Subject(s)
Breast Neoplasms/pathology , Plasmacytoma/pathology , Adult , Aged , Female , Humans , Neoplasms, Multiple Primary/pathologySubject(s)
Brain Diseases/etiology , Thyroiditis, Autoimmune/complications , Female , Humans , Middle AgedABSTRACT
Extra-cutaneous manifestations of neutrophilic dermatosis are exceptional and diverse: they consist of inflammatory infiltrates with neutrophil polymorphonuclears, without evidence of infectious agents. Localisations to the lung are the most frequently observed. A single observation of spleen involvement has been reported in a case of Sneddon-Wilkinson's disease. Herein we report the case of an aseptic splenic abscess during the course of a Sweet's syndrome.
Subject(s)
Abscess/etiology , Splenic Diseases/etiology , Sweet Syndrome/complications , Adult , Female , Humans , Sweet Syndrome/physiopathologySubject(s)
Acquired Immunodeficiency Syndrome/surgery , HIV-1 , Splenectomy , Viremia/surgery , Adult , Humans , MaleABSTRACT
Surrogate markers generally used for observation of patients infected with human immunodeficiency virus (HIV) and their plasma and cellular viral load were assayed in a series of 40 patients before initiation of zidovudine therapy. Plasma viremia was positive in 62.5% of patients and was statistically correlated with clinical stage, CD4+ T cell count, CD8+ T cell count, beta 2-microglobulin level, neopterin level, and immunoglobulin A level. Cellular viremia was positive in 95% of patients and was correlated with clinical stage, CD4+ T cell count, beta 2-microglobulin, neopterin levels, and disease progression during the following months. A discordance was found between p24 antigenemia, even after acid dissociation of immune complexes, and plasma viremia. In fact, p24 antigenemia was correlated with only biological markers of immune activation as beta 2-microglobulin and neopterin levels. The measurement of anti-p24 antibodies did not appear discriminative in our staging. Plasma viremia, like CD4+ T cell count, reflects the patient's status at the time of assessment. Cellular viremia could be more informative for the prediction of future clinical progression.
Subject(s)
HIV Infections/immunology , HIV-1/immunology , Viremia/immunology , Adult , Biopterins/analogs & derivatives , Biopterins/blood , CD4-Positive T-Lymphocytes/immunology , Female , HIV Antibodies/blood , HIV Core Protein p24/blood , HIV Core Protein p24/immunology , HIV Infections/drug therapy , HIV Infections/microbiology , HIV-1/growth & development , Humans , Immunoglobulin A/blood , Leukocyte Count , Male , Middle Aged , Neopterin , Prognosis , Proportional Hazards Models , T-Lymphocytes, Regulatory/immunology , Thymidine Kinase/blood , Viremia/drug therapy , Viremia/microbiology , Zidovudine/therapeutic use , beta 2-Microglobulin/analysisABSTRACT
A case of myasthenia associated with Hodgkin's disease with probable invasion of the thymus is reported. Five cases of association between lymphomatous thymoma and myasthenia (2 Hodgkin's thymomas and 3 non-Hodgkin's lymphomatous thymomas) have previously been reported. Myasthenia healed after the lymphoma was treated. This association raises pathogenic problems in the 3 cases of non-Hodgkin's thymoma where invasion of the thymus erased all its normal structure.
