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J Cutan Pathol ; 48(5): 694-700, 2021 May.
Article in English | MEDLINE | ID: mdl-33533041

ABSTRACT

Lymphomatoid papulosis (LyP) type E is a rare variant of the primary cutaneous CD30+ lymphoproliferative disorders, characterized clinically by large necrotic eschar-like lesions and histopathologically by angiodestructive and angioinvasive infiltrates of CD30+ lymphocytes. As in other forms of lymphomatoid papulosis, type E lesions may undergo spontaneous regression after weeks, with frequent recurrences. We report a 21-year old male with an angiodestructive infiltrate of CD30+ lymphocytes manifesting as a papular eruption rather than ulceration, and suggest that this clinical phenotype might be related to the presence of CD4+ lymphocytes in the inflammatory cell infiltrate.


Subject(s)
Blood Vessels/pathology , CD4-Positive T-Lymphocytes/metabolism , Lymphomatoid Papulosis/pathology , Skin Neoplasms/pathology , Black or African American/ethnology , Diagnosis, Differential , Folliculitis/diagnosis , Folliculitis/etiology , Humans , Ki-1 Antigen/metabolism , Lost to Follow-Up , Lymph Nodes/pathology , Lymphoma, Primary Cutaneous Anaplastic Large Cell/diagnosis , Lymphoma, Primary Cutaneous Anaplastic Large Cell/pathology , Lymphomatoid Papulosis/classification , Lymphomatoid Papulosis/diagnosis , Male , Middle Aged , Phenotype , Prognosis , Young Adult
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