1.
Chembiochem
; 14(1): 132-6, 2013 Jan 02.
Article
in English
| MEDLINE
| ID: mdl-23203902
ABSTRACT
Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea: botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long-standing mystery in the biosynthesis of botcinins.
Subject(s)
Botrytis/genetics , Botrytis/metabolism , Gene Deletion , Lactones/metabolism , Pyrones/metabolism , Lactones/chemistry
2.
Nat Prod Commun
; 6(4): 443-50, 2011 Apr.
Article
in English
| MEDLINE
| ID: mdl-21560756
ABSTRACT
The asymmetric synthesis of key fragments of the phytotoxic toxins botcinolide/botcinin is reported. The synthesis of 1 and 1a are based on a convergent route via esterification and alkene metathesis of fragments A, B or C, B, which were obtained by Evans aldol condensation and stereoselective crotylation, respectively.