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1.
Paediatr Anaesth ; 15(3): 190-3, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15725314

ABSTRACT

BACKGROUND: No simple method exists to distinguish children in need for premedication. The present study was planned to detect preoperative anxiety levels of children by rating their drawings. METHODS: Sixty ASA I children aged 4-7 years undergoing adenoidectomy were divided into AGIT and CALM groups according to agitation level observed during venous cannulation. All children drew a picture at three different times: (i) just after arrival in the day-case unit, (ii) 10 min before operation and, (iii) prior to leaving for home. The children were also randomized to three premedication groups: group D, rectal diazepam 0.5 mg x kg(-1); group P, 0.9% NaCl 0.1 ml x kg(-1) rectally; group NT, no premedication. Five features (size of the drawing, form of the drawing line, colors used, mark of the pen and clarity of the picture) from the children's drawings were rated with a 3-point scale. The ratings of each feature were made to form a sum score of anxiety ranging from 0 to 10. In the analysis of variance for repeated measures both the premedication group and agitation score were taken into the model as factors. RESULTS: The anxiety score of the drawings of the agitated children (during venous cannulation) was significantly higher already after arrival in the hospital [AGIT 4.76 (95% CI: 3.56-5.96) Vs CALM 3.67 (95% CI: 2.97-4.37) P = 0.029], but there were no statistical differences between the different premedication groups. CONCLUSIONS: When routine sedative premedication is not used the drawings of the children might detect the children needing sedative premedication.


Subject(s)
Anxiety/diagnosis , Anxiety/psychology , Preanesthetic Medication , Adenoidectomy , Child , Child, Preschool , Female , Humans , Male
2.
Pain ; 110(1-2): 175-81, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15275765

ABSTRACT

Gabapentin alleviates and/or prevents acute nociceptive and inflammatory pain both in animals and volunteers, especially when given before trauma. Gabapentin might also reduce postoperative pain. To test the hypothesis that gabapentin reduces the postoperative need for additional pain treatment (postoperative opioid sparing effect of gabapentin in humans), we gave 1200 mg of gabapentin or 15 mg of oxazepam (active placebo) 2.5 h prior to induction of anaesthesia to patients undergoing elective vaginal hysterectomy in an active placebo-controlled, double blind, randomised study. Gabapentin reduced the need for additional postoperative pain treatment (PCA boluses of 50 microg of fentanyl) by 40% during the first 20 postoperative hours. During the first 2 postoperative hours pain scores at rest and worst pain score (VAS 0-100 mm) were significantly higher in the active placebo group compared to the gabapentin-treated patients. Additionally, pretreatment with gabapentin reduced the degree of postoperative nausea and incidence of vomiting/retching possibly either due to the diminished need for postoperative pain treatment with opioids or because of an anti-emetic effect of gabapentin itself. No preoperative differences between the two groups were encountered with respect to the side effects of the premedication. However, 15 mg oxazepam was more effective in relieving preoperative anxiety than 1200 mg gabapentin.


Subject(s)
Acetates/therapeutic use , Amines , Calcium Channel Blockers/therapeutic use , Cyclohexanecarboxylic Acids , Hysterectomy, Vaginal/adverse effects , Pain, Postoperative/prevention & control , gamma-Aminobutyric Acid , Adult , Case-Control Studies , Double-Blind Method , Female , Fentanyl/therapeutic use , Gabapentin , Humans , Hypnotics and Sedatives/therapeutic use , Male , Middle Aged , Narcotics/therapeutic use , Oxazepam/therapeutic use , Pain Measurement/methods , Pain, Postoperative/etiology , Postoperative Nausea and Vomiting/etiology , Postoperative Nausea and Vomiting/prevention & control , Time Factors
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