Procura-PALavras (P-PAL): A Web-based interface for a new European Portuguese lexical database.

In this article, we present Procura-PALavras (P-PAL), a Web-based interface for a new European Portuguese (EP) lexical database. Based on a contemporary printed corpus of over 227 million words, P-PAL provides a broad range of word attributes and statistics, including several measures of word frequency (e.g., raw counts, per-million word frequency, logarithmic Zipf scale), morpho-syntactic information (e.g., parts of speech [PoSs], grammatical gender and number, dominant PoS, and frequency and relative frequency of the dominant PoS), as well as several lexical and sublexical orthographic (e.g., number of letters; consonant-vowel orthographic structure; density and frequency of orthographic neighbors; orthographic Levenshtein distance; orthographic uniqueness point; orthographic syllabification; and trigram, bigram, and letter type and token frequencies), and phonological measures (e.g., pronunciation, number of phonemes, stress, density and frequency of phonological neighbors, transposed and phonographic neighbors, syllabification, and biphone and phone type and token frequencies) for ~53,000 lemmatized and ~208,000 nonlemmatized EP word forms. To obtain these metrics, researchers can choose between two word queries in the application: (i) analyze words previously selected for specific attributes and/or lexical and sublexical characteristics, or (ii) generate word lists that meet word requirements defined by the user in the menu of analyses. For the measures it provides and the flexibility it allows, P-PAL will be a key resource to support research in all cognitive areas that use EP verbal stimuli. P-PAL is freely available at http://p-pal.di.uminho.pt/tools .

Emotional self-other voice processing in schizophrenia and its relationship with hallucinations: ERP evidence.

Abnormalities in self-other voice processing have been observed in schizophrenia, and may underlie the experience of hallucinations. More recent studies demonstrated that these impairments are enhanced for speech stimuli with negative content. Nonetheless, few studies probed the temporal dynamics of self versus nonself speech processing in schizophrenia and, particularly, the impact of semantic valence on self-other voice discrimination. In the current study, we examined these questions, and additionally probed whether impairments in these processes are associated with the experience of hallucinations. Fifteen schizophrenia patients and 16 healthy controls listened to 420 prerecorded adjectives differing in voice identity (self-generated [SGS] versus nonself speech [NSS]) and semantic valence (neutral, positive, and negative), while EEG data were recorded. The N1, P2, and late positive potential (LPP) ERP components were analyzed. ERP results revealed group differences in the interaction between voice identity and valence in the P2 and LPP components. Specifically, LPP amplitude was reduced in patients compared with healthy subjects for SGS and NSS with negative content. Further, auditory hallucinations severity was significantly predicted by LPP amplitude: the higher the SAPS "voices conversing" score, the larger the difference in LPP amplitude between negative and positive NSS. The absence of group differences in the N1 suggests that self-other voice processing abnormalities in schizophrenia are not primarily driven by disrupted sensory processing of voice acoustic information. The association between LPP amplitude and hallucination severity suggests that auditory hallucinations are associated with enhanced sustained attention to negative cues conveyed by a nonself voice.

Is this my voice or yours? The role of emotion and acoustic quality in self-other voice discrimination in schizophrenia.

INTRODUCTION: Impairments in self-other voice discrimination have been consistently reported in schizophrenia, and associated with the severity of auditory verbal hallucinations (AVHs). This study probed the interactions between voice identity, voice acoustic quality, and semantic valence in a self-other voice discrimination task in schizophrenia patients compared with healthy subjects. The relationship between voice identity discrimination and AVH severity was also explored. METHODS: Seventeen chronic schizophrenia patients and 19 healthy controls were asked to read aloud a list of adjectives characterised by emotional or neutral content. Participants' voice was recorded in the first session. In the behavioural task, 840 spoken words differing in identity (self/non-self), acoustic quality (undistorted/distorted), and semantic valence (negative/positive/neutral) were presented. Participants indicated if the words were spoken in their own voice, another person's voice, or were unsure. RESULTS: Patients were less accurate than controls in the recognition of self-generated speech with negative content only. Impaired recognition of negative self-generated speech was associated with AVH severity ("voices conversing"). CONCLUSIONS: These results suggest that abnormalities in higher order processes (evaluation of the salience of a speech stimulus) modulate impaired self-other voice discrimination in schizophrenia. Abnormal processing of negative self-generated speech may play a role in the experience of AVH.

Did you or I say pretty, rude or brief? An ERP study of the effects of speaker's identity on emotional word processing.

During speech comprehension, multiple cues need to be integrated at a millisecond speed, including semantic information, as well as voice identity and affect cues. A processing advantage has been demonstrated for self-related stimuli when compared with non-self stimuli, and for emotional relative to neutral stimuli. However, very few studies investigated self-other speech discrimination and, in particular, how emotional valence and voice identity interactively modulate speech processing. In the present study we probed how the processing of words' semantic valence is modulated by speaker's identity (self vs. non-self voice). Sixteen healthy subjects listened to 420 prerecorded adjectives differing in voice identity (self vs. non-self) and semantic valence (neutral, positive and negative), while electroencephalographic data were recorded. Participants were instructed to decide whether the speech they heard was their own (self-speech condition), someone else's (non-self speech), or if they were unsure. The ERP results demonstrated interactive effects of speaker's identity and emotional valence on both early (N1, P2) and late (Late Positive Potential - LPP) processing stages: compared with non-self speech, self-speech with neutral valence elicited more negative N1 amplitude, self-speech with positive valence elicited more positive P2 amplitude, and self-speech with both positive and negative valence elicited more positive LPP. ERP differences between self and non-self speech occurred in spite of similar accuracy in the recognition of both types of stimuli. Together, these findings suggest that emotion and speaker's identity interact during speech processing, in line with observations of partially dependent processing of speech and speaker information.

Abnormalities in the processing of emotional prosody from single words in schizophrenia.

BACKGROUND: Abnormalities in emotional prosody processing have been consistently reported in schizophrenia and are related to poor social outcomes. However, the role of stimulus complexity in abnormal emotional prosody processing is still unclear. METHOD: We recorded event-related potentials in 16 patients with chronic schizophrenia and 16 healthy controls to investigate: 1) the temporal course of emotional prosody processing; and 2) the relative contribution of prosodic and semantic cues in emotional prosody processing. Stimuli were prosodic single words presented in two conditions: with intelligible (semantic content condition-SCC) and unintelligible semantic content (pure prosody condition-PPC). RESULTS: Relative to healthy controls, schizophrenia patients showed reduced P50 for happy PPC words, and reduced N100 for both neutral and emotional SCC words and for neutral PPC stimuli. Also, increased P200 was observed in schizophrenia for happy prosody in SCC only. Behavioral results revealed higher error rates in schizophrenia for angry prosody in SCC and for happy prosody in PPC. CONCLUSIONS: Together, these data further demonstrate the interactions between abnormal sensory processes and higher-order processes in bringing about emotional prosody processing dysfunction in schizophrenia. They further suggest that impaired emotional prosody processing is dependent on stimulus complexity.

The interplay of phonology and orthography in visual cognate word recognition: an ERP study.

This study examined the role of phonological and orthographic overlap in the recognition of cognate words by recording electrophysiological and behavioral data. One hundred and ninety-two words were selected: 96 cognate words listed according to their phonological and orthographic overlap vs. 96 noncognate words. Twenty-four proficient European Portuguese-English bilinguals performed a silent reading task with a masked priming paradigm. The results showed that phonology interacts with semantic activation at N400 modulations. Phonological priming effects were dependent on the orthographic overlap of cognate words. Thus, the distinctive processing of cognate words seems to be due to their cross-linguistic similarity, which is consistent with a localist connectionist account on cognate representation and processing.

Correlação entre achados ecográficos e histopatológicos em lesões mamárias

O presente estudo tem por objetivo correlacionar as categorias de BI-RADS das imagens ecográficas aos achados histopatológicos nos casos submetidos a CB em nossa instituição. Paralelamente também se espera demonstrar a acurácia diagnóstica da classificação de BI-RADS ecográfico, tendo o exame anatomopatológico da biópsia como padrão-ouro.

Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study.

Williams syndrome (WS), a neurodevelopmental genetic disorder due to a microdeletion in chromosome 7, is described as displaying an intriguing socio-cognitive phenotype. Deficits in prosody production and comprehension have been consistently reported in behavioral studies. It remains, however, to be clarified the neurobiological processes underlying prosody processing in WS. This study aimed at characterizing the electrophysiological response to neutral, happy, and angry prosody in WS, and examining if this response was dependent on the semantic content of the utterance. A group of 12 participants (5 female and 7 male), diagnosed with WS, with age range between 9 and 31 years, was compared with a group of typically developing participants, individually matched for chronological age, gender and laterality. After inspection of EEG artifacts, data from 9 participants with WS and 10 controls were included in ERP analyses. Participants were presented with neutral, positive and negative sentences, in two conditions: (1) with intelligible semantic and syntactic information; (2) with unintelligible semantic and syntactic information ('pure prosody' condition). They were asked to decide which emotion was underlying the auditory sentence. Atypical event-related potentials (ERP) components were related with prosodic processing (N100, P200, N300) in WS. In particular, reduced N100 was observed for prosody sentences with semantic content; more positive P200 for sentences with semantic content, in particular for happy and angry intonations; and reduced N300 for both types of sentence conditions. These findings suggest abnormalities in early auditory processing, indicating a bottom-up contribution to the impairment in emotional prosody processing and comprehension. Also, at least for N100 and P200, they suggest the top-down contributions of semantic processes in the sensory processing of speech. This study showed, for the first time, that abnormalities in ERP measures of early auditory processing in WS are also present during the processing of emotional vocal information. This may represent a physiological signature of underlying impaired on-line language and socio-emotional processing.

A cross-dialect acoustic description of vowels: Brazilian and European Portuguese.

This paper examines four acoustic correlates of vowel identity in Brazilian Portuguese (BP) and European Portuguese (EP): first formant (F1), second formant (F2), duration, and fundamental frequency (F0). Both varieties of Portuguese display some cross-linguistically common phenomena: vowel-intrinsic duration, vowel-intrinsic pitch, gender-dependent size of the vowel space, gender-dependent duration, and a skewed symmetry in F1 between front and back vowels. Also, the average difference between the vocal tract sizes associated with /i/ and /u/, as measured from formant analyses, is comparable to the average difference between male and female vocal tract sizes. A language-specific phenomenon is that in both varieties of Portuguese the vowel-intrinsic duration effect is larger than in many other languages. Differences between BP and EP are found in duration (BP has longer stressed vowels than EP), in F1 (the lower-mid front vowel approaches its higher-mid counterpart more closely in EP than in BP), and in the size of the intrinsic pitch effect (larger for BP than for EP).