Analysis of lncRNAs in Lupinus mutabilis (Tarwi) and Their Potential Role in Drought Response.

Lupinus mutabilis is a legume with high agronomic potential and available transcriptomic data for which lncRNAs have not been studied. Therefore, our objective was to identify, characterize, and validate the drought-responsive lncRNAs in L. mutabilis. To achieve this, we used a multilevel approach based on lncRNA prediction, annotation, subcellular location, thermodynamic characterization, structural conservation, and validation. Thus, 590 lncRNAs were identified by at least two algorithms of lncRNA identification. Annotation with the PLncDB database showed 571 lncRNAs unique to tarwi and 19 lncRNAs with homology in 28 botanical families including Solanaceae (19), Fabaceae (17), Brassicaceae (17), Rutaceae (17), Rosaceae (16), and Malvaceae (16), among others. In total, 12 lncRNAs had homology in more than 40 species. A total of 67% of lncRNAs were located in the cytoplasm and 33% in exosomes. Thermodynamic characterization of S03 showed a stable secondary structure with -105.67 kcal/mol. This structure included three regions, with a multibranch loop containing a hairpin with a SECIS-like element. Evaluation of the structural conservation by CROSSalign revealed partial similarities between L. mutabilis (S03) and S. lycopersicum (Solyc04r022210.1). RT-PCR validation demonstrated that S03 was upregulated in a drought-tolerant accession of L. mutabilis. Finally, these results highlighted the importance of lncRNAs in tarwi improvement under drought conditions.

[Basilar dolichoectasia and fusiform vertebral artery aneurysm: ischemic stroke of dual cause] / Dolicoectasia basilar y aneurisma fusiforme de arteria vertebral: accidente cerebrovascular isquémico de causa dual.

A 76-year-old woman arrived at the emergency department due to an ischemic stroke that affected the territory of the left anterior choroidal and basilar arteries. Imaging studies showed dolichoectasia basilar associated with a fusiform aneurysm with thrombi inside it in the left vertebral artery. Both anatomic abnormalities are associated with ischemic stroke.

Mujer de 76 años que acudió al servicio de urgencias por un accidente cerebro vascular isquémico que afectó el territorio de arteria coroidea anterior izquierda y basilar. Los estudios de imagen mostraron dolicoectasia basilar asociada a un aneurisma fusiforme con trombos en su interior en la arteria vertebral izquierda. Las dos anomalías anatómicas están asociadas a accidente cerebrovascular isquémico.

Effect of receiving a customizable brochure on breast cancer patients' knowledge about their diagnosis and treatment: A randomized clinical trial.

BACKGROUND: Patients' lack of knowledge about their own disease may function as a barrier to shared decision-making and well-being. This study aimed to evaluate the impact of written educational materials on breast cancer patients. METHODS: This multicenter, parallel, unblinded, randomized trial included Latin American women aged ≥18 years with a recent breast cancer diagnosis yet to start systemic therapy. Participants underwent randomization in a 1:1 ratio to receive a customizable or standard educational brochure. The primary objective was accurate identification of molecular subtype. Secondary objectives included identification of clinical stage, treatment options, participation in decision-making, perceived quality of information received, and illness uncertainty. Follow-up occurred at 7-21 and 30-51 days post-randomization. CLINICALTRIALS: gov identifier: NCT05798312. RESULTS: One hundred sixty-five breast cancer patients with a median age of 53 years and 61 days from diagnosis were included (customizable: 82; standard: 83). At first available assessment, 52%, 48%, and 30% identified their molecular subtype, disease stage, and guideline-endorsed systemic treatment strategy, respectively. Accurate molecular subtype and stage identification were similar between groups. Per multivariate analysis, customizable brochure recipients were more likely to identify their guideline-recommended treatment modalities (OR: 4.20,p = 0.001). There were no differences between groups in the perceived quality of information received or illness uncertainty. Customizable brochure recipients reported increased participation in decision-making (p = 0.042). CONCLUSIONS: Over one third of recently diagnosed breast cancer patients are incognizant of their disease characteristics and treatment options. This study demonstrates a need to improve patient education and shows that customizable educational materials increase patients' understanding of recommended systemic therapies according to individual breast cancer characteristics.

Evaluation of in vitro susceptibility to sparteine in four strains of Mycobacterium tuberculosis. / Evaluación de la susceptibilidad in vitro a esparteína, en cuatro cepas de Mycobacterium tuberculosis.

Sparteine is an alkaloid with bacteriostatic activity on the genus Mycobacterium. The aim of this study was to evaluate the antimicrobial activity of sparteine on the growth of 4 ATCC strains of Mycobacterium tuberculosis (susceptible, resistant to isoniazid, resistant to rifampicin and multidrug-resistant) in vitro. Validation of bactericidal activity of sparteine sulfate was carried out through an adaptation of the Microscopic-Observation Drug-Susceptibility (MODS) method according to the guidelines of the Peruvian National Health Institute. The results demonstrate that at concentrations of 25; 50 and 100 Mm of sparteine sulfate, there is no development of colony-forming units in any of the 4 evaluated strains. Our results demonstrate the potential in vitro antimicrobial effect of sparteine on multidrug-resistant tuberculosis.

La esparteína es un alcaloide con actividad bacteriostática sobre el género Mycobacterium. El objetivo de este trabajo fue evaluar la acción antimicrobiana de la esparteína en el crecimiento de cuatro cepas ATCC de Mycobacterium tuberculosis (susceptible, resistente a isoniazida, resistente a rifampicina y multidrogorresistente) in vitro. La evaluación de la actividad bactericida del sulfato de esparteína se realizó a través de una adaptación del método de ensayo de cultivo y susceptibilidad a medicamentos antituberculosos mediante observación microscópica (MODS, por sus siglas en inglés), según el protocolo descrito en el manual técnico elaborado por el Instituto Nacional de Salud. Los resultados demuestran que a concentraciones de 25; 50 y 100 mM de sulfato de esparteína, no se desarrollan unidades formadoras de colonia en las cuatro cepas evaluadas de Mycobacterium tuberculosis. Los resultados demuestran el potencial efecto antimicrobiano in vitro de la esparteína en la tuberculosis multidrogorresistente.

Prognosis of breast cancer diagnosed during pregnancy and early postpartum according to immunohistochemical subtype: A matched case-control study.

PURPOSE: Pregnancy-associated breast cancer (PABC) poses a clinical challenge and its prognosis remains controversial. During the pregnancy and postpartum periods, the breast undergoes biological events that may uniquely influence disease behavior and treatment response. This study aimed to assess if a PABC diagnosis influences survival compared to non-PABC. METHODS: A single-center record review was performed to identify PABC patients diagnosed from January 2007 through June 2018. Two controls were matched to each PABC case by stage, immunohistochemical (IHC) subtype, age (± 3) and year of diagnosis (± 2). Disease-free survival (DFS) and overall survival (OS) were estimated with the Kaplan-Meier method and compared with the log-rank test. Multivariate analysis was used to assess the impact of PABC on outcomes. RESULTS: 125 PABC patients (pregnant: 62; postpartum: 63) and 250 controls were included. Median follow-up was 67.7 and 73.4 months, respectively. 4-year DFS was 62% in pregnant vs 78% in controls (p = 0.010), and 63% in postpartum vs 83% in controls (p = 0.034). Subanalysis by IHC subtype revealed a significantly inferior DFS in PABC with hormone receptor-positive/HER2-negative (p = 0.032) and HER2-positive disease (p = 0.005) compared to corresponding non-PABC patients. 4-year OS was similar between case groups and controls. Multivariate analysis supported the independent impact of pregnant and postpartum status on DFS (p < 0.05). CONCLUSION: Patients diagnosed during pregnancy and early postpartum are at high risk of recurrence. Further research is warranted to better characterize PABC tumor biology and enable the identification of novel therapeutic interventions to improve treatment outcomes.

Adjuvant endocrine therapy for premenopausal women with breast cancer: Patient adherence and physician prescribing practices in Mexico.

BACKGROUND: In resource-constrained settings, data regarding breast cancer patients' adherence to endocrine therapy (ET) and physicians' prescribing practices is limited. This study aims to decrease this knowledge gap in a real-world clinical practice. METHODS: Premenopausal women with stage 0-III hormone-sensitive breast cancer and receiving adjuvant ET during the past 1-5 years were identified in three Mexican referral centers. Participants' self-reported ET compliance, clinicopathologic characteristics, ET-related knowledge and beliefs, experienced adverse effects, social support, and patient-physician relationships were evaluated. Physician ET prescribing practices were compared with the gold standard according to international and national guidelines to assess clinicians' adherence to standard-of-care prescription. RESULTS: In total, 95/132 (72%) and 35/132 (27%) participants reported complete and acceptable adherence, respectively. Incomplete adherence was mainly attributed to forgetfulness, adverse effects, and unwillingness to take ET. Being employed/studying (p = 0.042), worrying about long-term ET use (p = 0.031), and experiencing >7 ET-related symptoms (p = 0.018) were associated with incomplete adherence. Guideline-endorsed regimens were prescribed in 84/132 (64%) patients, while the rest should have undergone ovarian function suppression (OFS) but instead received tamoxifen monotherapy. CONCLUSIONS: Premenopausal Mexican women self-report remarkably high rates of adequate ET adherence. However, a considerable proportion misses ≥1 doses/month, usually because of forgetfulness. Notably, only 64% receive standard-of-care ET due to suboptimal prescription of OFS. Interventions that remind patients to take their ET, refine physicians' knowledge on the importance of OFS in high-risk patients, and increase access to OFS could prove pivotal to enhance optimal ET implementation and adherence, which could translate into improved patient outcomes.

Clinical utility of genomic signatures in young breast cancer patients: a systematic review.

Risk stratification by genomic signatures has been shown to improve prognostication and guide treatment decisions among patients with hormone-sensitive breast cancer. However, their role in young women has not been fully elucidated. In this review, a systematic search was conducted for published articles and abstracts from major congresses that evaluated the use of genomic signatures in young breast cancer patients. A total of 71 studies were analyzed, including 561,188 patients of whom 27,748 (4.9%) were young. Women aged ≤40 years were subjected to genomic testing at a similar rate to older women but had a higher proportion of intermediate- to high-risk tumors when classified by EndoPredict (p = 0.04), MammaPrint (p < 0.01), and Oncotype DX (p < 0.01). In young women with low genomic risk, 6-year distant recurrence-free survival was 94%, while 5-year overall survival was nearly 100%. Nonetheless, young patients classified as low-risk had a higher tendency to receive chemotherapy compared to their older counterparts. In conclusion, genomic tests are useful tools for identifying young patients in whom chemotherapy omission is appropriate.

Successful Implementation of a Quality Improvement Intervention Toward a QOPI-Certified Breast Cancer Center in Mexico.

INTRODUCTION: As part of a quality improvement (QI) project undertaken during the 2018 edition of the American Society of Clinical Oncology's Quality Training Program (QTP), we evaluated our practice's compliance to 70 measures regarding the Core, Symptom/Toxicity and Breast Cancer modules from the Quality Oncology Practice Initiative (QOPI) database. Thirteen measures were identified as being consistently low in documentation rate in our medical records (MR). METHODS: After establishing a multidisciplinary QI team, we defined to accomplish 100% documentation rate of these 13 QOPI measures in ≥ 80% of the monthly new patient MRs during the 6-month QTP. We designed a Microsoft Word MR template and implemented a new pre-consultation process. Monthly Plan-Do-Study-Act cycles were conducted to assess the performance of the intervention. RESULTS: After the 6-month QI intervention, > 80% of our monthly MRs achieved 100% compliance to the aimed-for 13 QOPI measures. Furthermore, our new pre-consultation process proved to be valuable in facilitating the documentation of data without interfering with the oncology appointment. CONCLUSION: The development of a systematic QI approach effectively enhanced our compliance to 13 QOPI measures over a 6-month period. These results led to the standardization of the current model of care at our institution. To our knowledge, Hospital Zambrano Hellion's Breast Cancer Center is the first Mexican cancer center to pursue a QOPI certified practice.

Prioritization of Patients with Abnormal Breast Findings in the Alerta Rosa Navigation Program to Reduce Diagnostic Delays.

INTRODUCTION: In Mexico, there are considerable health system delays in the diagnosis and treatment initiation of women with breast cancer. Alerta Rosa is a navigation program in Nuevo Leon that aims to reduce barriers that impede the timely management of these patients. PATIENTS AND METHODS: Since December 2017, women who registered to receive medical evaluations by Alerta Rosa were stratified based on their clinical characteristics into three priority groups ("Red," "Yellow," and "Green"). According to the category assigned, patients were scheduled imaging studies and medical appointments with breast specialists on a preferential basis. RESULTS: Up until December 2019, 561 patients were scheduled for medical evaluations. Of them, 59% were classified as "Red," 25% "Yellow," and 16% "Green" priority. The median time from stratification to first medical evaluation was 4, 6, and 7 days, respectively (p = .003). Excluding those who had a prior breast cancer diagnosis, 21 patients were diagnosed by Alerta Rosa, with the initial "Red" priority classification demonstrating a sensitivity of 95% (95% confidence interval [CI], 75.1%-99.9%) and specificity of 42% (95% CI, 37.1%-47.1%) for breast cancer. The median time elapsed from initial patient contact to diagnosis and treatment initiation was 16 days and 39 days, respectively. The majority (72%) of patients were diagnosed at an early stage (0-II). CONCLUSION: This patient prioritization system adequately identified women with different probabilities of having breast cancer. Efforts to replicate similar triage systems in resource-constrained settings where screening programs are ineffective could prove to be beneficial in reducing diagnostic intervals and achieving early-stage diagnoses. IMPLICATIONS FOR PRACTICE: Low- and middle-income countries such as Mexico currently lack the infrastructure to achieve effective breast cancer screening and guarantee prompt access to health care when required. To reduce the disease burden in such settings, strategies targeting early detection are urgently needed. Patient navigation programs aid in the reduction of health system intervals and optimize the use of available resources. This article presents the introduction of a triage system based on initial patient concern. Appointment prioritization proved to be successful at reducing health system intervals and achieving early-stage diagnoses by overcoming barriers that impede early access to quality medical care.

Family context and the physical activity of adolescents: comparing differences. / Contexto familiar e atividade física de adolescentes: cotejando diferenças.

INTRODUCTION: Family context plays an important role with regard to the physical activity (PA) of adolescents. Intense changes in family composition, including an increase of single-parent structures can affect behavior. OBJECTIVE: To estimate the prevalence of PA, between boys and girls of 11-17 years old, and investigate its association with family context variables. METHODS: A cross-sectional population-based study "The BH Health Study" was conducted in two health districts of Belo Horizonte. The outcome was PA (≥ 300 minutes/week), which was created from a score that combined time and frequency of cycling and walking to school and leisure time. The independent variables were family context, sociodemographic characteristics and nutritional status. Poisson regression was used with a robust variance and was stratified by gender. RESULTS: 1,015 adolescents participated, 52.8% of whom were male, with a mean age of 14 (± 1.9) years old. The prevalence of PA was 38.8% for girls and 54.5% for boys. Among girls, the family context variables were not significantly associated with PA. Boys were more active when there was an adult in the household reported who did PA (PR = 1.26; 95%CI 1.02 - 1.55) and when living with a single mother (PR = 1.63; 95%CI 1.01 - 2.63). It was also observed that boys that live with their mother and father (PR=1.90; 95%CI 1.06 - 3.41) or only with their mother (PR = 1.82; 95%CI 1.01 - 3.27) reported did PA more frequently in their free time. CONCLUSION: The presence of an active adult in the household, mainly the mother, appears to be an important factor associated with boys' PA.

INTRODUÇÃO: O contexto familiar desempenha papel importante sobre a prática de atividade física (AF) de adolescentes. As intensas mudanças na composição familiar, com aumento das estruturas monoparentais, podem modular de maneira distinta esse comportamento. OBJETIVO: Estimar a prevalência de AF e associação da sua prática em meninos e meninas de 11 a 17 anos com variáveis de contexto familiar, ajustado por características sociodemográficas e estado nutricional. MÉTODOS: Estudo transversal de base populacional, denominado "Saúde em Beagá", realizado em dois distritos sanitários de Belo Horizonte. O desfecho foi AF ≥ 300 minutos/semana, criado a partir de um escore que combinou tempo e frequência de deslocamento para a escola e AF de lazer. As variáveis do contexto familiar foram: presença dos pais e de adulto ativo no domicílio. Foi utilizada regressão de Poisson com variância robusta, estratificada por sexo. RESULTADOS: Participaram 1.015 adolescentes, sendo 52,8% meninos e idade média de 14 (± 1,9) anos. A prevalência de AF foi de 38,8% para meninas e de 54,5% para meninos. Entre meninas, as variáveis de contexto familiar não foram significativamente associadas à AF. Meninos foram mais ativos quando havia um adulto no domicílio que praticava AF (RP = 1,26; IC95% 1,02 - 1,55) e quando moravam somente com a mãe (RP = 1,63; IC95% 1,01 - 2,63). Observou-se, ainda, que meninos que moravam com mãe e pai (RP = 1,90; IC95% 1,06 - 3,41) ou somente com mãe (RP = 1,82; IC95% 1,01 - 3,27) praticavam em maior frequência AF no seu tempo de lazer. CONCLUSÃO: A presença de adulto no domicílio, em especial a mãe, parece ser importante fator associado à prática de AF de meninos.

Contexto familiar e atividade física de adolescentes: cotejando diferenças / Family context and the physical activity of adolescents: comparing differences

RESUMO: Introdução: O contexto familiar desempenha papel importante sobre a prática de atividade física (AF) de adolescentes. As intensas mudanças na composição familiar, com aumento das estruturas monoparentais, podem modular de maneira distinta esse comportamento. Objetivo: Estimar a prevalência de AF e associação da sua prática em meninos e meninas de 11 a 17 anos com variáveis de contexto familiar, ajustado por características sociodemográficas e estado nutricional. Métodos: Estudo transversal de base populacional, denominado "Saúde em Beagá", realizado em dois distritos sanitários de Belo Horizonte. O desfecho foi AF ≥ 300 minutos/semana, criado a partir de um escore que combinou tempo e frequência de deslocamento para a escola e AF de lazer. As variáveis do contexto familiar foram: presença dos pais e de adulto ativo no domicílio. Foi utilizada regressão de Poisson com variância robusta, estratificada por sexo. Resultados: Participaram 1.015 adolescentes, sendo 52,8% meninos e idade média de 14 (± 1,9) anos. A prevalência de AF foi de 38,8% para meninas e de 54,5% para meninos. Entre meninas, as variáveis de contexto familiar não foram significativamente associadas à AF. Meninos foram mais ativos quando havia um adulto no domicílio que praticava AF (RP = 1,26; IC95% 1,02 - 1,55) e quando moravam somente com a mãe (RP = 1,63; IC95% 1,01 - 2,63). Observou-se, ainda, que meninos que moravam com mãe e pai (RP = 1,90; IC95% 1,06 - 3,41) ou somente com mãe (RP = 1,82; IC95% 1,01 - 3,27) praticavam em maior frequência AF no seu tempo de lazer. Conclusão: A presença de adulto no domicílio, em especial a mãe, parece ser importante fator associado à prática de AF de meninos.

ABSTRACT: Introduction: Family context plays an important role with regard to the physical activity (PA) of adolescents. Intense changes in family composition, including an increase of single-parent structures can affect behavior. Objective: To estimate the prevalence of PA, between boys and girls of 11-17 years old, and investigate its association with family context variables. Methods: A cross-sectional population-based study "The BH Health Study" was conducted in two health districts of Belo Horizonte. The outcome was PA (≥ 300 minutes/week), which was created from a score that combined time and frequency of cycling and walking to school and leisure time. The independent variables were family context, sociodemographic characteristics and nutritional status. Poisson regression was used with a robust variance and was stratified by gender. Results: 1,015 adolescents participated, 52.8% of whom were male, with a mean age of 14 (± 1.9) years old. The prevalence of PA was 38.8% for girls and 54.5% for boys. Among girls, the family context variables were not significantly associated with PA. Boys were more active when there was an adult in the household reported who did PA (PR = 1.26; 95%CI 1.02 - 1.55) and when living with a single mother (PR = 1.63; 95%CI 1.01 - 2.63). It was also observed that boys that live with their mother and father (PR=1.90; 95%CI 1.06 - 3.41) or only with their mother (PR = 1.82; 95%CI 1.01 - 3.27) reported did PA more frequently in their free time. Conclusion: The presence of an active adult in the household, mainly the mother, appears to be an important factor associated with boys' PA.

Leisure-time physical activity in the vicinity of Academias da Cidade Program in Belo Horizonte, Minas Gerais State, Brazil: the impact of a health promotion program on the community.

This study analyzed leisure-time physical activity among 1,621 adults who were non-users of the Academias da Cidade Program in Belo Horizonte, Minas Gerais State, Brazil, but who lived in the vicinity of a fitness center in operation (exposed Group I) or in the vicinity of two sites reserved for future installation of centers (control Groups II and III). The dependent variable was leisure-time physical activity, and linear distance from the households to the fitness centers was the exposure variable, categorized in radial buffers: < 500m; 500-1,000m; and 1,000-1,500m. Binary logistic regression was performed with the Generalized Estimation Equations method. Residents living within < 500m of the fitness center gave better ratings to the physical environment when compared to those living in the 1,000 and 1,500m buffers and showed higher odds of leisure-time physical activity (OR = 1.16; 95%CI: 1.03-1.30), independently of socio-demographic factors; the same was not observed in the control groups (II and III). The findings suggests the program's potential for influencing physical activity in the population living closer to the fitness center and thus provide a strategic alternative for mitigating inequalities in leisure-time physical activity.

Leisure-time physical activity in the vicinity of Academias da Cidade Program in Belo Horizonte, Minas Gerais State, Brazil: the impact of a health promotion program on the community / La actividad física de ocio en las áreas del Programa Academias da Cidade, Belo Horizonte, Minas Gerais, Brasil: el efecto de la presencia de un programa de promoción de la salud en la comunidad / Atividade física de lazer no território das Academias da Cidade, Belo Horizonte, Minas Gerais, Brasil: o efeito da presença de um programa de promoção da saúde na comunidade

Abstract This study analyzed leisure-time physical activity among 1,621 adults who were non-users of the Academias da Cidade Program in Belo Horizonte, Minas Gerais State, Brazil, but who lived in the vicinity of a fitness center in operation (exposed Group I) or in the vicinity of two sites reserved for future installation of centers (control Groups II and III). The dependent variable was leisure-time physical activity, and linear distance from the households to the fitness centers was the exposure variable, categorized in radial buffers: < 500m; 500-1,000m; and 1,000-1,500m. Binary logistic regression was performed with the Generalized Estimation Equations method. Residents living within < 500m of the fitness center gave better ratings to the physical environment when compared to those living in the 1,000 and 1,500m buffers and showed higher odds of leisure-time physical activity (OR = 1.16; 95%CI: 1.03-1.30), independently of socio-demographic factors; the same was not observed in the control groups (II and III). The findings suggests the program’s potential for influencing physical activity in the population living closer to the fitness center and thus provide a strategic alternative for mitigating inequalities in leisure-time physical activity.

Resumen El estudio investigó la actividad física de ocio de 1.621 adultos, como usuarios del Programa Academias da Cidade de Belo Horizonte, Minas Gerais, Brasil, y residentes en las proximidades de una zona con presencia del Programa, con un grupo de intervención (Grupo I), y dos zonas con espacios reservados para su construcción, así como grupos no-intervención (Grupos II y III). La variable dependiente fue la actividad física de ocio y la distancia euclidiana de los hogares en relación con la zona; la variable de exposición principal fue categorizada en buffers: < 500; 500-1.000m; 1.000-1.500m. Se utilizó la regresión logística binaria por ecuaciones de estimación generalizadas. Los residentes en el buffer < 500m de la intervención evaluaron mejor los atributos del medio ambiente y, en comparación con los residentes 1.000-1.500m, eran más propensos a ser activos en su tiempo libre (OR = 1,16; IC95: 1,03-1,30), independientemente de los factores socio-demográficos; la misma asociación no fue observada en los Grupos II y III. Los resultados sugieren el potencial del programa para influir en la práctica de actividad física de ocio de la población más cercana a la intervención.

Resumo O estudo investigou a atividade física no lazer de 1.621 adultos não-usuários o Programa Academias da Cidade de Belo Horizonte, Minas Gerais, Brasil, e de residentes no entorno de um polo do Programa, Grupo Intervenção (Grupo I), e de dois polos com locais reservados para sua construção, grupos sem intervenção (Grupos II e III . A variável dependente foi atividade física no lazer, e a distância euclidiana dos domicílios em relação ao polo, principal variável de exposição, foi categorizada nos buffers: < 500m; 500-1.000m; 1.000-1.500m. A regressão logística binária foi realizada pelo método Generalized Estimation Equations. Residentes no raio < 500m da intervenção avaliaram melhor os atributos do ambiente e, quando comparados aos residentes de 1.000-1.500m, apresentaram maior chance de serem ativos no lazer (OR = 1,16; IC95%: 1,03-1,30), independentemente dos fatores sociodemográficos; o mesmo não foi observado nos Grupos II e III. Os resultados sugerem a potencialidade do programa em influenciar a prática de atividade física no lazer da população residente mais próxima à intervenção sendo, portanto, estratégico na mitigação de iniquidades em atividade física.

Validity of data collected by telephone survey: a comparison of VIGITEL 2008 and 'Saúde em Beagá' survey.

OBJECTIVE: To assess the validity of the estimates obtained through telephone survey and to measure the impact of the post-stratification weighting factor to adjust estimates. METHODS: The same questionnaire was completed by two independent samples of the population living in the municipality of Belo Horizonte city (Barreiro and West regions). One sample (n=440) completed the questionnaire of VIGITEL 2008 (telephone survey), and the other (n=4,048) of Saúde em Beagá (face to face household interview). The results of the two samples for 18 health-related variables were compared by means of test statistics. At first, residents who had a landline telephone line were compared to those who reported not having a telephone line; then, VIGITEL estimates, with and without post-stratification weight, were compared with Saúde em Beagá estimates. RESULTS: Subjects who owned a landline telephone line had indicators for better economic conditions (housing, schooling, and skin color); higher prevalence of chronic diseases; lower exposure to risk factors for chronic diseases; and improved access to health services, compared to the those who reported not having a telephone line. Most VIGITEL estimates (without post-stratification weight) were similar to the sample of Saúde em Beagá that reported owning a residential landline, showing no major impact of the methodology to obtain this data (lower information bias). Even without post-stratification weight, VIGITEL estimates were similar to those of Saúde em Beagá. With post-stratification weight, the estimates of "number of residents", "skin color" and "physical activity" did not differ from those obtained by the face to face survey. CONCLUSION: The results of both surveys were very similar. Because of the lower cost, the telephone interview is a good option in public health for the behavioral risk-factor surveillance system.

Validade de estimativas obtidas por inquérito telefônico: comparação entre VIGITEL 2008 e inquérito Saúde em Beagá / Validity of data collected by telephone survey: a comparison of VIGITEL 2008 and 'Saúde em Beagá' survey

OBJETIVO: Verificar a validade externa das estimativas obtidas por inquérito telefônico, e o impacto do uso do fator de ponderação pós-estratificação na correção das estimativas. MÉTODOS: Foram utilizadas informações de moradores das regiões Oeste e Barreiro de Belo Horizonte (MG), obtidas por inquérito telefônico VIGITEL 2008 (n=440) e por inquérito domiciliar, realizado face a face, Saúde em Beagá (SB) (n=4.048). Estimativas de variáveis relevantes para vigilância epidemiológica foram comparadas entre os estudos, por meio das estatísticas de teste. Inicialmente, compararam-se grupos segundo a posse de linha telefônica fixa e em seguida as estimativas do VIGITEL, com e sem a utilização de peso pós-estratificação, com as estimativas do SB. RESULTADOS: Indivíduos que possuíam telefone fixo residencial apresentaram marcadores de melhores condições econômicas (local de moradia, escolaridade e cor de pele), maior prevalência de doenças crônicas não transmissíveis (DCNT), menor exposição a fatores de risco para DCNT e maior acesso/utilização de serviços de saúde, quando comparados aos demais. A maioria das estimativas do VIGITEL (sem o uso do peso pós-estratificação) foi semelhante às estimativas para a amostra do SB que referiu ter telefone fixo residencial, demonstrando não haver grande impacto da metodologia utilizada na obtenção dos dados (reduzido viés de informação). Mesmo sem utilizar o fator de pós-estratificação, as estimativas do VIGITEL se assemelharam às do SB; após a ponderação, as poucas estimativas viciadas (número de moradores, cor de pele e atividade física) não diferiram mais das obtidas pelo inquérito face a face exceto para a variável "ter plano de saúde", cuja correção da estimativa reduziu a diferença observada, e para as variáveis "consumo de verduras/legumes" e "tabagismo atual", em que não foi possível corrigir as estimativas. CONCLUSÃO: Recomenda-se a vigilância epidemiológica de DCNT por meio de inquéritos telefônicos porque fornecem estimativas aproximadas do que seria esperado para a população total, com menores investimentos financeiros e menor tempo.

OBJECTIVE: To assess the validity of the estimates obtained through telephone survey and to measure the impact of the post-stratification weighting factor to adjust estimates. METHODS: The same questionnaire was completed by two independent samples of the population living in the municipality of Belo Horizonte city (Barreiro and West regions). One sample (n=440) completed the questionnaire of VIGITEL 2008 (telephone survey), and the other (n=4,048) of Saúde em Beagá (face to face household interview). The results of the two samples for 18 health-related variables were compared by means of test statistics. At first, residents who had a landline telephone line were compared to those who reported not having a telephone line; then, VIGITEL estimates, with and without post-stratification weight, were compared with Saúde em Beagá estimates. RESULTS: Subjects who owned a landline telephone line had indicators for better economic conditions (housing, schooling, and skin color); higher prevalence of chronic diseases; lower exposure to risk factors for chronic diseases; and improved access to health services, compared to the those who reported not having a telephone line. Most VIGITEL estimates (without post-stratification weight) were similar to the sample of Saúde em Beagá that reported owning a residential landline, showing no major impact of the methodology to obtain this data (lower information bias). Even without post-stratification weight, VIGITEL estimates were similar to those of Saúde em Beagá. With post-stratification weight, the estimates of "number of residents", "skin color" and "physical activity" did not differ from those obtained by the face to face survey. CONCLUSION: The results of both surveys were very similar. Because of the lower cost, the telephone interview is a good option in public health for the behavioral risk-factor surveillance system.