÃO: A reclassificação dos laudos citopatológicos de PAAF de tireóide para a nomenclatura de Bethesda esteve dentro de índices recomendados, auxiliando no monitoramento de boas práticas e controle de qualidade na emissão dos resultados de PAAF de tireóide
AIM: To classify the results of thyroid punctures previous aspiration according to the Bethesda system and verify their distribution across the new classification. MATERIALS AND METHODS : We conducted a retrospective study using cytological reports of patients with thyroid nodules whose FNA were analyzed in Curitiba Pathology Center - Hospital Nossa Senhora das Graças , Curitiba - PR, from January 2009 to December 2010. The sample consisted of 1833 reports . RESULTS: 1833 reports recataloged FNA of cytopathology of 1476 patients, 572 (31%) reports of 2009 and 1262 (69%) in the year 2010. Based on 1833 results of FNA analyzed, we found 14,73%% of thyroid nodules classified as Unsatisfactory, 70,64% as benign, 7,04% as atypia of undetermined significance or follicular lesions of undetermined significance, and 2,13% follicular neoplasm or suspicious for follicular neoplasm, suspicious for malignancy 1,2% and 4,26% malignant. CONCLUSION: The reclassification of cytopathology reports from thyroid FNA for the nomenclature of Bethesda was within recommended levels, assisting in the monitoring of good practices and quality control in issuing the results of thyroid FNA
ABSTRACT
Estabelecer a relação entre a etiologia das queimaduras com a idade dos pacientes e traçar o perfil epidemiológico das queimaduras na população estudada. Métodos: Foi realizado um estudo quantitativo, retrospectivo e transversal pela análise de prontuários de 666 crianças que deram entrada e foram atendidas no setor de Queimados do Hospital Universitário Evangélico de Curitiba, PR, entre julho de 2013 e junho de 2014. Os critérios de inclusão foram crianças menores de 5 anos vítimas de queimaduras; já os de exclusão foram crianças cujos prontuários não estavam preenchidos completamente e/ou corretamente. Foram analisados indicadores sobre o total de internações, sexo, idade, os locais acometidos pelas queimaduras, a porcentagem da superfície corporal queimada e o agente causador. Resultados: Cinquenta e nove por cento dos pacientes eram do sexo masculino e 41% do feminino, com idade média de 1 ano e 6 meses. A taxa de internação foi de 15%. A faixa etária mais prevalente foi a de 1 ano de idade, com 300 crianças. Quanto ao agente etiológico, a escaldadura foi o mais frequente, sendo responsável por 56,1% dos casos. Conclusão: A escaldadura foi a causa mais frequente de queimaduras na faixa etária estudada. O perfil epidemiológico neste estudo foi o de um menino, com idade de 1 ano, apresentando queimadura na(s) mão(s), tendo sofrido lesão por escaldadura e que não necessita de internamento...
The objectives were to establish the relationship between the burns etiology and the patients age and define the epidemiological burns profile among the studied population. Methods: It was performed a quantitative, retrospective and transversal research by the analysis of 666 childrens records. Those patients were admitted to the Burns Department of the Hospital Universitário Evangélico of Curitiba from July 2013 to June 2014. The inclusion criteria were children under five year old victims of burns; as well, the exclusion criteria involved records that were not filled out completely or correctly. The researchers analysed the number of internments, childrens gender and age, the body region strickened by the lesions and the burn causal agent. Results: Fifty nine percent of the patients were male and 41% were female. The average age was one year and six months. The internment rate was 15%. The age most affected was one year, represented by 300 patients. The main etiological agent was the scald being responsible for 56.1% of the occurrences. Conclusion: The scald was the most frequent agent of the burns at the studied age. The epidemiological profile in this research was a one year-old boy that suffered a scald burn in his hand or hands that did not result in an internment...
Establecer la relación entre la etiología de las quemaduras a la edad de los pacientes y definir el perfil epidemiológico de las quemaduras en esta población. Metodo: Se realizó un estudio cuantitativo, retrospectivo y transversal mediante el análisis de las historias clínicas de 666 niños que fueron asisitidos en el Servicio de Quemaduras del Hospital Universitário Evangélico de Curitiba entre julio de 2013 y junio de 2014. Los criterios de inclusión fueron niños menores de cinco años víctimas de quemaduras, ya que la exclusión eran niños que sus registros no fueron llenados complectamete o correctamente. Se analizaron los ingresos totales, el sexo, la edad, los sitios afectados por quemaduras y el agente causante. Resultados: Cincuenta y nueve por ciento de los pacientes eran hombres y 41% mujeres, mientras que la edad media fue de 1 año y 6 meses. La tasa de hospitalización fue de 15%. La edad más frecuente fue de 1 año (300 niños). Como el agente etiologico, la escaldadura fue el más frecuente con 56,1% de los casos. Conclusión: La escaldadura fue la causa más frecuente de las quemaduras en el grupo de edad estudiado. Como se encuentra en este estudio, el perfil epidemiológico de niño a la edad de un año que sufrió lesión por escaldadura en la(s) mano(s) y no requiere hospitalización...
Subject(s)
Humans , Male , Female , Child , Burns/epidemiologyABSTRACT
É relatado um caso de escolar com abscesso de espaço perigoso de pescoço, provavelmente oriundo de uma sinusite inicial, com complicação posterior à mediastinite. Através de drenagem cirúrgica e antibioticoterapia de amplo espectro instituídas precocemente, evitou-se um desfecho fatal, apesar do índice de mortalidade nesses casos chegar até 50% dos casos em alguns serviços.
It is reported a case with school abscess neck dangerous space, probably originating from an initial sinusitis with subsequent complication to mediastinitis. By surgical drainage and antibiotics broad spectrum started early, avoided a fatal outcome, although the mortality rate in these cases reach 50% of cases in some services.
ABSTRACT
É apresentado relato de caso de uma pré-escolar grande queimada encaminhada a um serviço hospitalar de referência, a qual evoluiu com óbito devido à sepse subsequente à infecção de cateter, a despeito da utilização de terapia antimicrobiana guiada por antibiograma. O objetivo desse estudo é alertar a equipe pediátrica quanto às particularidades da criança grande queimada, principalmente quando em vigência de infecção, e levantar discussões quanto ao uso precoce, mas não profilático, de antibióticos.
It is presented a case report of a major burn in a preschool referred to a hospital service reference, which evolved to death due to subsequent sepsis infection catheter, despite the use of antimicrobial therapy guided by antibiogram. The aim of this study is to alert the pediatric team and the particularities of major burned kid, especially when in presence of infection, and raise discussions on the early use, but not prophylactic, antibiotics.
ABSTRACT
PURPOSE: To compare controlled liver regeneration in rats submitted to 60% hepatic resection having L-arginine supplemented diet, based on weight changes of the regenerated liver, laboratory parameters of liver function and pathological findings. METHODS: Thirty-six rats were divided into two groups, control and L- arginine. The first received standard chow and saline solution by gavage. The second had supplementation with L- arginine. Animals were killed on postoperative period at 24h, 72h and seven days. For analysis of liver regeneration was used Kwon formula for weight, laboratory tests and mitosis. RESULTS: Weight, showed no benefit with L- arginine supplementation; however, intergroup comparison in the first 24h observed positive effect on supplementation (p=0.008). Alkaline phosphatase was increased in arginine group (p<0.04). The number of mitoses showed no difference between the two groups; however, in the first 24 hours, the supplemented group had higher number of mitoses within the groups (p=0.03). CONCLUSION: Supplementation with L-arginine did not show benefits in liver regeneration; however, supplemented group in the first 24 hours showed benefits over 72 hours and seven days of the evaluation by weight gain and number of mitosis.
Subject(s)
Arginine/pharmacology , Dietary Supplements , Liver Regeneration/drug effects , Animals , Hepatectomy , Liver/drug effects , Liver/pathology , Liver/physiology , Liver Regeneration/physiology , Male , Mitosis/drug effects , Mitosis/physiology , Organ Size , Rats, Wistar , Time FactorsABSTRACT
PURPOSE: To compare controlled liver regeneration in rats submitted to 60% hepatic resection having L-arginine supplemented diet, based on weight changes of the regenerated liver, laboratory parameters of liver function and pathological findings. METHODS: Thirty-six rats were divided into two groups, control and L- arginine. The first received standard chow and saline solution by gavage. The second had supplementation with L- arginine. Animals were killed on postoperative period at 24h, 72h and seven days. For analysis of liver regeneration was used Kwon formula for weight, laboratory tests and mitosis. RESULTS: Weight, showed no benefit with L- arginine supplementation; however, intergroup comparison in the first 24h observed positive effect on supplementation (p=0.008). Alkaline phosphatase was increased in arginine group (p<0.04). The number of mitoses showed no difference between the two groups; however, in the first 24 hours, the supplemented group had higher number of mitoses within the groups (p=0.03). CONCLUSION: Supplementation with L-arginine did not show benefits in liver regeneration; however, supplemented group in the first 24 hours showed benefits over 72 hours and seven days of the evaluation by weight gain and number of mitosis. .
Subject(s)
Animals , Male , Arginine/pharmacology , Dietary Supplements , Liver Regeneration/drug effects , Hepatectomy , Liver Regeneration/physiology , Liver/drug effects , Liver/pathology , Liver/physiology , Mitosis/drug effects , Mitosis/physiology , Organ Size , Rats, Wistar , Time FactorsABSTRACT
PURPOSE: To assess the action of iodine cadexomer in the healing process of surgical wounds in rats and if cytotoxicity occurs with the systemic absorption of iodine. METHODS: Thirty six Wistar rats were used and performed 53 wounds with surgical punch of 6 mm diameter on them. Two lesions were made diametrically opposed on groups with distilled water (GAD) and sodium chloride (GCS); on the right lesions were used bandage with distilled water and on the left ones dressing with sodium chloride. In cadexomer iodine (GCI) group, a punch injury was made only on the left side and the dressing was carried out with cadexomer iodine. The groups were divided in two sub-groups according to the day of death (7 and 14). Microscopically was used H&E staining, through which the inflammation could be observed and also the neovascularization. Staining with Masson trichrome studied fibrosis. TSH and free T4 were used for absorption recognition of iodine, and its toxic potential was performed before death with the animal anesthetized. RESULTS: Microscopic analysis showed more marked intensity of inflammation in group GAD, subgroup 14 days. Neovascularization showed be discrete in GCS sub-group 14 days. Fibrosis was more pronounced in the group GCI. Comparing the types of treatment, there was statistical significance between groups GCI and GCS (p<0.013). The TSH and T4, showed no difference between the control group and GCI in relation to the absorption of iodine. In evaluating the GCI and control groups, within each treatment, statistical significance was found between them (p<0.001) when compared the days of observation. CONCLUSION: Cadexomer iodine had beneficial effects in all phases of the healing process without cytotoxicity due iodine absorption.
Subject(s)
Anti-Infective Agents, Local/administration & dosage , Iodophors/administration & dosage , Wound Healing/drug effects , Animals , Anti-Infective Agents, Local/toxicity , Fibrosis/pathology , Inflammation/pathology , Iodophors/toxicity , Male , Neovascularization, Physiologic/drug effects , Random Allocation , Rats , Rats, Wistar , Time FactorsABSTRACT
PURPOSE: To assess vthe action of iodine cadexomer in the healing process of surgical wounds in rats and if cytotoxicity occurs with the systemic absorption of iodine. METHODS: Thirty six Wistar rats were used and performed 53 wounds with surgical punch of 6 mm diameter on them. Two lesions were made diametrically opposed on groups with distilled water (GAD) and sodium chloride (GCS); on the right lesions were used bandage with distilled water and on the left ones dressing with sodium chloride. In cadexomer iodine (GCI) group, a punch injury was made only on the left side and the dressing was carried out with cadexomer iodine. The groups were divided in two sub-groups according to the day of death (7 and 14). Microscopically was used H&E staining, through which the inflammation could be observed and also the neovascularization. Staining with Masson trichrome studied fibrosis. TSH and free T4 were used for absorption recognition of iodine, and its toxic potential was performed before death with the animal anesthetized. RESULTS: Microscopic analysis showed more marked intensity of inflammation in group GAD, subgroup 14 days. Neovascularization showed be discrete in GCS sub-group 14 days. Fibrosis was more pronounced in the group GCI. Comparing the types of treatment, there was statistical significance between groups GCI and GCS (p<0.013). The TSH and T4, showed no difference between the control group and GCI in relation to the absorption of iodine. In evaluating the GCI and control groups, within each treatment, statistical significance was found between them (p<0.001) when compared the days of observation. CONCLUSION: Cadexomer iodine had beneficial effects in all phases of the healing process without cytotoxicity due iodine absorption.
OBJETIVO: Avaliar a ação do cadexômero iodo na cicatrização de feridas cirúrgicas em ratos e se ocorre citotoxicidade com a absorção sistêmica do iodo. MÉTODOS: Utilizou-se 36 ratos Wistar nos quais realizaram-se 53 feridas cirúrgicas com punch de 6 mm de diâmetro. Foram confeccionados duas lesões diametralmente opostas nos animais dos grupos água destilada (GAD) e cloreto de sódio (GCS). Na lesão do lado direito foi utilizado curativo com água destilada e, na do esquerdo, curativo com cloreto de sódio. No grupo cadexômero iodo (GCI), foi feita apenas uma lesão com o punch no lado esquerdo e o curativo foi realizado com cadexômero iodo. Os grupos foram divididos em dois subgrupos conforme o dia da morte (7 e 14). Microscopicamente foi utilizada a coloração H&E, através da qual foi observado o processo inflamatório e a neovascularização. Com a coloração tricômio de Masson foi estudada a fibrose. Para o reconhecimento da absorção do iodo e o seu potencial tóxico foi realizado, antes da morte com o animal anestesiado, dosagem do TSH e do T4 livre. RESULTADOS: Na análise microscópica a intensidade da inflamação apresentou-se mais acentuada no grupo GAD, subgrupo 14 dias. Na análise da neovascularização ela apresentou-se discreta no GCS subgrupo 14 dias. Na avaliação da fibrose foi mais acentuada no grupo GCI. Na comparação nos tipos de tratamento houve significância estatística entre os grupos GCI e GCS (p<0,013). A dosagem do TSH e T4, não apresentou diferença entre o grupo controle e GCI em relação à absorção do iodo. Na avaliação dos grupos GCI e controle, dentro de cada tratamento, houve significância estatística entre eles (p<0,001), quando comparados os dias. CONCLUSÃO: O cadexômero iodo apresentou efeito benéfico em todas as fases do processo cicatricial sem citotoxicidade pela absorção do iodo.
Subject(s)
Animals , Male , Rats , Anti-Infective Agents, Local/administration & dosage , Iodophors/administration & dosage , Wound Healing/drug effects , Anti-Infective Agents, Local/toxicity , Fibrosis/pathology , Inflammation/pathology , Iodophors/toxicity , Neovascularization, Physiologic/drug effects , Random Allocation , Rats, Wistar , Time FactorsABSTRACT
PURPOSE: To investigate the results of the healing process on surgical wounds in the back of Wistar rats using nanocristaline and ionic silver dressing. METHODS: Sixty rats Wistar were submitted to surgical wounds with punch of 8 mm in diameter. In 30 animals (groups PN - nanocristaline and AD - control) two surgical wounds were done diametrically opposite on the upper back side. On the right side was used nanocristaline (PN) silver dressing and on the left side, distilled water dressing (AD). On the other group of 30 rats, only one wound was made with the punch, on the right side, and was used ionic silver dressing. So, the groups were divided into three subgroups, according to the day of death (7(th), 14(th) and 21(st) day). In each of these days the wounds diameter were measured to evaluate the wound contraction. Microscopic data were analyzed using the H&E staining to verify the inflammatory process and neovascularization. The Masson trichrome staining was used to verify the fibrosis. RESULTS: Macroscopically only the subgroup of 21(st) day showed statistical significance; between the groups AD and PI inflammatory process appeared in the 7(th) day subgroup in 90% of the cases. In neovascularization there was statistical significance between the groups PN and AD in the subgroup of 7(th) day. Fibrosis did not show statistical significance in the studied groups. CONCLUSIONS: In relation to wound contraction, PN and PI groups showed better results than the AD group. In regard to histological analysis, H&E staining showed that there was presence of inflammation in all groups, and at the end, the control group (AD) on 7(th) day, was superior to PN and PI groups. In relationship to fibrosis, no differences were obtained among groups.
Subject(s)
Occlusive Dressings , Silver/therapeutic use , Wound Healing/drug effects , Wounds and Injuries/drug therapy , Animals , Disease Models, Animal , Fibrosis , Male , Metal Nanoparticles/chemistry , Metal Nanoparticles/therapeutic use , Neovascularization, Physiologic/drug effects , Neovascularization, Physiologic/physiology , Rats , Rats, Wistar , Reproducibility of Results , Silver/chemistry , Time Factors , Treatment Outcome , Wound Healing/physiology , Wounds and Injuries/pathologyABSTRACT
PURPOSE: To investigate the results of the healing process on surgical wounds in the back of Wistar rats using nanocristaline and ionic silver dressing. METHODS: Sixty rats Wistar were submitted to surgical wounds with punch of 8mm in diameter. In 30 animals (groups PN - nanocristaline and AD - control) two surgical wounds were done diametrically opposite on the upper back side. On the right side was used nanocristaline (PN) silver dressing and on the left side, distilled water dressing (AD). On the other group of 30 rats, only one wound was made with the punch, on the right side, and was used ionic silver dressing. So, the groups were divided into three subgroups, according to the day of death (7th, 14th and 21st day). In each of these days the wounds diameter were measured to evaluate the wound contraction. Microscopic data were analyzed using the H&E staining to verify the inflammatory process and neovascularization. The Masson trichrome staining was used to verify the fibrosis. RESULTS: Macroscopically only the subgroup of 21st day showed statistical significance; between the groups AD and PI inflammatory process appeared in the 7th day subgroup in 90% of the cases. In neovascularization there was statistical significance between the groups PN and AD in the subgroup of 7th day. Fibrosis did not show statistical significance in the studied groups. CONCLUSIONS: In relation to wound contraction, PN and PI groups showed better results than the AD group. In regard to histological analysis, H&E staining showed that there was presence of inflammation in all groups, and at the end, the control group (AD) on 7th day, was superior to PN and PI groups. In relationship to fibrosis, no differences were obtained among groups.
OBJETIVO: Investigar os resultados da cicatrização de feridas cirúrgicas em dorso de ratos, utilizando curativos de prata nanocristalina e iônica. MÉTODOS: Sessenta ratos Wistar foram submetidos à feridas cirúrgicas com punch de 8mm de diâmetro. Foram confeccionadas duas lesões diametralmente opostas nos animais dos grupos prata nanocristalina (PN) e controle água destilada (AD). Na lesão do lado direito foi utilizado curativo com prata nanocristalina e na do lado esquerdo curativo com água destilada. No outro grupo de 30 ratos, apenas foi realizada uma lesão com o punch no lado esquerdo e curativo com prata iônica. Os grupos foram divididos em subgrupos conforme o dia da morte (7º, 14º e 21º dias), o que caracterizou a existência de três subgrupos, nos quais foram tomadas as medidas do centro das lesões para estudar macroscopicamente a contração da ferida Microscopicamente foi utilizada a coloração H&E, através da qual foi observado o processo inflamatório e a neovascularização. Com a coloração Tricômio de Masson, foi estudada a fibrose. RESULTADOS: Macroscopicamente apenas o subgrupo 21 dias apresentou significância estatística entre os grupos AD e prata iônica (PI), porém quando comparados os dias de avaliação, dois a dois, dentro de cada tratamento, todos os subgrupos apresentaram significância estatística (p<0,05). A variável intensidade da inflamação apresentou-se de forma acentuada no subgrupo sete dias em 90% dos casos, entre os grupos AD e PI. Na variável neovascularização houve significância estatística entre os grupos PN e AD no subgrupo sete dias. A variável fibrose não apresentou significância estatística nos subgrupos estudados. CONCLUSÕES: Em relação à contração da ferida, os grupos PN e PI apresentaram resultados superiores ao grupo AD. Com relação à análise histológica, na coloração H&E observou-se que houve presença de processo inflamatório nos grupos estudados sendo que, ao final, o grupo controle (AD) no 7º dia mostrou-se superior aos grupos PN e PI. Com relação à variável fibrose, não houve diferenças entre os grupos.