ABSTRACT
Dose escalation improves local control in carcinoma prostate, but rectal toxicity remains a concern. Various techniques have been there to reduce the dose to the rectum. Mobility of the prostate results in a necessary expansion of the target volume. We describe a new intrarectal fixative, developed in-house with transrectal ultrasonography through the fixative itself for localization of the organ by reporting a case with early carcinoma prostate. Concerns of rectal toxicity limit dose escalation in the treatment of prostate cancer. Intra- and interfraction prostate motion is a concern in dose conformity techniques. The intrarectal fixative system developed in-house physically separates the prostate and rectum during radiation treatment. Thus, both intra- and inter-fractional movement of the organ are addressed, therefore planning target volume expansion can be kept minimal.
Subject(s)
Carcinoma/radiotherapy , Prostatic Neoplasms/radiotherapy , Radiotherapy Planning, Computer-Assisted , Aged , Carcinoma/diagnostic imaging , Carcinoma/pathology , Dose Fractionation, Radiation , Humans , Male , Prostate/diagnostic imaging , Prostate/pathology , Prostate/radiation effects , Prostatic Neoplasms/diagnostic imaging , Prostatic Neoplasms/pathology , Radiotherapy Dosage , Radiotherapy, Intensity-Modulated/methods , Rectum/diagnostic imaging , Rectum/pathology , Rectum/radiation effects , Tomography, X-Ray ComputedABSTRACT
Extranodal non-Hodgkin lymphomas (NHLs) arising in soft tissue is rare. This study describes a rare case of chemo-resistant large B-cell NHL of skeletal muscle, characterized by voluminous swelling in the thigh which responded well to radiotherapy. In this patient, recurrent NHL showed refractoriness to various chemotherapy regimens and was treated with radiation therapy repeatedly with excellent local response and no evidence of disease for 18 months. Most of the published literature describes surgery or chemotherapy as treatment for NHL soft tissue. This is the first case report describing the durable response with radiation without in-field recurrence in chemo-resistant large B-cell NHL skeletal muscle.
Subject(s)
Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/radiotherapy , Humans , Lymphoma, Non-Hodgkin/pathology , Male , Middle Aged , Thigh/pathology , Thigh/radiation effectsABSTRACT
Skin cancer is rare in India with an incidence of about less than 1% of all cancers. Saree Cancer, a kind of skin cancer is rarer entity, which arises from the frequent abrasion over skin caused by tying the rope in inskirts, often tied tightly so that the saree does not slip. This causes hyperpigmented abrasion, ulcer and then may lead to cancer. This report is about a 40-year-old female with non-healing ulcer of six months duration with rapid increase in size over the past one month. The ulcer measured 4x2 cm in size. The patient underwent excision of the tumour and the margins were positive. Re-excision was done for positive margins and re-growth of the tumour. This is one the first few reports on saree cancer.
