ABSTRACT
Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, the alarms issued by regulatory agencies and therapeutic alternatives. (AU)
Las fluoroquinolonas son una de las clases de antibióticos más prescritas. Aunque inicialmente fueron bien toleradas en ensayos clínicos aleatorizados, estudios epidemiológicos posteriores han informado de un mayor riesgo de efectos adversos efectos adversos amenazantes, graves, duraderos, incapacitantes e irreversibles, relacionados con la neurotoxicidad y la degradación del colágeno, como tendinitis, rotura del tendón de Aquiles, aneurisma aórtico y desprendimiento de retina. Este artículo repasa los principales efectos adversos potencialmente amenazadores, las alarmas emitidas por las agencias reguladoras y las alternativas terapéuticas. (AU)
Subject(s)
Humans , Fluoroquinolones/adverse effects , Fluoroquinolones/pharmacology , Retinal Detachment , Aortic Aneurysm , Anti-Bacterial Agents , Epidemiologic StudiesABSTRACT
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Subject(s)
Humans , Male , Female , Middle Aged , Aged , Coronavirus Infections/complications , Pneumonia, Viral/complications , Pandemics , Mediastinal Emphysema/virology , Mediastinal Emphysema/diagnostic imagingSubject(s)
Betacoronavirus , Coronavirus Infections/complications , Mediastinal Emphysema/etiology , Pneumonia, Viral/complications , Aged , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/methods , Coronavirus Infections/diagnosis , Fatal Outcome , Female , Humans , Male , Mediastinal Emphysema/diagnostic imaging , Middle Aged , Pandemics , Pneumonia, Viral/diagnosis , Radiography, Thoracic , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2 , Tomography, X-Ray ComputedABSTRACT
Metastatic vertebral compression fractures pose a significant clinical problem to cancer patients including pain, spinal deformity, and neurologic deficit. Treatment of metastases to the spine is complex and challenging and may require local and systemic therapies. Percutaneous vertebroplasty (PVP) was adopted to treat spinal metastases since its introduction during the late 1980s. The main indications for PVP in the treatment of spinal metastases are analgesia and spinal stabilization. Complications of PVP in malignant compression fractures are more common than in nonmalignant ones. We present 1 case of tumor seeding along the needle tract of a breast cancer patient who had undergone PVP.