ABSTRACT
Early pregnancy ultrasound must satisfy objective criteria to make a safe diagnosis of miscarriage. The differential diagnosis of low-lying gestational sac includes cervical stage of miscarriage and cervical and caesarean scar ectopic pregnancies. Misdiagnosis can lead to significant maternal morbidity. We describe a pregnancy in a 36-year-old primiparous woman where ultrasound findings of a low-lying gestation sac satisfied criteria for miscarriage; however, dilatation and curettage of pregnancy contents resulted in brisk cervical bleeding. Ultrasound at 6 weeks 6 days of gestation showed an intra-uterine pregnancy of uncertain viability. Repeat scan after 11 days confirmed miscarriage based on an absence of interval progression between scans and no embryonic heartbeat. The collapsed gestational sac (GS) was seen at the level of the internal os with decidual reaction and peri-trophoblastic blood flow. Inferior to the sac, minimally vascular trophoblastic appearing tissue was beginning to distend the upper cervical canal: the sliding sign was positive for the GS and negative for the upper cervical contents. Cervical stroma was clearly seen circumferential to the distending tissue. The patient underwent dilatation and curettage of the uterus complicated by 2000 ml haemorrhage requiring blood transfusion and medical and surgical management with intra-cavitary placement of a Foley catheter. Histopathology confirmed pregnancy tissue with the disruption of cervical epithelium but no true invasion. The patient was counselled to attend a specialist obstetric imaging facility for an early dating ultrasound in future pregnancies. The current body of literature does not describe cases of low-lying gestation sac miscarriage with high-risk features of trophoblastic extension into the cervical canal. We suggest maintaining a high index of suspicion and excluding differential diagnoses as the majority of women have no risk factors for ectopic pregnancy. These cases should be recommended for surgical management.
ABSTRACT
Decreased fetal movements (DFM) are a non-specific and common symptom in the third trimester of pregnancy that hold an association with fetal compromise. A 28-year-old woman at 31 weeks and 3 days of gestation presented with DFM and was found to have a pathological fetal heart rate trace. Following emergency Caesarean section the fetus was diagnosed with transient abnormal myelopoeisis (TAM). Timely treatment was initiated and the neonatal outcome was good. Transient myeloproliferative disorders are almost uniquely found in infants with trisomy 21 (T21). This is the first case report of TAM in the absence of T21 wherein the diagnostic process was commenced antenatally due to non-reassuring fetal status and highlights the importance of antenatal heart rate abnormalities.
ABSTRACT
BACKGROUND: In the investigation of abnormal uterine bleeding, hysteroscopy with endometrial biopsy is considered the gold standard. Fly Thru™ imaging is a new application used to generate virtual hysteroscopy clips. AIMS: We aimed to investigate the feasibility and diagnostic accuracy of sonohysterogram with virtual hysteroscopy as an alternative to outpatient diagnostic hysteroscopy. MATERIALS AND METHODS: Two separate cohorts of women were recruited. The first cohort was to assess feasibility of the application. The second cohort included women recruited to undergo a sonohysterogram, with virtual hysteroscopy, prior to their scheduled outpatient hysteroscopy. Pain scores were recorded after each procedure. RESULTS: Sixteen women were recruited to the feasibility cohort and virtual hysteroscopy post-processing was successfully applied in 14/16 (88%). Clips were produced in less than one minute in 12/16 (75%). Both tubal ostia were identified in 12/16 (75%). Twenty-nine women were enrolled in the correlation cohort with two women excluded as they did not proceed to hysteroscopy according to study protocol. Virtual hysteroscopy, successfully generated in 23/27 women (85%), detected all intra-cavitary pathologies (9/27) detected on outpatient hysteroscopy. Tubal ostia were visualised less often with virtual hysteroscopy (37%) when compared with outpatient hysteroscopy (74%). Sonohysterogram with virtual hysteroscopy was associated with less pain with a median difference in pain score of 2 (interquartile range 1.0-4.0, P < 0.0001). CONCLUSIONS: Sonohysterogram with virtual hysteroscopy is feasible; however, the addition of virtual hysteroscopy to sonohysterogram alone has limited value. Larger studies are required to determine whether it can be used as a diagnostic alternative to outpatient hysteroscopy.