The impact of different co-morbidities on clinical outcomes and resource utilization in critically ill burn and surgical patients: A population-based analysis of social determinants of health.

BACKGROUND: This study aims to establish the significance of social determinants of health and prevalent co-morbidities on multiple indicators for quality of care in patients admitted to the Burn and Surgical Intensive Care Unit (ICU). METHODS: We performed a retrospective analysis of population group data for patients admitted at the Burn and Surgical ICU from January 1, 2016, to November 18, 2019. The primary outcomes were length of hospital stay (LOS), mortality, 30-day readmission, and hospital charges. Pearson's chi-square test for categorical variables and t-test for continuous variables were used to compare population health groups. RESULTS: We analyzed a total of 487 burn and 510 surgical patients. When comparing ICU patients, we observed significantly higher mean hospital charges and length of stay (LOS) in BICU v. SICU patients with a history of mental health ($93,259.40 v. $50,503.36, p = 0.013 and 16.28 v. 9.16 days, p = 0.0085), end-stage-renal-disease (ESRD) ($653,871.05 v. $75,746.35, p = 0.0047 and 96.15 v. 17.53 days, p = 0.0104), sepsis ($267,979.60 v. $99,154.41, p = <0.001 and 39.1 v. 18.42 days, p = 0.0043), and venous thromboembolism (VTE) ($757,740.50 v. $117,816.40, p = <0.001 and 93.11 v. 20.21 days, p = 0.002). Also, higher mortality was observed in burn patients with ESRD, ST-Elevation Myocardial Infarction (STEMI), sepsis, VTE, and diabetes mellitus. 30-day-readmissions were greater among burn patients with a history of mental health, drug dependence, heart failure, and diabetes mellitus. CONCLUSIONS: Our study provides new insights into the variability of outcomes between burn patients treated in different critical care settings, underlining the influence of comorbidities on these outcomes. By comparing burn patients in the BICU with those in the SICU, we aim to highlight how differences in patient backgrounds, including the quality of care received, contribute to these outcomes. This comparison underscores the need for tailored healthcare strategies that consider the unique challenges faced by each patient group, aiming to mitigate disparities in health outcomes and healthcare spending. Further research to develop relevant and timely interventions that can improve these outcomes.

Patients Age 40 Years and Younger With Multiple Myeloma Have the Same Prognosis as Older Patients: An Analysis of Real-World Patients' Evidence From Latin America.

PURPOSE: Multiple myeloma (MM) is a highly heterogeneous, incurable disease most frequently diagnosed in the elderly. Therefore, data on clinical characteristics and outcomes in the very young population are scarce. PATIENTS AND METHODS: We analyzed clinical characteristics, response to treatment, and survival in 103 patients with newly diagnosed MM age 40 years or younger compared with 256 patients age 41-50 years and 957 patients age 51 years or older. RESULTS: There were no statistical differences in sex, isotype, International Scoring System, renal involvement, hypercalcemia, anemia, dialysis, bony lesions, extramedullary disease, and lactate dehydrogenase (LDH). The most used regimen in young patients was cyclophosphamide, bortezomib, dexamethasone, followed by cyclophosphamide, thalidomide, dexamethasone and bortezomib, thalidomide, dexamethasone. Of the patients age 40 years or younger, only 53% received autologous stem-cell transplant (ASCT) and 71.1% received maintenance. There were no differences in overall survival (OS) in the three patient cohorts. In the multivariate analysis, only high LDH, high cytogenetic risk, and ASCT were statistically associated with survival. CONCLUSION: In conclusion, younger patients with MM in Latin America have similar clinical characteristics, responses, and OS compared with the elderly.

Energy transfer in N-component nanosystems enhanced by pulse-driven vibronic many-body entanglement.

The processing of energy by transfer and redistribution, plays a key role in the evolution of dynamical systems. At the ultrasmall and ultrafast scale of nanosystems, quantum coherence could in principle also play a role and has been reported in many pulse-driven nanosystems (e.g. quantum dots and even the microscopic Light-Harvesting Complex II (LHC-II) aggregate). Typical theoretical analyses cannot easily be scaled to describe these general N-component nanosystems; they do not treat the pulse dynamically; and they approximate memory effects. Here our aim is to shed light on what new physics might arise beyond these approximations. We adopt a purposely minimal model such that the time-dependence of the pulse is included explicitly in the Hamiltonian. This simple model generates complex dynamics: specifically, pulses of intermediate duration generate highly entangled vibronic (i.e. electronic-vibrational) states that spread multiple excitons - and hence energy - maximally within the system. Subsequent pulses can then act on such entangled states to efficiently channel subsequent energy capture. The underlying pulse-generated vibronic entanglement increases in strength and robustness as N increases.

Clinical outcomes in 'diabese' burn patients: A systematic review and meta-analysis.

OBJECTIVE: The objective of this study was to update the current status of clinical outcomes in diabetic (type II) and obese (BMI: 30-39.9 kg/m2) burn patients. METHODS: We adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We searched MEDLINE (PubMed), Google Scholar, Scopus, and Embase for studies related to a number of comorbidities and burn outcomes. Search terms for each of these databases are listed in the Appendix. From this search, we screened 6923 articles. Through our selection criteria, 12 articles focusing on either diabetes or obesity were selected for systematic review and meta-analysis. Data was analyzed using the "meta" package in R software to produce pooled odds ratios from the random effect model. RESULTS: Diabetic patients had 2.38 times higher odds of mortality [OR: 2.38, 95% CI:1.66, 3.41], however no statistically significant difference was found in mortality in obese patients [OR: 2.49, 95% CI: 0.36, 17.19]. Obese patients had 2.18 times higher odds of inhalation injury [95%CI: 1.23, 3.88], whereas diabetic patients did not show a difference in odds of inhalation injury [OR:1.02, 95% CI: 0.57, 1.81]. Diabetic patients had higher odds of complications resulting from infection: 5.47 times higher odds of wound, skin, or soft tissue infections [95% CI:1.97, 15.18]; 2.28 times higher odds of UTI or CAUTI [95% CI:1.50, 3.46]; and 1.78 times higher odds of pneumonia or respiratory tract infections [95% CI:1.15, 2.77]. Obese patients also had similar complications related to infection: 2.15 times higher odds of wound infection [95% CI: 1.04, 4.42] and 1.96 times higher odds of pneumonia [95% CI: 1.08, 3.56]. Other notable complications in diabetic patients were higher odds of amputation [OR: 37, 95% CI: 1.76, 779.34], respiratory failure [OR: 4.39, 95% CI: 1.85, 10.42], heart failure [OR: 6.22, 95% CI: 1.93, 20.06], and renal failure [OR: 2.95, 95% CI: 1.1, 7.86]. CONCLUSIONS: Diabetic patients have higher odds of mortality, whereas no statistically significant difference of mortality was found in obese patients. Obese patients had higher odds of inhalation injury, whereas odds of inhalation injury was unchanged in diabetic patients. Diabetic patients had higher odds of failure in multiple organs, whereas such failure in obese patients was not reported. Both diabetic and obese patients had multiple complications related to infection.

Evaluating the Efficacy, Safety, and Tolerance of Silver Sulfadiazine Dressings Once Daily Versus Twice Daily in the Treatment of Burn Wounds.

Topical silver sulfadiazine (SSD) is an effective antimicrobial therapy used to prevent burn wound infection and promote healing, but the frequency of application has not been previously examined. This study compares once versus twice daily dressing changes with SSD, focusing on development of wound infections, incidence of hospital acquired complications, patient pain scores, and length of stay. The objective of this study was to evaluate whether a once-daily or twice-daily application of SSD impacts burn wound healing outcomes. Our institution maintained a twice-daily dressing change standard of care until January 1, 2019. Patients admitted after that date had their dressing changed once daily. We performed a noninferiority analysis which indicated that a sample size of 75 per group would be sufficient to detect a significant difference with a power of 0.80. Our goal is to review outcomes for 75 patients before the change-of-practice and 75 patients after. Our main outcomes recorded are wound infection, average pain scores, average daily narcotic requirements, and length-of-stay. Results from 75 pre-change-of-practice and 75 post-change-of-practice patients showed slightly better outcomes in the post-change-of-practice group. The wound-infection rates were the same for both groups (pre = 5.33%, post = 5.33%), average daily pain levels for the pre-change group were slightly higher but the difference was negligible and not statistically significant (pre = 5.27, post = 5.25), hospital-related complication rates (unrelated to wound care) were higher pre-change (pre = 10.67%, post = 6.67%), and length-of-stay, was longer in the pre-change group (pre = 11.97, post = 10.31). The amount average amount of SSD (g/day) used per patient per hospital stay was higher as well (pre = 320.14, post = 202.12). Further statistical analysis of the results, particularly in the distribution of burn type, age, and burn depth showed no discrepancy and a generalized decreased length-of-stay with once-daily SSD dressing change. Our results show that once-daily dressing changes of SSD in burn wounds have no negative impact on wound outcomes. However, it is associated with a decreased length-of-stay, decreased pain levels, and less hospital-acquired complications. A decreased length-of-stay means reduced medical expenses for the patient and the hospital. In addition, less hospital-acquired complications result in better patient recovery. Since the difference in wound outcomes is negligible and statistically insignificant, changing the standard-of-care to once daily could prove beneficial.

Different outcomes for transplant-eligible newly diagnosed multiple myeloma patients in Latin America according to the public versus private management: a GELAMM study.

The aim of this study was to describe clinical and survival characteristics of transplant-eligible multiple myeloma (MM) patients in Latin America (LA), with a special focus on differences between public and private healthcare facilities. We included 1293 patients diagnosed between 2010 and 2018. A great disparity in outcomes and survival between both groups was observed. Late diagnosis and low access to adequate frontline therapy and ASCT in public institutions probably explain these differences. Patients treated with novel drug induction protocols, followed by autologous stem cell transplantation (ASCT) and maintenance, have similar overall survival compared to that published internationally.

Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

The recent outbreak of COVID-19 has put significant strain on the current health system and has exposed dangers previously overlooked. The pathogen known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is notable for attacking the pulmonary system causing acute respiratory distress, but it can also severely affect other systems in at-risk individuals including cardiovascular compromise, gastrointestinal distress, acute kidney injury, coagulopathies, cutaneous manifestations, and ultimately death from multi-organ failure. Unfortunately, the reliability of negative test results is questionable and the high infectious burden of the virus calls for extended safety precautions, especially in symptomatic patients. We present a confirmed COVID-19 case that was transferred to our burn center for concern of Steven Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap syndrome after having two negative confirmatory COVID-19 tests at an outside hospital. A 58-year-old female with a history of morbid obesity, HTN, gout, CML managed with imatinib, and chronic kidney disease presented as a transfer from a community hospital to our burn center. The patient was admitted to her community hospital with febrile, acute respiratory distress. Imaging and clinical presentation was consistent with COVID-19 and lab tests for the pathogen were ordered. During observation, while waiting for results, she was placed under patient under investigation (PUI) protocol. Once negative results were obtained, the PUI protocol was abandoned despite ongoing symptoms. Subsequently, dermatological symptoms developed and transfer to our burn center was initiated. After a second negative test result, the symptomatic patient was transferred to our burn center for expert wound management. Given the lack of resolve of respiratory symptoms and concern for the burn patient population, the patient was placed in PUI protocol and an internal COVID-19 was ordered. The patient's initial exam under standard COVID-19 airborne precautions revealed 5% total body surface area of loss of epidermis affecting bilateral thighs, bilateral arms, and face. A dermatopathological biopsy suggested a bullous drug reaction with an erythema multiform-like reaction pattern versus SJS/TEN. Moreover, the internal COVID-19 test returned positive. The delayed positive test results and complicated hospital course with our patient required us to scale back and notify every patient and staff member whom they came in contact with, across multiple institutions. We suggest that whenever a suspected COVID-19 patient is transferred to a specialized center, they should be isolated and re-checked before joining the new patient population for treatment of the unique condition.

Real world outcomes with Bortezomib Thalidomide dexamethasone and Cyclophosphamide Bortezomib dexamethasone induction treatment for transplant eligible multiple myeloma patients in a Latin American country. A Retrospective Cohort Study from Grupo Argentino de Mieloma Múltiple.

Data about treatment outcomes and toxicity in Latin America are scarce. There are differences with central countries based on access to healthcare system and socioeconomic status. Argentinean Society of Hematology recommends bortezomib-based triplets for induction treatment of transplant eligible newly diagnosed multiple myeloma patients. Most common options are CyBorD (cyclophosphamide, bortezomib and dexamethasone) and VTD (bortezomib, thalidomide and dexamethasone). Main goal of our retrospective, multicentric study was to compare very good partial response rate (VGPR) or better after induction treatment in a real-world setting in Argentina. Secondary objectives included comparison of complete response (CR) post-induction and after bone marrow transplantation, grade 3-4 adverse events (AEs), progression-free survival (PFS) and overall survival (OS). Three hundred twenty-two patients were included (median age at diagnosis: 57 years; 52% male; 28% had ISS3; 14% with high-risk cytogenetics; median follow up: 34 months). CyBorD was indicated in 74% and 26% received VTD. In VTD arm, 72.62% of patients achieved at least VGPR vs 53.36% receiving CyBorD (odds ratio, OR: 1.96 [95% confidence interval, CI: 1.08-3.57; P = .026] after adjusting by age, ISS [International Staging System], lactate dehydrogenase levels (LDH) and cytogenetic risk. Difference in VGPR was 19.26% (95% CI: 15-24). CR rate were 35.92% (VTD) vs 22.55% (CyBorD) (adjusted OR: 2.13 [95% CI: 1.12-4.05]). Difference in CR was 13.37% (95% CI: 9.6-17.53). Adverse events (AEs) were more common with VTD (69.05% vs 55.46% for CyBorD; P = .030), especially grade 3-4 neuropathy (P = .005) and thrombosis (P = .001). Thromboprophylaxis was inadequate in 20.24% of patients. Hematological AEs were more common with CyBorD, especially thrombocytopenia (P = .017). PFS and OS at 24 months were not different between treatments. In this real-world setting, VTD was associated with better CR and VGPR than CyBorD. Nevertheless, CyBorD continues to be the preferred induction regimen in Argentina, based on safety profile. Frontline autologous stem cell transplantation improves quality of responses, especially in countries with limited access to new drugs.

E-Cigarette Battery Explosions: Review of the Acute Management of the Burns and the Impact on Our Population.

Electronic cigarettes, also known as e-cigarettes (E-cig), are lithium-battery-powered devices, which became available for sale in the United States in 2017. It has gained significant popularity among younger-generation tobacco smokers due to its advertisement as a non-toxic inhalation property and a potential smoking-cessation aid. The US Food and Drug Administration (FDA) has been regulating e-cigarettes as tobacco products and not as drug-delivery devices, as many medical experts think it should be categorized. In the last few years, the medical community has encountered increasing episodes of burn injuries secondary to e-cigarette battery explosion. Explosions occur through a process known as a "thermal runaway." This process occurs when the battery overheats and the internal battery temperature increases dangerously high, to the point of inner fire and explosion. Overcharge, puncture, external heat, short circuit, amongst others, are conditions that cause a "thermal runaway." This is a retrospective review and analysis of six patients with superficial, partial, and full-thickness burn injuries related to e-cigarette battery explosions managed at Johns Hopkins Bayview Burn Center over the course of one year. Lund-Browder diagrams and calculations were used to assess the total body surface area (TBSA) burns. Laser Doppler imaging (LDI) was used to evaluate the indeterminate depth of the burn. Only one of our six patients required tangential excision and skin grafting. The rest of our patients were treated conservatively with complex wound care, which included the mixed combination of topical collagenase and bacitracin, collagenase and mafenide, or silver sulfadiazine as a single-agent treatment with an excellent response. Five patients were discharged home within a week, including the patient who required operative excision and auto-grafting. One patient stayed for eight days for pain control and complex wound care. Our experience with these burns has been similar to what is previously reported. Most of these burns are managed with complex wound care without any surgical interventions. The e-cigarette batteries seem more prone to failure due to an inherent weakness in their structural design. This makes them particularly susceptible to the "thermal runaway." Therefore, we recognized the need to expand the regulation and control of the quality of these devices. Prevention of these burns will require continuing education for the community on the use of E-cig. products and its potential hazardous implications. New efforts should be made to educate the community and healthcare providers regarding the potential hazardous implication of carrying these batteries. Also, there is insufficient data to support or deny the long-term health effects of using e-cigarettes.

A Multidisciplinary Approach to the Management of Severe Purpura Fulminans in a Burn Center: A Case Series.

Purpura fulminans is a life-threatening hematological emergency characterized by skin necrosis and disseminated intravascular coagulation requiring rapid diagnosis and treatment. We present a case series of patients with severe purpura fulminans who were managed via a multidisciplinary approach at a regional burn center. We report the burn unit perspective which includes current intensive care guidelines with early surgical intervention, in addition to a review of the pathology and clinical features of the disease. Proper wound management and expeditious surgical evaluation can help reduce the mortality and minimize amputations. Early referral to a burn center with a multidisciplinary team is recommended for the best outcomes in these patients.

Waking Up Blind in the ICU: A Case Report of Ischemic Optic Neuropathy in a Burn Patient.

The objective of this report is to analyze and summarize the current literature of ischemic optic neuropathy (ION), a rare complication in severe burn and trauma victims, while presenting an urban burn center's experience with the condition. This is an unfortunate condition and this report will raise awareness to a potential complication in the burn patient population as well as in critically ill patients in other settings. We present the case of a 27-year-old healthy male patient admitted to our Burn Center with 85% total body surface area (TBSA) full-thickness burns sustained in a house fire. The patient had a complicated hospital course but improved over time and was weaned off of prolonged ventilation and sedation. Subsequently, he complained of bilateral blindness. A fundoscopic examination demonstrated bilateral pale optic nerves with sparing of the remaining peripheral retina consistent with ION. The patient suffered complete bilateral vision loss. He had multiple factors that could have instigated the development of ION, including several episodes of septicemia, hypovolemic shock and severe adult respiratory distress syndrome (ARDS) with refractory hypoxemia requiring a prolong ventilation support and vasopressor therapy.  Due to the advancement of the treatment of acute burns, the survival rate of patients that once would have succumbed to their burn injury, is increasing. With these new achievements, we are facing new challenges and complications. ION has a significant impact on the quality of the patient's life. The early diagnosis will not necessarily translate into a benefit for these patients as no treatment has been proven successful. Extensive retrospective and prospective studies are necessary to identify and treat this patient population.

Substance use and inhalation injury in adult burn patients: retrospective study of the impact on outcomes.

BACKGROUND: Substance use, alcohol use, and smoking use have all been associated with burn injury. Few studies have investigated associations with substances, alcohol, smoking, inhalational only burns, and patient outcomes. The purpose of the study was to identify risk factors for pulmonary failure in patients suffering inhalation injury, focusing on the impact of substance, alcohol, and cigarette use. METHODS: This is a single-center retrospective analysis of 115 patients admitted to the Johns Hopkins Bayview Burn Center with inhalational injury from January 1, 2010, through September 30, 2018. Patients were excluded if they were under the age of 18 years or had burn involvement of the skin > 5%. Primary outcome variables measured were if patients were intubated, length of total time intubated, substance use, alcohol use, and smoking use. Secondary outcome variables measured were types of substances used (amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, codeine/morphine), total number of substances used, intensive care unit (ICU) length of stay (LOS), hospital LOS, secondary complications, and patient mortality. Analysis was performed with Fisher's exact test and the Mann-Whitney U test. A sub-group analysis for each substance, alcohol, smoking, and control sub-group was compared to its respective sub-group without substance, alcohol, smoking, and control within the no intubation and intubation group. A sub-group analysis of substance use, alcohol use, smoking use, and control was further analyzed with binomial logistic regression within the intubation group. RESULTS: Following inhalation injury, 50/115 (43%) patients required intubation. Forty-two of the 50 (84%) patients intubated had substance use (p < 0.001). Thirty-one of the 50 (62%) patients intubated had history of smoking (p = 0.038). Among the specific substances used, 26/50 (52%) patients intubated were using benzodiazepines (p < 0.001) and 7/50 (14%) patients were using cocaine (p = 0.022). The lengths of intubation, ICU LOS, and hospital LOS with no substance use were shorter than with substance use (p < 0.001). Following the adjusted sub-group analysis, patients with substance use (odds ratio (OR) 6.4, 95% confidence interval (CI) [2.5-16.3]; p < 0.001) and smoking use (OR 2.5, 95% CI [1.2-5.1]; p = 0.013) were more likely to be intubated on admission than those without substance or smoking use. CONCLUSIONS: In patients admitted with an inhalational injury with less than or equal to 5% external burns, the presence of a substance and smoking use on admission provides a further risk of intubation and respiratory compromise. Substance use on admission poses a greater risk of longer intubation, ICU LOS, and hospital LOS. A higher potential for substance use should be suspected in this patient population with prompt treatment.

Complication of solar branding: Report of a case and the review of the literature.

Branding is a type of scarification, a body modification that permanently transforms the skin by causing a visible scar. For centuries, it has been used on the skin of animals and slaves as well as criminals to convey ownership and also as a proof of guilt. More recently (in the 20th and 21st centuries), branding has become a symbol of personal identity, rites of passage, spiritual beliefs, and body decoration in some particular microcultures. Different means have been classically used to perform the desired branding designs including electrocautery, laser, chemicals, freezing, or a heated metal stencil. Solar branding is a new concept that involves using a focusing lens and a light source, usually the sunlight, to induce thermal injury. It is an emerging technique to perform body modifications and tattooing. As with other types of branding, solar branding also has its complications which may require surgical excision and grafting. We present a case of an acute skin infection following solar branding body modification, which to our knowledge is the first case reported in the literature.

Dangerous games: Pool shock chemical burn to the face.

Today information about fascinating chemical reactions is readily available on the internet. Unfortunately, these experiments can have catastrophic consequences. Pool chemicals account for a significant number of injuries in the United States. Pool Shock (calcium hypochlorite) is a powder widely used to disinfect swimming pools and has the potential to cause injury, as described in previous studies. Here, we report a case of a young male patient with a superficial chemical burn to the face and eyes due to a combined explosion of Pool Shock and regular Coke in a bottle. This type of chemical burn secondary to this chemical combination has not been reported elsewhere. We discuss the chemistry involved in producing significant inadvertent blast injury and present the management to treat these cases.

Factores clínicos preoperatorios predictivos de conversión del método quirúrgico / Perioperative Predictive Clinical Factors of Surgical Method Conversion

Introducción: la enfermedad vesicular es una condición médica común. Generalmente, los pacientes con enfermedad vesicular presentan un cuadro clínico típico. La conversión de los casos laparoscópicos a la técnica convencional ocurre por diferentes razones. Objetivos: relacionar los factores predictivos de la conversión de la colecistectomía laparoscópica al método tradicional desde el preoperatorio. Método: estudio analítico, retrospectivo. Se aplicaron pruebas no paramétricas y cálculo de Odds ratio y riesgo atribuible. Resultados: media de índice de masa corporal de 24, promedio de edad de 42,2 ± 14 años. El 18 por ciento fueron hipertensos, 22 por ciento tuvieron cólico biliar previos, 78 por ciento fueron mujeres, 11 por ciento se convirtieron y 41,1 por ciento eran fumadores. El cólico biliar incrementó el riesgo en 12,1 ocasiones de convertirse al método tradicional. Los hombres tuvieron 1,25 veces más de riesgo. No hubo incremento en el riesgo por inexperiencia del médico. Los pacientes que presentaron una úlcera duodenal tuvieron un incremento del riesgo de conversión de 1,33 veces. Es frecuente el cambio del método quirúrgico en pacientes con cicatriz previa (X2 0,00).Conclusiones: los factores de predicción más importantes fueron el índice de masa corporal mayor de 25, el sexo masculino, el antecedente de cólico biliar o colecistitis, la presencia de úlcera duodenal activa y las cicatrices previas en el abdomen, principalmente hemiabdomen superior. La edad del paciente y la experiencia del cirujano no constituyeron factores de riesgo(AU)

Introduction: the vesicular disease is a common medical condition. Generally, patients with vesicular disease have typical clinical features. Converting laparoscopic cases to the conventional technique occurs by different reasons.Objectives: relate predictors of laparoscopic cholecystectomy conversion to the traditional method from the preoperative stage. Results: the average body mass index was 24, average age was 42.2 ± 14 years. 18 percent were hypertensive, 22 percent had previous biliary colic, 78 percent were women, 11% were converted and 41.1percent were smokers. Biliary colic increases 12.1 times the risk of being converted to the traditional method. Men are 1.25 times more in risk. There is no increased risk for inexperienced doctor. Patients who have a duodenal ulcer have increased risk of conversion 1.33 times. The change of surgical method in patients with previous scar (X2 0.00) often occurs. Conclusions: the most important predictive factors were body mass index greater than 25, male gender, history of biliary colic or cholecystitis, presence of active duodenal ulcer and previous scars on the abdomen, upper abdomen mainly. Age and experience of the surgeon did not constitute risk factors(AU)

Factores clínicos preoperatorios predictivos de conversión del método quirúrgico / Perioperative Predictive Clinical Factors of Surgical Method Conversion

Introducción: la enfermedad vesicular es una condición médica común. Generalmente, los pacientes con enfermedad vesicular presentan un cuadro clínico típico. La conversión de los casos laparoscópicos a la técnica convencional ocurre por diferentes razones. Objetivos: relacionar los factores predictivos de la conversión de la colecistectomía laparoscópica al método tradicional desde el preoperatorio. Método: estudio analítico, retrospectivo. Se aplicaron pruebas no paramétricas y cálculo de Odds ratio y riesgo atribuible. Resultados: media de índice de masa corporal de 24, promedio de edad de 42,2 ± 14 años. El 18 por ciento fueron hipertensos, 22 por ciento tuvieron cólico biliar previos, 78 por ciento fueron mujeres, 11 por ciento se convirtieron y 41,1 por ciento eran fumadores. El cólico biliar incrementó el riesgo en 12,1 ocasiones de convertirse al método tradicional. Los hombres tuvieron 1,25 veces más de riesgo. No hubo incremento en el riesgo por inexperiencia del médico. Los pacientes que presentaron una úlcera duodenal tuvieron un incremento del riesgo de conversión de 1,33 veces. Es frecuente el cambio del método quirúrgico en pacientes con cicatriz previa (X2 0,00). Conclusiones: los factores de predicción más importantes fueron el índice de masa corporal mayor de 25, el sexo masculino, el antecedente de cólico biliar o colecistitis, la presencia de úlcera duodenal activa y las cicatrices previas en el abdomen, principalmente hemiabdomen superior. La edad del paciente y la experiencia del cirujano no constituyeron factores de riesgo(AU)

Introduction: the vesicular disease is a common medical condition. Generally, patients with vesicular disease have typical clinical features. Converting laparoscopic cases to the conventional technique occurs by different reasons. Objectives: relate predictors of laparoscopic cholecystectomy conversion to the traditional method from the preoperative stage. Results: the average body mass index was 24, average age was 42.2 ± 14 years. 18 percent were hypertensive, 22 percent had previous biliary colic, 78 percent were women, 11 percent were converted and 41.1 percent were smokers. Biliary colic increases 12.1 times the risk of being converted to the traditional method. Men are 1.25 times more in risk. There is no increased risk for inexperienced doctor. Patients who have a duodenal ulcer have increased risk of conversion 1.33 times. The change of surgical method in patients with previous scar (X2 0.00) often occurs. Conclusions: the most important predictive factors were body mass index greater than 25, male gender, history of biliary colic or cholecystitis, presence of active duodenal ulcer and previous scars on the abdomen, upper abdomen mainly. Age and experience of the surgeon did not constitute risk factors(AU)

Extreme alien light allows survival of terrestrial bacteria.

Photosynthetic organisms provide a crucial coupling between the Sun's energy and metabolic processes supporting life on Earth. Searches for extraterrestrial life focus on seeking planets with similar incident light intensities and environments. However the impact of abnormal photon arrival times has not been considered. Here we present the counterintuitive result that broad classes of extreme alien light could support terrestrial bacterial life whereas sources more similar to our Sun might not. Our detailed microscopic model uses state-of-the-art empirical inputs including Atomic Force Microscopy (AFM) images. It predicts a highly nonlinear survivability for the basic lifeform Rsp. Photometricum whereby toxic photon feeds get converted into a benign metabolic energy supply by an interplay between the membrane's spatial structure and temporal excitation processes. More generally, our work suggests a new handle for manipulating terrestrial photosynthesis using currently-available extreme value statistics photon sources.

Light-harvesting mechanism of bacteria exploits a critical interplay between the dynamics of transport and trapping.

Light-harvesting bacteria Rhodospirillum photometricum were recently found to adopt strikingly different architectures depending on illumination conditions. We present analytic and numerical calculations which explain this observation by quantifying a dynamical interplay between excitation transfer kinetics and reaction center cycling. High light-intensity membranes exploit dissipation as a photoprotective mechanism, thereby safeguarding a steady supply of chemical energy, while low light-intensity membranes efficiently process unused illumination intensity by channeling it to open reaction centers. More generally, our analysis elucidates and quantifies the trade-offs in natural network design for solar energy conversion.

Actitudes de los estudiantes de la salud de la Universidad de Chile hacia las personas con discapacidad / Universidad de Chile health students attitudes toward people with dissabilities

El estudio de las actitudes hacia las personas con discapacidad es un tema de interés para los futuros profesionales del área de la salud que de forma directa o indirecta estarán en contacto con este colectivo de personas. El presente trabajo aporta información sobre las actitudes que tienen 258 estudiantes de 7 escuelas de la Facultad de Medicina de la Universidad de Chile, se aplicó una Escala de Actitudes hacia las Personas con Discapacidad. Los resultados muestran variación en los alumnos de las diversas escuelas, identificándose actitudes positivas en la Escuela de Terapia Ocupacional en factores relacionados con la interacción, el reconocimiento de derechos y la atribución de rasgos de personalidad, se destacan también resultados positivos obtenidos por los estudiantes de otras escuelas. Al comparar las actitudes de estudiantes de escuelas de rehabilitación no se encuentran evidencias de mejores actitudes , por el contrario una de ellas tiene actitudes más negativas. Las diferencias encontradas nos estimulan a conocer las causas y a implementar programas de formación centrados en la valoración de la diferencia y la integración social de las personas con discapacidad que serán atendidos por los futuros profesionales de la salud.

The study of the attitudes towards the people with disability is a subject of interest for the professional futures of the area of the health that of direct or indirect form will be in contact with the enemy with this group of people. The present work contributes information on the attitudes that have 258 students of 7 schools of the Medicine Faculty of the University of Chile, was applied a Scale of Attitudes towards the People with Disability. The results show to variation in the students of the diverse schools, identifying themselves positive attitudes in the School of Occupational Therapy in factors related to the interaction, the recognition of rights and the attribution of personality characteristics, positive results obtained by the students of other schools also stand out. When comparing the attitudes of students of rehabilitation schools are not evidences of better attitudes, on the contrary one of them has more negative attitudes. The found differences stimulate to us to know the causes and to implement formation programs trims in the valuation of the difference and the social integration of the people with disability who will be taken care of by the professional futures of the health.