POEMS syndrome: A rare cause of ascites and pelvic effusion.

POEMS syndrome is a rare clonal plasma cell disease associated with multisystem involvement. We reported a case of 48-year-old woman with large volume of exudative ascites with an increased level of λ-light chain and hepatosplenomegaly. The patient was treated with thalidomide and dexamethasone and showed a good clinical response.

Ionic Rigid Organic Dual-State Emission Compound With Rod-Shaped and Conjugated Structure for Sensitive Al3+ Detection.

Dual-state emission (DSE) luminogens, a type of luminescent material which can effectively emit light in both dilute solution and solid states, have attracted tremendous attention, due to their widespread applications in chemical sensing, biological imaging, organic electronic devices, and so on. They overcome the shortcomings of aggregation-induced emission (AIE)-type compounds that do not emit light in dilute solutions and aggregation-caused quenching (ACQ)-type compounds that do not emit light in a concentrated or aggregated state. This work reports a novel ionic DSE material based on rigid rod-shaped organic conjugated structure using 4,4'-bis(2-sulfonatostyryl) biphenyl disodium salt (BSBDS); the ion repulsion effect can reduce the strong π-π interaction in aggregation and achieve high-efficiency luminescence in solution and solid states. In addition to excellent DSE characteristics, BSBDS also exhibits a mechanochromic nature and sensitive detection performance for aluminum ion (Al3+).

Room-temperature phosphorescent polymers with excitation-wavelength and delay-time emission dependencies.

Novel room-temperature phosphorescent materials based on commercialized poly(4-styrenesulfonic acid-co-maleic acid) salt have been identified with aggregation-induced emission and room temperature phosphorescence emission characteristics. We systematically investigated their excitation-wavelength and delay-time dependencies to provide new insight into the potentiality of these materials for multiple industrial applications, such as optical storage and anti-counterfeit labelling.

AIE-active polyanetholesulfonic acid sodium salts with room-temperature phosphorescence characteristics for Fe3+ detection.

Room-temperature phosphorescent materials have been a major focus of research and development during the past decades, due to their applications in OLEDs, photovoltaic cells, chemical sensors, and bioimaging. However, achieving polymeric phosphorescent materials without heavy-metal atoms and halogens under ambient conditions remains a major challenge. Here, we report a polymeric phosphor, namely polyanetholesulfonic acid sodium salt, which not only has room temperature phosphorescence characteristic but also aggregation-induced emission and dependence on the excitation wavelength characteristics. Moreover, it can recognize Fe3+ effectively.

[The impact of telmisartan on angiotensin converting enzyme 2 mRNA expression in monocyte-derived macrophages of diabetic hypertensive patients].

OBJECTIVE: To investigate the effects of telmisartan on the expression of angiotensin converting enzyme 2 (ACE2) mRNA in monocyte-derived macrophages of hypertensive patients accompanied with diabetes. METHODS: 62 essential hypertensive patients accompanied with diabetes were randomly divided into two groups: regular treatment group, and telmisartan group. Then the content of ACE and ACE2 in serum was detected by ELISA, and the expression of ACE mRNA and ACE2 mRNA in monocyte-derived macrophages of patients was detected by RT-PCR before and after having been treated. RESULTS: (1) After having been treated for 4 weeks and 12 weeks, the blood pressure of the patients in two groups were decreased significantly, Comparing with regular group, telmisartan group seemed to have more obvious therapeutic effect (P < 0.05); (2) After having been treated for 12 weeks, glycosylated hemoglobin diseased in both group, but there was no significant difference between the two group (P > 0.05); (3) In telmisartan group, the content of ACE2 in serum was increased after having been treated for 12 weeks than that in regular treatment group, [(23.9 ± 8.2) U/L vs (16.3 ± 8.9) U/L, P < 0.05]; and the expression of ACE2 mRNA in monocyte-derived macrophages in telmisartan group was obviously increased after 12 weeks comparing with regular treatment group (0.73 ± 0.06 vs 0.51 ± 0.04, P < 0.01). CONCLUSION: The role of telmisartan in decreasing blood pressure and it's advantage to the metabolism of glucose are partly related with the up-regulation of ACE2 mRNA.