ABSTRACT
Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.
Subject(s)
Androgen Antagonists/chemistry , Cortodoxone/analogs & derivatives , Propionates/chemistry , Skin Diseases/drug therapy , Administration, Topical , Androgen Antagonists/therapeutic use , Cortodoxone/chemistry , Cortodoxone/therapeutic use , Crystallization , Humans , Magnetic Resonance Spectroscopy , Propionates/therapeutic use , X-Ray DiffractionABSTRACT
Budesonide is the 16alpha,17alpha-acetal of 16alpha-hydroxyprednisolone with n-butyraldehyde, endowed with anti-inflammatory activity. In a sample of budesonide tablets, kept for 3 years at 25 degrees C and 60% RH unknown impurities, not reported in European Pharmacopoiea, were present. Their identification was achieved by means of chemical and spectroscopic methods.