ABSTRACT
Systemic Inflammatory Response in a Young Woman Abstract. A 21-year-old patient with fever attacks, arthralgias, salmon-colored skin rash, neutrophilic leukocytosis, elevated CRP, ferritin, ASAT and ALAT was diagnosed with the rare systemic autoinflammatory disease, called adult Still disease, after having excluded other possible causes. An initial treatment with non steroidal anti-inflammatory drugs (NSAID) and prednisolone was not sufficiently effective, consecutively the therapy was escalated with the IL-6 antagonist tocilizumab. This immunosuppressive therapy resulted in fairly well controlled symptoms.
Subject(s)
Exanthema , Still's Disease, Adult-Onset , Adult , Arthralgia , Female , Humans , Prednisolone/therapeutic use , Still's Disease, Adult-Onset/diagnosis , Still's Disease, Adult-Onset/drug therapy , Systemic Inflammatory Response Syndrome/diagnosis , Young AdultSubject(s)
Coronavirus Infections , Coronavirus , Pandemics , Pneumonia, Viral , Betacoronavirus , COVID-19 , Humans , SARS-CoV-2ABSTRACT
OBJECTIVES: Given the traditionally low CDAD (Clostridium difficile associated diarrhoea) prevalence in Switzerland, CDAD patients are not routinely contact-isolated in our institution. In light of the globally changing C. difficile epidemiology, we sought to determine our institutional CDAD rate and to detect possible hospital transmission by means of epidemiological linkage. METHODS: We included every CDAD patient hospitalised in our institution, a tertiary-care hospital in eastern Switzerland, in 2009/2010. Patients with healthcare facility associated (HCFA) CDAD were grouped into cases with and without exposure to an infectious CDAD patient. Exposure was defined as sharing the room/ward with an infectious patient before symptom onset, either at the same time or within 30 days after discharge of the infectious patient. Molecular strain typing was not performed. RESULTS: We registered 141 CDAD episodes. Among them 108 were HCFA (associated with our institution), corresponding to an incidence of 2.3/10,000 patient days. Fifty-six percent (60/108) were exposed to an infectious CDAD patient, suggesting hospital transmission. The number of patients without exposure remained relatively stable, whereas presumably transmitted cases - often occurring within spatiotemporal clusters - showed high variability over time. Presumably transmitted cases were significantly older (p = 0.032) and more likely to have a Charlson score >1 (p = 0.001). CONCLUSION: In our setting, 56% of healthcare associated CDAD cases have been exposed to an infectious CDAD patient. In view of the clustering of these presumed hospital transmissions, we consider an intensification of our current infection control measures, mainly on wards with elderly and comorbid patients which are particularly prone to C. difficile transmission.
Subject(s)
Clostridioides difficile , Cross Infection/epidemiology , Diarrhea/epidemiology , Enterocolitis, Pseudomembranous/epidemiology , Age Distribution , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Clostridium Infections/epidemiology , Clostridium Infections/immunology , Clostridium Infections/transmission , Cross Infection/immunology , Cross Infection/transmission , Diarrhea/microbiology , Enterocolitis, Pseudomembranous/immunology , Enterocolitis, Pseudomembranous/transmission , Female , Humans , Immunocompromised Host , Incidence , Infection Control , Male , Middle Aged , Switzerland/epidemiology , Tertiary Care CentersABSTRACT
After returning from Thailand, a 35-year-old man from Switzerland was hospitalized with an abscess of the head. Material cultured from the abscess and adjacent bone grew a gram-negative rod, which was misidentified by an automated microbiology system as Burkholderia cepacia. The organism was eventually identified by molecular methods as B. pseudomallei.
