ABSTRACT
Recurrent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin infections are an increasingly common problem. However, there are no data on the efficacy of decolonization regimens. We prospectively evaluated 31 patients with recurrent CA-MRSA skin infections who received nasal mupirocin, topical hexachlorophene body wash, and an oral anti-MRSA antibiotic. The mean number of MRSA infections after the intervention decreased significantly from baseline (0.03 versus 0.84 infections/month, P = <0.0001). This regimen appears promising at preventing recurrent CA-MRSA infections.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Community-Acquired Infections/prevention & control , Hexachlorophene/therapeutic use , Methicillin-Resistant Staphylococcus aureus/drug effects , Mupirocin/therapeutic use , Staphylococcal Skin Infections/prevention & control , Administration, Intranasal , Administration, Oral , Administration, Topical , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/pharmacology , Anti-Infective Agents, Local , Community-Acquired Infections/drug therapy , Community-Acquired Infections/microbiology , Female , Hexachlorophene/administration & dosage , Hexachlorophene/pharmacology , Humans , Male , Middle Aged , Mupirocin/administration & dosage , Mupirocin/pharmacology , Recurrence , Staphylococcal Skin Infections/drug therapy , Staphylococcal Skin Infections/microbiology , Treatment Outcome , Young AdultABSTRACT
We describe 10 patients with 2009 H1N1 influenza and concurrent invasive group A streptococcal infection with marked associated morbidity and mortality. Seven patients required intensive care, 8 required mechanical ventilation, and 7 died. Five of the patients, including 4 of the fatalities, were previously healthy.
