Subject(s)
IgA Vasculitis/diagnosis , Myelodysplastic Syndromes/diagnosis , Polychondritis, Relapsing/diagnosis , Skin Diseases, Genetic/diagnosis , Aged , Humans , IgA Vasculitis/complications , Male , Mutation, Missense , Myelodysplastic Syndromes/genetics , Polychondritis, Relapsing/complications , Skin Diseases, Genetic/genetics , Ubiquitin-Activating Enzymes/geneticsABSTRACT
Identifying serum pre-treatment molecular markers that can predict response to therapy is of great interest in head and neck oncology and is required to develop personalized treatments that maximize survival while minimizing morbidity. The main aim was to investigate the potential prognostic significance of tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and its receptors, fibroblast growth factor-inducible 14 (Fn14) and CD163, in head and neck squamous cell carcinoma (HNSCC). The study comprised 37 consecutive patients with pathologically confirmed, untreated HNSCC. Serum and tissue samples from these patients were available for study. We determined sTWEAK and sCD163 levels in serum from 37 HNSCC patients by ELISA. TWEAK, CD163, Fn14 and TNF-α gene expression were detected by real-time RT-PCR in 111 matched tissue samples (tumoral, adjacent and distal/normal mucosa). Our results showed a significant relationship between low sTWEAK levels and poor locoregional control of the disease. Kaplan-Meier curves indicated that the locoregional recurrence-free survival rate in patients with low sTWEAK circulating levels was significantly lower than in patients with high levels, and that high CD136/TWEAK expression ratio in tumors was also related to poor prognosis. sTWEAK pre-treatment serum levels might be used as prognostic non-invasive biomarkers for locoregional control in patients with HNSCC. Future investigations are warranted to determine the potential prognostic significance of this non-invasive biomarker in the rapid discrimination according to the locoregional control achieved in patients who received a non-surgical organ preservation treatment.
Subject(s)
Antigens, CD/blood , Antigens, Differentiation, Myelomonocytic/blood , Carcinoma, Squamous Cell , Drug Resistance, Neoplasm/genetics , Head and Neck Neoplasms , Neoplasm Recurrence, Local , Receptors, Cell Surface/blood , Receptors, Tumor Necrosis Factor , Tumor Necrosis Factor-alpha/blood , Tumor Necrosis Factors/blood , Aged , Apoptosis/genetics , Biomarkers/blood , Carcinoma, Squamous Cell/blood , Carcinoma, Squamous Cell/genetics , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/therapy , Cytokine TWEAK , Female , Gene Expression Profiling , Head and Neck Neoplasms/blood , Head and Neck Neoplasms/genetics , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/therapy , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Neoplasm Recurrence, Local/genetics , Neoplasm Staging , Prognosis , Receptors, Tumor Necrosis Factor/blood , Receptors, Tumor Necrosis Factor/genetics , Squamous Cell Carcinoma of Head and Neck , TWEAK ReceptorABSTRACT
Myofibroblastoma of the breast is a rare, benign mesenchymal tumor derived from the stroma and tends to occur mainly in middle-aged to elderly men. There are a few cases reported in the literature describing its cytological features. We report the cytological and histological findings of a breast myofibroblastoma in a 68-year-old man. He presented with a palpable nodule of 2-months duration in his left breast. The cytological smears obtained by fine needle aspiration showed less cohesive cellularity in a fascicular arrangement consisting of spindle cells with elongated cytoplasm, occasional nuclear grooves, and intranuclear cytoplasmic inclusions associated to fragments of stromal collagen. The cytological diagnosis was a mesenchymal proliferation suggesting the possibility of myofibroblastoma which was confirmed on histopathological examination. The breast myofibroblastoma has distinctive cytological features that in conjunction with the clinical and radiological data allow a specific diagnosis.
Subject(s)
Breast Neoplasms, Male/diagnosis , Breast Neoplasms, Male/pathology , Neoplasms, Muscle Tissue/diagnosis , Neoplasms, Muscle Tissue/pathology , Aged , Biopsy, Fine-Needle , Breast Neoplasms, Male/diagnostic imaging , Histocytochemistry , Humans , Male , Neoplasms, Muscle Tissue/diagnostic imaging , UltrasonographyABSTRACT
Intrauterine intussusception is an uncommon cause of intestinal atresia. We report a case of ileal atresia owing to antenatal intussusception revealed as an intraluminal polypoid lesion after surgical intervention.
Subject(s)
Fetal Diseases/diagnosis , Fetal Diseases/epidemiology , Ileal Diseases/etiology , Ileum/abnormalities , Intestinal Atresia/etiology , Intussusception/diagnosis , Intussusception/epidemiology , Female , Humans , Ileal Diseases/diagnosis , Ileal Diseases/embryology , Infant, Newborn , Intestinal Atresia/diagnosis , Intestinal Atresia/embryology , Intestinal Obstruction/etiology , Intussusception/embryology , Male , Pregnancy , Ultrasonography, PrenatalABSTRACT
BACKGROUND: Home treatment of patients with acute deep vein thrombosis (DVT) leads to cost savings and improved quality of life. However, little information is known about what influences the clinical outcome in these patients. METHODS: The Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) is an ongoing registry of consecutive patients with symptomatic, objectively confirmed, acute DVT or pulmonary embolism (PE). In this analysis evaluated the clinical outcome Subject(s)
Fibrinolytic Agents/therapeutic use
, Hemorrhage/etiology
, Pulmonary Embolism/etiology
, Registries
, Venous Thrombosis/drug therapy
, Aged
, Angiography
, Female
, Fibrinolytic Agents/adverse effects
, Follow-Up Studies
, Hemorrhage/epidemiology
, Humans
, Incidence
, Male
, Outpatients
, Prognosis
, Pulmonary Embolism/epidemiology
, Retrospective Studies
, Risk Factors
, Survival Rate
, Tomography, X-Ray Computed
, Venous Thrombosis/complications
, Venous Thrombosis/diagnosis
Subject(s)
Cholesterol , Pericardial Effusion/etiology , Pericarditis, Constrictive/etiology , Biopsy , Cholesterol/analysis , Crystallization , Follow-Up Studies , Humans , Male , Middle Aged , Pericardial Effusion/chemistry , Pericardiectomy , Pericardiocentesis , Pericarditis, Constrictive/diagnosis , Pericarditis, Constrictive/pathology , Pericarditis, Constrictive/surgery , Pericardium/pathology , Time Factors , Treatment OutcomeSubject(s)
Actinomyces/isolation & purification , Actinomycosis/diagnosis , Maxillary Sinusitis/microbiology , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/diagnostic imaging , AIDS-Related Opportunistic Infections/microbiology , Actinomycosis/diagnostic imaging , Actinomycosis/microbiology , Acute Disease , Adult , Female , Humans , Maxillary Sinusitis/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
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