Weight-adaptive joint mixed-precision quantization and pruning for neural network-based equalization in short-reach direct detection links.

Neural network (NN)-based equalizers have been widely applied for dealing with nonlinear impairments in intensity-modulated direct detection (IM/DD) systems due to their excellent performance. However, the computational complexity (CC) is a major concern that limits the real-time application of NN-based receivers. In this Letter, we propose, to our knowledge, a novel weight-adaptive joint mixed-precision quantization and pruning approach to reduce the CC of NN-based equalizers, where only integer arithmetic is taken into account instead of floating-point operations. The NN connections are either directly cutoff or represented by a proper number of quantization bits by weight partitioning, leading to a hybrid compressed sparse network that computes much faster and consumes less hardware resources. The proposed approach is verified in a 50-Gb/s 25-km pulse amplitude modulation (PAM)-4 IM/DD link using a directly modulated laser (DML) in the C-band. Compared with the traditional fully connected NN-based equalizer operated with standard floating-point arithmetic, about 80% memory can be saved at a minimum network size without degrading the system performance. Quantization is also shown to be more suitable to over-parameterized NN-based equalizers compared with NNs selected at a minimum size.

Experimental investigation of a Tonpilz transducer operating in the frequency band of 20-80 kHz (L).

The drive-stack design principle for the Tonpilz transducer aiming to transmit the acoustic signal in an ultra-wideband has been proposed [(2023). J. Acoust. Soc. Am. 154, 3709-3725], in which the design method is obtained and validated through simulation. This letter presents the experimental investigation of a fabricated transducer prototype and gives the measurement results of electroacoustic performance, including the electrical admittance, transmitting voltage response, directivity beam pattern, electroacoustic efficiency, and source level. The results indicate that the transducer can operate in the frequency band from 20 to 80 kHz without deep response notches within the band.

Quasi-Reaction Coarse-Grained Simulation: Unveiling the Mesoscale Interfacial Response of CSH/PVA Fiber.

The lack of a comprehensive force field and understanding at the mesoscale for hydrated calcium silicate (CSH)/polyvinyl alcohol (PVA) fiber has hindered the upscaling and bridging of nanoscale to macroscale phenomena. In this study, we propose a coarse-grained (CG) force field that incorporates bond-breaking operations to endow fiber reactivity, abrasion, and fracture properties. By employing a cubic lattice modeling, we effectively address the challenges associated with semicrystalline relaxation of fibers. For the first time, quasi-reaction CG simulation successfully replicates slip-hardening behaviors and surface abrasion. We demonstrate that abrasion improves interface load transfer and triggers slip-hardening by redistributing stress. Additionally, the influences of single and coupled factors, such as nonbonding interactions and surface roughness, are investigated. Mesoscale understanding provides insights for enabling precise control of load transfer paths and fabrication of interface damage-predictable materials.

Early Prone Position Ventilation in the Efficacy for Severe Hypoxemia and Neurological Complications Following Acute Type A Aortic Dissection (TAAD) Surgery.

OBJECTIVE: To analyze the efficacy of early prone position ventilation in the treatment of severe hypoxemia after surgery for acute type A aortic dissection (TAAD). METHODS: The patients were divided into a control group and a treatment group. Parameters assessed included blood gas analysis indicators [arterial oxygen partial pressure (PaO2). RESULTS: (1) Blood gas analysis: Before treatment, there was no significant difference in PaO2, SpO2, and OI levels between the two groups; after treatment, the PaO2, SpO2, and OI levels in both groups significantly increased compared to pre-treatment, with a more pronounced improvement in the treatment group than in the control group (p < 0.05). (2) Hemodynamics: Before treatment, there was no significant difference in MAP and HR levels between the two groups; after treatment, the MAP levels increased significantly in both groups compared to pre-treatment, while HR levels decreased significantly, with no significant difference between the groups. (3) Prognosis recovery: MV time, ICU stay, and total hospital stay were significantly lower in the treatment group than in the control group; the 30-day mortality rate was 14.58% in the control group and 12.50% in the treatment group, with no significant difference in 30-day mortality rate between the groups. CONCLUSION: Early prone position ventilation has shown promising application in the treatment of severe hypoxemia after TAAD surgery. Compared to traditional supine position ventilation, the use of early prone position ventilation can further improve blood gas analysis indicators in patients, and shorten MV time, ICU stay, and total hospital stay, thereby accelerating patient recovery.

Mode-division-multiplexing self-homodyne coherent transmission over a weakly coupled few-mode fiber for optical interconnections.

Self-homodyne coherent transmission has recently received extensive investigation as a coherent lite candidate for high-speed short-reach optical networks. In this Letter, we propose a weakly coupled mode-division-multiplexing (MDM) self-homodyne coherent scheme using a multiple-ring-core few-mode fiber, in which one of the modes transmits a self-homodyne local oscillator (LO) and the rest are utilized for carrying signals. Multiple rings of index perturbations in the fiber core are applied to achieve low modal crosstalk, allowing the signals and the remote LO to be transmitted independently. We experimentally demonstrate a 7.2-Tb/s (5.64-Tb/s net rate) self-homodyne coherent transmission with an 800-Gb/s data rate for each of the nine information-bearing modes formatted in 80-GBaud probabilistic constellation-shaped 64-quadrature-amplitude modulation. To the best of our knowledge, this is the first experimental demonstration of an MDM self-homodyne coherent transmission with up to 10 spatial modes. The proposed scheme may pave the way for future high-capacity data center interconnections.

Results and Follow-Up of a Sequential Q-Switched Laser Therapy for Nevus of Ota in Infants.

Background and Aim: There is a dearth of scholarly investigation pertaining to the effectiveness and safety of laser therapy for nevus of Ota manifestation in infants. The objective of this study is to examine the efficacy and safety of administering laser therapy at an early stage to treat nevus of Ota in infants. Methods: A total of 102 infants below the age of one who had nevus of Ota were treated at the Laser Center at Hangzhou Third People's Hospital. The treatment approach involved a combination of the Q-switched laser (with a wavelength of 755 nm) and the Q-switched laser (with a wavelength of 1064 nm). The treatment sessions were conducted at six-month intervals. Prior to and after each session, photographs and relevant parameters were documented, including any skin reactions. Subsequent follow-up was conducted through phone calls, WeChat, and text messages, and the parents/guardians of the infants completed a general questionnaire as well as Conner's Abbreviated Symptom Questionnaire. Results: Laser therapy exhibited significant efficacy in the treatment of nevus of Ota in infants. Success rates reached 88.7% after four sessions and 99.3% after seven sessions. No instances of serious adverse reactions, except for pain, were reported. Among the 47 infants subject to follow-up, 14 experienced a recurrence, resulting in a recurrence rate of 29.8%. Factors contributing to these recurrences included lesion size, subtypes, exposure to the sun, and location. Subsequent laser treatments, typically involving two to three additional sessions, proved effective in mitigating recurrences. Notably, none of the infants exhibited any signs of fear, anxiety, or other psychological abnormalities following laser therapy, and the overall satisfaction rate was markedly high. Conclusion: Commencing laser therapy promptly for nevus of Ota in infants is recommended. This early intervention significantly contributes to the overall well-being of infants, addressing both physical and psychological aspects.

Gradient-descent noise whitening techniques for short-reach IM-DD optical interconnects with severe bandwidth limitation.

Bandwidth limitation in optoelectrical components and the chromatic dispersion-induced power fading phenomenon cause severe inter-symbol interference (ISI) in high-speed intensity modulation and direct detection (IM-DD) optical interconnects. While the equalizer implemented in the receiver's digital signal processing procedure can mitigate ISI, it also inevitably enhances the noise located in the decayed frequency region, known as equalization-enhanced colored noise (EECN). Additionally, the nonlinear impairments of the modulator and photodetector also deteriorate the performance of the IM-DD system, especially for high-order modulation formats. In this work, we propose a gradient-descent noise whitening (GD-NW) algorithm to address EECN and extend it by introducing nonlinear kernels to simultaneously mitigate EECN and nonlinear impairments. The proposed algorithms are compared with conventional counterparts in terms of the achievable baud rate and the receiver optical power sensitivity. As a proof-of-concept experiment, we validate the principles of the proposed algorithms by successfully transmitting 360-GBd on-off-keying (OOK) and 180-GBd 4-level pulse-amplitude-modulation (PAM-4) signals in the back-to-back case under a 62-GHz brick-wall bandwidth limitation. 280-GBd OOK and 150-GBd PAM-4 transmissions are also demonstrated over 1-km standard single-mode fiber with a bit error rate below 7% hard-decision forward error correction aided by the proposed approach.

Bandwidth extension of the Tonpilz transducer using high-order longitudinal vibrations.

Tonpilz transducers mainly work near the first-order longitudinal resonance. Until now, the cognition, research, and application of third-order resonance and above are still inadequate. By coupling the first-order resonance with other high-order resonances, it is possible to extend the bandwidth of the Tonpilz transducer to more than two octaves. Three difficulties hinder the achievement of the ultra-wideband, including how to activate consecutive high-order resonances, how to eliminate the response notches between resonances, and how to control the response values of resonances to reduce band fluctuation. This paper addresses these key issues. The results show that the number, position, length, and applied voltage of the drive-stack all significantly affect the band. We finally propose a drive-stack design principle that can activate the first four longitudinal resonances with close response values to be coupled to form the ultra-wideband. When applying this principle to the Tonpilz transducer, many variables need to be optimized. To solve this problem, an efficient and accurate optimization technology is proposed, consisting of simulated annealing initial optimization and finite element re-optimization, through which an ultra-wideband covering the frequency range of 19.5-90 kHz is obtained, verifying the effectiveness of the proposed principle. The designed transducer has three drive-stacks, and the band contains four longitudinal resonances.

Fast polarization state tracking for dual-polarization direct detection with Jones-space field recovery.

Direct detection system is expected to possess the phase and polarization diversity in order to achieve high spectral efficiency and fiber impairment compensation such as chromatic dispersion and polarization rotation. In this Letter, we theoretically extend the concept of the proposed Jones-space field recovery (JSFR) to include a dynamic polarization rotation matrix and experimentally demonstrate the rapid polarization state tracking ability of the JSFR receiver based on a 3 × 3 optical coupler. Under a rotation of the state of polarization at a rate of 1 Mrad/s, we successfully transmit 59-GBd dual-polarization 16-ary quadrature-amplitude-modulation signals over an 80-km standard single-mode fiber based on a decision-directed least mean square (DD-LMS) or a recursive least square (DD-RLS), with a bit-error rate below the 14% hard-decision forward error correction threshold of 1 × 10-2. The experimental results indicate that the legacy polarization tracking algorithms designed for coherent optical communication are also applicable for this direct detection scheme. To our best knowledge, this work demonstrates the first polarization rotation-tolerant direct detection system with phase and polarization diversity, providing a low-cost and high-speed solution for short-reach communications.

Deep transfer learning-based variable Doppler underwater acoustic communications.

This paper proposes a deep transfer learning (DTL)-based variable Doppler frequency-hopping binary frequency-shift keying underwater acoustic communication system. The system uses a convolutional neural network (CNN) as the demodulation module of the receiver. This approach directly demodulates the received signal without estimating the Doppler. The DTL first uses the simulated communication signal data to complete the CNN training. It then copies a part of the convolution layers from the pre-trained CNN to the target CNN. After randomly initializing the remaining layers for the target CNN, it is trained by the data samples from the specific communication scenarios. During the training process, the CNN learns the corresponding frequency from each symbol in the selected frequency-hopping group through the Mel-spectrograms. Simulation and experimental data processing results show that the performance of the proposed system is better than conventional systems, especially when the transmitter and receiver of the communication system are in variable speed motion in shallow water acoustic channels.

Satellite record reveals 1960s acceleration of Totten Ice Shelf in East Antarctica.

Wilkes Land and Totten Glacier (TG) in East Antarctica (EA) have been losing ice mass significantly since 1989. There is a lack of knowledge of long-term mass balance in the region which hinders the estimation of its contribution to global sea level rise. Here we show that this acceleration trend in TG has occurred since the 1960s. We reconstruct ice flow velocity fields of 1963-1989 in TG from the first-generation satellite images of ARGON and Landsat-1&4, and build a five decade-long record of ice dynamics. We find a persistent long-term ice discharge rate of 68 ± 1 Gt/y and an acceleration of 0.17 ± 0.02 Gt/y2 from 1963 to 2018, making TG the greatest contributor to global sea level rise in EA. We attribute the long-term acceleration near grounding line from 1963 to 2018 to basal melting likely induced by warm modified Circumpolar Deep Water. The speed up in shelf front during 1973-1989 was caused by a large calving front retreat. As the current trend continues, intensified monitoring in the TG region is recommended in the next decades.

Treatment of Combined Freckles with Chloasma Using Q-Switched 1064 nm Laser.

Objective: The present study observed the therapeutic effect and possible side effects of Q-switch 1064-nm laser with large-spot and low-energy technology in the treatment of patients with combined freckles and chloasma. Methods: A Q1064-nm laser with a large-spot diameter of 6-8 mm, energy level of 2.0-3.3 J/cm2, frequency of 10 Hz, and pulse width of 10 ns was employed for the treatment. Each patient underwent treatment 10-15 times, with an interval of 10-15 days each time. Facial care was administered before and after treatment; attention was paid to cleaning and moisturizing, avoiding light, and using sunscreens strictly. The therapeutic effects were observed and evaluated. Results: Freckles basically subsided (effective rate = 100%) and chloasma faded (effective rate = 39.4%). Furthermore, whitening and delicacy improvement were observed in the surrounding normal skin area. After laser treatment, confocal laser scanning microscopy revealed a large number of melanin particles in the upper part of the granular layer. Moreover, the amount of melanin in the middle and lower parts of the basal layer and spinous layer was significantly decreased. None of the patients developed postinflammatory pigmentation. Conclusion: In the treatment of freckles with chloasma, Q 1064-nm laser large-spot, low-energy technology not only removed freckles and faded chloasma but, most importantly, also reduced the incidence of postinflammatory pigmentation and improved patient satisfaction. This provided new methods and ideas for freckle laser treatment.

Automated extraction of baleen whale calls based on the pseudo-Wigner-Ville distribution.

Baleen whales produce a wide variety of frequency-modulated calls. Extraction of the time-frequency (TF) structures of these calls forms the basis for many applications, including abundance estimation and species recognition. Typical methods to extract the contours of whale calls from a spectrogram are based on the short-time Fourier transform and are, thus, restricted by a fixed TF resolution. Considering the low-frequency nature of baleen whale calls, this work represents the contours using a pseudo-Wigner-Ville distribution for a higher TF resolution at the cost of introducing cross terms. An adaptive threshold is proposed followed by a modified Gaussian mixture probability hypothesis density filter to extract the contours. Finally, the artificial contours, which are caused by the cross terms, can be removed in post-processing. Simulations were conducted to explore how the signal-to-noise ratio influences the performance of the proposed method. Then, in experiments based on real data, the contours of the calls of three kinds of baleen whales were extracted in a highly accurate manner (with mean deviations of 5.4 and 0.051 Hz from the ground-truth contours at sampling rates of 4000 and 100 Hz, respectively) with a recall of 75% and a precision of 78.5%.

Mitigating nonlinear penalty induced from a low-speed optical supervisory channel on coherent signals.

With the increasing signal rates of a long-haul backbone dense-wavelength-division-multiplexing (DWDM) transmission system, e.g., from 100 Gb/s to 400 Gb/s and even to 800 Gb/s, optical path impairments simultaneously become more severe. Harmful factors being formerly insignificant become noticeable, e.g., nonlinear phase noise (NPN) on main DWDM channels induced by the cross-phase modulation (XPM) from the low-speed optical supervisory channel (OSC). Field trials show that a greater than 5.13-dB penalty can be observed on the shortest channel of 400G DP-16QAM-PCS over G.654.E links, which greatly degrades the overall transmission performance and limits the maximum reach. In this paper, we propose a dual-OSC structure with opposite signals to compensate for performance degradation caused by OSC-induced NPN. This method involves no extra digital signal processing (DSP), which is not only simple but also applicable for universal signal rates. By experimental demonstration, a 1.32-dB gain in Q (dB) for 200G DP-16QAM transmission over 1618-km G.652.D can be done, almost achieving the same performance as the no OSC case.

Amarogentin inhibits vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia via AMPK activation.

OBJECTIVES: Recent studies validated the expression of extraoral bitter taste receptors and established the importance of regulatory functions that are associated with various cellular biological processes of these receptors. However, the importance of bitter taste receptors' activity in neointimal hyperplasia has not yet been recognized. The bitter taste receptors activator amarogentin (AMA) is known to regulate a variety of cellular signals, including AMP-activated protein kinase (AMPK), STAT3, Akt, ERK, and p53, which are associated with neointimal hyperplasia. MATERIALS AND METHODS: The present study assessed the effects of AMA on neointimal hyperplasia and explored the potential underlying mechanisms. RESULTS: No cytotoxic concentration of AMA significantly inhibited the proliferation and migration of VSMCs induced by serum (15 % FBS) and PDGF-BB. In addition, AMA significantly inhibited neointimal hyperplasia of the cultured great saphenous vein in vitro and ligated mouse left carotid arteries in vivo, while the inhibitory effect of AMA on the proliferation and migration of VSMCs was mediated via the activation of AMPK-dependent signaling, which could be blocked via AMPK inhibition. CONCLUSION: The present study revealed that AMA inhibited the proliferation and migration of VSMCs and attenuated neointimal hyperplasia, both in ligated mice carotid artery and cultured saphenous vein, which was mediated via a mechanism that involved AMPK activation. Importantly, the study highlighted the potential of AMA to be explored as a new drug candidate for neointimal hyperplasia.

Robust unsupervised Tursiops aduncus whistle enhancement based on complete ensembled empirical optimal envelope local mean decomposition with adaptive noise.

Whistle enhancement is an essential preprocessing step in studying dolphin behavior and population distributions. We propose a robust unsupervised whistle enhancement scheme based on improved local mean decomposition using adaptive noise estimation and logarithmic spectral amplitude. First, to further mitigate the mode aliasing problem effect in whistle signal decomposition and achieve better spectral separation of modes, we present a complete ensembled empirical optimal envelope local mean decomposition with adaptive noise algorithm. According to the envelope characteristics of the whistle signals, the proposed algorithm optimally and adaptively decomposes the noisy signal into product functions (PFs) with amplitude and frequency modulation. Second, the whistle enhancement framework consists of the improved minima-controlled recursive averaging for adaptive noise estimation, optimally modified log-spectral amplitude for each noisy product function enhancement, and the Hurst index for reconstructing pure whistle signal estimations with the least damaged PFs. Finally, the proposed scheme is applied to a dataset of long calls from two Tursiops aduncus individuals. After constructing the pure whistle dataset, the experimental results show that the proposed scheme performs better than other compared whistle enhancement schemes under different signal-to-noise ratios.

Effects of receiving position and shell material on in-band full-duplex underwater communications' self-interference signal.

Despite the recent intensive research on adaptive algorithms for self-interference (SI) cancellation (SIC) in in-band full-duplex (IBFD) underwater acoustic communication (UWAC), there has been relatively little exploration of how the IBFD-UWAC modem shell affects the SI signal. This paper analyzes the effects of the shell material and the near-end receiver position on the SI signal. The analysis is done with a two-dimensional finite-element model in a free-field simulation environment, which combines the differential equation of motion and the time-dependent solver. The SI signal strength around the modem shell in the far-field conditions is obtained. The simulation and pool experiment results both show that (i) the strength of the received SI signal is lowest when the near-end receiver is on a line extending from the shell's geometric center perpendicularly to its central axis and (ii) a shell material with a high elastic coefficient is more conducive to suppressing the SI signal. A pool experiment showed that changing the spatial position of the near-end receiver and the shell material from aluminum to stainless steel enhanced the SIC performance of the IBFD-UWAC system by at least 12 and 4 dB, respectively.

The use of biological amniotic membranes in the treatment of recurrent macular holes.

To evaluate the clinical therapeutic effects of a technique in which biological amniotic membranes (bAMs) are used in the treatment of patients with recurrent macular holes. In this prospective nonrandomized case series study, 23 eyes of 23 patients with recurrent macular holes who had already undergone surgery with pars plana vitrectomy with internal limiting membrane peeling were evaluated. In the surgery, a bAM was used to cover the macular area, and C3F8 tamponade was performed on these patients. Phacoemulsification combined with intraocular lens implantation was performed simultaneously in patients who had cataracts. Patients were followed up for at least half a year. The main outcomes were whether the macular hole closed, the morphological changes in the macular graft, the best-corrected visual acuity, intraocular pressure (IOP) and other indicators. In all eyes, the recurrent macular holes were closed. Two cases (8.69%, 2/23) had bAM shifting half a month after surgery, and these patients underwent a second surgery to adjust the position of the bAM and perform C3F8 tamponade. In the 6-month follow-up, 21 patients (91.30%, 21/23) had improved visual acuity (VA), and 2 patients (8.69%, 2/23) had no change in VA. The mean VA increased from 1.73 ± 0.32 before surgery to 1.12 ± 0.42 after surgery (t = 10.63, P = 0.00 < 0.01), and the mean IOP decreased from 22.13 ± 5.56 before surgery to 17.23 ± 1.71 after surgery (t = 5.14, P = 0.00 < 0.01). No serious complications occurred in any of the cases. The technique of using a biological amniotic membrane can be an effective treatment for patients with recurrent macular holes.

Wideband signal detection in multipath environment affected by impulsive noise.

Detecting the presence or absence of a known signal is an important aspect of underwater acoustic (UWA) communications as it is a vital first step to process the received data. The influence of impulsive noise and multipath propagation on detection are both considered in this paper. Many robust detectors have been designed to cope with impulsive noise, but they tend to ignore the impact of multipath propagation, which may decrease the detection probability. To emphasize the role of multipath channel, we propose two-stage detection methods. In the first stage, the channel is estimated based on robust orthogonal matching pursuit, while in the second stage, detectors that use the channel estimation from the first stage, namely augmented log-likelihood ratio detector and augmented pseudo-correlation detector, are developed. The former detector is parametric and the latter one is non-parametric. The improved performance is demonstrated in simulated multipath channel and actual UWA channel with both simulated noise and recorded snapping shrimp noise, indicating that the proposed detectors are resistant to impulsive noise. It is also shown that the use of multipath information helps to improve the detection performance.

Robust unsupervised Tursiops aduncus whistle-event detection using gammatone multi-channel Savitzky-Golay based whistle enhancement.

Detecting whistle events is essential when studying the population density and behavior of cetaceans. After eight months of passive acoustic monitoring in Xiamen, we obtained long calls from two Tursiops aduncus individuals. In this paper, we propose an algorithm with an unbiased gammatone multi-channel Savitzky-Golay for smoothing dynamic continuous background noise and interference from long click trains. The algorithm uses the method of least squares to perform a local polynomial regression on the time-frequency representation of multi-frequency resolution call measurements, which can effectively retain the whistle profiles while filtering out noise and interference. We prove that it is better at separating out whistles and has lower computational complexity than other smoothing methods. In order to further extract whistle features in enhanced spectrograms, we also propose a set of multi-scale and multi-directional moving filter banks for various whistle durations and contour shapes. The final binary adaptive decisions at frame level for whistle events are obtained from the histograms of multi-scale and multi-directional spectrograms. Finally, we explore the entire data set and find that the proposed scheme achieves the highest frame-level F1-scores when detecting T. aduncus whistles than the baseline schemes, with an improvement of more than 6%.