ABSTRACT
In a series of experiments, groups of cattle, undergoing patent East Coast fever (ECF) reactions induced by the inoculation of tick-derived stabilates of Theileria parva infective particles, were treated by parenteral administration of 2 tetracyclines. Ten cattle were treated with n-pyrrolidinomethyl tetracycline at 15 mg/kg for 5 days, starting on the first day macroschizonts were detected in lymph node biopsy smears. Nine of these treated cattle survived ECF reactions induced by an inoculum which killed 7 of 10 untreated controls. The same tetracycline, at 10 mg/kg daily for 5 days from the first day of febrile response had no effect on the disease. Oxytetracycline was administered at 15 mg/kg daily for 5 days to 2 groups of cattle infected with ECF. All 5 cattle survived which were treated on the first day parasites were seen. Four of 5 survived in which treatment was delayed till the onset of febrile response. All 5 untreated controls in this experiment died.
Subject(s)
Tetracyclines/therapeutic use , Theileriasis/drug therapy , Animals , Apicomplexa/drug effects , Cattle , Injections, Intramuscular , Injections, Intravenous , Tetracyclines/administration & dosage , Tetracyclines/pharmacologyABSTRACT
Cattle were immunized against East Coast fever by the inoculation of a tick-derived stabilate of Theileria parva infective particles and the intramuscular injection, at daily intervals, of n-pyrrolidinomethyl tetracycline at a dose level of 5 mg/kg. Four doses of the tetracycline, starting on the day of inoculation of the infective stabilate, minimised the ECF reactions in the cattle during immunization. Immunity to homologous T. parva stabilate challenge was demonstrated in 27 out of 27 cattle infected and treated in this manner.
Subject(s)
Eukaryota/immunology , Rolitetracycline/administration & dosage , Theileriasis/prevention & control , Vaccines , Animals , Cattle , Immunization , Injections, Intramuscular , Injections, Subcutaneous , Vaccines/administration & dosageABSTRACT
The immunocompetence of cattle undergoing East Coast Fever (ECF) reactions of varying degrees of intensity was evaluated using the neutralising antibody response of these cattle to the vaccine response was found in animals undergoing severe ECF reactions. The results suggest that the massive lymphoid cell involvement of such severe ECF reactions diminishes the immune responsiveness of cattle to rinderpest vaccine.
