Hard Magnetic Properties and the Features of Nanostructure of High-Temperature Sm-Co-Fe-Cu-Zr Magnet with Abnormal Temperature Dependence of Coercivity.

This paper presents methods and approaches that can be used for production of Sm-Co-Fe-Cu-Zr permanent magnets with working temperatures of up to 550 °C. It is shown that the content of Sm, Cu, and Fe significantly affects the coercivity (Hc) value at high operating temperatures. A decrease in the content of Fe, which replaces Co, and an increase in the content of Sm in Sm-Co-Fe-Cu-Zr alloys lead to a decrease in Hc value at room temperature, but significantly increase Hc at temperatures of about 500 °C. Increasing the Cu concentration enhances the Hc values at all operating temperatures. From analysis of the dependence of temperature coefficients of the coercivity on the concentrations of various constituent elements in this alloy, the optimum chemical composition that qualifies for high-temperature permanent magnet (HTPM) application were determined. 3D atom probe tomography analysis shows that the nanostructure of the HTPM is characterized by the formation of Sm2(Co,Fe)17 (2:17) cells relatively smaller in size along with the slightly thickened Sm(Co,Cu)5 (1:5) boundary phase compared to those of the high-energy permanent magnet compositions. An inhomogeneous distribution of Cu was also noticed in the 1:5 phase. At the boundary between 1:5 and 2:17 phases, an interface with lowered anisotropy constants has developed, which could be the reason for the observed high coercivity values.

Old dog, new tricks: Influenza A virus NS1 and in vitro fibrillogenesis.

The influenza NS1 protein is involved in suppression of the host immune response. Recently, there is growing evidence that prion-like protein aggregation plays an important role in cellular signaling and immune responses. In this work, we obtained a recombinant, influenza A NS1 protein and showed that it is able to form amyloid-like fibrils in vitro. Using proteolysis and subsequent mass spectrometry, we showed that regions resistant to protease hydrolysis highly differ between the native NS1 form (NS1-N) and fibrillar form (NS1-F); this indicates that significant structural changes occur during fibril formation. We also found a protein fragment that is capable of inducing the process of fibrillogenesis at 37 °C. The discovery of the ability of NS1 to form amyloid-like fibrils may be relevant to uncovering relationships between influenza A infection and modulation of the immune response.

[Mixed infection: viral hepatitis A and hemorrhagic fever with renal syndrome. Case report].

The article considers a case from clinical practice: a mixed infection of viral hepatitis A and hemorrhagic fever with renal syndrome. Hepatitis had a protracted course and proceeded with the development of acute hepatic encephalopathy. Hemorrhagic fever was characterized by an atypical course with lung and heart damage.

[Association of tension-free inguinal hernia repair and pathospermia in fertile men]. / Assotsiatsiya nenatyazhnoi pakhovoi gernioplastiki i patospermii u muzhchin reproduktivnogo vozrasta.

OBJECTIVE: To reveal the association of tension-free inguinal hernia repair and pathospermia in fertile men. MATERIAL AND METHODS: We have retrospectively analyzed medical records of 512 men who appealed to andrologist with complaints of the absence of pregnancy in wife in 2018. We evaluated duration and features of infertility, presence/absence of previous inguinal hernia repair, spermogram data (according to WHO criteria, 2010) in all patients. RESULTS: Duration of infertility in men after inguinal hernia repair persists for 4.2±2.1 years. Right-sided hernia repair was performed in 36 (48.6%) patients, left-side - 23 (31%), bilateral repair - 15 (20.2%) patients. Men with impaired sperm motility prevailed among patients after right-sided inguinal hernia repair (17 (47.2%) people). Left-sided hernia repair was followed by asthenozoospermia in 8 (34.7%) cases, bilateral hernia repair - in 3 (20%) cases. The most severe abnormalities in semen analysis (azoospemia) develop after bilateral hernia repair. CONCLUSION: Inguinal tension-free hernia repair is a risk factor for male infertility in 14.4% of cases. It is very important to examine a man in case of infertile marriage. Previous surgical interventions including inguinal hernia repair should be considered.

Superinfection of hepatitis E as a factor in the development of acute hepatic encephalopathy on the background of HBV-cirrhosis of the liver.

The article presents an analysis of the clinical case of superinfection of autochthonous acute hepatitis E against the background of HBV-cirrhosis of the liver. HEV infection was diagnosed in a 39 year old man who did not travel outside the region and the country for a long time and used unboiled water. The peculiarity of the disease in the non-endemic region was: a severe course of hepatitis E against the background of HBV etiology, with the development of the clinic for acute hepatic insufficiency and encephalopathy, the presence of severe cytolysis syndrome, cholestasis, hepatic-cell insufficiency and prolonged convalescence. Timely treatment of the patient for medical aid and intensive pathogenetic therapy of hepatit-E superinfection with compensated HBV-cirrhosis allowed to save the patient's life. However, the prognosis for the patient's later life is unfavorable, due to submissive liver necrosis and the risk of rapid decompensation of cirrhosis. When deciphering undifferentiated in Russia acute hepatitis in persons with cirrhosis of another etiology (viral, alcoholic, medicinal), it is necessary to include the definition of HEVRNA and HEV IgM and G. in the survey design.

[The use of fibrin-collagen substance in case of spleen injuries].

Spleen damage is one of the most common injuries of the abdomen. Thus, splenectomy is one of the most common embodiments of the surgical procedure. Justified by the desire of surgeons to perform organ save surgery, which was made possible by the emergence of new hemostatic agents. In this paper, an experimental and clinical study of the effectiveness of fibrin-collagen substance (FCC) "Tachocomb" to hemostasis of spleen injuries was submitted.

[Effects of inguinal hernioplasty mesh implant on reproductive function].

In vivo experiment involved 95 white breedless male rats of pubertal age. The animals were divided in three groups: 1st group had unilateral hernioplasty with mesh implant; 2nd group had bilateral mesh implantation and 3rd group had animals with hernioplasty with lavsan thread. The results were assessed with the use of morphological method, the state of reproductive organs - with the use of biological method and compared with the control (intact) group. Stable progressive increase of thickness of epithelium and spermatic duct wall during the whole observation time was registered after hernioplasty with mesh implantation. In the group after hernioplasty with lavsan thread the above mentioned changes returned to normal values by the end of the first month after the operation. Disorders of the reproductive system in animals after bilateral mesh implantation turned out to be essential and resulted in sterility within the whole time of the observation. Mildly decreased or average fertility was observed among animals after unilateral mesh implantation and hernioplasty. Notably, that after hernioplasty with lavsan thread, fertility was sufficient. The study demonstrated the negative influence of mesh implant on spermatic duct structure, which may cause infertility.

[Method of laparoscopic treatment of gastroesophageal reflux with mesh implant]. / Sposob laparoskopicheskogo lecheniia gastroézofageal'nogo refliuksa s ispol'zovaniem setchatogo implantata.

Modern potential of endoscopic surgery promoted expansion of indications for surgical treatment of gastroesophageal reflux disease. The majority of laparoscopic methods has a number of significant disadvantages. Methods of laparoscopic treatment of gastroesophageal reflux using the implant with partial anterior fundoplication or without it were developed. These methods simplify surgical technique, permit to save topographoanatomical relationships of organs and at the same time restore Hiss angle and ensure work of sphincter that satisfy requirements to antireflux operations.

[Male reproductive function after inguinal hernia]. / Reproduktivnaia funktsiia muzhchin posle pakhovogo gryzhesecheniia.

Reproductive function and treatment results have been analysed for 59 patients aged 17 to 32 years after herniotomy. 28 and 31 of them underwent standard and endosurgical interventions, respectively. The control group consisted of 30 healthy males matched for age. As shown by 6-month follow-up, the endosurgical herniotomy was not associated with such complications as hydroscheocele, hydrocele, testicular atrophy, diminution of blood flow along the testicular arteries. Ejaculate, levels of sex hormones in the blood, cremasteric reflex remained intact. After routine herniotomy there appeared defects in scrotal and testicular microcirculation with partial testicular atrophy in 25% of cases, testicular circulation fell 2.2-2.5-fold, deterioration of spermogram and cremasteric reflex parameters, reduction of serum testosterone were observed.

[Leukinferon in immunological correction of acute inflammatory diseases of the abdominal organs]. / Immunokorrektsiia leikinferonom pri ostrykh vospalitel'nykh zabolevaniiakh organov briushnoi polosti.

Addition of (intramuscular+intravenous) leukinferon (LF) to the schemes for the treatment of acute peritonitis promoted a more rapid positive development of the time course of clinical signs and decreasing of leukocytosis in the presence of a pronounced tendency to normalization of the main immunological indices i. e. the counts of differential T-lymphocytes and T-helper cells. There was also activation of neutrophil phagocytic function. A rapid decrease in objective signs of endotoxicosis was recorded: the intoxication leukocytic index and the level of medium-mass molecules. In parallel with the decrease in the intoxication leukocytic index, there was a decrease in cytosis of the peritoneal exudate. The use of LF in the treatment of elderly patients with acute cholecystitis eliminated the clinical signs and normalized the main laboratory indices without surgical interventions which allowed one to make a planned operation with the minimum risk.